KEGG   PATHWAY: smw00230
Entry
smw00230                    Pathway                                
Name
Purine metabolism - Serratia marcescens WW4
Class
Metabolism; Nucleotide metabolism
Pathway map
smw00230  Purine metabolism
smw00230

Module
smw_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:smw00230]
smw_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:smw00230]
smw_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:smw00230]
smw_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:smw00230]
smw_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:smw00230]
Other DBs
GO: 0006163 0042278
Organism
Serratia marcescens WW4 [GN:smw]
Gene
SMWW4_v1c01670  gpp; guanosine pentaphosphatase/exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
SMWW4_v1c01880  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
SMWW4_v1c02980  purD; phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase [KO:K01945] [EC:6.3.4.13]
SMWW4_v1c02990  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
SMWW4_v1c03780  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
SMWW4_v1c03950  cpdB; 2':3'-cyclic-nucleotide 2'-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
SMWW4_v1c04710  nrdD; anaerobic ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
SMWW4_v1c04990  [KO:K01081] [EC:3.1.3.5]
SMWW4_v1c06540  deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
SMWW4_v1c06550  deoD; purine-nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
SMWW4_v1c06690  yjjX; inosine/xanthosine triphosphatase [KO:K01529]
SMWW4_v1c07080  apaH; diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
SMWW4_v1c07610  guaC; GMP reductase [KO:K00364] [EC:1.7.1.7]
SMWW4_v1c07740  dgt; deoxyguanosine triphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
SMWW4_v1c07780  relA; (p)ppGpp synthetase I/GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
SMWW4_v1c07790  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
SMWW4_v1c07970  cysD; sulfate adenylyltransferase, subunit 2 [KO:K00957] [EC:2.7.7.4]
SMWW4_v1c07980  cysN; sulfate adenylyltransferase, subunit 1 [KO:K00956] [EC:2.7.7.4]
SMWW4_v1c07990  cysC; adenosine 5'-phosphosulfate kinase [KO:K00860] [EC:2.7.1.25]
SMWW4_v1c08080  surE; broad specificity 5'(3')-nucleotidase and polyphosphatase [KO:K03787] [EC:3.1.3.5 3.1.3.6]
SMWW4_v1c08500  [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
SMWW4_v1c08640  [KO:K00839] [EC:2.6.1.112]
SMWW4_v1c08650  [KO:K02083] [EC:3.5.3.9]
SMWW4_v1c08890  gpt; guanine-hypoxanthine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
SMWW4_v1c09890  [KO:K09913] [EC:2.4.2.1 2.4.2.2]
SMWW4_v1c10730  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
SMWW4_v1c10780  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
SMWW4_v1c10830  gsk; inosine/guanosine kinase [KO:K00892] [EC:2.7.1.73]
SMWW4_v1c10860  ushA; bifunctional UDP-sugar hydrolase/5'-nucleotidase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
SMWW4_v1c11090  allA; ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
SMWW4_v1c11160  [KO:K14977] [EC:3.5.3.26]
SMWW4_v1c11180  allC; allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
SMWW4_v1c11190  allD; ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
SMWW4_v1c11230  ybcF; putative carbamate kinase [KO:K00926] [EC:2.7.2.2]
SMWW4_v1c11310  purK; N5-carboxyaminoimidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
SMWW4_v1c11320  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
SMWW4_v1c11920  nagD; UMP phosphatase [KO:K02566] [EC:3.1.3.5]
SMWW4_v1c12060  pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
SMWW4_v1c12170  [KO:K01120] [EC:3.1.4.17]
SMWW4_v1c12350  [KO:K01119] [EC:3.1.4.16 3.1.3.6]
SMWW4_v1c20070  prs; phosphoribosylpyrophosphate synthase [KO:K00948] [EC:2.7.6.1]
SMWW4_v1c20500  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
SMWW4_v1c22760  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
SMWW4_v1c23180  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
SMWW4_v1c25460  [KO:K01951] [EC:6.3.5.2]
SMWW4_v1c28230  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
SMWW4_v1c31780  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
SMWW4_v1c33790  nrdA; ribonucleoside-diphosphate reductase 1 alpha subunit [KO:K00525] [EC:1.17.4.1]
SMWW4_v1c33800  nrdB; ribonucleoside-diphosphate reductase 1 beta subunit [KO:K00526] [EC:1.17.4.1]
SMWW4_v1c34200  yfbR; 5'-nucleotidase [KO:K08722] [EC:3.1.3.89]
SMWW4_v1c34430  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
SMWW4_v1c36180  purC; phosphoribosylaminoimidazole-succinocarboxamide synthetase [KO:K01923] [EC:6.3.2.6]
SMWW4_v1c36390  purM; phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
SMWW4_v1c36400  purN; phosphoribosylglycinamide formyltransferase 1 [KO:K11175] [EC:2.1.2.2]
SMWW4_v1c36520  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
SMWW4_v1c37040  guaA; GMP synthetase (glutamine aminotransferase) [KO:K01951] [EC:6.3.5.2]
SMWW4_v1c37050  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
SMWW4_v1c37220  ndk; multifunctional nucleoside diphosphate kinase and apyrimidinic endonuclease and 3'-phosphodiesterase [KO:K00940] [EC:2.7.4.6]
SMWW4_v1c37550  [KO:K01952] [EC:6.3.5.3]
SMWW4_v1c38470  nrdE; ribonucleoside-diphosphate reductase 2, alpha subunit [KO:K00525] [EC:1.17.4.1]
SMWW4_v1c38480  nrdF; ribonucleoside-diphosphate reductase 2, beta subunit [KO:K00526] [EC:1.17.4.1]
SMWW4_v1c39220  [KO:K06966] [EC:3.2.2.10 3.2.2.-]
SMWW4_v1c41070  [KO:K00760] [EC:2.4.2.8]
SMWW4_v1c41370  rdgB; dITP/XTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
SMWW4_v1c41880  xapA; purine nucleoside phosphorylase II [KO:K03783] [EC:2.4.2.1]
SMWW4_v1c41980  cpdA; 3',5' cAMP phosphodiesterase [KO:K03651] [EC:3.1.4.53]
SMWW4_v1c42000  nudF; ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
SMWW4_v1c42790  [KO:K01951] [EC:6.3.5.2]
SMWW4_v1c43630  rihB; ribonucleoside hydrolase 2 [KO:K25589]
SMWW4_v1c45660  nudE; adenosine nucleotide hydrolase [KO:K08312] [EC:3.6.1.-]
SMWW4_v1c45680  yrfG; GMP/IMP nucleotidase [KO:K20881] [EC:3.1.3.-]
SMWW4_v1c46440  [KO:K01488] [EC:3.5.4.4]
SMWW4_v1c47850  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
SMWW4_v1c47870  spoT; bifunctional (p)ppGpp synthetase II/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
smw00030  Pentose phosphate pathway
smw00220  Arginine biosynthesis
smw00250  Alanine, aspartate and glutamate metabolism
smw00260  Glycine, serine and threonine metabolism
smw00340  Histidine metabolism
smw00630  Glyoxylate and dicarboxylate metabolism
smw00730  Thiamine metabolism
smw00740  Riboflavin metabolism
smw00790  Folate biosynthesis
KO pathway
ko00230   

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