KEGG   PATHWAY: umr04612
Entry
umr04612                    Pathway                                
Name
Antigen processing and presentation - Ursus maritimus (polar bear)
Class
Organismal Systems; Immune system
Pathway map
umr04612  Antigen processing and presentation
umr04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103656225  CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
103656357  [KO:K06751]
103656761  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
103656858  IFNG; interferon gamma [KO:K04687]
103658259  [KO:K06698]
103658293  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
103659802  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
103662283  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
103663821  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
103664050  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
103664107  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
103664419  [KO:K08063]
103664818  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
103665491  [KO:K08058]
103665506  [KO:K06752]
103665508  [KO:K06752]
103665509  [KO:K06752]
103665513  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
103665515  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
103665516  [KO:K06752]
103665517  [KO:K06752]
103665518  [KO:K06752]
103665519  [KO:K06752]
103665521  [KO:K06752]
103665522  [KO:K06752]
103665562  [KO:K06752]
103667516  RFX5; DNA-binding protein RFX5 isoform X1 [KO:K08061]
103667539  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
103668824  CIITA; MHC class II transactivator isoform X2 [KO:K08060] [EC:2.7.11.1]
103669127  [KO:K06541]
103669128  [KO:K06541]
103669129  [KO:K06541]
103669132  KLRD1; natural killer cells antigen CD94 isoform X1 [KO:K06516]
103669174  [KO:K06541]
103669175  [KO:K06541]
103670076  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
103670323  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
103670850  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
103671471  CD8A; T-cell surface glycoprotein CD8 alpha chain isoform X1 [KO:K06458]
103671473  CD8B; T-cell surface glycoprotein CD8 beta chain isoform X1 [KO:K06459]
103672248  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
103672268  [KO:K06751]
103672590  PSME3; proteasome activator complex subunit 3 [KO:K06698]
103673380  B2M; beta-2-microglobulin [KO:K08055]
103673527  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
103674922  RFXANK; DNA-binding protein RFXANK [KO:K08062]
103674945  IFI30; gamma-interferon-inducible lysosomal thiol reductase [KO:K08059]
103675931  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
103676483  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
103679276  PSME1; proteasome activator complex subunit 1 [KO:K06696]
103679277  PSME2; proteasome activator complex subunit 2 [KO:K06697]
103679986  CANX; calnexin [KO:K08054]
103680441  [KO:K06751]
103680561  [KO:K06751]
103682146  CALR; calreticulin [KO:K08057]
103682209  [KO:K01365] [EC:3.4.22.15]
103682224  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
103682229  [KO:K01365] [EC:3.4.22.15]
103682293  [KO:K03283]
103682294  [KO:K03283]
103682295  [KO:K03283]
103682322  TNF; tumor necrosis factor [KO:K03156]
103682344  [KO:K06751]
121104340  [KO:K06751]
121106055  [KO:K03283]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
umr03050  Proteasome
umr04650  Natural killer cell mediated cytotoxicity
umr04660  T cell receptor signaling pathway
KO pathway
ko04612   

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