KEGG   PATHWAY: xgl00830
Entry
xgl00830                    Pathway                                
Name
Retinol metabolism - Xiphias gladius (swordfish)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
xgl00830  Retinol metabolism
xgl00830

Other DBs
GO: 0006776
Organism
Xiphias gladius (swordfish) [GN:xgl]
Gene
120783021  rdh5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]
120783078  [KO:K11151] [EC:1.1.1.-]
120783103  [KO:K11151] [EC:1.1.1.-]
120783462  [KO:K09516] [EC:1.3.99.23]
120783931  retsat.2; all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
120784326  dgat1b; diacylglycerol O-acyltransferase 1b isoform X1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
120784530  [KO:K11153] [EC:1.1.1.300]
120785338  [KO:K00121] [EC:1.1.1.284 1.1.1.1]
120785579  [KO:K00121] [EC:1.1.1.284 1.1.1.1]
120786827  dgat1a; diacylglycerol O-acyltransferase 1a [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
120789528  rdh10a; retinol dehydrogenase 10-A isoform X1 [KO:K11151] [EC:1.1.1.-]
120789703  si:dkey-73n8.3; retinol dehydrogenase 12 isoform X1 [KO:K11153] [EC:1.1.1.300]
120789704  zgc:112332; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
120789757  [KO:K00699] [EC:2.4.1.17]
120789809  rdh12l; retinol dehydrogenase 12, like isoform X1 [KO:K11153] [EC:1.1.1.300]
120790011  bco1; beta,beta-carotene 15,15'-dioxygenase isoform X1 [KO:K00515] [EC:1.13.11.63]
120790833  [KO:K11158] [EC:3.1.1.64 5.3.3.22]
120791000  zgc:109982; retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
120791156  si:ch211-107o10.3; retinol dehydrogenase 13 [KO:K11153] [EC:1.1.1.300]
120791475  aldh1a2; retinal dehydrogenase 2 [KO:K07249] [EC:1.2.1.36]
120791604  aldh1a3; aldehyde dehydrogenase family 1 member A3 [KO:K07249] [EC:1.2.1.36]
120792803  [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
120793039  [KO:K00699] [EC:2.4.1.17]
120793403  [KO:K17951] [EC:1.14.19.53]
120793779  [KO:K11153] [EC:1.1.1.300]
120794141  [KO:K00699] [EC:2.4.1.17]
120794332  [KO:K07437] [EC:1.14.14.-]
120794479  [KO:K11161] [EC:1.1.1.300]
120794665  si:ch1073-13h15.3; inactive all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
120795054  [KO:K00121] [EC:1.1.1.284 1.1.1.1]
120795187  rdh12; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
120795441  [KO:K00121] [EC:1.1.1.284 1.1.1.1]
120796547  [KO:K12665] [EC:1.14.14.-]
120796826  [KO:K07424] [EC:1.14.14.1]
120797038  ugt5g1; UDP glucuronosyltransferase 5 family, polypeptide G1 [KO:K00699] [EC:2.4.1.17]
120797300  [KO:K00678] [EC:2.3.1.135]
120797305  lratb.2; lecithin retinol acyltransferase b, tandem duplicate 2 [KO:K00678] [EC:2.3.1.135]
120797602  [KO:K12664] [EC:1.14.14.-]
120797608  dhrs4; dehydrogenase/reductase SDR family member 4 [KO:K11147] [EC:1.1.-.-]
120797958  bco1l; beta-carotene oxygenase 1, like isoform X1 [KO:K00515] [EC:1.13.11.63]
120798177  pnpla4; patatin-like phospholipase domain-containing protein 4 isoform X1 [KO:K11157] [EC:3.1.1.-]
120798313  aox6; aldehyde oxidase 6 isoform X1 [KO:K00157] [EC:1.2.3.1]
120798784  rpe65a; retinoid isomerohydrolase isoform X1 [KO:K11158] [EC:3.1.1.64 5.3.3.22]
120798833  [KO:K00699] [EC:2.4.1.17]
120798871  [KO:K15734] [EC:1.1.1.105]
120799967  [KO:K11150] [EC:1.1.1.-]
120800556  si:dkey-30k22.5; lecithin retinol acyltransferase family protein [KO:K00678] [EC:2.3.1.135]
120800617  lrata; lecithin retinol acyltransferase a [KO:K00678] [EC:2.3.1.135]
120800946  [KO:K07424] [EC:1.14.14.1]
120800947  [KO:K07424] [EC:1.14.14.1]
120802009  [KO:K00699] [EC:2.4.1.17]
120803081  ugt5d1; UDP glucuronosyltransferase 5 family, polypeptide D1 [KO:K00699] [EC:2.4.1.17]
120804233  [KO:K07424] [EC:1.14.14.1]
120805001  [KO:K00699] [EC:2.4.1.17]
120805125  [KO:K00699] [EC:2.4.1.17]
120805334  [KO:K07249] [EC:1.2.1.36]
120805458  rdh8a; retinol dehydrogenase 8a [KO:K11150] [EC:1.1.1.-]
120805635  [KO:K00699] [EC:2.4.1.17]
120806027  [KO:K00699] [EC:2.4.1.17]
120806156  [KO:K00699] [EC:2.4.1.17]
120807122  [KO:K11150] [EC:1.1.1.-]
120807538  dhrs3b; short-chain dehydrogenase/reductase 3b [KO:K11146] [EC:1.1.1.300]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   

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