KEGG   PATHWAY: spu00564
Entry
spu00564                    Pathway                                
Name
Glycerophospholipid metabolism - Strongylocentrotus purpuratus (purple sea urchin)
Class
Metabolism; Lipid metabolism
Pathway map
spu00564  Glycerophospholipid metabolism
spu00564

Module
spu_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:spu00564]
spu_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:spu00564]
spu_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:spu00564]
Other DBs
GO: 0006650
Organism
Strongylocentrotus purpuratus (purple sea urchin) [GN:spu]
Gene
763067  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
576660  glycerol-3-phosphate dehydrogenase, mitochondrial [KO:K00111] [EC:1.1.5.3]
115919756  glycerol-3-phosphate dehydrogenase, mitochondrial-like [KO:K00111] [EC:1.1.5.3]
585988  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
585343  glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
576124  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
757187  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
592014  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
105439485  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha-like [KO:K13509] [EC:2.3.1.51]
586692  1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
576769  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
578225  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
115919369  1-acyl-sn-glycerol-3-phosphate acyltransferase delta-like [KO:K13523] [EC:2.3.1.51 2.3.1.-]
115919371  1-acyl-sn-glycerol-3-phosphate acyltransferase delta-like [KO:K13523] [EC:2.3.1.51 2.3.1.-]
764420  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
105439599  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
577366  lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
100893263  lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
115919075  lysocardiolipin acyltransferase 1-like [KO:K13513] [EC:2.3.1.- 2.3.1.51]
100892514  lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
587591  lysophospholipid acyltransferase 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
590838  dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
576030  phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
100893799  phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
100890064  uncharacterized protein LOC100890064 [KO:K01080] [EC:3.1.3.4]
105445477  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
582841  phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
582470  phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
580494  diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
591406  diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
765159  diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
105445671  diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
763773  cholinephosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
579234  phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
591829  phospholipase D1 [KO:K01115] [EC:3.1.4.4]
588536  phospholipase D3 [KO:K16860] [EC:3.1.4.4]
590364  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
752200  phospholipase A2 [KO:K01047] [EC:3.1.1.4]
757138  phospholipase A2 AP-PLA2-I-like [KO:K01047] [EC:3.1.1.4]
762932  phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100889667  uncharacterized protein LOC100889667 [KO:K01047] [EC:3.1.1.4]
752643  phospholipase A2 [KO:K01047] [EC:3.1.1.4]
764996  phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100893735  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
105439400  acidic phospholipase A2 homolog [KO:K01047] [EC:3.1.1.4]
105445152  uncharacterized protein LOC105445152 [KO:K01047] [EC:3.1.1.4]
115918498  phospholipase A2 AP-PLA2-I-like [KO:K01047] [EC:3.1.1.4]
100893578  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
115922228  acidic phospholipase A2 BpirPLA2-I-like [KO:K01047] [EC:3.1.1.4]
105443781  basic phospholipase A2 pseudexin A chain-like [KO:K01047] [EC:3.1.1.4]
115923063  basic phospholipase A2 pseudexin A chain-like [KO:K01047] [EC:3.1.1.4]
755117  neutral phospholipase A2 3 [KO:K01047] [EC:3.1.1.4]
100893270  acidic phospholipase A2 BpirPLA2-I [KO:K01047] [EC:3.1.1.4]
100892599  phospholipase A2 AP-PLA2-II [KO:K01047] [EC:3.1.1.4]
105441109  acidic phospholipase A2 homolog [KO:K01047] [EC:3.1.1.4]
592012  phospholipase A2 AP-PLA2-I [KO:K01047] [EC:3.1.1.4]
757121  acidic phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100890616  acidic phospholipase A2 natratoxin [KO:K01047] [EC:3.1.1.4]
100891186  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
115920298  phospholipase A2 AP-PLA2-II-like [KO:K01047] [EC:3.1.1.4]
584558  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
115920685  acidic phospholipase A2 natratoxin-like [KO:K01047] [EC:3.1.1.4]
115920713  neutral phospholipase A2 3-like [KO:K01047] [EC:3.1.1.4]
115923327  basic phospholipase A2 nigroxin A-like [KO:K01047] [EC:3.1.1.4]
115918731  acidic phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
579697  phospholipase A2 AP-PLA2-II [KO:K01047] [EC:3.1.1.4]
115928854  phospholipase A2 AP-PLA2-II-like [KO:K01047] [EC:3.1.1.4]
591784  phospholipase A2 AP-PLA2-I [KO:K01047] [EC:3.1.1.4]
115928556  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
115928589  acidic phospholipase A2 homolog [KO:K01047] [EC:3.1.1.4]
576520  85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
100892711  phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
100894066  phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
100890912  phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
100894143  phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
578635  phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
579107  lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
580778  lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
593457  lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
100892797  lysophospholipid acyltransferase 5 isoform X1 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
115924721  lysophospholipid acyltransferase 5-like [KO:K13515] [EC:2.3.1.23 2.3.1.-]
588190  group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
584566  acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
105443374  patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
594641  glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
574696  choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
762935  cholinesterase 2 [KO:K01049] [EC:3.1.1.7]
589995  cholinesterase 1 [KO:K01049] [EC:3.1.1.7]
115929629  acetylcholinesterase-like [KO:K01049] [EC:3.1.1.7]
100890586  cholinesterase 1 [KO:K01049] [EC:3.1.1.7]
587899  acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
105436985  acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
115919978  acetylcholinesterase-like [KO:K01049] [EC:3.1.1.7]
585202  cholinesterase 1 [KO:K01049] [EC:3.1.1.7]
105437565  cholinesterase 1-like [KO:K01049] [EC:3.1.1.7]
588635  cholinesterase 1 [KO:K01049] [EC:3.1.1.7]
100891067  cholinesterase 1 [KO:K01049] [EC:3.1.1.7]
578590  cholinesterase 1 [KO:K01049] [EC:3.1.1.7]
583569  cholinesterase 1 [KO:K01049] [EC:3.1.1.7]
115919856  cholinesterase 1-like [KO:K01049] [EC:3.1.1.7]
589500  cholinesterase 1-like [KO:K01049] [EC:3.1.1.7]
581909  cholinesterase 1 [KO:K01049] [EC:3.1.1.7]
105445668  cholinesterase 1-like [KO:K01049] [EC:3.1.1.7]
100891732  cholinesterase 2 [KO:K01049] [EC:3.1.1.7]
115927311  cholinesterase 2-like [KO:K01049] [EC:3.1.1.7]
584499  cholinesterase 1 [KO:K01049] [EC:3.1.1.7]
763207  cholinesterase 1 [KO:K01049] [EC:3.1.1.7]
581939  cholinesterase 1-like [KO:K01049] [EC:3.1.1.7]
574707  cholinesterase 1 [KO:K01049] [EC:3.1.1.7]
576889  cholinesterase 1 [KO:K01049] [EC:3.1.1.7]
115917894  carboxylesterase 5A-like [KO:K01049] [EC:3.1.1.7]
580506  cholinesterase 1-like [KO:K01049] [EC:3.1.1.7]
763248  choline/ethanolamine kinase isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
752968  choline-phosphate cytidylyltransferase A isoform X1 [KO:K00968] [EC:2.7.7.15]
115917918  choline-phosphate cytidylyltransferase A-like [KO:K00968] [EC:2.7.7.15]
583967  ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
578881  ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
587421  ethanolamine-phosphate cytidylyltransferase isoform X1 [KO:K00967] [EC:2.7.7.14]
589652  phosphoethanolamine N-methyltransferase 1 [KO:K05929] [EC:2.1.1.103]
588990  ethanolamine-phosphate phospho-lyase isoform X2 [KO:K14286] [EC:4.2.3.2]
581512  phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
115918642  phosphatidyl-N-methylethanolamine N-methyltransferase-like [KO:K00551] [EC:2.1.1.17 2.1.1.71]
581564  phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
115919114  phosphatidylethanolamine N-methyltransferase-like [KO:K00551] [EC:2.1.1.17 2.1.1.71]
590057  phosphatidate cytidylyltransferase 2 isoform X1 [KO:K00981] [EC:2.7.7.41]
115921647  phosphatidate cytidylyltransferase 2-like [KO:K00981] [EC:2.7.7.41]
590626  phosphatidylserine synthase 1 isoform X1 [KO:K08729] [EC:2.7.8.-]
100890899  phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
593856  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
581340  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
587370  probable cardiolipin synthase (CMP-forming) isoform X1 [KO:K08744] [EC:2.7.8.41]
591740  tafazzin [KO:K13511] [EC:2.3.1.-]
593468  CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
580204  lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
115923545  lysophospholipid acyltransferase 7-like [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
spu00010  Glycolysis / Gluconeogenesis
spu00260  Glycine, serine and threonine metabolism
spu00561  Glycerolipid metabolism
spu00562  Inositol phosphate metabolism
spu00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
spu00565  Ether lipid metabolism
spu00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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