KEGG   PATHWAY: cpoc04010
Entry
cpoc04010                   Pathway                                
Name
MAPK signaling pathway - Cavia porcellus (domestic guinea pig)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cpoc04010  MAPK signaling pathway
cpoc04010

Other DBs
GO: 0000165
Organism
Cavia porcellus (domestic guinea pig) [GN:cpoc]
Gene
100726277  Cacna1a; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
100735203  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
100135490  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
100726255  Cacna1d; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
100716749  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X6 [KO:K04852]
100720484  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100728128  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X22 [KO:K04854]
100720102  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X3 [KO:K04855]
100735927  Cacna1i; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
100734741  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
100728887  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
100734097  Cacna2d2; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
100724165  Cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
100716046  Cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
100721141  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
100192393  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
100730569  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
100723776  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
100720127  Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
100719693  Cacng2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
100722578  Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
100713348  Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
100720411  Cacng5; voltage-dependent calcium channel gamma-5 subunit isoform X2 [KO:K04870]
100729890  Cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
100734510  Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
100730163  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
100735694  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100712694  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100713627  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100717697  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
100733947  Prkcg; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
100726202  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100719463  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1 [KO:K04347]
100727741  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100725315  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100728974  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
106027879  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
100721882  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
100731687  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
100724898  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X2 [KO:K12326]
100735488  Rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
100722152  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
100712845  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
100727572  Rasgrp4; RAS guanyl-releasing protein 4 [KO:K12363]
100725604  LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2-like [KO:K08018]
100726875  LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2-like [KO:K08018]
100725331  rap guanine nucleotide exchange factor 2-like [KO:K08018]
100725060  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X3 [KO:K08018]
100730274  Nf1; neurofibromin [KO:K08052]
100726441  Rasa1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
100730767  Rasa2; ras GTPase-activating protein 2 isoform X2 [KO:K08053]
100713608  Rap1a; ras-related protein Rap-1A [KO:K04353]
100713271  ras-related protein Rap-1b-like [KO:K07836]
100734094  Rap1b; ras-related protein Rap-1b [KO:K07836]
100714471  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
100715763  Ereg; proepiregulin [KO:K09784]
100732447  Areg; amphiregulin [KO:K09782]
100727152  Fgf1; fibroblast growth factor 1 isoform X2 [KO:K18496]
100721182  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
100722934  Fgf5; fibroblast growth factor 5 isoform X2 [KO:K04358]
100730085  Fgf10; fibroblast growth factor 10 [KO:K04358]
100723648  Fgf16; fibroblast growth factor 16 [KO:K04358]
100730876  Fgf6; fibroblast growth factor 6 [KO:K04358]
100727356  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100718957  Fgf7; fibroblast growth factor 7 [KO:K04358]
100715152  Fgf18; fibroblast growth factor 18 [KO:K04358]
100732836  Fgf20; LOW QUALITY PROTEIN: fibroblast growth factor 20 [KO:K04358]
100727609  Fgf9; fibroblast growth factor 9 [KO:K04358]
100716446  Fgf3; fibroblast growth factor 3 [KO:K04358]
100730350  Fgf4; fibroblast growth factor 4 [KO:K04358]
100721186  Fgf22; fibroblast growth factor 22 [KO:K04358]
100728398  Fgf21; fibroblast growth factor 21 [KO:K22429]
100717518  Fgf23; fibroblast growth factor 23 [KO:K22428]
100733367  Ngf; beta-nerve growth factor [KO:K02582]
100730257  Bdnf; brain-derived neurotrophic factor isoform X2 [KO:K04355]
100718910  Ntf3; neurotrophin-3 isoform X1 [KO:K04356]
100729889  Ntf4; neurotrophin-4 [KO:K12457]
100379579  Ins; insulin precursor [KO:K04526]
100135551  Igf1; insulin-like growth factor I precursor [KO:K05459]
100135552  Igf2; insulin-like growth factor II isoform X2 [KO:K13769]
100731469  Pdgfb; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
100722571  Pdgfc; platelet-derived growth factor C [KO:K05450]
100713757  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
100732898  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100721734  Kitlg; kit ligand isoform X1 [KO:K05461]
100723994  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
100713483  Vegfa; vascular endothelial growth factor A isoform X2 [KO:K05448]
100724743  Vegfb; vascular endothelial growth factor B isoform X2 [KO:K16858]
100734450  Pgf; placenta growth factor isoform X3 [KO:K16859]
100724469  Vegfc; vascular endothelial growth factor C [KO:K05449]
100733371  Vegfd; LOW QUALITY PROTEIN: vascular endothelial growth factor D [KO:K05449]
100730730  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
100716420  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
100716962  Angpt2; angiopoietin-2 [KO:K05466]
100714243  angiopoietin-4 [KO:K05467]
100735338  Efna5; ephrin-A5 isoform X1 [KO:K05462]
100732408  Efna1; ephrin-A1 [KO:K05462]
100734666  Efna2; ephrin-A2 [KO:K05462]
100713685  Efna4; ephrin-A4 [KO:K05462]
100714142  Efna3; ephrin-A3 isoform X1 [KO:K05462]
100717276  Gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
100719545  Nrtn; neurturin [KO:K25414]
100719457  Artn; artemin [KO:K25415]
100717500  Pspn; persephin [KO:K25416]
100725363  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
100727657  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100712946  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100724678  Erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
100731156  Fgfr1; fibroblast growth factor receptor 1 isoform X5 [KO:K04362] [EC:2.7.10.1]
100379152  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
100732948  Fgfr3; fibroblast growth factor receptor 3 isoform X9 [KO:K05094] [EC:2.7.10.1]
100733523  Fgfr4; fibroblast growth factor receptor 4 isoform X4 [KO:K05095] [EC:2.7.10.1]
100716626  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100725325  Ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100723565  BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
106028780  BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
100718484  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100734840  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100726209  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100726506  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
100726053  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100726397  Kit; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
100732047  Flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
100732326  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100715831  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100726761  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100718790  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
100713324  Tek; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
100712747  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
100733392  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100715453  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
100721165  Sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
100726398  Sos2; son of sevenless homolog 2 [KO:K03099]
100735038  Hras; GTPase HRas isoform X1 [KO:K02833]
100716262  Kras; GTPase KRas isoform X3 [KO:K07827]
100135584  Nras; GTPase NRas [KO:K07828]
100725452  Rras; ras-related protein R-Ras [KO:K07829]
100730714  Rras2; ras-related protein R-Ras2 [KO:K07830]
100731678  Mras; ras-related protein M-Ras isoform X1 [KO:K07831]
100727629  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100717765  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
100720110  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100712888  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100728923  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100727855  Lamtor3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
100715180  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100725692  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100720835  Mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K04372] [EC:2.7.11.1]
100734192  Mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
100728619  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
100729439  Rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
100721226  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
100731385  Rps6ka6; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
100732296  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100727907  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
100719249  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
100724557  Myc; myc proto-oncogene protein isoform X2 [KO:K04377]
100715998  Srf; serum response factor isoform X1 [KO:K04378]
100713572  Fos; proto-oncogene c-Fos [KO:K04379]
100735442  Mapt; microtubule-associated protein tau isoform X8 [KO:K04380]
100732759  Stmn1; stathmin [KO:K04381]
100715719  Pla2g4a; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
100735123  Pla2g4f; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100734841  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100721732  Pla2g4e; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100135630  Tnf; tumor necrosis factor [KO:K03156]
100135555  Il1a; interleukin-1 alpha [KO:K04383]
100135556  Il1b; interleukin-1 beta [KO:K04519]
100135628  Tgfb1; transforming growth factor beta-1 precursor [KO:K13375]
100720726  Tgfb2; transforming growth factor beta-2 isoform X3 [KO:K13376]
100715426  Tgfb3; transforming growth factor beta-3 [KO:K13377]
100713890  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X3 [KO:K03158]
100724206  Il1r1; interleukin-1 receptor type 1 [KO:K04386]
100714704  Il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
100715237  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100718284  Tgfbr2; TGF-beta receptor type-2 isoform X3 [KO:K04388] [EC:2.7.11.30]
100714139  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100726403  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100735312  Cd14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14 [KO:K04391]
100727219  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
100731468  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
100736181  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100717195  Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
100732953  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100718309  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100733145  Traf2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
100730008  Daxx; LOW QUALITY PROTEIN: death domain-associated protein 6 [KO:K02308]
100733381  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100735146  Irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
100729751  Irak4; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
100724447  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100719739  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100730773  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100735373  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100717911  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
100726429  Ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
100716179  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
100723651  Map4k4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
100732370  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
100714662  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100713135  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100715685  Stk4; serine/threonine-protein kinase 4 [KO:K04411]
100729700  Stk3; serine/threonine-protein kinase 3 [KO:K04412]
100722708  Map4k2; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
100725834  Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
100723456  Map3k1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
100730722  Map3k11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
100723690  Map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
100731994  Map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
100715894  Map3k9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
100716869  Map3k10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
100728261  Map3k21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
100731317  Map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X2 [KO:K04423] [EC:2.7.11.25]
100727150  Map3k13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
100730684  Map3k20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
100724385  Map3k6; mitogen-activated protein kinase kinase kinase 6 isoform X3 [KO:K04425] [EC:2.7.11.25]
100722979  Map3k5; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100718100  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100724828  Map3k4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
100724014  Taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
100732053  Taok2; serine/threonine-protein kinase TAO2 isoform X4 [KO:K04429] [EC:2.7.11.1]
100720924  Taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
100733674  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100731057  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X2 [KO:K04431] [EC:2.7.12.2]
100726100  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
100731419  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100725179  Mapk8ip1; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
100724140  Mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
100725966  Mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X9 [KO:K04436]
100725162  Flna; filamin-A isoform X2 [KO:K04437]
100718486  Crk; adapter molecule crk [KO:K04438]
100723968  Crkl; crk-like protein [KO:K04438]
100731801  Arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
100716149  Arrb2; LOW QUALITY PROTEIN: beta-arrestin-2 [KO:K04439]
100722333  Mapk8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
100718766  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100714249  Mapk9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100724974  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100723285  Mapk14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100729280  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100730794  Mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
100715906  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
100719631  Mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
100725484  Rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
100716989  Rps6ka4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
100716851  Cdc25b; LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
100730044  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X4 [KO:K04446]
100728433  Nfatc3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
100728775  Jun; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
100734608  Jund; transcription factor jun-D [KO:K04449]
100726889  Atf2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
100379269  Tp53; cellular tumor antigen p53 [KO:K04451]
101787388  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
100718960  Max; protein max isoform X5 [KO:K04453]
100725079  Mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
100724197  Hspb1; heat shock protein beta-1 [KO:K04455]
100719925  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100714724  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100724315  Akt3; LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100734826  Ppm1a; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
100715069  Ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
100716019  Ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
100723664  Ptpn7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
100725668  Dusp1; LOW QUALITY PROTEIN: dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
100728615  Dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100728293  Dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100723186  Dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100731539  Dusp8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100729004  Dusp5; LOW QUALITY PROTEIN: dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100723574  Dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100720904  Dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
100713707  Dusp9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
100733434  Dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
100730437  Dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
100715770  Ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
100719242  Ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
100713849  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
100717205  heat shock 70 kDa protein 1B [KO:K03283]
100717481  heat shock 70 kDa protein 1-like [KO:K03283]
100715119  Hspa6; heat shock 70 kDa protein 6 [KO:K03283]
100729464  heat shock 70 kDa protein 1B-like [KO:K03283]
100727638  Mecom; MDS1 and EVI1 complex locus protein EVI1 isoform X2 [KO:K04462] [EC:2.1.1.367]
100732076  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X3 [KO:K04463] [EC:2.7.12.2]
100728396  Mapk7; LOW QUALITY PROTEIN: mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
100732875  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
100719582  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100726357  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100724538  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100722308  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100729077  Nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
100730075  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100715820  Nfkb2; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p100 subunit [KO:K04469]
100724366  Rela; transcription factor p65 isoform X1 [KO:K04735]
100719391  Relb; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
cpoc04070  Phosphatidylinositol signaling system
cpoc04110  Cell cycle
cpoc04115  p53 signaling pathway
cpoc04210  Apoptosis
cpoc04310  Wnt signaling pathway
cpoc04668  TNF signaling pathway
KO pathway
ko04010   
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