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ENTRY	nt06028
Name	Dopamine and serotonin metabolism
Category	Pathway view; Amino acid metabolism
Pathway	hsa00350 Tyrosine metabolism hsa00380 Tryptophan metabolism hsa00790 Folate biosynthesis hsa04728 Dopaminergic synapse
Module	hsa_M00842 Tetrahydrobiopterin biosynthesis, GTP => BH4
Display	drug-target relation   disease type

N01530    Tyr+BH4 − TH → L-Dopa − DDC → Dopamine − MAO → DOPAL     Dopa-responsive dystonia     TH*               D1  |     AADC deficiency             DDC*     Brunner syndrome                     MAOA*   N01037    PD SNCA* ⌿ TH → L-Dopa N01039    PD                 PRKN* ⌿ MAO → DOPAL N01040                    Dopamine − VMAT → Dopamine(SV) N01041    PD                 SNCA* ⊣ VMAT2     PKDYS2                     VMAT2* N01790                    Dopamine(outer) − DAT → Dopamine(inner)     PKDYS1                     DAT*   N01550    Dopamine − DBH → Noradrenaline − PNMT → Adrenaline − MAO → DOPEGAL     DBH deficiency     DBH*     Brunner syndrome                     MAOA*   N01551        Trp − TPH1/2 ⇉ DDC → Serotonin − MAO → 5-HIAL     MDD/ADHD         TPH2*               D1  |     AADC deficiency             DDC*     Brunner syndrome                     MAOA*   N01552    Tyr − TYR → Dopaquinone − DCT ⇉ TYRP1 → Eumelanin     OCA1     TYR*     OCA8             DCT*     OCA3                 TYRP1*   N00702    GTP − GCH1 ⇉ PTS ⇉ SPR → BH4     Dopa-responsive dystonia     GCH1*     SPR deficiency             SPR*

		Disease name	Disease category
Dopa-responsive dystonia	H02557	Dopa-responsive dystonia	Nervous system disease
AADC deficiency	H01161	Aromatic L-amino acid decarboxylase deficiency	Nervous system disease
Brunner syndrome	H00548	Brunner syndrome	Inherited metabolic disorder
PD	H00057	Parkinson disease	Neurodegenerative disease
PKDYS2	H02676	Infantile-onset parkinsonism-dystonia	Nervous system disease
PKDYS1	H02676	Infantile-onset parkinsonism-dystonia	Nervous system disease
DBH deficiency	H01005	Dopamine beta-hydroxylase deficiency	Nervous system disease
MDD/ADHD	H01646	Major depressive disorder	Mental and behavioural disorder
	H01895	Attention deficit hyperactivity disorder (ADHD)	Mental and behavioural disorder
OCA1	H00168	Oculocutaneous albinism	Inherited metabolic disorder
OCA8	H00168	Oculocutaneous albinism	Inherited metabolic disorder
OCA3	H00168	Oculocutaneous albinism	Inherited metabolic disorder
Dopa-responsive dystonia	H02557	Dopa-responsive dystonia	Nervous system disease
SPR deficiency	H02597	Sepiapterin reductase deficiency	Inherited metabolic disorder

		Drug name
D1	D12407	Eladocagene exuparvovec (USAN/INN)