KEGG   PATHWAY: vsr00260
Entry
vsr00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Vibrio spartinae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
vsr00260  Glycine, serine and threonine metabolism
vsr00260

Module
vsr_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:vsr00260]
vsr_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:vsr00260]
vsr_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:vsr00260]
vsr_M00555  Betaine biosynthesis, choline => betaine [PATH:vsr00260]
vsr_M00621  Glycine cleavage system [PATH:vsr00260]
vsr_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:vsr00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Vibrio spartinae [GN:vsr]
Gene
Vspart_00036  ilvA; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
Vspart_00255  metL; Aspartokinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
Vspart_00440  [KO:K00018] [EC:1.1.1.29]
Vspart_00492  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Vspart_00561  lpdA; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
Vspart_00950  glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Vspart_01488  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Vspart_01505  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
Vspart_01506  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Vspart_01601  dat_1; Diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
Vspart_01626  [KO:K01079] [EC:3.1.3.3]
Vspart_01833  sdaA_1; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
Vspart_01835  hcr_1; NADH oxidoreductase hcr [KO:K21832] [EC:1.14.13.251]
Vspart_01836  antA; Anthranilate 1,2-dioxygenase large subunit [KO:K00479] [EC:1.14.13.251]
Vspart_01895  [KO:K25961]
Vspart_01896  etfA_1; Electron transfer flavoprotein large subunit [KO:K25960]
Vspart_01897  [KO:K21834]
Vspart_01898  stcD; putative N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
Vspart_01902  sdaA_2; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
Vspart_01904  [KO:K00305] [EC:1.5.3.24 1.5.3.1]
Vspart_01905  gcvT_1; Aminomethyltransferase [KO:K00302] [EC:1.5.3.24 1.5.3.1]
Vspart_01906  [KO:K00304] [EC:1.5.3.24 1.5.3.1]
Vspart_01907  soxB_2; Sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
Vspart_01908  glyA2; Serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
Vspart_02238  asd1; Aspartate-semialdehyde dehydrogenase 1 [KO:K00133] [EC:1.2.1.11]
Vspart_02363  asd2; Aspartate-semialdehyde dehydrogenase 2 [KO:K00133] [EC:1.2.1.11]
Vspart_02582  serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
Vspart_02596  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
Vspart_02597  thrB_1; Homoserine kinase [KO:K00872] [EC:2.7.1.39]
Vspart_02598  thrA; Aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
Vspart_02692  lysC_1; Aspartokinase [KO:K00928] [EC:2.7.2.4]
Vspart_02985  lysC_2; Lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
Vspart_02987  pucG_1; Purine catabolism protein PucG [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Vspart_03093  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
Vspart_03116  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
Vspart_03369  yoaD_1; Putative 2-hydroxyacid dehydrogenase YoaD [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Vspart_03397  betB; Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Vspart_03398  betA; Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
Vspart_03500  [KO:K25316]
Vspart_03501  yoaD_2; Putative 2-hydroxyacid dehydrogenase YoaD [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Vspart_03814  gcvP; Glycine dehydrogenase [decarboxylating] [KO:K00281] [EC:1.4.4.2]
Vspart_03815  gcvH; Glycine cleavage system H protein [KO:K02437]
Vspart_03817  gcvT_2; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
Vspart_03898  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
Vspart_03899  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
Vspart_04113  thrB_2; Homoserine kinase [KO:K02204] [EC:2.7.1.39]
Vspart_04124  garK; Glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
Vspart_04411  lysC_3; Lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
Vspart_04412  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
Vspart_04413  ectB; Diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
Vspart_04414  ectA; L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
vsr00010  Glycolysis / Gluconeogenesis
vsr00020  Citrate cycle (TCA cycle)
vsr00230  Purine metabolism
vsr00250  Alanine, aspartate and glutamate metabolism
vsr00270  Cysteine and methionine metabolism
vsr00290  Valine, leucine and isoleucine biosynthesis
vsr00300  Lysine biosynthesis
vsr00330  Arginine and proline metabolism
vsr00460  Cyanoamino acid metabolism
vsr00470  D-Amino acid metabolism
vsr00564  Glycerophospholipid metabolism
vsr00600  Sphingolipid metabolism
vsr00620  Pyruvate metabolism
vsr00630  Glyoxylate and dicarboxylate metabolism
vsr00640  Propanoate metabolism
vsr00680  Methane metabolism
vsr00860  Porphyrin metabolism
vsr00920  Sulfur metabolism
KO pathway
ko00260   

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