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Viral entry protein - human receptor protein interactions

Type Virus Taxid Genome Entry protein (KO) Human receptor (hsa ID) PMID
dsDNA-RT HBV 10407 T40004 S HSPG2, (SLC10A1+EGFR) 26776362 26239691 30952782
ssRNA-RT HTLV-1 11908 T40003 gp46 SLC2A1, NRP1 21994754
HTLV-2 11909 gp46 14622599 16809290
HIV-1 11676 T40001 gp120 CD4, CCR5, CXCR4, CD209, CLEC4M 23806647 12960231 10721995 11226297
HIV-2 11709 T40002 gp120 CD4, CCR5, CXCR4, CLEC4M 12029140 11226297
dsRNA Rotavirus A 28875 T40092 VP4 (ITGA2+ITGB1) 9144247
VP7 (ITGAX+ITGB2), (ITGA4+ITGB1), (ITGAV+ITGB3) 15165605 9144247 11114176
Rotavirus C 36427 T40094 VP4 (ITGA2+ITGB1), (ITGA4+ITGB1), HSPA8 15165605 9144247 10590110 12805424
+ssRNA SARS-CoV-2 2697049 T40361 S ACE2, CD209, CLEC4M 32142651 32607506
SARS-CoV 227984 T40069 S ACE2, CD209, CLEC4M 14647384 15140961 15496474 17243893
MERS-CoV 1335626 T40090 S DPP4 23486063
HCoV-229E 11137 T40364 S ANPEP 12551991 1350662
HCoV-NL63 277944 T40365 S ACE2 15897467
Human poliovirus 1/2/3 138950 T40344 T40345 T40346 VP1+VP2+VP3 PVR 25631086 12663789
Enterovirus A71 138948 T40343 VP1+VP2 SCARB2 31924205
VP1 SELPLG, ANXA2, NCL, VIM, FN1 19543284 29467312 31924205
Coxsackievirus A16 138948 T40331 VP2 SCARB2 22438546 31924205
Coxsackievirus A24 138950 T40332 VP1+VP2+VP3 ICAM1 29284752
Coxsackievirus B3 12072 VP1+VP2 CD55 31104841 35046043
Human parechovirus 1 12063 VP1 (ITGAV+ITGB3), (ITGAV+ITGB1) 10846065
DENV 1-4 11053 11060 11069 11070 T40048 T40373 T40374 T40375 E CD209, MRC1, CLEC4M 22500135 18266465 12682107
DENV-2 11060 T40373 E (HSPA1+HSP90AB1), HSPA5 15795242 22500135 15098107
DENV 1-3 11053 11060 11069 T40048 T40373 T40374 E RPSA 15790424 22500135
JEV 11072 T40052 E HSPA1, PLVAP, CD209, CLEC4M 19068261 30082709 26629951 24623090
TBEV 11084 T40061 E RPSA, (ITGAV+ITGB3) 19961413 25319621
WNV 11082 T40029 E RPSA, (ITGAV+ITGB3), CLEC4M 18061925 20618137 16415006
ZIKV 64320 T40049 E HAVCR1, CD209, TYRO3 32641828 26085147
HCV 11103 T40066 E2 SCARB1, CD81, CLDN1, OCLN 24520529 23836234 29971069
CHIKV 37124 T40026 E2 MXRA8, PHB1 29769725
E1+E2 HAVCR1 33091085
EEEV 11021 T40054 E1+E2 HAVCR1 33091085 23555248
VEEV 11036 T40028 E2 RPSA 19961413
RRV 11029 T40071 E1+E2 HAVCR1 33091085
Sindbis virus 11034 T40377 E2 SLC11A2, CD209, CLEC4M 21843867 14581539
E1+E2 HAVCR1 33091085
Semliki Forest virus 11033 T40127 E2 CD209, CLEC4M 21738680
Rubella virus 11041 T40070 E1 MOG 21880773
Hom-1 vesivirus 1960046 VP1 F11R 28196955
-ssRNA Measles virus 11234 T40033 H CD46, SLAMF1, NECTIN4 22049305 16690907 21901103
F+H CD209 22049305 16690907
N FCGR2B 16690907 22049305
HMPV 162145 T40095 G/SH CD209, CLEC4M 27334579
Hendra henipavirus 63330 T40046 G EFNB2, EFNB3 17376907
Nipah henipavirus 121791 T40047 G EFNB2, EFNB3 16007075 16477309
RSV 11250 T40045 F IGF1R, NCL 32494007 21841784 27903593
G TLR4, CX3CR1 27903593
Rabies virus 11292 T40022 G CHRNA1, NCAM1, NGFR 15804965 9696812
European bat 2 lyssavirus 57483 T40025 G NGFR 11714960
ZEBOV 186538 T40012 GP HAVCR1, CD209, CLEC4M 21536871 12504546
ZEBOV, SEBOV, BDBV 186538 186540 565995 T40012 T40014 T40121 GP NPC1 21866101
MARV 11269 T40015 GP ASGR1 7844558
MACV, GTOV, JUNV, SABV 11628 45219 2169991 2907957 T40006 T40007 T40005 T40008 GP1 TFRC 17287727
LASV 11620 T40010 GP1 LAMP1 24970085
LCMV 11623 T40091 GP1 DAG1 9851928
LUJV 649188 T40333 GP1 NRP2 30150732
ANDV 1980456 T40021 Gn/Gc PCDH1 30464266
SNV 1980491 T40020 Gn/Gc PCDH1 30464266
CCHFV 1980519 T40011 GP CD209 26935918
LACV 11577 T40056 Gn/Gc CD209 23388721
SFTSV 992212 T40096 Gn/Gc CD209 23388721
Gn MYH9 24155382
RVFV 11588 T40030 Gn/Gc CD209 21767814 27223297
Uukuniemi virus 11591 Gn/Gc CD209 21767814
dsDNA HSV-1 10298 T40073 gB PILRA 20221426 15056211
gD TNFRSF14, NECTIN1, NECTIN2, IGF2R 20221426 15056211 7745699
gH (ITGA5+ITGB3) 23150579
gL (ITGA5+ITGB3) 23150579
HSV-2 10310 T40074 gD TNFRSF14, NECTIN1, NECTIN2, IGF2R 11511370 8898196 9696799 9657005 7745699
B virus 10325 T40077 gD NECTIN1 22345445
VZV 10335 T40078 gE IDE 17055432
HCMV 10359 T40080 gB EGFR, PDGFRA, CD209, CLEC4M 12879076 24839861 12433371
gH (ITGAV+ITGB3) 15834425
gH+gL+gO PDGFRA 27573107
gH+gL+ UL128+UL130+UL131A NRP2, OR14I1 30057110 30894498
HHV-6A 32603 gH+gL+gQ CD46 12663806
HHV-6B 32604 T40075 gH+gL+gQ TNFRSF4 23674671
EBV 10376 T40079 gp350 CR2 28408983 21429244
gp42 HLA-DR 28408983 21429244
gB EPHA2 29292383
gH+gL EPHA2 29292383
KSHV 37296 T40081 gB (ITGA3+ITGB1), (ITGAV+ITGB3), (ITGAV+ITGB5) 11853674 18045938 18829766
VACV 10245 T40360 A26L DAG1 17166913 22983091
Human mastadenovirus A 129875 T40337 L5 CXADR 9733828 16160140
Human mastadenovirus B 108098 T40100 L5 CD46, CD80, CD86 15078926 15110532
Human mastadenovirus C 129951 T40338 L2 (ITGAM+ITGB2), (ITGAL+ITGB2) 8676475 16160140
L5 CXADR 9036860
Human mastadenovirus D 130310 T40102 L5 CXADR, CD46 9733828 15047806
Human mastadenovirus E 130308 T40101 L5 CXADR 9733828 16160140
Human mastadenovirus F 130309 T40339 L5 CXADR 9733828 16160140
HPV6b 10600 T40097 L1 (ITGA6+ITGB4), (ITGA6+ITGB1) 9032382
HPV18 337042 T40088 L1 (ITGA6+ITGB4), ITGA6 16781758 11341777
ssDNA B19 virus 10798 T40084 VP2 (ITGA5+ITGB1), XRCC5 12907437 16076874

Viral entry protein - non-protein receptor interactions

Type Virus Taxid Genome Entry protein (KO) Non-protein receptor Compound/Glycan ID PMID
ssRNA-RT HTLV-1 11908 T40003 gp46 Heparan sulfate proteoglycans (HSPGs) 12941902
HIV-1 11676 T40001 gp160 Heparan sulfate C00925 7884870
dsRNA Rotavirus 28875 36427 VP4 GM1 ganglioside C04911 24501414
A, H-type histo-blood group antigen (HBGA) 22504179 22345472
+ssRNA HCoV-NL63 277944 T40365 Heparan sulfate C00925 25187545
HCoV-OC43 31631 T40362 S1 9-O-acetylated sialic acid 30679277 31160783
HCoV-HKU1 290028 T40363 S1 9-O-acetylated sialic acid 30679277
MERS-CoV 1335626 T40090 S1 α2,3-linked sialic acid (Sia) 28923942
Norovirus GI 122928 T40107 VP1 A-, H-type HBGAs 12825167
Norovirus GII 122929 T40107 VP1 A-, B-, H-type HBGAs 21345963
EV-A71 138948 T40343 VP1 Heparan sulfate proteoglycans (HSPGs) 31924205
Enterovirus D68 42789 VP1 a2-6-linked sialic acids 24371050
EV70 138951 T40334 a2,3-linked sialic acid 15890948 12388686
CVA16 138948 T40331 VP1 Heparan sulfate glycosaminoglycans (HS GAGs) 28745308
CVA24 138950 T40332 VP1 a2,3- and a2,6-linked Neu5Ac 25329320 18184708
Hepatitis E virus 1678143 T40067 ORF2 Heparan sulfate proteoglycans (HSPGs) 19812150
CHIKV 37124 T40026 E2 Heparan sulfate C00925 31167876 28404855
EEEV 11021 T40054 E2 Heparan sulfate C00925 23720725 33091085
RRV 11029 T40071 E2 Heparan sulfate C00925 11413296 33091085
SFV 11033 T40127 Heparan sulfate C00925 12239287 33091085
Sindbis virus 11034 T40377 E2 Heparan sulfate C00925 9696832 20300181
VEEV 11036 T40028 E2 Heparan sulfate C00925 11021998
DENV 1-4 11053 11060 11069 11070 T40048 T40373 T40374 T40375 E Heparan sulfate C00925 9256277 22500135
JEV 11072 T40052 E Heparan sulfate C00925 14981764
TBEV 11084 T40061 E Heparan sulfate C00925 11356970
YFV 11089 T40057 Heparan sulfate C00925 28471403
ZIKV 64320 T40049 E Glycosaminoglycans (GAGs) C02545 28151637
HCV 41856 T40066 E2 Heparan sulfate C00925 12867431
-ssRNA hPIV-1 12730 T40043 HN neolacto-series gangliosides containing a terminal NeuAcα2-3Galβ1-4GlcNAc 11312330
hPIV-3 11216 T40044 HN gangliosides with a terminal NeuAcα2-3Gal-, NeuAcα2-6Gal- or NeuGcα2-3Galβ1-4GlcNAc 11312330
hPIV-2 2560525 T40042 HN Sialylated molecules 16575518
hPIV-4 11224 T40122 HN Sialylated molecules 16575518
MuV 2560602 T40034 HN Trisaccharide containing α2,3-linked sialic acid 27671656
HMPV 162145 T40095 F Heparan sulfate C00925 22238303
RSV 11250 T40045 G Iduronic Acid-Containing Glycosaminoglycans 10860881 16575518
Heparan sulfate proteoglycans (HSPGs) 9229012 27903593
IAV 211044 488241 335341 93838 1332244 130760 T40035 T40036 T40037 T40041 T40350 T40038 HA Neu5Ac-α2,6-Gal 24161712
IAV 93838 1332244 T40041 T40350 HA Neu5Ac-α2,3-Gal 24161712
IBV 518987 T40039 Neu5Aca2-6Galb1-4GlcNAc(6VSLN) 9191848
ICV 11553 T40040 HEF N-acetyl-9-O-acetylneuraminic acid 26215728
HDV 12475 T40085 Heparan sulfate proteoglycans (HSPGs) 23161433
dsDNA HSV-1 10298 T40073 gB Heparan sulfate C00925 18358807
gC
gD 3-O-sulfonated-heparan sulfate (3-O-S-HS) 10520990
HSV-2 10310 T40074 gB Heparan sulfate C00925 22491462
gC
VZV 10335 T40078 gB Heparan sulfate proteoglycans (HSPGs) 9620211
HCMV 10359 T40080 gB Heparan sulfate glycosaminoglycans (HS GAGs) 8384757 22440964
gM/gN
HHV-7 10372 T40076 gB Heparan sulfate proteoglycans (HSPGs) 9151851
gp65 Heparan sulfate proteoglycans (HSPGs) 10775589
KSHV 37296 T40081 gB Heparan sulfate C00925 19923183
gpK8.1A
ORF4
gH
VACV 10245 T40360 D8L Chondroitin sulfate C00607 10482629
H3L Heparan sulfate C00925 10708453
A27L Heparan sulfate C00925 9445060
MCPyV 493803 T40051 VP1 Neu5Ac-a2,3-Gal disaccharide (3SLN, DSL, GD1a and GT1b oligosaccharides) 22910713
Glycosaminoglycans (GAGs) C02545
BK polyomavirus 1891762 VP1 b-series gangliosides (GD3, GD2, GD1b and GT1b) C06133 C06134 C06141 C06140 24130487 16415013
JC virus 10632 T40072 VP1 Lactoseries tetrasaccharide c (LSTc) G11147 24089568
SV40 1891767 T40086 VP1 GM1 C04911 12941687 20023649
HPV18 337042 T40088 L1 Heparan sulfate oligosaccharide 21115492
HPV16 333760 T40087 L1 Heparan sulfate oligosaccharide 21115492
ssDNA Adeno-associated virus 2 10804 Heparan sulfate proteoglycans (HSPGs) 9445046
B19 virus 10798 T40084 VP1/VP2 Glycosphingolipid globoside (Gb4Cer) G00094 8211117 24889255

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Last updated: August 9, 2022