KEGG   PATHWAY: ecb05163
Entry
ecb05163                    Pathway                                
Name
Human cytomegalovirus infection - Equus caballus (horse)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
ecb05163  Human cytomegalovirus infection
ecb05163

Organism
Equus caballus (horse) [GN:ecb]
Gene
100059815  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100051623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100058141  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100051753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100052122  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100050227  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100146348  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100064671  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100054961  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100061130  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100066615  TSC1; hamartin isoform X1 [KO:K07206]
100065679  TSC2; tuberin isoform X2 [KO:K07207]
100064440  RHEB; GTP-binding protein Rheb [KO:K07208]
100051341  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
100057875  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100053005  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100057481  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100070393  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100050167  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100058432  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100067894  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X4 [KO:K02580]
100057483  RELA; transcription factor p65 [KO:K04735]
100067755  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100051866  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100053889  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100066282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100064473  KRAS; GTPase KRas isoform X1 [KO:K07827]
100051785  LOW QUALITY PROTEIN: GTPase KRas-like [KO:K07827]
100059469  NRAS; GTPase NRas [KO:K07828]
100051110  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100065996  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100063190  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100051388  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100629527  SP1; transcription factor Sp1 [KO:K04684]
100068706  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100009709  ITGB3; integrin beta-3 precursor [KO:K06493]
100069870  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100061732  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100054701  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
100054738  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100053343  RHOA; transforming protein RhoA [KO:K04513]
100067982  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
100062046  TMEM173; stimulator of interferon genes protein isoform X2 [KO:K12654]
100051650  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100055868  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
100064468  interferon alpha-2-like [KO:K05414]
100064551  interferon alpha-2-like [KO:K05414]
100052921  interferon alpha-4 precursor [KO:K05414]
100052818  IFN-ALPHA2; interferon alpha-2 precursor [KO:K05414]
100629951  interferon alpha-1 [KO:K05414]
100053110  interferon alpha-4 [KO:K05414]
100053022  IFNA1; interferon alpha-1 precursor [KO:K05414]
100053210  interferon alpha-2-like [KO:K05414]
100064612  interferon alpha-2-like [KO:K05414]
100064731  IFND1; interferon delta 1 precursor [KO:K05414]
100064975  IFND2; interferon-delta 2 precursor [KO:K05414]
100629885  interferon alpha-2-like [KO:K05414]
100052545  IFNB1; interferon beta precursor [KO:K05415]
100052658  interferon beta-like [KO:K05415]
100147174  interferon beta [KO:K05415]
100033834  TNF; tumor necrosis factor [KO:K03156]
100059548  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100058015  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
100065824  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
100055119  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
100068006  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
100034237  IL1B; interleukin-1 beta [KO:K04519]
100052414  IL1B; interleukin-1 beta [KO:K04519]
111768185  interleukin-1 beta-like [KO:K04519]
100009699  IL1R1; interleukin-1 receptor type 1 precursor [KO:K04386]
100058000  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100034136  CCL2; C-C motif chemokine 2 precursor [KO:K14624]
100033925  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
100037400  CXCL8; interleukin-8 precursor [KO:K10030]
100034196  IL6; interleukin-6 precursor [KO:K05405]
100061395  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100067486  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100052560  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X2 [KO:K07825]
100058274  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100146498  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100630067  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100063795  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100058605  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100064813  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100059736  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
106782014  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100630493  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100051499  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100063518  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100630574  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100065327  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100051430  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
100069660  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X2 [KO:K04549]
100063136  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100067327  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100057315  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100051558  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100055407  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100051485  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100052808  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100064557  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100053019  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100057133  CALML5; calmodulin-like protein 5 [KO:K02183]
100062752  CALM1; calmodulin-1 [KO:K02183]
100070422  calmodulin-like protein 3 [KO:K02183]
100071150  CALM3; calmodulin-3 [KO:K02183]
100629145  CALM2; calmodulin-2 [KO:K02183]
100064482  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
100052798  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
100057357  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100067434  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
100072862  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100061874  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102148270  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100065378  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100052657  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X4 [KO:K17332]
100053856  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100054213  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
791253  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
100055673  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100062085  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100058238  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
100051282  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
100065563  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100071337  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100055961  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100054305  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100070498  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100051295  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
100058891  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100057796  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100066046  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100052828  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100064302  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
100057909  CCL3; C-C motif chemokine 3 precursor [KO:K05408]
100057859  CCL4; C-C motif chemokine 4 [KO:K12964]
102150350  CX3CL1; fractalkine isoform X1 [KO:K05508]
100060005  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100062972  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
102150569  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
100064689  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X2 [KO:K12331]
100071503  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532]
100070242  AKAP13; A-kinase anchor protein 13 isoform X1 [KO:K16529]
100034056  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
100072339  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
100055241  CTNNB1; catenin beta-1 [KO:K02105]
111774267  PTGER1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
100067279  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
111769596  LOW QUALITY PROTEIN: prostaglandin E2 receptor EP2 subtype-like [KO:K04259]
100053557  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X3 [KO:K04260]
100053208  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
100056464  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
100050675  neuroendocrine secretory protein 55 [KO:K04632]
100061033  GSK3B; glycogen synthase kinase-3 beta isoform X6 [KO:K03083] [EC:2.7.11.26]
102149114  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100068097  MYC; myc proto-oncogene protein [KO:K04377]
102148787  IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055]
100054008  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100034011  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100033839  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
100053056  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100056278  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100056239  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100063532  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
106782258  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100066388  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
100053304  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100070334  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100062307  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100064828  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100057002  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100067794  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100063153  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
100054803  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100059348  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
100049872  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
100050974  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100063318  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100069215  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100062549  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100054547  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
100058245  PTK2; focal adhesion kinase 1 isoform X12 [KO:K05725] [EC:2.7.10.2]
100068908  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
100072356  CRK; adapter molecule crk isoform X1 [KO:K04438]
100050855  CRKL; crk-like protein [KO:K04438]
100053811  PXN; paxillin isoform X1 [KO:K05760]
100071172  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
100052549  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
100055552  CXCR2; C-X-C chemokine receptor type 2 isoform X1 [KO:K05050]
100065466  C-C chemokine receptor type 1 [KO:K04176]
100065437  CCR3; C-C chemokine receptor type 3 [KO:K04178]
100048935  CCR5; C-C chemokine receptor type 5 [KO:K04180]
100060845  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
100052423  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
100061515  TAPBP; tapasin [KO:K08058]
100056198  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
100064107  CALR; calreticulin [KO:K08057]
100062428  calreticulin [KO:K08057]
100034212  MHCB3; MHC class I heavy chain precursor [KO:K06751]
100056062  MHC class I antigen 9.2 precursor [KO:K06751]
100034210  EQMHCB2; MHC class I heavy chain precursor [KO:K06751]
100054114  HLA class I histocompatibility antigen, alpha chain G isoform X1 [KO:K06751]
100051657  7-51 putative nonclassical MHC class I antigen precursor [KO:K06751]
100057920  HLA class I histocompatibility antigen, Cw-12 alpha chain isoform X2 [KO:K06751]
100050550  EQMCE1; MHC class I antigen 3.7 precursor [KO:K06751]
100056182  HLA class I histocompatibility antigen, B-40 alpha chain isoform X1 [KO:K06751]
100056391  MHCX1; MHC class I antigen 3.5 precursor [KO:K06751]
100034211  EQMHCC1; MHC class I heavy chain precursor [KO:K06751]
100049798  class I histocompatibility antigen, Gogo-OKO alpha chain isoform X12 [KO:K06751]
100050473  class I histocompatibility antigen, Gogo-B*0103 alpha chain isoform X1 [KO:K06751]
100050706  saoe class I histocompatibility antigen, A alpha chain isoform X1 [KO:K06751]
100053918  HLA class I histocompatibility antigen, B-46 alpha chain isoform X2 [KO:K06751]
100054397  saoe class I histocompatibility antigen, A alpha chain [KO:K06751]
100054448  HLA class I histocompatibility antigen, alpha chain G isoform X3 [KO:K06751]
100056309  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
100056099  HLA class I histocompatibility antigen, alpha chain G isoform X1 [KO:K06751]
100056231  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
100059994  HLA class I histocompatibility antigen, B-15 alpha chain isoform X1 [KO:K06751]
100060096  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
100034203  B2M; beta-2-microglobulin precursor [KO:K08055]
100146270  cyclin-dependent kinase 4 inhibitor B [KO:K06621]
100052084  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100062044  TP53; cellular tumor antigen p53 [KO:K04451]
100064022  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100051005  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
100061625  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100057080  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
100069192  E2F1; transcription factor E2F1 [KO:K17454]
100057866  E2F2; transcription factor E2F2 isoform X2 [KO:K09389]
100052248  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
100052326  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100071639  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100061802  FADD; FAS-associated death domain protein [KO:K02373]
100066502  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100054988  BID; BH3-interacting domain death agonist [KO:K04726]
100054674  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100061755  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
100053958  CYCS; cytochrome c [KO:K08738]
111768755  cytochrome c, testis-specific [KO:K08738]
100054331  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100034083  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
  Authors
Roy S, Arav-Boger R
  Title
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Related
pathway
ecb00590  Arachidonic acid metabolism
ecb03050  Proteasome
ecb04010  MAPK signaling pathway
ecb04064  NF-kappa B signaling pathway
ecb04110  Cell cycle
ecb04150  mTOR signaling pathway
ecb04151  PI3K-Akt signaling pathway
ecb04210  Apoptosis
ecb04612  Antigen processing and presentation
ecb04623  Cytosolic DNA-sensing pathway
ecb04630  JAK-STAT signaling pathway
ecb04668  TNF signaling pathway
ecb04810  Regulation of actin cytoskeleton
KO pathway
ko05163   
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