KEGG PATHWAY: spu00260

PATHWAY: spu00260

Entry

spu00260                    Pathway

Name

Glycine, serine and threonine metabolism - Strongylocentrotus purpuratus (purple sea urchin)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

spu00260

Glycine, serine and threonine metabolism

Module

spu_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:spu00260]

spu_M00047

Creatine pathway [PATH:spu00260]

spu_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:spu00260]

spu_M00555

Betaine biosynthesis, choline => betaine [PATH:spu00260]

spu_M00621

Glycine cleavage system [PATH:spu00260]

spu_M00974

Betaine metabolism, animals, betaine => glycine [PATH:spu00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Strongylocentrotus purpuratus (purple sea urchin) [GN:spu]

Gene

579654

probable low-specificity L-threonine aldolase 2 isoform X1 [KO:K01620] [EC:4.1.2.48]

593509

serine hydroxymethyltransferase, cytosolic isoform X2 [KO:K00600] [EC:2.1.2.1]

754129

serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]

575497

serine--pyruvate aminotransferase, mitochondrial [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

588349

glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

115921758

glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]

105438914

glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]

585085

glycerate kinase [KO:K11529] [EC:2.7.1.165]

591606

2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]

590971

D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

580016

phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

578165

phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

115926729

phosphoserine phosphatase-like [KO:K01079] [EC:3.1.3.3]

583773

2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform X1 [KO:K00639] [EC:2.3.1.29]

584440

L-threonine 3-dehydrogenase, mitochondrial isoform X1 [KO:K15789] [EC:1.1.1.103]

115918996

L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]

587689

inactive L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]

588142

5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]

590013

amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]

115918590

probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]

583484

probable flavin-containing monoamine oxidase A isoform X1 [KO:K00274] [EC:1.4.3.4]

590198

probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]

100891493

amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]

105443950

amine oxidase [flavin-containing] B-like [KO:K00274] [EC:1.4.3.4]

578453

glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]

579900

aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

577103

dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

576609

uncharacterized protein LOC576609 [KO:K02437]

576222

LOW QUALITY PROTEIN: D-aspartate oxidase [KO:K00273] [EC:1.4.3.3]

590228

D-aspartate oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]

594821

alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]

581473

glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]

578397

guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]

115919361

guanidinoacetate N-methyltransferase-like [KO:K00542] [EC:2.1.1.2]

591798

choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

591835

LOW QUALITY PROTEIN: uncharacterized protein LOC591835 [KO:K00108] [EC:1.1.99.1]

589191

choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

587688

choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

588376

alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

575553

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

105438577

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

588895

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

580174

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

115918144

S-methylmethionine--homocysteine S-methyltransferase BHMT2-like [KO:K00544] [EC:2.1.1.5]

589758

S-methylmethionine--homocysteine S-methyltransferase BHMT2 [KO:K00544] [EC:2.1.1.5]

105447246

betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]

115918913

betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]

582813

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

579857

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

752628

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

115929946

betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]

115928328

betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]

100891161

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

587447

dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]

591772

LOW QUALITY PROTEIN: peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

592753

peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

575397

peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]

578086

peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

593952

peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

576973

sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

579000

glycine N-methyltransferase-like [KO:K00552] [EC:2.1.1.20]

575025

glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

580044

glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

752758

glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

105438157

glycine N-methyltransferase-like [KO:K00552] [EC:2.1.1.20]

105439109

glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

589953

glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

579441

LOW QUALITY PROTEIN: glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

591266

cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]

105443556

cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]

762952

cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

583271

uncharacterized protein LOC583271 isoform X1 [KO:K01754] [EC:4.3.1.19]

115918011

uncharacterized protein LOC115918011 isoform X1 [KO:K01754] [EC:4.3.1.19]

594261

L-serine dehydratase/L-threonine deaminase isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]

583979

serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]

586391

serine racemase [KO:K12235] [EC:5.1.1.18]

105443552

serine racemase-like isoform X1 [KO:K12235] [EC:5.1.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721