KEGG   PATHWAY: uar04612
Entry
uar04612                    Pathway                                
Name
Antigen processing and presentation - Ursus americanus (American black bear)
Class
Organismal Systems; Immune system
Pathway map
uar04612  Antigen processing and presentation
uar04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Ursus americanus (American black bear) [GN:uar]
Gene
123776265  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
123776405  B2M; beta-2-microglobulin [KO:K08055]
123777718  CALR; calreticulin [KO:K08057]
123778170  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
123779155  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
123779887  RFXANK; DNA-binding protein RFXANK [KO:K08062]
123779984  IFI30; gamma-interferon-inducible lysosomal thiol reductase isoform X1 [KO:K08059]
123780238  [KO:K06751]
123780885  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
123781427  [KO:K01365] [EC:3.4.22.15]
123781454  [KO:K01365] [EC:3.4.22.15]
123781455  [KO:K01365] [EC:3.4.22.15]
123781609  [KO:K06541]
123781610  [KO:K06541]
123781611  [KO:K06541]
123781612  [KO:K06541]
123781627  TAPBPL; tapasin-related protein isoform X1 [KO:K28445]
123781677  KLRD1; natural killer cells antigen CD94 isoform X1 [KO:K06516]
123781683  CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
123781836  PSME3; proteasome activator complex subunit 3 [KO:K06698]
123783265  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
123783522  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
123783608  [KO:K06698]
123785045  [KO:K06751]
123786985  [KO:K07980]
123787294  IFNG; interferon gamma [KO:K04687]
123787711  RFX5; DNA-binding protein RFX5 isoform X1 [KO:K08061]
123787738  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
123787974  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
123790354  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
123790487  CANX; calnexin [KO:K08054]
123790925  [KO:K08058]
123790938  [KO:K06752]
123790941  [KO:K06752]
123790942  [KO:K06752]
123790943  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
123790946  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
123790948  [KO:K06752]
123790949  [KO:K06752]
123790950  [KO:K06752]
123790951  [KO:K06752]
123790953  [KO:K06752]
123790954  [KO:K06752]
123790987  [KO:K03283]
123790988  [KO:K03283]
123790989  [KO:K03283]
123791023  [KO:K06751]
123791025  [KO:K06751]
123791026  [KO:K06751]
123791029  [KO:K06751]
123791051  [KO:K06752]
123791076  TNF; tumor necrosis factor [KO:K03156]
123791799  [KO:K08063]
123792681  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
123793445  [KO:K06751]
123793572  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
123793833  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
123794091  [KO:K06752]
123794092  [KO:K06752]
123794160  [KO:K06751]
123795038  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
123795757  PSME1; proteasome activator complex subunit 1 [KO:K06696]
123795758  PSME2; proteasome activator complex subunit 2 [KO:K06697]
123798247  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
123798878  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
123799618  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
123799711  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
123800587  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
123803673  CD74; LOW QUALITY PROTEIN: HLA class II histocompatibility antigen gamma chain [KO:K06505]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
uar03050  Proteasome
uar04650  Natural killer cell mediated cytotoxicity
uar04660  T cell receptor signaling pathway
KO pathway
ko04612   

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