KEGG    Network variation - Interstrand crosslink repair
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ENTRYnt06508
NameInterstrand crosslink repair
CategoryPathway view; Replication and repair
Pathwayhsa03460 Fanconi anemia pathway
DiseaseH00238 Fanconi anemia
Display drug-target relation   disease type
N01464    FANCM+TOPBP1+MHF+F..→ATR→FAcore=FANCL+UBE2T→FANCD2+FANCI+Ub
    FANCM/POF15 FANCM*
    SCKL1/FCTS   ATR*
    FANCA     FANCA*
    FANCB     FANCB*
    FANCC     FANCC*
    FANCE     FANCE*
    FANCF     FANCF*
    FANCG     FANCG*
    FANCL       FANCL*
    FANCT       UBE2T*
    FANCD2         FANCD2*
    FANCI         FANCI*
 
N01465    FANCD2+FANCI+Ub→FAN1=SLX+MUS81+EME1=ERCC4+ERCC1+SNM1A→REV1,REV3L,REV7
    KMIN   FAN1*
    FANCP     SLX4*
    XPF/CS/FANCQ       ERCC4*
    COFS4       ERCC1*
    FANCV         REV7*
 
N01466    FANCD2+FANCI+Ub→BRCA1+BARD1=BRIP1=BRCA2+PALB2+DSS1=RPA=HROB+MCM8+MCM9
    BC/PNCA4/BROVCA1/FANCS   BRCA1*
    BC   BARD1*
    BC/FANCJ     BRIP1*
    BC/PNCA2/BROVCA2/FANCD       BRCA2*
    BC/PNCA3/FANCN       PALB2*
    PFBMFT6         RPA1*
    ODG11           HROB*
    POF10           MCM8*
    ODG4           MCM9*
 
N01539          RFWD3⊣RPA,RAD51=BCDX2+HELQ
    FANCW       RFWD3*
    BC/FANCR         RAD51*
    BROVCA3/FANCO           RAD51C*
    BROVCA4           RAD51D*
    FANCU/POF17           XRCC2*

Disease nameDisease category
FANCM/POF15H00238Fanconi anemiaHematologic disease
H00627Premature ovarian failureReproductive system disease
SCKL1/FCTSH00992Seckel syndromeCongenital malformation
H02576Familial cutaneous telangiectasia and cancer syndromeCongenital malformation
FANCAH00238Fanconi anemiaHematologic disease
FANCBH00238Fanconi anemiaHematologic disease
FANCCH00238Fanconi anemiaHematologic disease
FANCEH00238Fanconi anemiaHematologic disease
FANCFH00238Fanconi anemiaHematologic disease
FANCGH00238Fanconi anemiaHematologic disease
FANCLH00238Fanconi anemiaHematologic disease
FANCTH00238Fanconi anemiaHematologic disease
FANCD2H00238Fanconi anemiaHematologic disease
FANCIH00238Fanconi anemiaHematologic disease
KMINH02577Karyomegalic interstitial nephritisUrinary system disease
FANCPH00238Fanconi anemiaHematologic disease
XPF/CS/FANCQH01428Xeroderma pigmentosumCongenital malformation
H00076Cockayne syndromeNeurodegenerative disease
H00238Fanconi anemiaHematologic disease
COFS4H02570Cerebro-oculo-facio-skeletal syndromeCongenital malformation
FANCVH00238Fanconi anemiaHematologic disease
BC/PNCA4/BROVCA1/FANCSH00031Breast cancerCancer
H00019Pancreatic cancerCancer
H02531Familial breast-ovarian cancerCancer
H00238Fanconi anemiaHematologic disease
BCH00031Breast cancerCancer
BC/FANCJH00031Breast cancerCancer
H00238Fanconi anemiaHematologic disease
BC/PNCA2/BROVCA2/FANCDH00031Breast cancerCancer
H00019Pancreatic cancerCancer
H02531Familial breast-ovarian cancerCancer
H00238Fanconi anemiaHematologic disease
BC/PNCA3/FANCNH00031Breast cancerCancer
H00019Pancreatic cancerCancer
H00238Fanconi anemiaHematologic disease
PFBMFT6H02569Pulmonary fibrosis and/or bone marrow failure, telomere-relatedHematologic disease
ODG11H00599Ovarian dysgenesisReproductive system disease
POF10H00627Premature ovarian failureReproductive system disease
ODG4H00599Ovarian dysgenesisReproductive system disease
FANCWH00238Fanconi anemiaHematologic disease
BC/FANCRH00031Breast cancerCancer
H00238Fanconi anemiaHematologic disease
BROVCA3/FANCOH02531Familial breast-ovarian cancerCancer
H00238Fanconi anemiaHematologic disease
BROVCA4H02531Familial breast-ovarian cancerCancer
FANCU/POF17H00238Fanconi anemiaHematologic disease
H00627Premature ovarian failureReproductive system disease