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ENTRY	nt06508
Name	Interstrand crosslink repair
Category	Pathway view; Replication and repair
Pathway	hsa03460 Fanconi anemia pathway
Disease	H00238 Fanconi anemia
Display	drug-target relation   disease type

N01464    FANCM+TOPBP1+MHF+F.. → ATR → FAcore = FANCL+UBE2T → FANCD2+FANCI+Ub     FANCM/POF15 FANCM*     SCKL1/FCTS     ATR*     FANCA         FANCA*     FANCB         FANCB*     FANCC         FANCC*     FANCE         FANCE*     FANCF         FANCF*     FANCG         FANCG*     FANCL             FANCL*     FANCT             UBE2T*     FANCD2                 FANCD2*     FANCI                 FANCI* N01465    FANCD2+FANCI+Ub → FAN1 = SLX+MUS81+EME1 = ERCC4+ERCC1+SNM1A → REV1,REV3L,REV7     KMIN     FAN1*     FANCP         SLX4*     XPF/CS/FANCQ             ERCC4*     COFS4             ERCC1*     FANCV                 REV7* N01466    FANCD2+FANCI+Ub → BRCA1+BARD1 = BRIP1 = BRCA2+PALB2+DSS1 = RPA = HROB+MCM8+MCM9     BC/PNCA4/BROVCA1/FANCS     BRCA1*     BC     BARD1*     BC/FANCJ         BRIP1*     BC/PNCA2/BROVCA2/FANCD             BRCA2*     BC/PNCA3/FANCN             PALB2*     PFBMFT6                 RPA1*     POF10                     MCM8*     ODG4                     MCM9* N01539                RFWD3 ⊣ RPA,RAD51 = BCDX2+HELQ     FANCW             RFWD3*     BC/FANCR                 RAD51*     BROVCA3/FANCO                     RAD51C*     BROVCA4                     RAD51D*     FANCU/POF17                     XRCC2*

		Disease name	Disease category
FANCM/POF15	H00238	Fanconi anemia	Hematologic disease
	H00627	Premature ovarian failure	Reproductive system disease
SCKL1/FCTS	H00992	Seckel syndrome	Congenital malformation
	H02576	Familial cutaneous telangiectasia and cancer syndrome	Congenital malformation
FANCA	H00238	Fanconi anemia	Hematologic disease
FANCB	H00238	Fanconi anemia	Hematologic disease
FANCC	H00238	Fanconi anemia	Hematologic disease
FANCE	H00238	Fanconi anemia	Hematologic disease
FANCF	H00238	Fanconi anemia	Hematologic disease
FANCG	H00238	Fanconi anemia	Hematologic disease
FANCL	H00238	Fanconi anemia	Hematologic disease
FANCT	H00238	Fanconi anemia	Hematologic disease
FANCD2	H00238	Fanconi anemia	Hematologic disease
FANCI	H00238	Fanconi anemia	Hematologic disease
KMIN	H02577	Karyomegalic interstitial nephritis	Urinary system disease
FANCP	H00238	Fanconi anemia	Hematologic disease
XPF/CS/FANCQ	H01428	Xeroderma pigmentosum	Congenital malformation
	H00076	Cockayne syndrome	Neurodegenerative disease
	H00238	Fanconi anemia	Hematologic disease
COFS4	H02570	Cerebro-oculo-facio-skeletal syndrome	Congenital malformation
FANCV	H00238	Fanconi anemia	Hematologic disease
BC/PNCA4/BROVCA1/FANCS	H00031	Breast cancer	Cancer
	H00019	Pancreatic cancer	Cancer
	H02531	Familial breast-ovarian cancer	Cancer
	H00238	Fanconi anemia	Hematologic disease
BC	H00031	Breast cancer	Cancer
BC/FANCJ	H00031	Breast cancer	Cancer
	H00238	Fanconi anemia	Hematologic disease
BC/PNCA2/BROVCA2/FANCD	H00031	Breast cancer	Cancer
	H00019	Pancreatic cancer	Cancer
	H02531	Familial breast-ovarian cancer	Cancer
	H00238	Fanconi anemia	Hematologic disease
BC/PNCA3/FANCN	H00031	Breast cancer	Cancer
	H00019	Pancreatic cancer	Cancer
	H00238	Fanconi anemia	Hematologic disease
PFBMFT6	H02569	Pulmonary fibrosis and/or bone marrow failure, telomere-related	Hematologic disease
POF10	H00627	Premature ovarian failure	Reproductive system disease
ODG4	H00599	Ovarian dysgenesis	Reproductive system disease
FANCW	H00238	Fanconi anemia	Hematologic disease
BC/FANCR	H00031	Breast cancer	Cancer
	H00238	Fanconi anemia	Hematologic disease
BROVCA3/FANCO	H02531	Familial breast-ovarian cancer	Cancer
	H00238	Fanconi anemia	Hematologic disease
BROVCA4	H02531	Familial breast-ovarian cancer	Cancer
FANCU/POF17	H00238	Fanconi anemia	Hematologic disease
	H00627	Premature ovarian failure	Reproductive system disease