KEGG    Network variation - Glycine, serine and arginine metabolism
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ENTRYnt06033
NameGlycine, serine and arginine metabolism
CategoryPathway view; Amino acid metabolism
Pathwayhsa00260 Glycine, serine and threonine metabolism
hsa00330 Arginine and proline metabolism
hsa00670 One carbon pool by folate
Modulehsa_M00621 Glycine cleavage system
hsa_M00020 Serine biosynthesis, glycerate-3P => serine
hsa_M00974 Betaine metabolism, animals, betaine => glycine
hsa_M00047 Creatine pathway
hsa_M00972 Proline metabolism
hsa_M00970 Proline degradation, proline => glutamate
DiseaseH00191 Glycine encephalopathy
H00849 Cerebral creatine deficiency syndrome
H00190 Hyperprolinemia
Display drug-target relation   disease type
N01613    Gly+Lipoyl-HGLDCAMTMTHF+Dihydrolipoyl..
    GCE1   GLDC*
    GCE2     AMT*
N01610    Dihydrolipoyl-HDLDLipoyl-H
N01611    GCSH=(GLDC+AMT+DLD)
    MMDS7 GCSH*
 
N01791    Ser+THFSHMTGly+MTHF
    NEDCASB   SHMT2*
 
N01608    3-PGAPHGDHPSAT1PSPHSer
    PHGDH deficiency/NLS   PHGDH*
    PSAT deficiency/NLS     PSAT1*
    PSPH deficiency       PSPH*
 
N01789    GBBHMTDMGDHSarcosine(SARDH,PIPOX)Gly
    DMGDHD     DMGDH*
    Sarcosinemia       Sarcosine SARDH*
 
N01612    Arg+GlyGATMGAMTCrCKCrn
    CCDS3   GATM*
    CCDS2     GAMT*
N01615    CrSLC6A8Cr(intracellular)
    CCDS1   SLC6A8*
 
N01618    OrnOATPYCRPro
    Ornithinaemia   OAT*
N01622    ProPRODHALDH4A1Glu
    HYRPRO1   PRODH*
    HYRPRO2     ALDH4A1*
 
N01623    OrnODC1PutSRMSMSSpm
    NEDABA   ODC1*
    SRS         SMS*

Disease nameDisease category
GCE1H00191Nonketotic hyperglycinemiaInherited metabolic disorder
GCE2H00191Nonketotic hyperglycinemiaInherited metabolic disorder
MMDS7H01894Multiple mitochondrial dysfunctions syndromeInherited metabolic disorder, Mitochondrial disease
NEDCASBH02470Neurodevelopmental disorder with structural brain abnormalitiesCongenital malformation
PHGDH deficiency/NLSH010793-Phosphoglycerate dehydrogenase (3-PGDH) deficiencyInherited metabolic disorder
H02117Neu-Laxova syndromeInherited metabolic disorder
PSAT deficiency/NLSH01082Phosphoserine aminotransferase deficiencyInherited metabolic disorder
H02117Neu-Laxova syndromeInherited metabolic disorder
PSPH deficiencyH02116Phosphoserine phosphatase deficiencyInherited metabolic disorder
DMGDHDH01003Dimethylglycine dehydrogenase deficiencyInherited metabolic disorder
SarcosinemiaH02657SarcosinemiaInherited metabolic disorder
CCDS3H00849Cerebral creatine deficiency syndromeInherited metabolic disorder
CCDS2H00849Cerebral creatine deficiency syndromeInherited metabolic disorder
CCDS1H00849Cerebral creatine deficiency syndromeInherited metabolic disorder
OrnithinaemiaH00189OrnithinaemiaInherited metabolic disorder
HYRPRO1H00190HyperprolinemiaInherited metabolic disorder
HYRPRO2H00190HyperprolinemiaInherited metabolic disorder
NEDABAH02470Neurodevelopmental disorder with structural brain abnormalitiesCongenital malformation
SRSH00597Snyder-Robinson syndromeCongenital malformation