KEGG   PATHWAY: ptr05022
Entry
ptr05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Pan troglodytes (chimpanzee)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ptr05022  Pathways of neurodegeneration - multiple diseases
ptr05022

Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
473931  APP; amyloid-beta A4 protein precursor [KO:K04520]
450177  MAPT; microtubule-associated protein tau [KO:K04380]
461375  SNCA; alpha-synuclein [KO:K04528]
107974879  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
104002580  FUS; RNA-binding protein FUS [KO:K13098]
449637  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
452247  ATXN2; ataxin-2 isoform X1 [KO:K23625]
454017  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
461084  HTT; huntingtin isoform X1 [KO:K04533]
454229  ATXN1L; ataxin-1-like [KO:K23616]
747421  ATXN1; ataxin-1 [KO:K23616]
738729  ATXN3; ataxin-3 isoform X6 [KO:K11863] [EC:3.4.22.-]
736059  ATXN3L; ataxin-3-like protein [KO:K11863] [EC:3.4.22.-]
458076  PRNP; major prion protein preproprotein [KO:K05634]
451272  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
469725  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
503515  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
451353  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
463049  GRM1; metabotropic glutamate receptor 1 precursor [KO:K04603]
451472  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
472962  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
741350  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
453330  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
458093  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5 [KO:K05858] [EC:3.1.4.11]
469875  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
451290  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
458253  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
454832  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
453993  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
456276  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
471294  TRPC3; short transient receptor potential channel 3 isoform X4 [KO:K04966]
465062  SIGMAR1; sigma non-opioid intracellular receptor 1 isoform X2 [KO:K20719]
460134  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
473389  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
462618  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100612063  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
457846  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
453296  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
469860  PDYN; proenkephalin-B [KO:K15840]
468444  DLG4; disks large homolog 4 isoform X1 [KO:K11828]
465176  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
454396  GRIN2A; glutamate receptor ionotropic, NMDA 2A precursor [KO:K05209]
473373  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
454868  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
456180  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
471714  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
461570  GRIA2; glutamate receptor 2 isoform 1 precursor [KO:K05198]
465842  GRIA3; glutamate receptor 3 isoform X2 [KO:K05199]
466768  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
464893  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
466915  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
460447  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
740711  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
469635  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
742605  STX1A; syntaxin-1A [KO:K04560]
467639  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
454019  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
100613278  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
452231  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2 [KO:K05853] [EC:7.2.2.10]
739740  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
457790  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
464364  DERL1; derlin-1 isoform X2 [KO:K11519]
747490  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
735674  UBA52; ubiquitin-60S ribosomal protein L40 isoform X2 [KO:K02927]
104007830  ubiquitin-like [KO:K02927]
743830  40S ribosomal protein S27a [KO:K02977]
101059860  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
468372  UBB; polyubiquitin-B [KO:K04551]
467151  UBC; polyubiquitin-C [KO:K08770]
452861  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
472653  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
453569  PSMA4; proteasome subunit alpha type-4 isoform X2 [KO:K02728] [EC:3.4.25.1]
458383  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
468505  PSMA8; proteasome subunit alpha type-7-like isoform X1 [KO:K02731] [EC:3.4.25.1]
469795  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
112204966  proteasome subunit alpha type-5-like [KO:K02729] [EC:3.4.25.1]
112207728  proteasome subunit alpha type-5-like [KO:K02729] [EC:3.4.25.1]
451040  PSMA1; proteasome subunit alpha type-1 isoform X3 [KO:K02725] [EC:3.4.25.1]
467469  PSMA3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
454453  PSMB6; proteasome subunit beta type-6 isoform X2 [KO:K02738] [EC:3.4.25.1]
464723  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
454616  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
469277  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
467401  PSMB5; proteasome subunit beta type-5 isoform X1 [KO:K02737] [EC:3.4.25.1]
473258  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
457293  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
463632  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
453097  PSMC1; 26S proteasome regulatory subunit 4 isoform X2 [KO:K03062]
737578  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
452909  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
451172  PSMC3; 26S proteasome regulatory subunit 6A isoform X2 [KO:K03065]
454777  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
460887  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
470674  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
454640  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
465187  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
454836  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
454574  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
465457  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X2 [KO:K03037]
454240  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
450913  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
100192399  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
459686  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
456007  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
458386  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
747549  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
461185  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
749307  UBA1; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
744322  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
748061  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
466588  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X2 [KO:K04553] [EC:2.3.2.23]
457188  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
462883  UBE2J1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
474042  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X2 [KO:K04555] [EC:2.3.2.23]
750513  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X2 [KO:K10575] [EC:2.3.2.23]
738926  GPR37; prosaposin receptor GPR37 [KO:K04243]
458652  SEPT5; septin-5 isoform X2 [KO:K04557]
462021  SNCAIP; synphilin-1 isoform X1 [KO:K04558]
464733  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
469984  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X1 [KO:K10707]
457461  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X3 [KO:K09054]
452017  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
458735  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
454769  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
464876  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
463023  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
743199  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X3 [KO:K04431] [EC:2.7.12.2]
450445  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
461358  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
462336  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
466766  CASP12; inactive caspase-12 isoform X1 [KO:K04741] [EC:3.4.22.-]
468880  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
459388  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
452980  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
744513  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
750842  SLC6A3; sodium-dependent dopamine transporter isoform X1 [KO:K05036]
749028  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
807867  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
807865  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
807870  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
807863  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
807868  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
807860  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
807861  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
747209  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor [KO:K03942] [EC:7.1.1.2]
455295  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor [KO:K03943] [EC:7.1.1.2]
100608425  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
736470  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial precursor [KO:K03944]
100608263  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
462119  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X3 [KO:K03946]
100614219  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
741211  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
100609725  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X1 [KO:K03948]
739861  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
463686  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
458981  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
743262  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
464897  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
451766  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor [KO:K03953]
470696  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor [KO:K03954]
744435  NDUFAB1; acyl carrier protein, mitochondrial precursor [KO:K03955]
739803  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
452134  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
455877  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
453115  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
463780  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor [KO:K03958]
459871  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
107968313  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
460612  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
471008  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial precursor [KO:K03961]
100611615  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
468748  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
744716  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor [KO:K03964]
464380  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
746648  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
473588  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial precursor [KO:K11351]
459896  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor [KO:K03934] [EC:7.1.1.2]
747334  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor [KO:K03935] [EC:7.1.1.2]
451175  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial precursor [KO:K03936] [EC:7.1.1.2]
461878  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor [KO:K03937]
456776  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
107969209  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
100613331  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
742848  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor [KO:K03939]
100126358  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial precursor [KO:K03940] [EC:7.1.1.2]
451375  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial precursor [KO:K03941] [EC:7.1.1.2]
461494  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
451445  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
107974583  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
107970891  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
456526  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
747462  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X2 [KO:K00236]
451547  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X2 [KO:K00237]
112207632  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
741344  UQCRFS1; cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
807858  CYTB; cytochrome b [KO:K00412]
472893  CYC1; cytochrome c1, heme protein, mitochondrial [KO:K00413]
460348  UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
468094  UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
742376  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
464294  UQCRB; cytochrome b-c1 complex subunit 7 [KO:K00417]
107974864  cytochrome b-c1 complex subunit 8 [KO:K00418]
735808  UQCR10; cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
743144  cytochrome b-c1 complex subunit 10 [KO:K00420]
807869  COX3; cytochrome c oxidase subunit III [KO:K02262]
807866  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
807864  COX2; cytochrome c oxidase subunit II [KO:K02261]
469913  COX4I2; uncharacterized protein COX4I2 isoform X3 [KO:K02263]
454391  COX4I1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
100610650  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
453750  COX5A; cytochrome c oxidase subunit 5A, mitochondrial precursor [KO:K02264]
741789  COX5B; cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
742678  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
100616508  COX6A1; cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
745426  COX6B1; cytochrome c oxidase subunit 6B1 [KO:K02267]
112207846  cytochrome c oxidase subunit 6B1 [KO:K02267]
469014  COX6B2; cytochrome c oxidase subunit 6B2 [KO:K02267]
741071  COX6C; cytochrome c oxidase subunit 6C [KO:K02268]
459181  COX7A2L; cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
100609529  COX7A1; cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
738626  COX7A2; cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
100615314  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
465727  COX7B; cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
739452  COX7C; cytochrome c oxidase subunit 7C, mitochondrial precursor [KO:K02272]
740780  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
742828  COX8A; cytochrome c oxidase subunit 8A, mitochondrial precursor [KO:K02273]
100608033  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
455397  ATP5F1A; ATP synthase subunit alpha, mitochondrial precursor [KO:K02132]
451999  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
450294  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
742197  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
100613526  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
735962  ATP synthase subunit epsilon-like protein, mitochondrial [KO:K02135]
807859  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
457109  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
470584  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
455195  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
451943  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X2 [KO:K02128]
736468  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
473976  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
744512  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
807862  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
738409  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
745717  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X2 [KO:K05862]
469846  TOMM40L; mitochondrial import receptor subunit TOM40B isoform X1 [KO:K11518]
100615130  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
466291  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
737566  CALML5; calmodulin-like protein 5 [KO:K02183]
466008  CALML3; calmodulin-like protein 3 [KO:K02183]
459213  CALM2; calmodulin-2 [KO:K02183]
738819  CALM1; calmodulin-1 [KO:K02183]
456153  CALM3; calmodulin-3 [KO:K02183]
743250  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
453534  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
742406  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
461403  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
450898  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
736325  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100613118  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
100615623  BAD; bcl2-associated agonist of cell death [KO:K02158]
469584  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
738331  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
451389  FADD; FAS-associated death domain protein [KO:K02373]
746477  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
458635  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
747093  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
462616  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
745893  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 isoform X1 [KO:K08844] [EC:2.7.11.1]
459339  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
453868  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
738876  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
737891  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
461632  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
742937  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
736938  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
107972834  ADP/ATP translocase 3 [KO:K05863]
101057286  ADP/ATP translocase 3-like [KO:K05863]
112206875  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
450545  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X2 [KO:K09565] [EC:5.2.1.8]
742456  cytochrome c-like [KO:K08738]
744779  CYCS; cytochrome c [KO:K08738]
107972317  cytochrome c-like [KO:K08738]
104002760  cytochrome c [KO:K08738]
107967841  cytochrome c-like [KO:K08738]
107967209  cytochrome c-like [KO:K08738]
112204199  cytochrome c-like [KO:K08738]
107973044  cytochrome c-like isoform X1 [KO:K08738]
452153  APAF1; apoptotic protease-activating factor 1 isoform X2 [KO:K02084]
456457  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
461669  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
463479  HIP1; huntingtin-interacting protein 1 [KO:K04559]
470877  IFT57; intraflagellar transport protein 57 homolog [KO:K04638]
465649  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 isoform X2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
737256  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
465864  protein/nucleic acid deglycase DJ-1-like [KO:K05687] [EC:3.5.1.124]
746063  PARK7; protein/nucleic acid deglycase DJ-1 isoform X1 [KO:K05687] [EC:3.5.1.124]
458156  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
460861  MFN1; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
457958  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
736417  OPTN; optineurin isoform X2 [KO:K19946]
462333  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
746157  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
457857  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
740518  MAP1LC3B2; microtubule-associated proteins 1A/1B light chain 3 beta 2 [KO:K10435]
744937  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
100614312  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
452047  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
459685  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
461795  WDR41; WD repeat-containing protein 41 isoform X2 [KO:K23610]
465031  C9H9orf72; guanine nucleotide exchange C9orf72 homolog isoform X1 [KO:K23609]
468760  RAB8A; ras-related protein Rab-8A [KO:K07901]
741453  RAB39B; ras-related protein Rab-39B [KO:K07925]
459280  RAB1A; ras-related protein Rab-1A isoform X2 [KO:K07874]
457945  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
744289  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
454507  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
451914  ATG101; autophagy-related protein 101 [KO:K19730]
451155  ATG13; autophagy-related protein 13 [KO:K08331]
464173  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
451154  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
454700  BECN1; beclin-1 isoform X1 [KO:K08334]
473443  BECN2; beclin-2 [KO:K08334]
460692  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
744098  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
450488  NRBF2; nuclear receptor-binding factor 2 isoform X2 [KO:K21246]
455385  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
451304  ATG2A; autophagy-related protein 2 homolog A isoform X3 [KO:K17906]
453143  ATG2B; autophagy-related protein 2 homolog B isoform X2 [KO:K17906]
468309  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
737922  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
467502  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X2 [KO:K17603]
470613  ALS2; alsin [KO:K04575]
460217  RAB5A; ras-related protein Rab-5A [KO:K07887]
741907  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
735485  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
462932  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
453391  SPG11; spatacsin [KO:K19026]
494186  TNF; tumor necrosis factor [KO:K03156]
466934  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
457968  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
462613  DAXX; death domain-associated protein 6 isoform X2 [KO:K02308]
107972404  dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
112206088  dual specificity mitogen-activated protein kinase kinase 3-like [KO:K04432] [EC:2.7.12.2]
468310  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
450161  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
462644  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
747077  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
104003820  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
467139  NOS1; nitric oxide synthase, brain isoform X2 [KO:K13240] [EC:1.14.13.39]
451348  CCS; copper chaperone for superoxide dismutase [KO:K04569]
469325  GPX7; glutathione peroxidase 7 precursor [KO:K00432] [EC:1.11.1.9]
461015  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
471920  GPX6; glutathione peroxidase 6 precursor [KO:K00432] [EC:1.11.1.9]
471703  GPX3; glutathione peroxidase 3 precursor [KO:K00432] [EC:1.11.1.9]
467483  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
461872  GPX8; probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
451116  CAT; catalase [KO:K03781] [EC:1.11.1.6]
451877  PRPH; peripherin isoform X1 [KO:K07607]
464063  NEFL; neurofilament light polypeptide [KO:K04572]
745196  NEFM; neurofilament medium polypeptide [KO:K04573]
458741  NEFH; neurofilament heavy polypeptide [KO:K04574]
450390  KIF5B; kinesin-1 heavy chain [KO:K10396]
452019  KIF5A; kinesin heavy chain [KO:K10396]
470557  KIF5C; kinesin heavy chain [KO:K10396]
466670  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
468918  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
735843  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
453188  KLC1; kinesin light chain 1 isoform X11 [KO:K10407]
470654  TUBA4A; tubulin alpha-4A chain [KO:K07374]
451875  TUBA1A; tubulin alpha-1A chain [KO:K07374]
451876  TUBA1C; tubulin alpha-1C chain isoform X3 [KO:K07374]
458641  TUBA8; tubulin alpha-8 chain [KO:K07374]
452423  TUBA1B; tubulin alpha-1B chain [KO:K07374]
466007  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
736248  TUBA3E; tubulin alpha-3E chain [KO:K07374]
465169  TUBA3C; tubulin alpha-3 chain [KO:K07374]
104004490  LOW QUALITY PROTEIN: tubulin alpha-8 chain [KO:K07374]
107973630  LOW QUALITY PROTEIN: tubulin alpha-3 chain [KO:K07374]
455508  TUBB6; tubulin beta-6 chain isoform X2 [KO:K07375]
471960  TUBB; tubulin beta chain [KO:K07375]
462399  TUBB2A; tubulin beta-2A chain [KO:K07375]
462400  TUBB2B; tubulin beta-1 chain [KO:K07375]
465170  TUBB4B; tubulin beta-4B chain [KO:K07375]
736308  TUBB1; tubulin beta-1 chain [KO:K07375]
747817  tubulin beta-8 chain-like protein isoform X1 [KO:K07375]
750209  tubulin beta-8 chain isoform X2 [KO:K07375]
468685  TUBB4A; tubulin beta-4A chain [KO:K07375]
100613658  TUBB3; tubulin beta-3 chain [KO:K07375]
739035  TUBB8; tubulin beta-8 chain isoform X1 [KO:K07375]
112209436  tubulin beta-2B chain [KO:K07375]
746788  tubulin beta-8 chain-like [KO:K07375]
738663  tubulin beta-8 chain-like [KO:K07375]
100608468  tubulin beta chain-like [KO:K07375]
737774  LOW QUALITY PROTEIN: tubulin beta-8 chain-like protein [KO:K07375]
100616510  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
454131  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
458448  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
744778  CSNK2B; casein kinase II subunit beta isoform X2 [KO:K03115]
503511  BDNF; brain-derived neurotrophic factor precursor [KO:K04355]
459332  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
100615725  DCTN2; dynactin subunit 2 [KO:K10424]
465061  DCTN3; dynactin subunit 3 isoform X2 [KO:K10425]
462195  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
453990  DCTN5; dynactin subunit 5 [KO:K10427]
472730  DCTN6; dynactin subunit 6 [KO:K10428]
466191  ACTR1A; alpha-centractin [KO:K16575]
107973565  ACTR1B; beta-centractin isoform X1 [KO:K16575]
452933  ACTR10; actin-related protein 10 isoform X2 [KO:K16576]
743382  HAP1; huntingtin-associated protein 1 isoform X4 [KO:K04647]
453978  DNAH3; dynein heavy chain 3, axonemal isoform X1 [KO:K10408]
455211  DNAH2; dynein heavy chain 2, axonemal isoform X1 [KO:K10408]
460422  DNAH1; dynein heavy chain 1, axonemal isoform X1 [KO:K10408]
100613036  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
459842  DNAH7; dynein heavy chain 7, axonemal isoform X8 [KO:K10408]
461726  DNAH5; dynein heavy chain 5, axonemal isoform X1 [KO:K10408]
459354  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
455066  DNAH9; dynein heavy chain 9, axonemal isoform X1 [KO:K10408]
748237  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
460471  DNAH12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
452355  DNAH10; dynein heavy chain 10, axonemal isoform X3 [KO:K10408]
457773  DNAH14; dynein heavy chain 14, axonemal isoform X1 [KO:K10408]
101058516  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
456760  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
465060  DNAI1; dynein intermediate chain 1, axonemal isoform X1 [KO:K10409]
743985  DNAI2; dynein intermediate chain 2, axonemal isoform X1 [KO:K11143]
739908  DNAL1; dynein light chain 1, axonemal isoform X1 [KO:K10411]
100611328  DNAL4; dynein light chain 4, axonemal [KO:K10412]
461445  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X14 [KO:K04515] [EC:2.7.11.17]
462189  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
738330  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
738167  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
451317  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
457765  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
747897  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
463891  CDK5; cyclin-dependent-like kinase 5 isoform X2 [KO:K02090] [EC:2.7.11.22]
450745  CASP7; caspase-7 isoform X5 [KO:K04397] [EC:3.4.22.60]
450465  DKK1; dickkopf-related protein 1 [KO:K02165]
745875  DKK2; dickkopf-related protein 2 [KO:K02165]
737321  DKK4; dickkopf-related protein 4 [KO:K02165]
742674  WNT1; proto-oncogene Wnt-1 [KO:K03209]
463673  WNT2; protein Wnt-2 precursor [KO:K00182]
457103  WNT2B; protein Wnt-2b [KO:K00182]
100615247  WNT3A; protein Wnt-3a isoform X2 [KO:K00312]
107966366  WNT3; proto-oncogene Wnt-3 [KO:K00312]
469212  WNT4; protein Wnt-4 [KO:K00408]
467191  WNT5B; protein Wnt-5b isoform X5 [KO:K00444]
460458  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
742467  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
104003805  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
749914  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
471645  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
466182  WNT8B; protein Wnt-8b isoform X2 [KO:K00714]
468296  WNT9B; protein Wnt-9b isoform X1 [KO:K01064]
469697  WNT9A; protein Wnt-9a isoform X2 [KO:K01064]
451870  WNT10B; protein Wnt-10b [KO:K01357]
459952  WNT10A; protein Wnt-10a [KO:K01357]
451431  WNT11; protein Wnt-11 [KO:K01384]
737375  WNT16; protein Wnt-16 isoform X2 [KO:K01558]
463524  FZD1; frizzled-1 [KO:K02432]
459881  FZD7; frizzled-7 [KO:K02432]
454731  FZD2; frizzled-2 [KO:K02235]
472726  FZD3; frizzled-3 [KO:K02329]
466732  FZD4; frizzled-4 isoform X1 [KO:K02354]
470627  FZD5; frizzled-5 [KO:K02375]
466040  FZD8; frizzled-8 [KO:K02375]
464327  FZD6; frizzled-6 [KO:K02376]
467160  FZD10; frizzled-10 [KO:K02842]
472405  FZD9; frizzled-9 [KO:K02842]
451380  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
465295  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
458829  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
460882  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
455236  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
457191  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
466169  FRAT1; proto-oncogene FRAT1 [KO:K03069]
466170  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
453789  AXIN1; axin-1 isoform X1 [KO:K02157]
468301  AXIN2; axin-2 isoform X1 [KO:K04385]
461999  APC; adenomatous polyposis coli protein isoform X10 [KO:K02085]
455551  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
450183  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
467264  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
462182  CSNK1A1; casein kinase I isoform X4 [KO:K08957] [EC:2.7.11.1]
462584  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
466302  HRAS; GTPase HRas isoform X1 [KO:K02833]
473387  KRAS; GTPase KRas isoform X1 [KO:K07827]
742713  NRAS; GTPase NRas [KO:K07828]
100614256  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
463781  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
460182  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
450188  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
456390  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
454037  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
458680  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
465752  NOX1; NADPH oxidase 1 [KO:K08008]
465566  CYBB; cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
735636  NOX4; NADPH oxidase 4 isoform X10 [KO:K21423] [EC:1.6.3.-]
466665  RELA; transcription factor p65 [KO:K04735]
461406  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
455026  NOS2; LOW QUALITY PROTEIN: nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
469616  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
463288  IL6; interleukin-6 isoform X1 [KO:K05405]
470485  IL1A; interleukin-1 alpha [KO:K04383]
450200  IL1B; interleukin-1 beta [KO:K04519]
457127  CSF1; macrophage colony-stimulating factor 1 isoform X5 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
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Related
pathway
ptr00190  Oxidative phosphorylation
ptr03050  Proteasome
ptr04020  Calcium signaling pathway
ptr04120  Ubiquitin mediated proteolysis
ptr04137  Mitophagy - animal
ptr04140  Autophagy - animal
ptr04141  Protein processing in endoplasmic reticulum
ptr04142  Lysosome
ptr04210  Apoptosis
ptr04310  Wnt signaling pathway
ptr04724  Glutamatergic synapse
ptr04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
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