KEGG   Homo sapiens (human): 2902
Entry
2902              CDS       T01001                                 
Symbol
GRIN1, DEE101, GluN1, MRD8, NDHMSD, NDHMSR, NMD-R1, NMDA1, NMDAR1, NR1
Name
(RefSeq) glutamate ionotropic receptor NMDA type subunit 1
  KO
K05208  glutamate receptor ionotropic, NMDA 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06528  Calcium signaling
  Element
N00970  Transport of calcium
N00971  Mutation-caused aberrant PDYN to transport of calcium
N00987  Mutation-caused aberrant Htt to transport of calcium
N01003  Mutation-caused aberrant Abeta to transport of calcium
N01200  Scrapie conformation PrPSc to transport of calcium
N01642  Ca2+ entry, Ligand-gated Ca2+ channel
Disease
H00606  Early infantile epileptic encephalopathy
H00773  Autosomal dominant intellectual developmental disorder
H02705  Neurodevelopmental disorder with glutamatergic synapse dysfunction
Drug target
Acamprosate (DG00996): D02780<JP/US> D07058
Amantadine (DG00860): D00777<JP/US> D07441
Apimostinel: D11299
Aptiganel hydrochloride: D02973
Budipine (DG00866): D07306 D07589
Dalzanemdor: D12788
Delucemine hydrochloride: D03679
Dextromethorphan (DG01078): D00848<JP> D03742 D03744
Dextrorphan hydrochloride: D03746
Dizocilpine maleate: D03878
Esketamine (DG01829): D07283 D10627<US>
Esmethadone  
Dextromethadone (DG03176): D12214 D12215
Felbamate: D00536<US>
Gavestinel: D04308
Ketamine (DG00796): D00711<JP/US> D08098
Latrepirdine (DG01379): D09917 D09918
Levomethadone (DG01002): D08121 D08122
Licostinel: D04728
Memantine (DG00986): D04905<JP/US> D08174
Methadone (DG00999): D02102<JP/US> D08195
Nevadistinel: D12553
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Perzinfotel: D05447
Phencyclidine hydrochloride: D05453
Remacemide hydrochloride: D05714
Riluzole: D00775<JP/US>
Risevistinel: D12554
Selfotel: D02410
Tenocyclidine: D12702
Tiletamine (DG01380): D06146 D08596
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2902 (GRIN1)
   04015 Rap1 signaling pathway
    2902 (GRIN1)
   04020 Calcium signaling pathway
    2902 (GRIN1)
   04024 cAMP signaling pathway
    2902 (GRIN1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2902 (GRIN1)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2902 (GRIN1)
   04720 Long-term potentiation
    2902 (GRIN1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2902 (GRIN1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2902 (GRIN1)
   05014 Amyotrophic lateral sclerosis
    2902 (GRIN1)
   05016 Huntington disease
    2902 (GRIN1)
   05017 Spinocerebellar ataxia
    2902 (GRIN1)
   05020 Prion disease
    2902 (GRIN1)
   05022 Pathways of neurodegeneration - multiple diseases
    2902 (GRIN1)
  09165 Substance dependence
   05030 Cocaine addiction
    2902 (GRIN1)
   05031 Amphetamine addiction
    2902 (GRIN1)
   05033 Nicotine addiction
    2902 (GRIN1)
   05034 Alcoholism
    2902 (GRIN1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2902 (GRIN1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2902 (GRIN1)
SSDB
Motif
Pfam: Lig_chan ANF_receptor Lig_chan-Glu_bd SBP_bac_3 Ion_trans_2 Peripla_BP_6 DUF6724
Other DBs
NCBI-GeneID: 2902
NCBI-ProteinID: NP_015566
OMIM: 138249
HGNC: 4584
Ensembl: ENSG00000176884
UniProt: Q05586
Structure
LinkDB
Position
9:137139154..137168756
AA seq 938 aa
MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL
NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG
LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL
ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM
TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN
ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK
LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC
KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA
DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI
LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA
LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP
EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA
VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH
ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH
KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT
STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES
NT seq 2817 nt   +upstreamnt  +downstreamnt
atgagcaccatgcgcctgctgacgctcgccctgctgttctcctgctccgtcgcccgtgcc
gcgtgcgaccccaagatcgtcaacattggcgcggtgctgagcacgcggaagcacgagcag
atgttccgcgaggccgtgaaccaggccaacaagcggcacggctcctggaagattcagctc
aatgccacctccgtcacgcacaagcccaacgccatccagatggctctgtcggtgtgcgag
gacctcatctccagccaggtctacgccatcctagttagccatccacctacccccaacgac
cacttcactcccacccctgtctcctacacagccggcttctaccgcatacccgtgctgggg
ctgaccacccgcatgtccatctactcggacaagagcatccacctgagcttcctgcgcacc
gtgccgccctactcccaccagtccagcgtgtggtttgagatgatgcgtgtctacagctgg
aaccacatcatcctgctggtcagcgacgaccacgagggccgggcggctcagaaacgcctg
gagacgctgctggaggagcgtgagtccaaggcagagaaggtgctgcagtttgacccaggg
accaagaacgtgacggccctgctgatggaggcgaaagagctggaggcccgggtcatcatc
ctttctgccagcgaggacgatgctgccactgtataccgcgcagccgcgatgctgaacatg
acgggctccgggtacgtgtggctggtcggcgagcgcgagatctcggggaacgccctgcgc
tacgccccagacggcatcctcgggctgcagctcatcaacggcaagaacgagtcggcccac
atcagcgacgccgtgggcgtggtggcccaggccgtgcacgagctcctcgagaaggagaac
atcaccgacccgccgcggggctgcgtgggcaacaccaacatctggaagaccgggccgctc
ttcaagagagtgctgatgtcttccaagtatgcggatggggtgactggtcgcgtggagttc
aatgaggatggggaccggaagttcgccaactacagcatcatgaacctgcagaaccgcaag
ctggtgcaagtgggcatctacaatggcacccacgtcatccctaatgacaggaagatcatc
tggccaggcggagagacagagaagcctcgagggtaccagatgtccaccagactgaagatt
gtgacgatccaccaggagcccttcgtgtacgtcaagcccacgctgagtgatgggacatgc
aaggaggagttcacagtcaacggcgacccagtcaagaaggtgatctgcaccgggcccaac
gacacgtcgccgggcagcccccgccacacggtgcctcagtgttgctacggcttttgcatc
gacctgctcatcaagctggcacggaccatgaacttcacctacgaggtgcacctggtggca
gatggcaagttcggcacacaggagcgggtgaacaacagcaacaagaaggagtggaatggg
atgatgggcgagctgctcagcgggcaggcagacatgatcgtggcgccgctaaccataaac
aacgagcgcgcgcagtacatcgagttttccaagcccttcaagtaccagggcctgactatt
ctggtcaagaaggagattccccggagcacgctggactcgttcatgcagccgttccagagc
acactgtggctgctggtggggctgtcggtgcacgtggtggccgtgatgctgtacctgctg
gaccgcttcagccccttcggccggttcaaggtgaacagcgaggaggaggaggaggacgca
ctgaccctgtcctcggccatgtggttctcctggggcgtcctgctcaactccggcatcggg
gaaggcgcccccagaagcttctcagcgcgcatcctgggcatggtgtgggccggctttgcc
atgatcatcgtggcctcctacaccgccaacctggcggccttcctggtgctggaccggccg
gaggagcgcatcacgggcatcaacgaccctcggctgaggaacccctcggacaagtttatc
tacgccacggtgaagcagagctccgtggatatctacttccggcgccaggtggagctgagc
accatgtaccggcatatggagaagcacaactacgagagtgcggcggaggccatccaggcc
gtgagagacaacaagctgcatgccttcatctgggactcggcggtgctggagttcgaggcc
tcgcagaagtgcgacctggtgacgactggagagctgtttttccgctcgggcttcggcata
ggcatgcgcaaagacagcccctggaagcagaacgtctccctgtccatcctcaagtcccac
gagaatggcttcatggaagacctggacaagacgtgggttcggtatcaggaatgtgactcg
cgcagcaacgcccctgcgacccttacttttgagaacatggccggggtcttcatgctggta
gctgggggcatcgtggccgggatcttcctgattttcatcgagattgcctacaagcggcac
aaggatgctcgccggaagcagatgcagctggcctttgccgccgttaacgtgtggcggaag
aacctgcaggatagaaagagtggtagagcagagcctgaccctaaaaagaaagccacattt
agggctatcacctccaccctggcttccagcttcaagaggcgtaggtcctccaaagacacg
agcaccgggggtggacgcggcgctttgcaaaaccaaaaagacacagtgctgccgcgacgc
gctattgagagggaggagggccagctgcagctgtgttcccgtcatagggagagctga

KEGG   Homo sapiens (human): 2903
Entry
2903              CDS       T01001                                 
Symbol
GRIN2A, EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A
Name
(RefSeq) glutamate ionotropic receptor NMDA type subunit 2A
  KO
K05209  glutamate receptor ionotropic, NMDA 2A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
hsa05322  Systemic lupus erythematosus
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06528  Calcium signaling
  Element
N00970  Transport of calcium
N00971  Mutation-caused aberrant PDYN to transport of calcium
N00987  Mutation-caused aberrant Htt to transport of calcium
N01003  Mutation-caused aberrant Abeta to transport of calcium
N01200  Scrapie conformation PrPSc to transport of calcium
N01642  Ca2+ entry, Ligand-gated Ca2+ channel
Disease
H01514  Landau-Kleffner syndrome
H01827  Rolandic epilepsy, mental retardation, and speech dyspraxia
Drug target
Acamprosate (DG00996): D02780<JP/US> D07058
Amantadine (DG00860): D00777<JP/US> D07441
Apimostinel: D11299
Aptiganel hydrochloride: D02973
Budipine (DG00866): D07306 D07589
Dalzanemdor: D12788
Delucemine hydrochloride: D03679
Dextromethorphan (DG01078): D00848<JP> D03742 D03744
Dextrorphan hydrochloride: D03746
Dizocilpine maleate: D03878
Esketamine (DG01829): D07283 D10627<US>
Esmethadone  
Dextromethadone (DG03176): D12214 D12215
Felbamate: D00536<US>
Gavestinel: D04308
Ketamine (DG00796): D00711<JP/US> D08098
Latrepirdine (DG01379): D09917 D09918
Levomethadone (DG01002): D08121 D08122
Licostinel: D04728
Memantine (DG00986): D04905<JP/US> D08174
Methadone (DG00999): D02102<JP/US> D08195
Nevadistinel: D12553
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Perzinfotel: D05447
Phencyclidine hydrochloride: D05453
Remacemide hydrochloride: D05714
Riluzole: D00775<JP/US>
Risevistinel: D12554
Selfotel: D02410
Tenocyclidine: D12702
Tiletamine (DG01380): D06146 D08596
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2903 (GRIN2A)
   04015 Rap1 signaling pathway
    2903 (GRIN2A)
   04020 Calcium signaling pathway
    2903 (GRIN2A)
   04024 cAMP signaling pathway
    2903 (GRIN2A)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2903 (GRIN2A)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2903 (GRIN2A)
   04728 Dopaminergic synapse
    2903 (GRIN2A)
   04720 Long-term potentiation
    2903 (GRIN2A)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2903 (GRIN2A)
 09160 Human Diseases
  09163 Immune disease
   05322 Systemic lupus erythematosus
    2903 (GRIN2A)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2903 (GRIN2A)
   05014 Amyotrophic lateral sclerosis
    2903 (GRIN2A)
   05017 Spinocerebellar ataxia
    2903 (GRIN2A)
   05020 Prion disease
    2903 (GRIN2A)
   05022 Pathways of neurodegeneration - multiple diseases
    2903 (GRIN2A)
  09165 Substance dependence
   05030 Cocaine addiction
    2903 (GRIN2A)
   05031 Amphetamine addiction
    2903 (GRIN2A)
   05033 Nicotine addiction
    2903 (GRIN2A)
   05034 Alcoholism
    2903 (GRIN2A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2903 (GRIN2A)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2903 (GRIN2A)
SSDB
Motif
Pfam: NMDAR2_C Lig_chan Lig_chan-Glu_bd SBP_bac_3 ANF_receptor
Other DBs
NCBI-GeneID: 2903
NCBI-ProteinID: NP_000824
OMIM: 138253
HGNC: 4585
Ensembl: ENSG00000183454
UniProt: Q12879 Q547U9
Structure
LinkDB
Position
16:complement(9753404..10182908)
AA seq 1464 aa
MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQA
AGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHT
FVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY
REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLIL
SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT
TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR
LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE
DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLV
TNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS
NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT
IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVD
QVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSL
KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALL
QFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL
FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS
AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNM
NELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDS
IRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNH
KTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVT
LPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH
SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNP
ATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLL
EGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIG
RCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYS
TPRVLNSCSNRRVYKKMPSIESDV
NT seq 4395 nt   +upstreamnt  +downstreamnt
atgggcagagtgggctattggaccctgctggtgctgccggcccttctggtctggcgcggt
ccggcgccgagcgcggcggcggagaagggtccccccgcgctaaatattgcggtgatgctg
ggtcacagccacgacgtgacagagcgcgaacttcgaacactgtggggccccgagcaggcg
gcggggctgcccctggacgtgaacgtggtagctctgctgatgaaccgcaccgaccccaag
agcctcatcacgcacgtgtgcgacctcatgtccggggcacgcatccacggcctcgtgttt
ggggacgacacggaccaggaggccgtagcccagatgctggattttatctcctcccacacc
ttcgtccccatcttgggcattcatgggggcgcatctatgatcatggctgacaaggatccg
acgtctaccttcttccagtttggagcgtccatccagcagcaagccacggtcatgctgaag
atcatgcaggattatgactggcatgtcttctccctggtgaccactatcttccctggctac
agggaattcatcagcttcgtcaagaccacagtggacaacagctttgtgggctgggacatg
cagaatgtgatcacactggacacttcctttgaggatgcaaagacacaagtccagctgaag
aagatccactcttctgtcatcttgctctactgttccaaagacgaggctgttctcattctg
agtgaggcccgctcccttggcctcaccgggtatgatttcttctggattgtccccagcttg
gtctctgggaacacggagctcatcccaaaagagtttccatcgggactcatttctgtctcc
tacgatgactgggactacagcctggaggcgagagtgagggacggcattggcatcctaacc
accgctgcatcttctatgctggagaagttctcctacatccccgaggccaaggccagctgc
tacgggcagatggagaggccagaggtcccgatgcacaccttgcacccatttatggtcaat
gttacatgggatggcaaagacttatccttcactgaggaaggctaccaggtgcaccccagg
ctggtggtgattgtgctgaacaaagaccgggaatgggaaaaggtgggcaagtgggagaac
catacgctgagcctgaggcacgccgtgtggcccaggtacaagtccttctccgactgtgag
ccggatgacaaccatctcagcatcgtcaccctggaggaggccccattcgtcatcgtggaa
gacatagaccccctgaccgagacgtgtgtgaggaacaccgtgccatgtcggaagttcgtc
aaaatcaacaattcaaccaatgaggggatgaatgtgaagaaatgctgcaaggggttctgc
attgatattctgaagaagctttccagaactgtgaagtttacttacgacctctatctggtg
accaatgggaagcatggcaagaaagttaacaatgtgtggaatggaatgatcggtgaagtg
gtctatcaacgggcagtcatggcagttggctcgctcaccatcaatgaggaacgttctgaa
gtggtggacttctctgtgccctttgtggaaacgggaatcagtgtcatggtttcaagaagt
aatggcaccgtctcaccttctgcttttctagaaccattcagcgcctctgtctgggtgatg
atgtttgtgatgctgctcattgtttctgccatagctgtttttgtctttgaatacttcagc
cctgttggatacaacagaaacttagccaaagggaaagcaccccatgggccttcttttaca
attggaaaagctatatggcttctttggggcctggtgttcaataactccgtgcctgtccag
aatcctaaagggaccaccagcaagatcatggtatctgtatgggccttcttcgctgtcata
ttcctggctagctacacagccaatctggctgccttcatgatccaagaggaatttgtggac
caagtgaccggcctcagtgacaaaaagtttcagagacctcatgactattccccacctttt
cgatttgggacagtgcctaatggaagcacggagagaaacattcggaataactatccctac
atgcatcagtacatgaccaaatttaatcagaaaggagtagaggacgccttggtcagcctg
aaaacggggaagctggacgctttcatctacgatgccgcagtcttgaattacaaggctggg
agggatgaaggctgcaagctggtgaccatcgggagtgggtacatctttgccaccaccggt
tatggaattgcccttcagaaaggctctccttggaagaggcagatcgacctggccttgctt
cagtttgtgggtgatggtgagatggaggagctggagaccctgtggctcactgggatctgc
cacaacgagaagaacgaggtgatgagcagccagctggacattgacaacatggcgggcgta
ttctacatgctggctgccgccatggcccttagcctcatcaccttcatctgggagcacctc
ttctactggaagctgcgcttctgtttcacgggcgtgtgctccgaccggcctgggttgctc
ttctccatcagcaggggcatctacagctgcattcatggagtgcacattgaagaaaagaag
aagtctccagacttcaatctgacgggatcccagagcaacatgttaaaactcctccggtca
gccaaaaacatttccagcatgtccaacatgaactcctcaagaatggactcacccaaaaga
gctgctgacttcatccaaagaggttccctcatcatggacatggtttcagataaggggaat
ttgatgtactcagacaacaggtcctttcaggggaaagagagcatttttggagacaacatg
aacgaactccaaacatttgtggccaaccggcagaaggataacctcaataactatgtattc
cagggacaacatcctcttactctcaatgagtccaaccctaacacggtggaggtggccgtg
agcacagaatccaaagcgaactctagaccccggcagctgtggaagaaatccgtggattcc
atacgccaggattcactatcccagaatccagtctcccagagggatgaggcaacagcagag
aataggacccactccctaaagagccctaggtatcttccagaagagatggcccactctgac
atttcagaaacgtcaaatcgggccacgtgccacagggaacctgacaacagtaagaaccac
aaaaccaaggacaactttaaaaggtcagtggcctccaaataccccaaggactgtagtgag
gtcgagcgcacctacctgaaaaccaaatcaagctcccctagagacaagatctacactata
gatggtgagaaggagcctggtttccacttagatccaccccagtttgttgaaaatgtgacc
ctgcccgagaacgtggacttcccggacccctaccaggatcccagtgaaaacttccgcaag
ggggactccacgctgccaatgaaccggaaccccttgcataatgaagaggggctttccaac
aacgaccagtataaactctactccaagcacttcaccttgaaagacaagggttccccgcac
agtgagaccagcgagcgataccggcagaactccacgcactgcagaagctgcctttccaac
atgcccacctattcaggccacttcaccatgaggtcccccttcaagtgcgatgcctgcctg
cggatggggaacctctatgacatcgatgaagaccagatgcttcaggagacaggtaaccca
gccaccggggagcaggtctaccagcaggactgggcacagaacaatgcccttcaattacaa
aagaacaagctaaggattagccgtcagcattcctacgataacattgtcgacaaacctagg
gagctagaccttagcaggccctcccggagcataagcctcaaggacagggaacggcttctg
gagggaaatttttacggcagcctgtttagtgtcccctcaagcaaactctcggggaaaaaa
agctcccttttcccccaaggtctggaggacagcaagaggagcaagtctctcttgccagac
cacacctccgataaccctttcctccactcccacagggatgaccaacgcttggttattggg
agatgcccctcggacccttacaaacactcgttgccatcccaggcggtgaatgacagctat
cttcggtcgtccttgaggtcaacggcatcgtactgttccagggacagtcggggccacaat
gatgtgtatatttcggagcatgttatgccttatgctgcaaataagaataatatgtactct
acccccagggttttaaattcctgcagcaatagacgcgtgtacaagaaaatgcctagtatc
gaatctgatgtttaa

KEGG   Homo sapiens (human): 2904
Entry
2904              CDS       T01001                                 
Symbol
GRIN2B, DEE27, EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, NR3, hNR3
Name
(RefSeq) glutamate ionotropic receptor NMDA type subunit 2B
  KO
K05210  glutamate receptor ionotropic, NMDA 2B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
hsa05322  Systemic lupus erythematosus
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
  Element
N00970  Transport of calcium
N00971  Mutation-caused aberrant PDYN to transport of calcium
N00987  Mutation-caused aberrant Htt to transport of calcium
N01003  Mutation-caused aberrant Abeta to transport of calcium
N01200  Scrapie conformation PrPSc to transport of calcium
Disease
H00606  Early infantile epileptic encephalopathy
H00773  Autosomal dominant intellectual developmental disorder
Drug target
Acamprosate (DG00996): D02780<JP/US> D07058
Amantadine (DG00860): D00777<JP/US> D07441
Apimostinel: D11299
Aptiganel hydrochloride: D02973
Besonprodil: D03100
Budipine (DG00866): D07306 D07589
Dalzanemdor: D12788
Delucemine hydrochloride: D03679
Dextromethorphan (DG01078): D00848<JP> D03742 D03744
Dextrorphan hydrochloride: D03746
Dizocilpine maleate: D03878
Esketamine (DG01829): D07283 D10627<US>
Esmethadone  
Dextromethadone (DG03176): D12214 D12215
Felbamate: D00536<US>
Gavestinel: D04308
Ketamine (DG00796): D00711<JP/US> D08098
Latrepirdine (DG01379): D09917 D09918
Levomethadone (DG01002): D08121 D08122
Licostinel: D04728
Memantine (DG00986): D04905<JP/US> D08174
Methadone (DG00999): D02102<JP/US> D08195
Neramexane mesylate: D05145
Nevadistinel: D12553
Onfasprodil: D12787
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Perzinfotel: D05447
Phencyclidine hydrochloride: D05453
Remacemide hydrochloride: D05714
Riluzole: D00775<JP/US>
Risevistinel: D12554
Rislenemdaz: D11340
Selfotel: D02410
Tenocyclidine: D12702
Tiletamine (DG01380): D06146 D08596
Traxoprodil mesylate: D06204
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2904 (GRIN2B)
   04015 Rap1 signaling pathway
    2904 (GRIN2B)
   04020 Calcium signaling pathway
    2904 (GRIN2B)
   04024 cAMP signaling pathway
    2904 (GRIN2B)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2904 (GRIN2B)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2904 (GRIN2B)
   04728 Dopaminergic synapse
    2904 (GRIN2B)
   04720 Long-term potentiation
    2904 (GRIN2B)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2904 (GRIN2B)
 09160 Human Diseases
  09163 Immune disease
   05322 Systemic lupus erythematosus
    2904 (GRIN2B)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2904 (GRIN2B)
   05014 Amyotrophic lateral sclerosis
    2904 (GRIN2B)
   05016 Huntington disease
    2904 (GRIN2B)
   05017 Spinocerebellar ataxia
    2904 (GRIN2B)
   05020 Prion disease
    2904 (GRIN2B)
   05022 Pathways of neurodegeneration - multiple diseases
    2904 (GRIN2B)
  09165 Substance dependence
   05030 Cocaine addiction
    2904 (GRIN2B)
   05031 Amphetamine addiction
    2904 (GRIN2B)
   05033 Nicotine addiction
    2904 (GRIN2B)
   05034 Alcoholism
    2904 (GRIN2B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2904 (GRIN2B)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2904 (GRIN2B)
SSDB
Motif
Pfam: NMDAR2_C Lig_chan Lig_chan-Glu_bd SBP_bac_3 ANF_receptor
Other DBs
NCBI-GeneID: 2904
NCBI-ProteinID: NP_000825
OMIM: 138252
HGNC: 4586
Ensembl: ENSG00000273079
UniProt: Q13224 A0A8D9PHB2
Structure
LinkDB
Position
12:complement(13537337..13982134)
AA seq 1484 aa
MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFH
HLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTL
TPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQ
DFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYI
FEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAII
TTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHP
KLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE
SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYL
VTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSR
SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSF
TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYV
DQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLS
LKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAI
LQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH
LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILR
LLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS
DYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISK
KPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKR
RKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTK
ENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKN
LTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL
QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPR
SVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPD
RVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPA
RFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV
NT seq 4455 nt   +upstreamnt  +downstreamnt
atgaagcccagagcggagtgctgttctcccaagttctggttggtgttggccgtcctggcc
gtgtcaggcagcagagctcgttctcagaagagcccccccagcattggcattgctgtcatc
ctcgtgggcacttccgacgaggtggccatcaaggatgcccacgagaaagatgatttccac
catctctccgtggtaccccgggtggaactggtagccatgaatgagaccgacccaaagagc
atcatcacccgcatctgtgatctcatgtctgaccggaagatccagggggtggtgtttgct
gatgacacagaccaggaagccatcgcccagatcctcgatttcatttcagcacagactctc
acccccatcctgggcatccacgggggctcctctatgataatggcagataaggatgaatcc
tccatgttcttccagtttggcccatcaattgaacagcaagcttccgtaatgctcaacatc
atggaagaatatgactggtacatcttttctatcgtcaccacctatttccctggctaccag
gactttgtaaacaagatccgcagcaccattgagaatagctttgtgggctgggagctagag
gaggtcctcctactggacatgtccctggacgatggagattctaagatccagaatcagctc
aagaaacttcaaagccccatcattcttctttactgtaccaaggaagaagccacctacatc
tttgaagtggccaactcagtagggctgactggctatggctacacgtggatcgtgcccagt
ctggtggcaggggatacagacacagtgcctgcggagttccccactgggctcatctctgta
tcatatgatgaatgggactatggcctccccgccagagtgagagatggaattgccataatc
accactgctgcttctgacatgctgtctgagcacagcttcatccctgagcccaaaagcagt
tgttacaacacccacgagaagagaatctaccagtccaatatgctaaataggtatctgatc
aatgtcacttttgaggggaggaatttgtccttcagtgaagatggctaccagatgcacccg
aaactggtgataattcttctgaacaaggagaggaagtgggaaagggtggggaagtggaaa
gacaagtccctgcagatgaagtactatgtgtggccccgaatgtgtccagagactgaagag
caggaggatgaccatctgagcattgtgaccctggaggaggcaccatttgtcattgtggaa
agtgtggaccctctgagtggaacctgcatgaggaacacagtcccctgccaaaaacgcata
gtcactgagaataaaacagacgaggagccgggttacatcaaaaaatgctgcaaggggttc
tgtattgacatccttaagaaaatttctaaatctgtgaagttcacctatgacctttacctg
gttaccaatggcaagcatgggaagaaaatcaatggaacctggaatggtatgattggagag
gtggtcatgaagagggcctacatggcagtgggctcactcaccatcaatgaggaacgatcg
gaggtggtcgacttctctgtgcccttcatagagacaggcatcagtgtcatggtgtcacgc
agcaatgggactgtctcaccttctgccttcttagagccattcagcgctgacgtatgggtg
atgatgtttgtgatgctgctcatcgtctcagccgtggctgtctttgtctttgagtacttc
agccctgtgggttataacaggtgcctcgctgatggcagagagcctggtggaccctctttc
accatcggcaaagctatttggttgctctggggtctggtgtttaacaactccgtacctgtg
cagaacccaaaggggaccacctccaagatcatggtgtcagtgtgggccttctttgctgtc
atcttcctggccagctacactgccaacttagctgccttcatgatccaagaggaatatgtg
gaccaggtttctggcctgagcgacaaaaagttccagagacctaatgacttctcaccccct
ttccgctttgggaccgtgcccaacggcagcacagagagaaatattcgcaataactatgca
gaaatgcatgcctacatgggaaagttcaaccagaggggtgtagatgatgcattgctctcc
ctgaaaacagggaaactggatgccttcatctatgatgcagcagtgctgaactatatggca
ggcagagatgaaggctgcaagctggtgaccattggcagtgggaaggtctttgcttccact
ggctatggcattgccatccaaaaagattctgggtggaagcgccaggtggaccttgctatc
ctgcagctctttggagatggggagatggaagaactggaagctctctggctcactggcatt
tgtcacaatgagaagaatgaggtcatgagcagccagctggacattgacaacatggcaggg
gtcttctacatgttgggggcggccatggctctcagcctcatcaccttcatctgcgaacac
cttttctattggcagttccgacattgctttatgggtgtctgttctggcaagcctggcatg
gtcttctccatcagcagaggtatctacagctgcatccatggggtggcgatcgaggagcgc
cagtctgtaatgaactcccccaccgcaaccatgaacaacacacactccaacatcctgcgc
ctgctgcgcacggccaagaacatggctaacctgtctggtgtgaatggctcaccgcagagc
gccctggacttcatccgacgggagtcatccgtctatgacatctcagagcaccgccgcagc
ttcacgcattctgactgcaaatcctacaacaacccgccctgtgaggagaacctcttcagt
gactacatcagtgaggtagagagaacgttcgggaacctgcagctgaaggacagcaacgtg
taccaagatcactaccaccatcaccaccggccccatagtattggcagtgccagctccatc
gatgggctctacgactgtgacaacccacccttcaccacccagtccaggtccatcagcaag
aagcccctggacatcggcctcccctcctccaagcacagccagctcagtgacctgtacggc
aaattctccttcaagagcgaccgctacagtggccacgacgacttgatccgctccgatgtc
tctgacatctcaacccacaccgtcacctatgggaacatcgagggcaatgccgccaagagg
cgtaagcagcaatataaggacagcctgaagaagcggcctgcctcggccaagtcccgcagg
gagtttgacgagatcgagctggcctaccgtcgccgaccgccccgctcccctgaccacaag
cgctacttcagggacaaggaagggctacgggacttctacctggaccagttccgaacaaag
gagaactcaccccactgggagcacgtagacctgaccgacatctacaaggagcggagtgat
gactttaagcgcgactccgtcagcggaggagggccctgtaccaacaggtctcacatcaag
cacgggacgggcgacaaacacggcgtggtcagcggggtacctgcaccttgggagaagaac
ctgaccaacgtggagtgggaggaccggtccgggggcaacttctgccgcagctgtccctcc
aagctgcacaactactccacgacggtgacgggtcagaactcgggcaggcaggcgtgcatc
cggtgtgaggcttgcaagaaagcaggcaacctgtatgacatcagtgaggacaactccctg
caggaactggaccagccggctgccccagtggcggtgacgtcaaacgcctccaccactaag
taccctcagagcccgactaattccaaggcccagaagaagaaccggaacaaactgcgccgg
cagcactcctacgacaccttcgtggacctgcagaaggaagaagccgccctggccccgcgc
agcgtaagcctgaaagacaagggccgattcatggatgggagcccctacgcccacatgttt
gagatgtcagctggcgagagcacctttgccaacaacaagtcctcagtgcccactgccgga
catcaccaccacaacaaccccggcggcgggtacatgctcagcaagtcgctctaccctgac
cgggtcacgcaaaaccctttcatccccacttttggggacgaccagtgcttgctccatggc
agcaaatcctacttcttcaggcagcccacggtggcgggggcgtcgaaagccaggccggac
ttccgggcccttgtcaccaacaagccggtggtctcggcccttcatggggccgtgccagcc
cgtttccagaaggacatctgtatagggaaccagtccaacccctgtgtgcctaacaacaaa
aaccccagggctttcaatggctccagcaatgggcatgtttatgagaaactttctagtatt
gagtctgatgtctga

KEGG   Homo sapiens (human): 2905
Entry
2905              CDS       T01001                                 
Symbol
GRIN2C, GluN2C, NMDAR2C, NR2C
Name
(RefSeq) glutamate ionotropic receptor NMDA type subunit 2C
  KO
K05211  glutamate receptor ionotropic, NMDA 2C
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06528  Calcium signaling
  Element
N00970  Transport of calcium
N00971  Mutation-caused aberrant PDYN to transport of calcium
N00987  Mutation-caused aberrant Htt to transport of calcium
N01003  Mutation-caused aberrant Abeta to transport of calcium
N01200  Scrapie conformation PrPSc to transport of calcium
N01642  Ca2+ entry, Ligand-gated Ca2+ channel
Drug target
Acamprosate (DG00996): D02780<JP/US> D07058
Amantadine (DG00860): D00777<JP/US> D07441
Apimostinel: D11299
Aptiganel hydrochloride: D02973
Budipine (DG00866): D07306 D07589
Dalzanemdor: D12788
Delucemine hydrochloride: D03679
Dextromethorphan (DG01078): D00848<JP> D03742 D03744
Dextrorphan hydrochloride: D03746
Dizocilpine maleate: D03878
Esketamine (DG01829): D07283 D10627<US>
Esmethadone  
Dextromethadone (DG03176): D12214 D12215
Felbamate: D00536<US>
Gavestinel: D04308
Ketamine (DG00796): D00711<JP/US> D08098
Latrepirdine (DG01379): D09917 D09918
Levomethadone (DG01002): D08121 D08122
Licostinel: D04728
Memantine (DG00986): D04905<JP/US> D08174
Methadone (DG00999): D02102<JP/US> D08195
Nevadistinel: D12553
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Perzinfotel: D05447
Phencyclidine hydrochloride: D05453
Remacemide hydrochloride: D05714
Riluzole: D00775<JP/US>
Risevistinel: D12554
Selfotel: D02410
Tenocyclidine: D12702
Tiletamine (DG01380): D06146 D08596
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    2905 (GRIN2C)
   04024 cAMP signaling pathway
    2905 (GRIN2C)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2905 (GRIN2C)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2905 (GRIN2C)
   04720 Long-term potentiation
    2905 (GRIN2C)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2905 (GRIN2C)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2905 (GRIN2C)
   05014 Amyotrophic lateral sclerosis
    2905 (GRIN2C)
   05017 Spinocerebellar ataxia
    2905 (GRIN2C)
   05020 Prion disease
    2905 (GRIN2C)
   05022 Pathways of neurodegeneration - multiple diseases
    2905 (GRIN2C)
  09165 Substance dependence
   05030 Cocaine addiction
    2905 (GRIN2C)
   05031 Amphetamine addiction
    2905 (GRIN2C)
   05033 Nicotine addiction
    2905 (GRIN2C)
   05034 Alcoholism
    2905 (GRIN2C)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2905 (GRIN2C)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2905 (GRIN2C)
SSDB
Motif
Pfam: Lig_chan Lig_chan-Glu_bd SBP_bac_3 ANF_receptor NMDAR2_C
Other DBs
NCBI-GeneID: 2905
NCBI-ProteinID: NP_000826
OMIM: 138254
HGNC: 4587
Ensembl: ENSG00000161509
UniProt: Q14957 A0A8D9PH81 O15398
Structure
LinkDB
Position
17:complement(74842023..74861532)
AA seq 1233 aa
MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPL
EIQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPIL
SISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLE
GVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEA
AQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGA
HSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVV
IALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD
PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTN
GKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNG
TVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIG
KSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTV
SGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKM
GKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQF
LGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVY
WKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAA
RDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGW
GPPDGGRAALVRRAPQPPGRPPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASER
PLSPARCHYSSFPRADRSGRPFLPLFPELEDLPLLGPEQLARREALLHAAWARGSRPRHA
SLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRLAQAQSMCLPIYREACQEGEQAGA
PAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGHRGRTLGLGTGYRD
SGGLDEISRVARGTQGFPGPCTWRRISSLESEV
NT seq 3702 nt   +upstreamnt  +downstreamnt
atgggtggggccctggggccggccctgttgctcacctcgctcttcggtgcctgggcaggg
ctgggtccggggcagggcgagcagggcatgacggtggccgtggtgtttagcagctcaggg
ccgccccaggcccagttccgtgcccgcctcaccccccagagcttcctggacctacccctg
gagatccagccgctcacagttggggtcaacaccaccaaccccagcagcctcctcacccag
atctgcggcctcctgggtgctgcccacgtccacggcattgtctttgaggacaacgtggac
accgaggcggtggcccagatccttgacttcatctcctcccagacccatgtgcccatcctc
agcatcagcggaggctctgctgtggtcctcacccccaaggagccgggctccgccttcctg
cagctgggcgtgtccctggagcagcagctgcaggtgctgttcaaggtgctggaagagtac
gactggagcgccttcgccgtcatcaccagcctgcacccgggccacgcgctcttcctggag
ggcgtgcgcgccgtcgccgacgccagccacgtgagttggcggctgctggacgtggtcacg
ctggagctgggcccgggagggccgcgcgcgcgcacgcagcgcctgctgcgccagctcgac
gcgcccgtgtttgtggcctactgctcgcgcgaggaggccgaggtgctcttcgccgaggcg
gcgcaggccggtctggtggggcccggccacgtgtggctggtgcccaacctggcgctgggc
agcaccgatgcgccccccgccaccttccccgtgggcctcatcagcgtcgtcaccgagagc
tggcgcctcagcctgcgccagaaggtgcgcgacggcgtggccattctggccctgggcgcc
cacagctactggcgccagcatggaaccctgccagccccggccggggactgccgtgttcac
cctgggcccgtcagccctgcccgggaggccttctacaggcacctactgaatgtcacctgg
gagggccgagacttctccttcagccctggtgggtacctggtccagcccaccatggtggtg
atcgccctcaaccggcaccgcctctgggagatggtggggcgctgggagcatggcgtccta
tacatgaagtaccccgtgtggcctcgctacagtgcctctctgcagcctgtggtggacagt
cggcacctgacggtggccacgctggaagagcggccctttgtcatcgtggagagccctgac
cctggcacaggaggctgtgtccccaacaccgtgccctgccgcaggcagagcaaccacacc
ttcagcagcggggacgtggccccctacaccaagctctgctgtaagggattctgcatcgac
atcctcaagaagctggccagagtggtcaaattctcctacgacctgtacctggtgaccaac
ggcaagcatggcaagcgggtgcgcggcgtatggaacggcatgattggggaggtgtactac
aagcgggcagacatggccatcggctccctcaccatcaatgaggaacgctccgagatcgta
gacttctctgtaccctttgtggagacgggcatcagtgtgatggtggctcgcagcaatggc
accgtctccccctcggccttcttggagccatatagccctgcagtgtgggtgatgatgttt
gtcatgtgcctcactgtggtggccatcaccgtcttcatgttcgagtacttcagccctgtc
agctacaaccagaacctcaccagaggcaagaagtccgggggcccagctttcactatcggc
aagtccgtgtggctgctgtgggcgctggtcttcaacaactcagtgcccatcgagaacccg
cggggcaccaccagcaagatcatggttctggtctgggccttctttgctgtcatcttcctc
gccagctacacggccaacctggccgccttcatgatccaagagcaatacatcgacactgtg
tcgggcctcagtgacaagaagtttcagcggcctcaagatcagtacccacctttccgcttc
ggcacggtgcccaacggcagcacggagcggaacatccgcagtaactaccgtgacatgcac
acccacatggtcaagttcaaccagcgctcggtggaggacgcgctcaccagcctcaagatg
gggaagctggatgccttcatctatgatgctgctgtcctcaactacatggcaggcaaggac
gagggctgcaagctggtcaccattgggtctggcaaggtctttgctaccactggctacggc
atcgccatgcagaaggactcccactggaagcgggccatagacctggcgctcttgcagttc
ctgggggacggagagacacagaaactggagacagtgtggctctcagggatctgccagaat
gagaagaacgaggtgatgagcagcaagctggacatcgacaacatggcaggcgtcttctac
atgctgctggtggccatggggctggccctgctggtcttcgcctgggagcacctggtctac
tggaagctgcgccactcggtgcccaactcatcccagctggacttcctgctggctttcagc
aggggcatctacagctgcttcagcggggtgcagagcctcgccagcccaccgcggcaggcc
agcccggacctcacggccagctcggcccaggccagcgtgctcaagatgctgcaggcagcc
cgcgacatggtgaccacggcgggcgtaagcagctccctggaccgcgccactcgcaccatc
gagaattggggtggcggccgccgtgcgcccccaccgtccccctgcccgaccccgcggtct
ggccccagcccatgcctgcccacccccgacccgcccccagagccgagccccacgggctgg
ggaccgccagacgggggtcgcgcggcgcttgtgcgcagggctccgcagcccccgggccgc
cccccgacgccggggccgcccctgtccgacgtctcccgagtgtcgcgccgcccagcctgg
gaggcgcggtggccggtgcggaccgggcactgcgggaggcacctctcggcctccgagcgg
cccctgtcgcccgcgcgctgtcactacagctcctttcctcgagccgaccgatccggccgc
cccttcctcccgctcttcccggagctggaggacctgccgctgctcggtccggagcagctg
gcccggcgggaggccctgctgcacgcggcctgggcccggggctcgcgcccgcgtcacgct
tccctgcccagctccgtggccgaggccttcgctcggcccagctcgctgcccgctgggtgc
accggccccgcctgcgcccgccccgacggccactcggcctgcaggcgcttggcgcaggcg
cagtcgatgtgcttgccgatctaccgggaggcctgccaggagggcgagcaggcaggggcc
cccgcctggcagcacagacagcacgtctgcctgcacgcccacgcccacctgccattttgc
tggggggctgtctgtcctcaccttccaccctgtgccagccacggctcctggctctccggg
gcctgggggcctctggggcacaggggcaggactctggggctgggcacaggctacagagac
agtgggggactggacgagatcagcagggtagcccgtgggacgcaaggcttcccgggaccc
tgcacctggagacggatctccagtctggagtcagaagtgtga

KEGG   Homo sapiens (human): 2906
Entry
2906              CDS       T01001                                 
Symbol
GRIN2D, DEE46, EB11, EIEE46, GluN2D, NMDAR2D, NR2D
Name
(RefSeq) glutamate ionotropic receptor NMDA type subunit 2D
  KO
K05212  glutamate receptor ionotropic, NMDA 2D
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06528  Calcium signaling
  Element
N00970  Transport of calcium
N00971  Mutation-caused aberrant PDYN to transport of calcium
N00987  Mutation-caused aberrant Htt to transport of calcium
N01003  Mutation-caused aberrant Abeta to transport of calcium
N01200  Scrapie conformation PrPSc to transport of calcium
N01642  Ca2+ entry, Ligand-gated Ca2+ channel
Disease
H00606  Early infantile epileptic encephalopathy
Drug target
Acamprosate (DG00996): D02780<JP/US> D07058
Amantadine (DG00860): D00777<JP/US> D07441
Apimostinel: D11299
Aptiganel hydrochloride: D02973
Budipine (DG00866): D07306 D07589
Dalzanemdor: D12788
Delucemine hydrochloride: D03679
Dextromethorphan (DG01078): D00848<JP> D03742 D03744
Dextrorphan hydrochloride: D03746
Dizocilpine maleate: D03878
Esketamine (DG01829): D07283 D10627<US>
Esmethadone  
Dextromethadone (DG03176): D12214 D12215
Felbamate: D00536<US>
Gavestinel: D04308
Ketamine (DG00796): D00711<JP/US> D08098
Latrepirdine (DG01379): D09917 D09918
Levomethadone (DG01002): D08121 D08122
Licostinel: D04728
Memantine (DG00986): D04905<JP/US> D08174
Methadone (DG00999): D02102<JP/US> D08195
Nevadistinel: D12553
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Perzinfotel: D05447
Phencyclidine hydrochloride: D05453
Remacemide hydrochloride: D05714
Riluzole: D00775<JP/US>
Risevistinel: D12554
Selfotel: D02410
Tenocyclidine: D12702
Tiletamine (DG01380): D06146 D08596
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    2906 (GRIN2D)
   04024 cAMP signaling pathway
    2906 (GRIN2D)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2906 (GRIN2D)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2906 (GRIN2D)
   04720 Long-term potentiation
    2906 (GRIN2D)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2906 (GRIN2D)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2906 (GRIN2D)
   05014 Amyotrophic lateral sclerosis
    2906 (GRIN2D)
   05017 Spinocerebellar ataxia
    2906 (GRIN2D)
   05020 Prion disease
    2906 (GRIN2D)
   05022 Pathways of neurodegeneration - multiple diseases
    2906 (GRIN2D)
  09165 Substance dependence
   05030 Cocaine addiction
    2906 (GRIN2D)
   05031 Amphetamine addiction
    2906 (GRIN2D)
   05033 Nicotine addiction
    2906 (GRIN2D)
   05034 Alcoholism
    2906 (GRIN2D)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2906 (GRIN2D)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2906 (GRIN2D)
SSDB
Motif
Pfam: Lig_chan Lig_chan-Glu_bd SBP_bac_3 ANF_receptor NMDAR2_C
Other DBs
NCBI-GeneID: 2906
NCBI-ProteinID: NP_000827
OMIM: 602717
HGNC: 4588
Ensembl: ENSG00000105464
UniProt: O15399 Q59G17
Structure
LinkDB
Position
19:48393668..48444931
AA seq 1336 aa
MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGP
AYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDD
SRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLE
EYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSAQLRSVS
AQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPL
PAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESL
HRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYG
RFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPE
KRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSL
TINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVT
VFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVL
VWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEK
NIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGS
GKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKL
DIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAE
AAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADG
FHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPP
AGAFPGFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGGAG
GTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYP
YAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHD
GLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAGGW
DLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDL
GTRRGSAHFSSLESEV
NT seq 4011 nt   +upstreamnt  +downstreamnt
atgcgcggcgccggtggcccccgcggccctcggggccccgctaagatgctgctgctgctg
gcgctggcctgcgccagcccgttcccggaggaggcgccggggccgggcggggccggtggg
cccggcggcggcctcggcggggcgcggccgctcaacgtggcgctcgtgttctcggggccc
gcgtacgcggccgaggcggcacgcctgggcccggccgtggcggcggcggtgcgcagcccg
ggcctagacgtgcggcccgtggcgctggtgctcaacggctcggacccgcgcagcctcgtg
ctgcagctctgcgacctgctgtcggggttgcgcgtgcacggcgtggtcttcgaagacgac
tcgcgcgcgcccgccgtcgcgcccatcctcgacttcctgtcggcgcagacctcgctgccc
atcgtggccgtgcacggcggcgccgcgctcgtgctcacgcccaaggagaagggctccacc
ttcctgcagctgggctcttccaccgagcaacagcttcaggtcatctttgaggtgctggag
gagtatgactggacgtcctttgtagccgtgaccactcgtgcccctggccaccgggccttc
ctgtcctacattgaggtgctgactgacggtagtctggtgggctgggagcaccgcggagcg
ctgacgctggaccctggggcgggcgaggccgtgctcagtgcccagctccgcagtgtcagc
gcgcagatccgcctgctcttctgcgcccgagaggaggccgagcccgtgttccgcgcagct
gaggaggctggcctcactggatctggctacgtctggttcatggtggggccccagctggct
ggaggcgggggctctggggcccctggtgagccccctcttctgccaggaggcgcccccctg
cctgccgggctgtttgcagtgcgctcggctggctggcgggatgacctggctcggcgagtg
gcagctggcgtggccgtagtggccagaggtgcccaggccctgctgcgtgattatggtttc
cttcctgagctcggccacgactgtcgcgcccagaaccgcacccaccgcggcgagagtctg
cataggtacttcatgaacatcacgtgggataaccgggattactccttcaatgaggacggc
ttcctagtgaacccctccctggtggtcatctccctcaccagagacaggacgtgggaggtg
gtgggcagctgggagcagcagacgctccgcctcaagtacccgctgtggtcccgctatggt
cgcttcctgcagccagtggacgacacgcagcacctcacggtggccacgctggaggaaagg
ccgtttgtcatcgtggagcctgcagaccctatcagcggcacctgcatccgagactccgtc
ccctgccggagccagctcaaccgaacccacagccctccaccggatgccccccgcccggaa
aagcgctgctgcaagggtttctgcatcgacattctgaagcggctggcgcataccatcggc
ttcagctacgacctctacctggtcaccaatggcaagcacggaaagaagatcgatggcgtc
tggaacggcatgatcggggaggtgttctaccagcgcgcagacatggccatcggctccctc
accatcaacgaggagcgctccgagatcgtggacttctccgtccccttcgtggagaccggc
atcagcgtcatggtggcgcgcagcaatggcacggtgtccccctcggccttcctcgagccc
tacagccccgccgtgtgggtgatgatgttcgtcatgtgcctcactgtggtcgccgtcact
gttttcatcttcgagtacctcagtcctgttggttacaaccgcagcctggccacgggcaag
cgccctggcggttcaaccttcaccattgggaaatccatctggctgctctgggccctggtg
ttcaataattcggtgcccgtggagaacccccggggaaccaccagcaaaatcatggtgctg
gtgtgggccttcttcgccgtcatcttcctcgccagctacacagccaacctggccgccttc
atgatccaggaggagtacgtggatactgtgtctgggctcagtgaccgcaagttccagagg
ccccaggagcagtacccgcccctgaagtttgggaccgtgcccaacggctccacggagaag
aacatccgcagcaactatcccgacatgcacagctacatggtgcgctacaaccagccccgc
gtagaggaagcgctcactcagctcaaggcagggaagctggacgccttcatctacgatgct
gcagtgctcaattacatggcccgcaaggacgagggctgcaagcttgtcaccatcggctcc
ggcaaggtcttcgccacgacaggctatggcatcgccctgcacaagggctcccgctggaag
cggcccatcgacctggcgttgctgcagttcctgggggatgatgagatcgagatgctggag
cggctgtggctctctgggatctgccacaatgacaaaatcgaggtgatgagcagcaagctg
gacatcgacaacatggcgggcgtcttctacatgctcctggtggccatgggcctgtccctg
ctggtcttcgcctgggagcacctggtgtactggcgcctgcggcactgcctggggcccacc
caccgcatggacttcctgctggccttctccaggggcatgtacagctgctgcagcgctgag
gccgccccaccgcccgccaagcccccgccgccgccacagcccctgcccagccccgcgtac
cccgcgccgcggccggctcccgggcccgcacctttcgtgccccgcgagcgcgcctcagtg
gaccgctggcgccggaccaagggcgcggggccgccggggggcgcgggcctggccgacggc
ttccaccgctactacggccccatcgagccgcagggcctaggcctcggcctgggcgaagcg
cgcgcggcaccgcggggcgcagccgggcgcccgctgtccccgccggccgctcagcccccg
cagaagccgccgccctcctatttcgccatcgtacgcgacaaggagccagccgagcccccc
gccggcgccttccccggcttcccgtcgccgcccgcgccccccgccgccgcggccaccgcc
gtcgggccgccactctgccgcttggccttcgaggacgagagcccgccggcgcccgcgcgg
tggccgcgctcggaccccgagagccaacccctgctggggccaggcgcgggcggcgcgggg
ggcacggggggcgcaggcggaggagccccggccgctccgcccccgtgccgcgccgcgccg
cccccgtgcccttacctcgatctcgagccgtcgccgtcggactcggaggactcggagagc
ctgggcggcgcgtcgctgggcggcctggagccctggtggttcgccgacttcccttacccg
tatgccgagcgcctcgggccgccgcccggccgctactggtcggtcgacaagctcgggggc
tggcgcgccgggagctgggactacctgcccccgcgcagcggtccggccgcctggcactgt
cggcactgcgccagcctggagctgctgccgccgccgcgccatctcagctgctcgcacgat
ggcctggacggcggctggtgggcgccaccgcctccaccctgggccgccgggcccctgccc
cgacgccgggcccgctgcgggtgcccgcggtcgcacccgcaccgcccgcgggcctcgcac
cgcacgcccgccgccgccgcgccccaccaccacaggcaccggcgcgccgctgggggctgg
gacctcccgccgcccgcgcccacctcgcgctcgctcgaggacctcagctcgtgccctcgc
gccgcccctgcgcgcaggcttaccgggccctcccgccacgctcgcaggtgtccgcacgcc
gcgcactgggggccgccgctgcccacagcttcccaccggagacaccggggcggggacctg
ggcacccgcaggggctcggcgcacttctctagcctcgagtccgaggtatga

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