KEGG   PATHWAY: eai05022
Entry
eai05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Equus asinus (ass)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
eai05022  Pathways of neurodegeneration - multiple diseases
eai05022

Organism
Equus asinus (ass) [GN:eai]
Gene
106821745  DNAH1; LOW QUALITY PROTEIN: dynein axonemal heavy chain 1 [KO:K10408]
106821809  WNT3A; protein Wnt-3a [KO:K00312]
106821810  [KO:K01064]
106822066  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X8 [KO:K04851]
106822085  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
106822115  SEPTIN5; septin-5 isoform X3 [KO:K04557]
106822166  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 isoform X1 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
106822169  FADD; FAS-associated death domain protein [KO:K02373]
106822180  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
106822212  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
106822374  FZD6; frizzled-6 [KO:K02376]
106822491  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
106822570  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X2 [KO:K04553] [EC:2.3.2.23]
106822600  [KO:K00416]
106822678  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
106822757  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
106822767  TUBB4B; tubulin beta-4B chain [KO:K07375]
106822778  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
106822866  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
106822876  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
106823163  GPX6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
106823165  [KO:K00432] [EC:1.11.1.9]
106823182  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
106823191  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
106823264  CHMP2B; charged multivesicular body protein 2b isoform X1 [KO:K12192]
106823329  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
106823353  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
106823414  TUBB6; tubulin beta-6 chain [KO:K07375]
106823493  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
106823500  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
106823513  FZD8; frizzled-8 [KO:K02375]
106823553  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X3 [KO:K04857]
106823734  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
106823773  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
106823787  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
106823831  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
106823856  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
106823864  HTRA2; serine protease HTRA2, mitochondrial isoform X1 [KO:K08669] [EC:3.4.21.108]
106824021  WDR41; WD repeat-containing protein 41 isoform X3 [KO:K23610]
106824113  PDYN; proenkephalin-B [KO:K15840]
106824353  DNAH11; dynein axonemal heavy chain 11 [KO:K10408]
106824372  IL6; interleukin-6 [KO:K05405]
106824389  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
106824393  TUBB1; tubulin beta-1 chain [KO:K07375]
106824394  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
106824545  DCTN6; dynactin subunit 6 isoform X1 [KO:K10428]
106824547  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
106824582  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
106824611  DNAH8; dynein axonemal heavy chain 8 [KO:K10408]
106824632  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
106824834  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X1 [KO:K10707]
106824927  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
106824938  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
106824973  HRAS; GTPase HRas isoform X1 [KO:K02833]
106824997  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
106825034  TNF; tumor necrosis factor isoform X1 [KO:K03156]
106825044  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
106825084  KIF5C; kinesin heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
106825146  [KO:K21421] [EC:1.-.-.-]
106825237  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
106825365  CALM1; calmodulin-1 [KO:K02183]
106825368  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
106825375  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
106825388  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
106825466  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X1 [KO:K11353]
106825507  TUBB; tubulin beta chain [KO:K07375]
106825518  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
106825548  KRAS; GTPase KRas isoform X2 [KO:K07827]
106825678  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
106825688  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
106825702  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
106825951  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
106826025  CALM2; calmodulin-2 [KO:K02183]
106826047  TRAP1; LOW QUALITY PROTEIN: heat shock protein 75 kDa, mitochondrial [KO:K09488]
106826162  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
106826191  [KO:K07374]
106826226  NEFL; neurofilament light polypeptide [KO:K04572]
106826228  NEFM; neurofilament medium polypeptide [KO:K04573]
106826388  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
106826426  BECN1; beclin-1 isoform X1 [KO:K08334]
106826516  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
106826529  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
106826547  HAP1; huntingtin-associated protein 1 isoform X1 [KO:K04647]
106826627  [KO:K08738]
106826757  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
106826770  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
106826858  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
106826963  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
106826990  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
106827064  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
106827069  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
106827205  [KO:K03178] [EC:6.2.1.45]
106827252  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
106827325  [KO:K00419]
106827374  DNAH7; LOW QUALITY PROTEIN: dynein axonemal heavy chain 7 [KO:K10408]
106827382  NEFH; neurofilament heavy polypeptide isoform X1 [KO:K04574]
106827389  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
106827395  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
106827572  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
106827584  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
106827586  TOMM40L; mitochondrial import receptor subunit TOM40B isoform X1 [KO:K11518]
106827589  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
106827683  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
106827710  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X2 [KO:K17603]
106827725  DNAL1; dynein axonemal light chain 1 [KO:K10411]
106827778  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
106827800  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
106827890  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
106827983  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
106828005  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
106828058  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
106828149  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
106828163  FZD5; LOW QUALITY PROTEIN: frizzled-5 [KO:K02375]
106828225  TUBB3; tubulin beta-3 chain [KO:K07375]
106828340  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
106828357  RAB1A; ras-related protein Rab-1A [KO:K07874]
106828390  CTNNB1; catenin beta-1 [KO:K02105]
106828412  RAB39B; ras-related protein Rab-39B [KO:K07925]
106828591  WNT2B; protein Wnt-2b [KO:K00182]
106828596  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
106828604  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
106828659  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
106828722  KLC4; kinesin light chain 4 [KO:K10407]
106828959  DKK4; dickkopf-related protein 4 [KO:K02165]
106828962  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
106829023  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
106829100  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
106829117  DERL1; derlin-1 isoform X1 [KO:K11519]
106829176  [KO:K02263]
106829188  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
106829247  [KO:K02267]
106829307  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
106829311  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
106829331  [KO:K03948]
106829345  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
106829346  WNT2; protein Wnt-2 [KO:K00182]
106829376  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
106829397  [KO:K07827]
106829523  SNCA; alpha-synuclein [KO:K04528]
106829535  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
106829637  DNAH5; LOW QUALITY PROTEIN: dynein axonemal heavy chain 5 [KO:K10408]
106829744  [KO:K08738]
106829753  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
106829817  WNT16; protein Wnt-16 [KO:K01558]
106829821  DKK2; dickkopf-related protein 2 [KO:K02165]
106829867  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
106829874  GPR37; prosaposin receptor GPR37 [KO:K04243]
106829894  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
106829907  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
106829925  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
106830081  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
106830087  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
106830197  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
106830236  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
106830251  DNAI2; dynein axonemal intermediate chain 2 isoform X1 [KO:K11143]
106830277  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
106830527  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
106830557  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
106830578  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X2 [KO:K03938]
106830662  [KO:K00414]
106830689  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
106830706  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
106830813  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
106830826  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
106830899  ATXN1L; ataxin-1-like [KO:K23616]
106830991  [KO:K04366] [EC:2.7.11.1]
106831014  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
106831122  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
106831170  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
106831232  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
106831254  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
106831275  [KO:K02264]
106831384  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106831483  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
106831495  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
106831752  RAB5A; ras-related protein Rab-5A [KO:K07887]
106831788  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
106831875  [KO:K02266]
106831882  FUS; RNA-binding protein FUS isoform X2 [KO:K13098]
106832206  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
106832232  FZD1; frizzled-1 [KO:K02432]
106832251  APC; LOW QUALITY PROTEIN: adenomatous polyposis coli protein [KO:K02085]
106832295  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
106832322  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106832528  FZD3; frizzled-3 isoform X1 [KO:K02329]
106832625  ATG2B; LOW QUALITY PROTEIN: autophagy-related protein 2 homolog B [KO:K17906]
106832748  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
106832761  TUBB4A; tubulin beta-4A chain [KO:K07375]
106832810  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
106832829  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
106832883  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
106832969  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
106832994  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
106833003  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
106833005  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
106833007  KIF5A; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
106833065  GRIA2; LOW QUALITY PROTEIN: glutamate receptor 2 [KO:K05198]
106833076  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
106833174  GPX7; glutathione peroxidase 7 isoform X1 [KO:K00432] [EC:1.11.1.9]
106833485  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
106833515  SPTBN2; LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 2 [KO:K23932]
106833521  CCS; copper chaperone for superoxide dismutase [KO:K04569]
106833539  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
106833569  RELA; transcription factor p65 isoform X1 [KO:K04735]
106833590  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
106833611  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
106833626  BAD; bcl2-associated agonist of cell death [KO:K02158]
106833627  PLCB3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
106833641  [KO:K02273]
106833699  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
106833711  [KO:K02263]
106833712  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
106833785  CALML5; calmodulin-like protein 5 [KO:K02183]
106833786  [KO:K02183]
106833825  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
106834033  [KO:K07374]
106834056  [KO:K04809]
106834075  TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966]
106834121  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
106834176  [KO:K00420]
106834185  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2 [KO:K03940] [EC:7.1.1.2]
106834222  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
106834227  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
106834358  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
106834431  PPP3CA; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
106834450  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
106834518  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
106834527  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
106834586  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
106834593  DAXX; death domain-associated protein 6 [KO:K02308]
106834634  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
106834658  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
106834687  RYR2; ryanodine receptor 2 isoform X4 [KO:K04962]
106834887  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
106834911  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
106834965  [KO:K00411] [EC:7.1.1.8]
106835003  SPG11; spatacsin isoform X2 [KO:K19026]
106835144  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
106835172  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
106835210  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
106835240  ATG101; autophagy-related protein 101 isoform X1 [KO:K19730]
106835348  AXIN2; axin-2 isoform X1 [KO:K04385]
106835357  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
106835419  [KO:K00417]
106835533  PSMC5; 26S proteasome regulatory subunit 8 isoform X2 [KO:K03066]
106835560  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
106835567  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
106835569  ERN1; LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
106835678  NRAS; GTPase NRas [KO:K07828]
106835869  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
106835886  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
106835898  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
106836062  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
106836101  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
106836161  AXIN1; axin-1 isoform X1 [KO:K02157]
106836226  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
106836405  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
106836460  FZD2; frizzled-2 [KO:K02235]
106836490  WNT9B; protein Wnt-9b [KO:K01064]
106836496  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
106836509  WNT3; proto-oncogene Wnt-3 [KO:K00312]
106836661  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
106836664  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
106836676  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
106836681  [KO:K23600]
106836742  [KO:K04552] [EC:2.3.2.23]
106836764  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
106836805  PRPH; peripherin isoform X1 [KO:K07607]
106836806  [KO:K07374]
106836811  [KO:K07374]
106836816  WNT10B; protein Wnt-10b [KO:K01357]
106836901  WNT1; proto-oncogene Wnt-1 [KO:K03209]
106836928  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
106836932  OPTN; optineurin [KO:K19946]
106837091  HIP1; huntingtin-interacting protein 1 isoform X1 [KO:K04559]
106837103  STX1A; syntaxin-1A [KO:K04560]
106837127  FZD9; LOW QUALITY PROTEIN: frizzled-9 [KO:K02842]
106837192  MAP3K5; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
106837200  [KO:K02734] [EC:3.4.25.1]
106837226  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
106837498  CAT; catalase isoform X1 [KO:K03781] [EC:1.11.1.6]
106837615  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
106837626  DNAL4; dynein axonemal light chain 4 isoform X1 [KO:K10412]
106837654  [KO:K04741] [EC:3.4.22.-]
106837657  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
106837867  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
106837906  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial isoform X1 [KO:K02128]
106837924  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
106837945  [KO:K05862]
106837958  KIF5B; kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
106838081  ACTR1A; alpha-centractin [KO:K16575]
106838268  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
106838305  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
106838407  [KO:K10881]
106838418  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
106838461  WNT6; protein Wnt-6 isoform X3 [KO:K00445]
106838468  WNT10A; protein Wnt-10a [KO:K01357]
106838484  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
106838495  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
106838505  DCTN4; dynactin subunit 4 isoform X2 [KO:K10426]
106838556  IL1A; interleukin-1 alpha [KO:K04383]
106838557  [KO:K04519]
106838571  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
106838613  DNAH6; LOW QUALITY PROTEIN: dynein axonemal heavy chain 6 [KO:K10408]
106838669  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
106838780  [KO:K02927]
106838802  PSMA6; proteasome subunit alpha type-6 isoform X2 [KO:K02730] [EC:3.4.25.1]
106838853  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
106838857  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
106838864  UBB; polyubiquitin-B isoform X1 [KO:K04551]
106838868  IFT57; intraflagellar transport protein 57 homolog [KO:K04638]
106838884  [KO:K13098]
106838952  C9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
106839204  WNT8A; protein Wnt-8a isoform X3 [KO:K00714]
106839361  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
106839421  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
106839441  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
106839445  TUBA8; tubulin alpha-8 chain isoform X2 [KO:K07374]
106839455  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
106839611  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
106839766  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
106840003  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
106840050  PINK1; serine/threonine-protein kinase PINK1, mitochondrial isoform X1 [KO:K05688] [EC:2.7.11.1]
106840217  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
106840396  WNT11; LOW QUALITY PROTEIN: protein Wnt-11 [KO:K01384]
106840518  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
106840555  [KO:K07374]
106840558  [KO:K07374]
106840602  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
106840650  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
106840832  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
106840859  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
106840869  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X2 [KO:K03947]
106841008  [KO:K00418]
106841203  [KO:K02272]
106841227  [KO:K00432] [EC:1.11.1.9]
106841238  [KO:K02271]
106841278  UCHL1; LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
106841398  DNAI1; dynein axonemal intermediate chain 1 [KO:K10409]
106841402  DCTN3; dynactin subunit 3 [KO:K10425]
106841404  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
106841469  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
106841502  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
106841746  [KO:K00415]
106841840  FZD10; frizzled-10 [KO:K02842]
106841912  [KO:K00413]
106842003  HTT; huntingtin isoform X1 [KO:K04533]
106842050  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
106842138  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
106842269  ATXN2; ataxin-2 isoform X3 [KO:K23625]
106842285  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
106842301  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
106842344  DNAH10; dynein axonemal heavy chain 10 isoform X2 [KO:K10408]
106842364  [KO:K02268]
106842371  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
106842388  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
106842411  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
106842412  BECN2; beclin-2 [KO:K08334]
106842437  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
106842470  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
106842471  [KO:K04520]
106842512  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
106842542  [KO:K02265]
106842543  ACTR1B; beta-centractin isoform X1 [KO:K16575]
106842554  [KO:K02270]
106842618  BRAF; serine/threonine-protein kinase B-raf isoform X8 [KO:K04365] [EC:2.7.11.1]
106842621  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
106842647  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
106842713  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
106842752  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
106842833  [KO:K04558]
106842890  [KO:K03968]
106842901  NOX1; NADPH oxidase 1 [KO:K08008]
106842972  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X2 [KO:K04555] [EC:2.3.2.23]
106843101  TANK; TRAF family member-associated NF-kappa-B activator isoform X3 [KO:K12650]
106843140  FZD7; frizzled-7 [KO:K02432]
106843144  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X2 [KO:K03030]
106843147  ALS2; alsin [KO:K04575]
106843233  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
106843249  MAP3K10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
106843286  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
106843348  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
106843355  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
106843543  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
106843557  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
106843726  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
106843729  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
106843755  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
106843856  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
106843858  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
106843993  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
106843996  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
106844015  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
106844019  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
106844150  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
106844173  DLG4; disks large homolog 4 isoform X2 [KO:K11828]
106844176  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
106844220  DNAH2; dynein axonemal heavy chain 2 isoform X1 [KO:K10408]
106844271  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
106844280  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
106844306  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 isoform X2 [KO:K03963]
106844319  PARK7; Parkinson disease protein 7 [KO:K05687] [EC:3.5.1.124]
106844493  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X5 [KO:K03951]
106844503  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
106844553  DNAH14; dynein axonemal heavy chain 14 isoform X1 [KO:K10408]
106844596  NOS2; LOW QUALITY PROTEIN: nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
106844623  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
106844625  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
106844743  [KO:K07374]
106844790  [KO:K02266]
106844876  UBC; polyubiquitin-C [KO:K08770]
106844891  GPX2; LOW QUALITY PROTEIN: glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
106844950  FRAT1; LOW QUALITY PROTEIN: proto-oncogene FRAT1 [KO:K03069]
106845129  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
106845168  CALM3; calmodulin-3 [KO:K02183]
106845190  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
106845228  DVL1; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
106845238  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
106845334  DNAH17; LOW QUALITY PROTEIN: dynein axonemal heavy chain 17 [KO:K10408]
106845532  TRAF2; TNF receptor-associated factor 2 isoform X4 [KO:K03173] [EC:2.3.2.27]
106845601  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
106845632  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
106845772  DNAH9; LOW QUALITY PROTEIN: dynein axonemal heavy chain 9 [KO:K10408]
106845828  DCTN5; dynactin subunit 5 [KO:K10427]
106845859  PSMA3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
106845861  ACTR10; actin-related protein 10 [KO:K16576]
106845973  WNT7B; protein Wnt-7b isoform X2 [KO:K00572]
106846005  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
106846006  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
106846145  DNAH3; dynein axonemal heavy chain 3 isoform X1 [KO:K10408]
106846147  NDUFAB1; acyl carrier protein, mitochondrial isoform X2 [KO:K03955]
106846343  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
106846370  PSEN2; presenilin-2 isoform X3 [KO:K04522] [EC:3.4.23.-]
106846505  [KO:K02736] [EC:3.4.25.1]
106846512  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
106846749  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
106846753  WNT8B; protein Wnt-8b [KO:K00714]
106846783  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
106846922  [KO:K02271]
106846998  [KO:K13525]
106847177  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
106847199  ATXN1; ataxin-1 [KO:K23616]
106847316  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
106847495  DKK1; dickkopf-related protein 1 [KO:K02165]
106847681  [KO:K05634]
106847712  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
106847879  [KO:K07375]
106847891  [KO:K07375]
106847984  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
106847989  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
106847990  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
106848104  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
106848216  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
106848251  FZD4; frizzled-4 [KO:K02354]
106848262  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106848280  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
106848364  [KO:K02736] [EC:3.4.25.1]
106848374  [KO:K03947]
106848450  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
106848494  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
106848636  [KO:K02270]
106848653  DNAH12; dynein axonemal heavy chain 12 isoform X2 [KO:K10408]
106848670  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
123275613  [KO:K07374]
123276027  [KO:K02735] [EC:3.4.25.1]
123278957  FRAT2; LOW QUALITY PROTEIN: GSK-3-binding protein FRAT2 [KO:K03096]
123281166  [KO:K11518]
123285116  [KO:K03178] [EC:6.2.1.45]
123285498  [KO:K02268]
123286234  [KO:K04519]
123286693  [KO:K04519]
123286886  [KO:K02273]
123289075  [KO:K01064]
808054  COX3; cytochrome c oxidase subunit III [KO:K02262]
808055  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
808056  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
808057  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
808058  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
808059  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
808060  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
808061  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
808062  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
808063  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
808064  COX2; cytochrome c oxidase subunit II [KO:K02261]
808065  CYTB; cytochrome b [KO:K00412]
808066  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
J Cell Mol Med 14:457-87 (2010)
DOI:10.1111/j.1582-4934.2010.01010.x
Reference
PMID:19707851
  Authors
Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
  Journal
J Neural Transm (Vienna) 116:1111-62 (2009)
DOI:10.1007/s00702-009-0240-y
Reference
PMID:30743990
  Authors
Van Bulck M, Sierra-Magro A, Alarcon-Gil J, Perez-Castillo A, Morales-Garcia JA
  Title
Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
  Journal
Int J Mol Sci 20:E719 (2019)
DOI:10.3390/ijms20030719
Reference
PMID:15272267
  Authors
Ross CA, Poirier MA
  Title
Protein aggregation and neurodegenerative disease.
  Journal
Nat Med 10 Suppl:S10-7 (2004)
DOI:10.1038/nm1066
Reference
PMID:30250260
  Authors
Soto C, Pritzkow S
  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
  Journal
Nat Neurosci 21:1332-1340 (2018)
DOI:10.1038/s41593-018-0235-9
Reference
PMID:25132814
  Authors
Dantuma NP, Bott LC
  Title
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
  Journal
Front Mol Neurosci 7:70 (2014)
DOI:10.3389/fnmol.2014.00070
Reference
PMID:25413678
  Authors
Zheng C, Geetha T, Babu JR
  Title
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Related
pathway
eai00190  Oxidative phosphorylation
eai03050  Proteasome
eai04020  Calcium signaling pathway
eai04120  Ubiquitin mediated proteolysis
eai04137  Mitophagy - animal
eai04140  Autophagy - animal
eai04141  Protein processing in endoplasmic reticulum
eai04142  Lysosome
eai04210  Apoptosis
eai04310  Wnt signaling pathway
eai04724  Glutamatergic synapse
eai04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   

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