KEGG   PATHWAY: sxn00260
Entry
sxn00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces xanthii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sxn00260  Glycine, serine and threonine metabolism
sxn00260

Module
sxn_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sxn00260]
sxn_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sxn00260]
sxn_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:sxn00260]
sxn_M00555  Betaine biosynthesis, choline => betaine [PATH:sxn00260]
sxn_M00621  Glycine cleavage system [PATH:sxn00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces xanthii [GN:sxn]
Gene
IAG42_18950  aspartate kinase [KO:K00928] [EC:2.7.2.4]
IAG42_37080  aspartate kinase [KO:K00928] [EC:2.7.2.4]
IAG42_18955  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
IAG42_23440  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
IAG42_37085  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
IAG42_11140  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
IAG42_11130  homoserine kinase [KO:K00872] [EC:2.7.1.39]
IAG42_15935  threonine synthase [KO:K01733] [EC:4.2.3.1]
IAG42_11135  threonine synthase [KO:K01733] [EC:4.2.3.1]
IAG42_12305  threonine synthase [KO:K01733] [EC:4.2.3.1]
IAG42_31720  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
IAG42_07470  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
IAG42_10495  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
IAG42_11090  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
IAG42_13540  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
IAG42_06435  glycerate kinase [KO:K00865] [EC:2.7.1.165]
IAG42_16200  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
IAG42_10240  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
IAG42_15660  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
IAG42_27800  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
IAG42_05115  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
IAG42_05120  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
IAG42_33165  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
IAG42_02985  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
IAG42_07825  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
IAG42_30225  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
IAG42_05785  gcvPA; aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
IAG42_05790  gcvPB; aminomethyl-transferring glycine dehydrogenase subunit GcvPB [KO:K00283] [EC:1.4.4.2]
IAG42_10485  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
IAG42_25740  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
IAG42_04755  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
IAG42_10490  gcvH; glycine cleavage system protein GcvH [KO:K02437]
IAG42_05450  FAD-binding oxidoreductase [KO:K00273] [EC:1.4.3.3]
IAG42_37485  glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]
IAG42_06430  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
IAG42_07525  GMC family oxidoreductase N-terminal domain-containing protein [KO:K17755] [EC:1.1.3.17]
IAG42_07515  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
IAG42_09420  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
IAG42_09475  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
IAG42_13605  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
IAG42_07500  GcvT family protein [KO:K00309] [EC:1.5.3.10]
IAG42_36375  solA; N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
IAG42_07505  solA; N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
IAG42_03020  (2Fe-2S)-binding protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
IAG42_03010  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
IAG42_03025  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
IAG42_03015  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
IAG42_20950  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
IAG42_10500  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
IAG42_12950  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
IAG42_26460  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
IAG42_36775  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
IAG42_26455  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
IAG42_27500  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
IAG42_37105  diaminobutyrate--2-oxoglutarate transaminase family protein [KO:K00836] [EC:2.6.1.76]
IAG42_08725  diaminobutyrate--2-oxoglutarate transaminase family protein [KO:K00836] [EC:2.6.1.76]
IAG42_27505  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
IAG42_27495  ectoine synthase [KO:K06720] [EC:4.2.1.108]
IAG42_36780  ectoine synthase [KO:K06720] [EC:4.2.1.108]
IAG42_27490  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
IAG42_22700  desA; lysine decarboxylase DesA [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sxn00010  Glycolysis / Gluconeogenesis
sxn00020  Citrate cycle (TCA cycle)
sxn00230  Purine metabolism
sxn00250  Alanine, aspartate and glutamate metabolism
sxn00270  Cysteine and methionine metabolism
sxn00290  Valine, leucine and isoleucine biosynthesis
sxn00300  Lysine biosynthesis
sxn00330  Arginine and proline metabolism
sxn00460  Cyanoamino acid metabolism
sxn00470  D-Amino acid metabolism
sxn00564  Glycerophospholipid metabolism
sxn00600  Sphingolipid metabolism
sxn00620  Pyruvate metabolism
sxn00630  Glyoxylate and dicarboxylate metabolism
sxn00640  Propanoate metabolism
sxn00680  Methane metabolism
sxn00860  Porphyrin metabolism
sxn00920  Sulfur metabolism
KO pathway
ko00260   
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