KEGG   PATHWAY: ptr05022
Entry
ptr05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Pan troglodytes (chimpanzee)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ptr05022  Pathways of neurodegeneration - multiple diseases
ptr05022

Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
100126358  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial precursor [KO:K03940] [EC:7.1.1.2]
100192399  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
100608033  COX8C; cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
100608263  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
100608468  [KO:K07375]
100608972  [KO:K07375]
100609529  COX7A1; cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
100610650  [KO:K02263]
100611313  [KO:K10435]
100611328  DNAL4; dynein axonemal light chain 4 [KO:K10412]
100611615  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
100611792  [KO:K04369] [EC:2.7.12.2]
100612063  RYR1; ryanodine receptor 1 isoform X4 [KO:K04961]
100613036  DNAH17; dynein axonemal heavy chain 17 [KO:K10408]
100613118  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
100613278  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
100613526  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
100613658  TUBB3; tubulin beta-3 chain [KO:K07375]
100614219  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
100614256  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
100614312  [KO:K10435]
100615130  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
100615247  WNT3A; protein Wnt-3a isoform X2 [KO:K00312]
100615314  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
100615623  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
100615725  DCTN2; dynactin subunit 2 [KO:K10424]
100616510  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101057286  [KO:K05863]
101058516  DNAH11; dynein axonemal heavy chain 11 [KO:K10408]
101059860  RPS27A; ubiquitin-ribosomal protein eS31 fusion protein [KO:K02977]
104002580  FUS; RNA-binding protein FUS [KO:K13098]
104002760  [KO:K08738]
104003805  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
104003820  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104004490  TUBA5; LOW QUALITY PROTEIN: tubulin alpha-8 chain [KO:K07374]
104005313  [KO:K02128]
107966366  WNT3; proto-oncogene Wnt-3 [KO:K00312]
107967209  [KO:K08738]
107967339  [KO:K03948]
107967841  [KO:K08738]
107968018  [KO:K02272]
107968313  [KO:K03959]
107968821  [KO:K03948]
107969209  [KO:K03938]
107969751  [KO:K02272]
107970442  [KO:K03948]
107970561  [KO:K08738]
107970891  [KO:K00234] [EC:1.3.5.1]
107971002  [KO:K03948]
107972317  [KO:K08738]
107972404  [KO:K04432] [EC:2.7.12.2]
107972834  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
107973044  [KO:K08738]
107973565  ACTR1B; beta-centractin isoform X1 [KO:K16575]
107973630  [KO:K07374]
107973636  [KO:K11518]
107973920  [KO:K02735] [EC:3.4.25.1]
107974583  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X2 [KO:K00234] [EC:1.3.5.1]
107974864  UQCRQ; cytochrome b-c1 complex subunit 8 [KO:K00418]
107974879  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
107974919  [KO:K00417]
112204199  [KO:K08738]
112204966  [KO:K02729] [EC:3.4.25.1]
112207632  [KO:K00237]
112207728  [KO:K02729] [EC:3.4.25.1]
112209436  [KO:K07375]
129135234  HIP1; huntingtin interacting protein 1 [KO:K04559]
129135336  [KO:K07374]
129135691  [KO:K08738]
129135916  [KO:K02138]
129137198  [KO:K08957] [EC:2.7.11.1]
129137450  [KO:K08738]
129137950  [KO:K03038]
129138685  [KO:K03948]
129143398  [KO:K07374]
129143618  [KO:K03957]
129143885  [KO:K02270]
129144156  [KO:K10881]
129144202  [KO:K07375]
129144257  [KO:K02977]
134809375  ATXN3L; ataxin-3-like protein [KO:K11863] [EC:3.4.22.-]
134810435  [KO:K04559]
449637  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
450161  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
450177  MAPT; microtubule-associated protein tau [KO:K04380]
450183  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
450188  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
450200  IL1B; interleukin-1 beta [KO:K04519]
450294  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
450390  KIF5B; kinesin-1 heavy chain isoform X2 [KO:K10396]
450445  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
450465  DKK1; dickkopf-related protein 1 [KO:K02165]
450488  NRBF2; nuclear receptor-binding factor 2 isoform X2 [KO:K21246]
450545  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X2 [KO:K09565] [EC:5.2.1.8]
450745  CASP7; caspase-7 isoform X7 [KO:K04397] [EC:3.4.22.60]
450898  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
450913  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
451040  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
451116  CAT; catalase [KO:K03781] [EC:1.11.1.6]
451154  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
451155  ATG13; autophagy-related protein 13 isoform X3 [KO:K08331]
451172  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
451175  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial precursor [KO:K03936] [EC:7.1.1.2]
451272  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
451290  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
451304  ATG2A; autophagy-related protein 2 homolog A isoform X3 [KO:K17906]
451317  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
451348  CCS; copper chaperone for superoxide dismutase [KO:K04569]
451353  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
451375  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
451380  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
451389  FADD; FAS-associated death domain protein [KO:K02373]
451431  WNT11; protein Wnt-11 [KO:K01384]
451445  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
451472  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
451766  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor [KO:K03953]
451870  WNT10B; protein Wnt-10b [KO:K01357]
451875  TUBA1A; tubulin alpha-1A chain [KO:K07374]
451876  TUBA1C; tubulin alpha-1C chain [KO:K07374]
451877  PRPH; peripherin isoform X1 [KO:K07607]
451914  ATG101; autophagy-related protein 101 [KO:K19730]
451943  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X2 [KO:K02128]
451999  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
452017  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
452019  KIF5A; kinesin heavy chain [KO:K10396]
452047  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
452134  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
452153  APAF1; apoptotic protease-activating factor 1 isoform X2 [KO:K02084]
452231  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2 [KO:K05853] [EC:7.2.2.10]
452247  ATXN2; ataxin-2 isoform X3 [KO:K23625]
452355  DNAH10; dynein axonemal heavy chain 10 [KO:K10408]
452423  TUBA1B; tubulin alpha-1B chain [KO:K07374]
452861  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
452909  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
452921  [KO:K04552] [EC:2.3.2.23]
452933  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
452980  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
453097  PSMC1; 26S proteasome regulatory subunit 4 isoform X2 [KO:K03062]
453115  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
453143  ATG2B; autophagy-related protein 2 homolog B isoform X2 [KO:K17906]
453188  KLC1; kinesin light chain 1 isoform X18 [KO:K10407]
453296  RYR3; ryanodine receptor 3 isoform X7 [KO:K04963]
453330  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
453391  SPG11; spatacsin isoform X1 [KO:K19026]
453534  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
453569  PSMA4; proteasome subunit alpha type-4 isoform X2 [KO:K02728] [EC:3.4.25.1]
453750  COX5A; cytochrome c oxidase subunit 5A, mitochondrial precursor [KO:K02264]
453789  AXIN1; axin-1 isoform X1 [KO:K02157]
453868  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
453978  DNAH3; dynein axonemal heavy chain 3 isoform X1 [KO:K10408]
453990  DCTN5; dynactin subunit 5 [KO:K10427]
453993  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
454017  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
454019  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
454037  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
454131  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
454229  ATXN1L; ataxin-1-like [KO:K23616]
454240  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
454391  COX4I1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
454396  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X2 [KO:K05209]
454453  PSMB6; proteasome subunit beta type-6 isoform X2 [KO:K02738] [EC:3.4.25.1]
454507  ULK2; serine/threonine-protein kinase ULK2 isoform X2 [KO:K08269] [EC:2.7.11.1]
454574  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
454616  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
454640  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
454700  BECN1; beclin-1 isoform X2 [KO:K08334]
454731  FZD2; frizzled-2 [KO:K02235]
454769  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
454777  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
454832  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
454836  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
454868  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
455026  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
455066  DNAH9; dynein axonemal heavy chain 9 isoform X1 [KO:K10408]
455195  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
455211  DNAH2; dynein axonemal heavy chain 2 isoform X2 [KO:K10408]
455236  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
455295  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor [KO:K03943] [EC:7.1.1.2]
455385  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
455397  ATP5F1A; ATP synthase subunit alpha, mitochondrial precursor [KO:K02132]
455551  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
455877  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
456007  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
456153  CALM3; calmodulin-3 [KO:K02183]
456180  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
456276  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
456390  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
456457  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
456526  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
456760  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
456776  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
457103  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
457109  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X1 [KO:K02127]
457127  CSF1; macrophage colony-stimulating factor 1 isoform X5 [KO:K05453]
457188  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
457191  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
457293  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
457461  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X3 [KO:K09054]
457765  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
457773  DNAH14; dynein axonemal heavy chain 14 isoform X4 [KO:K10408]
457790  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
457846  RYR2; ryanodine receptor 2 isoform X22 [KO:K04962]
457857  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
457945  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
457958  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
457968  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X2 [KO:K05141]
458076  PRNP; major prion protein preproprotein [KO:K05634]
458093  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5 [KO:K05858] [EC:3.1.4.11]
458156  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
458253  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116] [EC:3.1.4.11]
458383  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
458386  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
458448  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
458635  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
458641  TUBA8; tubulin alpha-8 chain [KO:K07374]
458652  SEPTIN5; septin-5 isoform X3 [KO:K04557]
458680  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
458735  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
458741  NEFH; neurofilament heavy polypeptide [KO:K04574]
458829  CSNK1E; casein kinase I isoform X3 [KO:K08960] [EC:2.7.11.1]
458981  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
459181  COX7A2L; cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
459213  CALM2; calmodulin-2 [KO:K02183]
459280  RAB1A; ras-related protein Rab-1A isoform X2 [KO:K07874]
459332  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
459339  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
459354  DNAH6; dynein axonemal heavy chain 6 [KO:K10408]
459388  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
459685  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
459686  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X2 [KO:K03030]
459842  DNAH7; dynein axonemal heavy chain 7 isoform X8 [KO:K10408]
459871  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
459881  FZD7; frizzled-7 [KO:K02432]
459896  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor [KO:K03934] [EC:7.1.1.2]
459952  WNT10A; protein Wnt-10a isoform X2 [KO:K01357]
460134  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
460182  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
460217  RAB5A; ras-related protein Rab-5A [KO:K07887]
460348  UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
460422  DNAH1; dynein axonemal heavy chain 1 isoform X2 [KO:K10408]
460447  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X20 [KO:K04851]
460458  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
460612  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
460692  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
460861  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
460882  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
460887  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
461015  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
461084  HTT; huntingtin isoform X1 [KO:K04533]
461185  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
461194  [KO:K03960]
461358  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
461375  SNCA; alpha-synuclein [KO:K04528]
461403  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
461406  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
461445  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515] [EC:2.7.11.17]
461494  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
461570  GRIA2; glutamate receptor 2 isoform 1 precursor [KO:K05198]
461632  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
461669  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
461726  DNAH5; dynein axonemal heavy chain 5 isoform X2 [KO:K10408]
461795  WDR41; WD repeat-containing protein 41 isoform X5 [KO:K23610]
461872  GPX8; probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
461878  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor [KO:K03937]
461999  APC; adenomatous polyposis coli protein isoform X5 [KO:K02085]
462021  SNCAIP; synphilin-1 isoform X2 [KO:K04558]
462119  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X3 [KO:K03946]
462182  CSNK1A1; casein kinase I isoform X2 [KO:K08957] [EC:2.7.11.1]
462189  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
462195  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
462333  SQSTM1; sequestosome-1 isoform X2 [KO:K14381]
462336  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
462399  TUBB2A; tubulin beta-2A chain [KO:K07375]
462400  TUBB2B; tubulin beta-2A chain isoform X1 [KO:K07375]
462584  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
462613  DAXX; death domain-associated protein 6 [KO:K02308]
462616  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
462618  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
462644  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
462655  [KO:K02266]
462883  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X2 [KO:K10578] [EC:2.3.2.23]
462932  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
463023  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
463049  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
463288  IL6; interleukin-6 isoform X1 [KO:K05405]
463479  [KO:K04559]
463524  FZD1; frizzled-1 [KO:K02432]
463632  PSMC2; 26S proteasome regulatory subunit 7 isoform X1 [KO:K03061]
463673  WNT2; protein Wnt-2 precursor [KO:K00182]
463686  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
463780  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor [KO:K03958]
463781  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
463891  CDK5; cyclin-dependent kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
464063  NEFL; neurofilament light polypeptide [KO:K04572]
464173  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X3 [KO:K17589]
464183  [KO:K03064]
464294  UQCRB; cytochrome b-c1 complex subunit 7 [KO:K00417]
464327  FZD6; frizzled-6 [KO:K02376]
464380  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
464723  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
464733  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
464876  TRAF2; TNF receptor-associated factor 2 isoform X3 [KO:K03173] [EC:2.3.2.27]
464893  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
464897  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
465031  C9orf72; guanine nucleotide exchange factor C9orf72 homolog isoform X1 [KO:K23609]
465060  DNAI1; dynein axonemal intermediate chain 1 isoform X1 [KO:K10409]
465061  DCTN3; dynactin subunit 3 isoform X1 [KO:K10425]
465062  SIGMAR1; sigma non-opioid intracellular receptor 1 isoform X2 [KO:K20719]
465169  TUBA3C; tubulin alpha-3C chain [KO:K07374]
465170  TUBB4B; tubulin beta-4B chain [KO:K07375]
465176  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
465187  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
465295  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
465457  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X2 [KO:K03037]
465566  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
465649  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
465727  COX7B; cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
465752  NOX1; NADPH oxidase 1 [KO:K08008]
465842  GRIA3; glutamate receptor 3 isoform X2 [KO:K05199]
465864  [KO:K05687] [EC:3.5.1.124]
465884  [KO:K04392]
466007  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
466008  CALML3; calmodulin-like protein 3 [KO:K02183]
466040  FZD8; frizzled-8 [KO:K02375]
466169  FRAT1; proto-oncogene FRAT1 [KO:K03069]
466170  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
466182  WNT8B; protein Wnt-8b isoform X2 [KO:K00714]
466191  ACTR1A; alpha-centractin [KO:K16575]
466291  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
466302  HRAS; GTPase HRas isoform X1 [KO:K02833]
466588  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X2 [KO:K04553] [EC:2.3.2.23]
466665  RELA; transcription factor P65 [KO:K04735]
466670  KLC2; kinesin light chain 2 isoform X2 [KO:K10407]
466732  FZD4; frizzled-4 isoform X1 [KO:K02354]
466766  CASP12; inactive caspase-12 isoform X1 [KO:K04741] [EC:3.4.22.-]
466768  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
466915  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
466934  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
467061  [KO:K02138]
467139  NOS1; nitric oxide synthase 1 isoform X2 [KO:K13240] [EC:1.14.13.39]
467151  UBC; polyubiquitin-C [KO:K08770]
467160  FZD10; frizzled-10 [KO:K02842]
467191  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
467264  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
467320  [KO:K02128]
467401  PSMB5; proteasome subunit beta type-5 isoform X1 [KO:K02737] [EC:3.4.25.1]
467469  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
467483  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
467502  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X3 [KO:K17603]
467639  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
468094  UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
468296  WNT9B; protein Wnt-9b isoform X2 [KO:K01064]
468301  AXIN2; axin-2 isoform X1 [KO:K04385]
468309  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
468310  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
468313  [KO:K02183]
468372  UBB; polyubiquitin-B [KO:K04551]
468444  DLG4; disks large homolog 4 isoform X2 [KO:K11828]
468505  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
468685  TUBB4A; tubulin beta-4A chain [KO:K07375]
468748  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
468760  RAB8A; ras-related protein Rab-8A [KO:K07901]
468880  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
468918  KLC3; kinesin light chain 3 isoform X2 [KO:K10407]
469014  COX6B2; cytochrome c oxidase subunit 6B2 [KO:K02267]
469212  WNT4; protein Wnt-4 [KO:K00408]
469277  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
469325  GPX7; glutathione peroxidase 7 precursor [KO:K00432] [EC:1.11.1.9]
469584  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
469616  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
469635  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
469697  WNT9A; protein Wnt-9a isoform X2 [KO:K01064]
469725  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
469795  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
469846  TOMM40L; mitochondrial import receptor subunit TOM40B isoform X1 [KO:K11518]
469860  PDYN; proenkephalin-B [KO:K15840]
469875  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
469913  COX4I2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X3 [KO:K02263]
469984  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X1 [KO:K10707]
470485  IL1A; interleukin-1 alpha [KO:K04383]
470557  KIF5C; kinesin heavy chain [KO:K10396]
470584  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
470613  ALS2; alsin [KO:K04575]
470627  FZD5; frizzled-5 [KO:K02375]
470654  TUBA4A; tubulin alpha-4A chain [KO:K07374]
470674  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
470696  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor [KO:K03954]
470877  IFT57; intraflagellar transport protein 57 homolog [KO:K04638]
471008  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial precursor [KO:K03961]
471294  TRPC3; short transient receptor potential channel 3 isoform X4 [KO:K04966]
471645  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
471703  GPX3; glutathione peroxidase 3 precursor [KO:K00432] [EC:1.11.1.9]
471714  GRIA1; glutamate receptor 1 isoform X4 [KO:K05197]
471920  GPX6; glutathione peroxidase 6 precursor [KO:K00432] [EC:1.11.1.9]
471960  TUBB; tubulin beta chain [KO:K07375]
472405  FZD9; frizzled-9 [KO:K02842]
472653  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
472726  FZD3; frizzled-3 isoform X1 [KO:K02329]
472730  DCTN6; dynactin subunit 6 [KO:K10428]
472893  CYC1; cytochrome c1, heme protein, mitochondrial isoform X2 [KO:K00413]
472962  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
473258  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
473373  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
473387  KRAS; GTPase KRas isoform X1 [KO:K07827]
473389  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959]
473443  BECN2; beclin-2 [KO:K08334]
473588  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial precursor [KO:K11351]
473931  APP; amyloid-beta precursor protein precursor [KO:K04520]
473976  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
474042  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X2 [KO:K04555] [EC:2.3.2.23]
494186  TNF; tumor necrosis factor [KO:K03156]
503511  BDNF; brain-derived neurotrophic factor precursor [KO:K04355]
503515  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
735485  CHMP2B; charged multivesicular body protein 2b isoform X2 [KO:K12192]
735636  NOX4; NADPH oxidase 4 isoform X10 [KO:K21423] [EC:1.6.3.-]
735674  UBA52; ubiquitin-ribosomal protein eL40 fusion protein [KO:K02927]
735808  UQCR10; cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
735843  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
735962  [KO:K02135]
736308  TUBB1; tubulin beta-1 chain [KO:K07375]
736325  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
736417  OPTN; optineurin isoform X2 [KO:K19946]
736468  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
736470  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial precursor [KO:K03944]
736938  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
737256  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
737321  DKK4; dickkopf-related protein 4 [KO:K02165]
737375  WNT16; protein Wnt-16 isoform X2 [KO:K01558]
737566  CALML5; calmodulin-like protein 5 [KO:K02183]
737578  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
737891  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
737922  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
738167  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
738330  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X4 [KO:K04515] [EC:2.7.11.17]
738331  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
738409  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
738626  COX7A2; cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
738663  [KO:K07375]
738729  ATXN3; ataxin-3 isoform X6 [KO:K11863] [EC:3.4.22.-]
738819  CALM1; calmodulin-1 [KO:K02183]
738876  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
738926  GPR37; prosaposin receptor GPR37 [KO:K04243]
739035  TUBB8; tubulin beta-8 chain isoform X4 [KO:K07375]
739452  COX7C; cytochrome c oxidase subunit 7C, mitochondrial precursor [KO:K02272]
739740  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
739803  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
739861  [KO:K03948]
739908  DNAL1; dynein axonemal light chain 1 isoform X1 [KO:K10411]
740518  MAP1LC3B2; microtubule-associated proteins 1A/1B light chain 3 beta 2 [KO:K10435]
740711  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
740780  [KO:K02272]
741071  COX6C; cytochrome c oxidase subunit 6C [KO:K02268]
741211  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
741344  UQCRFS1; cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
741350  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
741453  RAB39B; ras-related protein Rab-39B [KO:K07925]
741789  COX5B; cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
741907  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
742197  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
742376  UQCRH; cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
742406  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
742456  [KO:K08738]
742467  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
742582  [KO:K00419]
742605  STX1A; syntaxin-1A isoform X1 [KO:K04560]
742674  WNT1; proto-oncogene Wnt-1 [KO:K03209]
742678  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
742713  NRAS; GTPase NRas [KO:K07828]
742793  [KO:K05862]
742828  COX8A; cytochrome c oxidase subunit 8A, mitochondrial precursor [KO:K02273]
742848  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor [KO:K03939]
742937  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
743144  UQCR11; cytochrome b-c1 complex subunit 10 [KO:K00420]
743199  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X3 [KO:K04431] [EC:2.7.12.2]
743250  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
743260  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
743262  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
743382  HAP1; huntingtin-associated protein 1 isoform X4 [KO:K04647]
743898  [KO:K00417]
743985  DNAI2; dynein axonemal intermediate chain 2 isoform X1 [KO:K11143]
744098  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
744289  ULK1; serine/threonine-protein kinase ULK1 isoform X6 [KO:K21357] [EC:2.7.11.1]
744322  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
744435  NDUFAB1; acyl carrier protein, mitochondrial precursor [KO:K03955]
744512  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
744513  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
744716  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor [KO:K03964]
744778  CSNK2B; casein kinase II subunit beta isoform X2 [KO:K03115]
744779  CYCS; cytochrome c isoform X1 [KO:K08738]
744937  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
745138  [KO:K02128]
745196  NEFM; neurofilament medium polypeptide [KO:K04573]
745426  COX6B1; cytochrome c oxidase subunit 6B1 [KO:K02267]
745717  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
745872  [KO:K02977]
745875  DKK2; dickkopf-related protein 2 [KO:K02165]
745893  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 isoform X1 [KO:K08844] [EC:2.7.11.1]
746063  PARK7; Parkinson disease protein 7 isoform X3 [KO:K05687] [EC:3.5.1.124]
746157  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
746477  CASP8; caspase-8 isoform X9 [KO:K04398] [EC:3.4.22.61]
746648  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
746788  [KO:K07375]
747077  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
747093  BAX; apoptosis regulator BAX isoform X4 [KO:K02159]
747209  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor [KO:K03942] [EC:7.1.1.2]
747334  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor [KO:K03935] [EC:7.1.1.2]
747421  ATXN1; ataxin-1 [KO:K23616]
747462  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X4 [KO:K00236]
747490  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
747549  SEM1; 26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
747817  [KO:K07375]
747897  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
748061  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X3 [KO:K04552] [EC:2.3.2.23]
748237  DNAH8; dynein axonemal heavy chain 8 isoform X1 [KO:K10408]
749028  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
749307  UBA1; ubiquitin-like modifier-activating enzyme 1 isoform X3 [KO:K03178] [EC:6.2.1.45]
749914  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
750209  [KO:K07375]
750513  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X2 [KO:K10575] [EC:2.3.2.23]
750842  SLC6A3; sodium-dependent dopamine transporter isoform X1 [KO:K05036]
807858  CYTB; cytochrome b [KO:K00412]
807859  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
807860  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
807861  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
807862  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
807863  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
807864  COX2; cytochrome c oxidase subunit II [KO:K02261]
807865  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
807866  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
807867  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
807868  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
807869  COX3; cytochrome c oxidase subunit III [KO:K02262]
807870  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
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Related
pathway
ptr00190  Oxidative phosphorylation
ptr03050  Proteasome
ptr04020  Calcium signaling pathway
ptr04120  Ubiquitin mediated proteolysis
ptr04137  Mitophagy - animal
ptr04140  Autophagy - animal
ptr04141  Protein processing in endoplasmic reticulum
ptr04142  Lysosome
ptr04210  Apoptosis
ptr04310  Wnt signaling pathway
ptr04724  Glutamatergic synapse
ptr04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   

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