[ Network menu | Network entry | Help ]

ENTRY	nt06462
Name	Spinocerebellar ataxia
Category	Disease view; Neurodegenerative disease
Pathway	hsa05017 Spinocerebellar ataxia
Disease	H00063 Spinocerebellar ataxia
Display	drug-target relation   disease type

Calcium signaling N00953    Glutamate → GRM1 → GNAQ → PLCB → IP3 → ITPR → Ca2+ → PKC ⊣ TRPC3 → Ca2+ N00960    SPTBN2* ⊣ GRM1 → GNAQ → PLCB → IP3 → ITPR → Ca2+ N00954    Glutamate → GRM1* → GNAQ → PLCB → IP3 → ITPR → Ca2+ N00958    Glutamate → GRM1 → GNAQ → PLCB → IP3 → ITPR1* → Ca2+ N00959    Glutamate → GRM1 → GNAQ → PLCB → IP3 → ITPR1* ⌿ Ca2+ N00955    Glutamate → GRM1 → GNAQ → PLCB → IP3 → ITPR → Ca2+ → PRKCG* ⌿ TRPC3 N00956    Glutamate → GRM1 → GNAQ → PLCB → IP3 → ITPR → Ca2+ → PRKCG* ⊣ TRPC3 N00961                                    TRPC3* → Ca2+ N00984    Glutamate → GRM5 → GNAQ → PLCB → IP3 → ITPR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00957    Glutamate → GRM1 → GNAQ → PLCB → IP3 → (ITPR1+(ATXN2*,ATX.. → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS N00967                    Ca2+(extracellular.. − VGCC → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00968                    Ca2+(extracellular.. − CACNA1A* → Ca2+ N00969                    Ca2+(extracellular.. ⌿ CACNA1A* ⌿ Ca2+ N00970                    Glutamate → NMDAR → Ca2+ N00971                    PDYN* → NMDAR → Ca2+   Potassium transport N00972    K+ − KCNC → K+(extracellular) N00973    K+ ⌿ KCNC3* ⌿ K+(extracellular) N00974    K+ − KCND → K+(extracellular) N00975    K+ ⌿ KCND3* ⌿ K+(extracellular)   Autophagy N00155    mTORC1 → ULK1_complex → PI3KC3-C1 N00962        ATXN3* ⌿ (BECN1+PIK3C3+ATG1..   PI3K signaling N00963    RELN → VLDLR = DAB1 → PI3K → PIP3 → AKT ⊣ (TSC1+TSC2) ⊣ RHEB → MTOR → S6K N00964    RELN → VLDLR = DAB1* → PI3K → PIP3 → AKT   Transcription N00965        (RORA+KAT5) ⇒ (ITPR1,SLC1A6,GRM1.. N00966    ATXN1* ⊣ (RORA+KAT5) ⇒ (ITPR1,SLC1A6,GRM1..