KEGG   PATHWAY: rbb05022
Entry
rbb05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Rhinopithecus bieti (black snub-nosed monkey)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
rbb05022  Pathways of neurodegeneration - multiple diseases
rbb05022

Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
108518214  APP; amyloid beta A4 protein isoform X1 [KO:K04520]
108529371  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
108521103  SNCA; alpha-synuclein isoform X1 [KO:K04528]
108539382  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
108528462  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
108536840  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
108538089  LOW QUALITY PROTEIN: superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
108512237  ATXN2; LOW QUALITY PROTEIN: ataxin-2 [KO:K23625]
108523670  ATXN2L; LOW QUALITY PROTEIN: ataxin-2-like protein [KO:K23625]
108522748  HTT; huntingtin isoform X1 [KO:K04533]
108514577  ataxin-1-like [KO:K23616]
108529163  ATXN1L; ataxin-1-like [KO:K23616]
108538793  ATXN1; ataxin-1 [KO:K23616]
108523901  putative ataxin-3-like protein [KO:K11863] [EC:3.4.22.-]
108544961  putative ataxin-3-like protein [KO:K11863] [EC:3.4.22.-]
108519113  ATXN3; LOW QUALITY PROTEIN: ataxin-3 [KO:K11863] [EC:3.4.22.-]
108533419  PRNP; major prion protein [KO:K05634]
108536133  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
108534413  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
108518797  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
108518666  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
108539155  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
108542641  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
108527984  PARK2; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
108526885  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
108542252  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
108527553  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
108527564  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
108519825  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
108517746  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
108538857  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
108529452  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
108515603  TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966]
108542166  SIGMAR1; sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
108528737  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
108523739  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
108516255  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
108538989  RYR1; ryanodine receptor 1 [KO:K04961]
108522194  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
108518794  RYR3; ryanodine receptor 3 [KO:K04963]
108529978  PDYN; proenkephalin-B [KO:K15840]
108514296  DLG4; disks large homolog 4 isoform X1 [KO:K11828]
108542864  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
108541249  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
108530279  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
108537403  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
108523108  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
108532018  GRIA1; LOW QUALITY PROTEIN: glutamate receptor 1 [KO:K05197]
108529017  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
108528828  LOW QUALITY PROTEIN: glutamate receptor 3-like [KO:K05199]
108513175  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
108542921  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
108522695  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
108515198  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
108521361  voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
108545075  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
108517367  STX1A; syntaxin-1A [KO:K04560]
108531792  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
108523688  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
108520719  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
108534362  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
108536192  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
108535935  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
108517777  DERL1; derlin-1 [KO:K11519]
108524470  VCP; transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
108540530  ubiquitin [KO:K02927]
108524569  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
108534205  UBA52; ubiquitin-60S ribosomal protein L40 isoform X1 [KO:K02927]
108529634  ubiquitin-60S ribosomal protein L40-like isoform X1 [KO:K02927]
108519777  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
108539645  LOW QUALITY PROTEIN: polyubiquitin-like [KO:K04551]
108519614  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
108522730  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
108537975  PSMA4; proteasome subunit alpha type-4 isoform X1 [KO:K02728] [EC:3.4.25.1]
108520537  PSMA8; proteasome subunit alpha type-7-like isoform X1 [KO:K02731] [EC:3.4.25.1]
108535266  PSMA7; LOW QUALITY PROTEIN: proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
108519637  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
108535520  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
108529724  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
108524844  PSMB6; LOW QUALITY PROTEIN: proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
108518216  proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
108531375  PSMB7; proteasome subunit beta type-7 isoform X1 [KO:K02739] [EC:3.4.25.1]
108533955  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
108537259  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
108523600  PSMB5; LOW QUALITY PROTEIN: proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
108515681  proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
108541286  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
108533229  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
108515543  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
108535903  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
108539058  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
108513654  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
108516314  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
108536276  PSMC5; 26S protease regulatory subunit 8 isoform X1 [KO:K03066]
108525031  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
108538318  PSMD1; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
108527793  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
108523391  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
108517733  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
108541378  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
108531525  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
108514539  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
108537987  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
108533239  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
108517714  PSMD14; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
108539077  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
108535274  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
108513536  SHFM1; 26S proteasome complex subunit DSS1 isoform X1 [KO:K10881]
108516888  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
108523037  UBA1; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
108526976  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
108536078  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
108514859  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
108544203  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
108532632  UBE2J1; LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
108539825  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
108520713  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
108530763  GPR37; prosaposin receptor GPR37 [KO:K04243]
108523246  prosaposin receptor GPR37 [KO:K04243]
108518388  SEPT5; septin-5 isoform X1 [KO:K04557]
108520390  SNCAIP; synphilin-1 isoform X1 [KO:K04558]
108531361  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
108515324  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X1 [KO:K10707]
108542583  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
108519685  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
108517565  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
108536259  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
108542901  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
108522968  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
108534524  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
108537794  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
108521141  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108517508  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
108513174  LOW QUALITY PROTEIN: inactive caspase-12-like [KO:K04741] [EC:3.4.22.-]
108539086  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
108518882  EIF2AK3; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
108533712  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
108520463  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
108513703  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
108515300  PINK1; serine/threonine-protein kinase PINK1, mitochondrial isoform X1 [KO:K05688] [EC:2.7.11.1]
10549380  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
10549368  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
10549374  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
10549376  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
10549375  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
10549377  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
10549378  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
108518679  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
108525115  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
108517346  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
108536327  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
108526355  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
108541984  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
108529459  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
108519700  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
108530843  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
108512012  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
108530974  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
108515311  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
108543568  NDUFA6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
108534515  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
108537102  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
108536503  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
108532675  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
108531931  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
108538844  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
108526312  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 isoform X1 [KO:K03956]
108521802  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
108515623  NDUFA13; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
108519146  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
108541536  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
108534879  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
108532175  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
108541689  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
108516239  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
108532882  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
108529800  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
108538409  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7-like [KO:K03963]
108514796  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
108537065  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7-like [KO:K03963]
108526074  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7-like [KO:K03963]
108535273  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
108519781  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
108538081  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
108519410  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
108523036  NDUFB11; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
108543433  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
108521164  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
108524673  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
108516683  NDUFS4; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
108518004  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
108515730  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
108512485  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
108542935  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
108514381  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
108522161  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
108530254  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
108518677  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
108522756  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
108543209  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
108515327  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
108521165  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
108517325  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
108530376  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
108536453  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
108532893  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
108530603  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
108530604  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
10549379  CYTB; cytochrome b [KO:K00412]
108536542  cytochrome c1, heme protein, mitochondrial [KO:K00413]
108527019  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
108514155  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
108535631  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
108531701  cytochrome b-c1 complex subunit 7 [KO:K00417]
108529577  cytochrome b-c1 complex subunit 8 [KO:K00418]
108517591  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
108514742  cytochrome b-c1 complex subunit 10 [KO:K00420]
108530245  cytochrome b-c1 complex subunit 10 [KO:K00420]
10549373  COX3; cytochrome c oxidase subunit III [KO:K02262]
10549369  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
10549370  COX2; cytochrome c oxidase subunit II [KO:K02261]
108521006  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
108524146  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
108531483  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
108529477  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
108527757  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
108529661  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
108512335  cytochrome c oxidase subunit 6B1 [KO:K02267]
108542547  cytochrome c oxidase subunit 6B2 [KO:K02267]
108536532  cytochrome c oxidase subunit 6C [KO:K02268]
108538160  cytochrome c oxidase subunit 6C [KO:K02268]
108541227  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6C-like [KO:K02268]
108526140  cytochrome c oxidase subunit 6C [KO:K02268]
108543345  cytochrome c oxidase subunit 6C-like [KO:K02268]
108513938  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
108542554  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
108535228  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
108513215  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
108535638  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
108519915  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
108530029  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
108527083  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108530984  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108531248  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108542095  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108541117  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
108538456  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108542119  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108518799  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108523175  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108516634  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
108540721  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
108525816  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108517636  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
108519118  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
108525188  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
108513794  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
108519025  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
108516042  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
108529918  ATP5C1; LOW QUALITY PROTEIN: ATP synthase subunit gamma, mitochondrial [KO:K02136]
108530260  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
108541621  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
10549372  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
108528082  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
108514651  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
108527161  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
108516511  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
108537436  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
108536866  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
108518287  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
10549371  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
108526412  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
108529563  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
108521188  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
108531118  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
108516879  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
108536001  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
108512653  CALM2; calmodulin [KO:K02183]
108514692  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
108529886  CALML3; calmodulin-like protein 3 [KO:K02183]
108529898  CALML5; calmodulin-like protein 5 [KO:K02183]
108531068  CALM3; calmodulin isoform X1 [KO:K02183]
108533995  calmodulin [KO:K02183]
108535906  CALM1; calmodulin [KO:K02183]
108542795  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
108516875  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108540785  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108537161  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
108542734  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
108526259  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108526609  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
108538801  FADD; FAS-associated death domain protein [KO:K02373]
108532002  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
108541711  BID; BH3-interacting domain death agonist [KO:K04726]
108523624  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
108516259  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
108538682  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
108531686  HTRA2; serine protease HTRA2, mitochondrial isoform X1 [KO:K08669] [EC:3.4.21.108]
108538302  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
108529513  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
108540717  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
108515615  ADP/ATP translocase 1 [KO:K05863]
108529787  ADP/ATP translocase 3-like [KO:K05863]
108520942  SLC25A6; ADP/ATP translocase 3 isoform X1 [KO:K05863]
108535888  LOW QUALITY PROTEIN: calcium-binding mitochondrial carrier SAL1-like [KO:K05863]
108538574  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
108518758  ADP/ATP translocase 2-like [KO:K05863]
108512004  ADP/ATP translocase 2 [KO:K05863]
108524230  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
108530087  cytochrome c-like [KO:K08738]
108532915  cytochrome c [KO:K08738]
108535521  cytochrome c [KO:K08738]
108524009  cytochrome c [KO:K08738]
108538827  cytochrome c-like [KO:K08738]
108536287  cytochrome c-like [KO:K08738]
108524923  cytochrome c-like [KO:K08738]
108523439  cytochrome c-like [KO:K08738]
108533297  cytochrome c-like [KO:K08738]
108543462  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
108524269  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
108512689  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
108518938  HIP1; huntingtin-interacting protein 1 isoform X1 [KO:K04559]
108528866  IFT57; intraflagellar transport protein 57 homolog [KO:K04638]
108520302  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
108520356  peptidyl-prolyl cis-trans isomerase D-like [KO:K05864] [EC:5.2.1.8]
108520362  peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
108517940  PARK7; protein deglycase DJ-1 [KO:K05687] [EC:3.5.1.124]
108524131  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
108532919  MFN1; LOW QUALITY PROTEIN: mitofusin-1 [KO:K21356] [EC:3.6.5.-]
108539352  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
108531309  OPTN; optineurin [KO:K19946]
108523366  SQSTM1; sequestosome-1 [KO:K14381]
108520768  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
108512512  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
108533773  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
108529966  TBK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
108513559  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
108544434  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
108516620  SMCR8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein [KO:K23611]
108527848  CUNH9orf72; protein C9orf72 homolog isoform X1 [KO:K23609]
108543281  RAB8A; ras-related protein Rab-8A [KO:K07901]
108540748  RAB39B; ras-related protein Rab-39B [KO:K07925]
108527867  ras-related protein Rab-1A-like [KO:K07874]
108540804  RAB1A; ras-related protein Rab-1A [KO:K07874]
108539366  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
108527503  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
108521945  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
108540897  serine/threonine-protein kinase ULK2-like [KO:K08269] [EC:2.7.11.1]
108521610  ATG101; autophagy-related protein 101 [KO:K19730]
108521955  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
108526927  RB1CC1; LOW QUALITY PROTEIN: RB1-inducible coiled-coil protein 1 [KO:K17589]
108526772  BECN1; beclin-1 isoform X1 [KO:K08334]
108512516  BECN2; beclin-2 [KO:K08334]
108522247  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
108530670  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
108533156  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
108525730  LOW QUALITY PROTEIN: nuclear receptor-binding factor 2-like [KO:K21246]
108537659  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
108519131  ATG2B; LOW QUALITY PROTEIN: autophagy-related protein 2 homolog B [KO:K17906]
108543000  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
108530419  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
108523042  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
108536212  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
108513034  ALS2; alsin isoform X1 [KO:K04575]
108521254  RAB5A; ras-related protein Rab-5A [KO:K07887]
108523982  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108515883  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
108512778  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
108540544  FIG4; LOW QUALITY PROTEIN: polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
108521290  SPG11; spatacsin [KO:K19026]
108520255  TNF; tumor necrosis factor isoform X1 [KO:K03156]
108536511  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
108539384  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
108540273  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
108521513  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
108523215  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
108528326  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
108528327  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
108539403  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
108539422  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
108539288  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
108518660  CCS; copper chaperone for superoxide dismutase isoform X1 [KO:K04569]
108540124  GPX5; epididymal secretory glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
108540127  GPX6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
108530977  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
108532034  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
108530299  glutathione peroxidase 1-like isoform X1 [KO:K00432] [EC:1.11.1.9]
108542423  GPX2; glutathione peroxidase 2 isoform X1 [KO:K00432] [EC:1.11.1.9]
108526993  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
108531237  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
108513829  CAT; catalase [KO:K03781] [EC:1.11.1.6]
108543959  PRPH; peripherin isoform X1 [KO:K07607]
108537813  NEFL; neurofilament light polypeptide [KO:K04572]
108520451  LOW QUALITY PROTEIN: neurofilament light polypeptide-like [KO:K04572]
108537822  NEFM; neurofilament medium polypeptide [KO:K04573]
108517592  NEFH; neurofilament heavy polypeptide isoform X1 [KO:K04574]
108534025  KIF5C; kinesin heavy chain [KO:K10396]
108519708  KIF5A; kinesin heavy chain [KO:K10396]
108515926  KIF5B; LOW QUALITY PROTEIN: kinesin-1 heavy chain [KO:K10396]
108533475  KLC4; kinesin light chain 4 [KO:K10407]
108518649  KLC2; kinesin light chain 2 [KO:K10407]
108531101  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
108521876  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
108541714  TUBA8; tubulin alpha-8 chain [KO:K07374]
108525726  tubulin alpha-1 chain [KO:K07374]
108529896  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
108518420  tubulin alpha-4A chain-like [KO:K07374]
108525461  tubulin alpha-1A chain-like [KO:K07374]
108522550  TUBB; tubulin beta chain [KO:K07375]
108520633  tubulin beta-7 chain [KO:K07375]
108515747  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
108524752  LOW QUALITY PROTEIN: tubulin beta-8 chain-like [KO:K07375]
108542832  TUBB4B; LOW QUALITY PROTEIN: tubulin beta-4B chain [KO:K07375]
108532059  tubulin beta-4B chain-like [KO:K07375]
108534562  TUBB4A; tubulin beta-4A chain [KO:K07375]
108529080  TUBB3; LOW QUALITY PROTEIN: tubulin beta-3 chain [KO:K07375]
108541619  TUBB1; tubulin beta-1 chain [KO:K07375]
108541757  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
108544543  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
108533896  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
108520243  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
108519651  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
108520672  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
108519684  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
108542163  DCTN3; dynactin subunit 3 isoform X1 [KO:K10425]
108532078  DCTN4; LOW QUALITY PROTEIN: dynactin subunit 4 [KO:K10426]
108514206  dynactin subunit 4 [KO:K10426]
108538851  DCTN5; dynactin subunit 5 [KO:K10427]
108518591  DCTN6; dynactin subunit 6 [KO:K10428]
108517728  LOW QUALITY PROTEIN: dynactin subunit 6-like [KO:K10428]
108515089  ACTR1A; alpha-centractin [KO:K16575]
108529479  ACTR1B; beta-centractin [KO:K16575]
108529707  ACTR10; LOW QUALITY PROTEIN: actin-related protein 10 [KO:K16576]
108534667  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
108527812  DNAH7; LOW QUALITY PROTEIN: dynein heavy chain 7, axonemal [KO:K10408]
108534178  DNAH17; dynein heavy chain 17, axonemal isoform X1 [KO:K10408]
108542812  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
108542989  DNAH5; LOW QUALITY PROTEIN: dynein heavy chain 5, axonemal [KO:K10408]
108522346  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
108514126  DNAH3; LOW QUALITY PROTEIN: dynein heavy chain 3, axonemal [KO:K10408]
108523235  LOW QUALITY PROTEIN: dynein heavy chain 7, axonemal-like [KO:K10408]
108528299  DNAH8; LOW QUALITY PROTEIN: dynein heavy chain 8, axonemal [KO:K10408]
108539990  DNAH10; LOW QUALITY PROTEIN: dynein heavy chain 10, axonemal [KO:K10408]
108514365  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
108543583  DNAH12; LOW QUALITY PROTEIN: dynein heavy chain 12, axonemal [KO:K10408]
108517314  DNAH9; LOW QUALITY PROTEIN: dynein heavy chain 9, axonemal [KO:K10408]
108529321  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
108542209  DNALI1; LOW QUALITY PROTEIN: axonemal dynein light intermediate polypeptide 1 [KO:K10410]
108542180  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
108537451  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
108534893  DNAL1; dynein light chain 1, axonemal isoform X1 [KO:K10411]
108521444  DNAL4; dynein light chain 4, axonemal [KO:K10412]
108532044  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
108544005  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
108529387  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
108516884  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
108512486  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
108543285  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
108528248  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
108541377  CDK5R1; cyclin-dependent kinase 5 activator 1 isoform X1 [KO:K11716]
108532531  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
108542466  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
108534889  DKK2; dickkopf-related protein 2 [KO:K02165]
108543282  DKK1; dickkopf-related protein 1 [KO:K02165]
108540716  DKK4; dickkopf-related protein 4 [KO:K02165]
108543922  WNT1; proto-oncogene Wnt-1 [KO:K03209]
108528095  WNT2B; protein Wnt-2b [KO:K00182]
108526536  WNT2; protein Wnt-2 [KO:K00182]
108536790  WNT3A; protein Wnt-3a [KO:K00312]
108529362  WNT3; proto-oncogene Wnt-3 [KO:K00312]
108538467  WNT4; LOW QUALITY PROTEIN: protein Wnt-4 [KO:K00408]
108543619  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
108522823  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
108518481  WNT6; protein Wnt-6 [KO:K00445]
108544845  WNT7A; protein Wnt-7a [KO:K00572]
108514489  WNT7B; protein Wnt-7b [KO:K00572]
108527856  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
108535264  WNT8B; protein Wnt-8b isoform X1 [KO:K00714]
108536803  WNT9A; protein Wnt-9a [KO:K01064]
108529352  WNT9B; protein Wnt-9b [KO:K01064]
108543904  WNT10B; protein Wnt-10b [KO:K01357]
108518480  WNT10A; protein Wnt-10a [KO:K01357]
108527394  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
108518499  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
108537219  FZD7; frizzled-7 [KO:K02432]
108525869  LOW QUALITY PROTEIN: frizzled-7-like [KO:K02432]
108544288  FZD1; frizzled-1 [KO:K02432]
108532224  FZD2; LOW QUALITY PROTEIN: frizzled-2 [KO:K02235]
108537384  FZD3; frizzled-3 isoform X1 [KO:K02329]
108514575  FZD4; frizzled-4 isoform X1 [KO:K02354]
108525086  frizzled-8 [KO:K02375]
108540357  FZD5; frizzled-5 [KO:K02375]
108537599  FZD6; frizzled-6 [KO:K02376]
108526709  FZD10; frizzled-10 [KO:K02842]
108518894  FZD9; frizzled-9 [KO:K02842]
108538510  LRP5; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5 [KO:K03068]
108523789  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
108521460  casein kinase I [KO:K08960] [EC:2.7.11.1]
108514297  DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
108522287  segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
108524838  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
108534484  FRAT1; LOW QUALITY PROTEIN: proto-oncogene FRAT1 [KO:K03069]
108534423  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
108521119  AXIN1; axin-1 isoform X1 [KO:K02157]
108517751  AXIN2; axin-2 isoform X1 [KO:K04385]
108540305  APC; LOW QUALITY PROTEIN: adenomatous polyposis coli protein [KO:K02085]
108530233  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
108542618  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
108525319  LOW QUALITY PROTEIN: casein kinase I-like [KO:K08957] [EC:2.7.11.1]
108539219  LOW QUALITY PROTEIN: casein kinase I-like [KO:K08957] [EC:2.7.11.1]
108532056  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
108516577  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
108524385  advanced glycosylation end product-specific receptor-like [KO:K19722]
108519888  AGER; LOW QUALITY PROTEIN: advanced glycosylation end product-specific receptor [KO:K19722]
108543525  HRAS; GTPase HRas isoform X1 [KO:K02833]
108523748  KRAS; GTPase KRas isoform X1 [KO:K07827]
108528122  NRAS; GTPase NRas [KO:K07828]
108530908  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
108541537  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
108517986  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108514672  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108512087  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108523695  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
108536070  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108521137  NOX1; NADPH oxidase 1 [KO:K08008]
108522897  LOW QUALITY PROTEIN: cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
108539154  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
108543519  RELA; transcription factor p65 [KO:K04735]
108532817  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
108539959  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
108523178  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
108529326  IL6; interleukin-6 isoform X1 [KO:K05405]
108541808  IL1A; interleukin-1 alpha [KO:K04383]
108541809  IL1B; interleukin-1 beta [KO:K04519]
108528053  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
J Cell Mol Med 14:457-87 (2010)
DOI:10.1111/j.1582-4934.2010.01010.x
Reference
PMID:19707851
  Authors
Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
  Journal
J Neural Transm (Vienna) 116:1111-62 (2009)
DOI:10.1007/s00702-009-0240-y
Reference
PMID:30743990
  Authors
Van Bulck M, Sierra-Magro A, Alarcon-Gil J, Perez-Castillo A, Morales-Garcia JA
  Title
Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
  Journal
Int J Mol Sci 20:E719 (2019)
DOI:10.3390/ijms20030719
Reference
PMID:15272267
  Authors
Ross CA, Poirier MA
  Title
Protein aggregation and neurodegenerative disease.
  Journal
Nat Med 10 Suppl:S10-7 (2004)
DOI:10.1038/nm1066
Reference
PMID:30250260
  Authors
Soto C, Pritzkow S
  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
  Journal
Nat Neurosci 21:1332-1340 (2018)
DOI:10.1038/s41593-018-0235-9
Reference
PMID:25132814
  Authors
Dantuma NP, Bott LC
  Title
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
  Journal
Front Mol Neurosci 7:70 (2014)
DOI:10.3389/fnmol.2014.00070
Reference
PMID:25413678
  Authors
Zheng C, Geetha T, Babu JR
  Title
Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
  Journal
Neurodegener Dis 14:161-75 (2014)
DOI:10.1159/000367694
Reference
PMID:32397599
  Authors
Park H, Kang JH, Lee S
  Title
Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.
  Journal
Int J Mol Sci 21:E3369 (2020)
DOI:10.3390/ijms21093369
Reference
PMID:31783880
  Authors
Malik BR, Maddison DC, Smith GA, Peters OM
  Title
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
  Journal
Mol Brain 12:100 (2019)
DOI:10.1186/s13041-019-0504-x
Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
  Title
Autophagy in Age-Associated Neurodegeneration.
  Journal
Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
  Title
Targeting autophagy in neurodegenerative diseases.
  Journal
Trends Pharmacol Sci 35:583-91 (2014)
DOI:10.1016/j.tips.2014.09.002
Reference
PMID:28279350
  Authors
Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Fullgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, Licitra F, Lopez Ramirez A, Pavel M, Puri C, Renna M, Ricketts T, Schlotawa L, Vicinanza M, Won H, Zhu Y, Skidmore J, Rubinsztein DC
  Title
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
  Journal
Neuron 93:1015-1034 (2017)
DOI:10.1016/j.neuron.2017.01.022
Reference
PMID:30030024
  Authors
Chu CT
  Title
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
  Journal
Neurobiol Dis 122:23-34 (2019)
DOI:10.1016/j.nbd.2018.07.015
Reference
PMID:19043451
  Authors
Kim I, Xu W, Reed JC
  Title
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 7:1013-30 (2008)
DOI:10.1038/nrd2755
Reference
PMID:21722302
  Authors
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A
  Title
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
  Journal
J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
PMID:28643372
  Authors
Halliday M, Hughes D, Mallucci GR
  Title
Fine-tuning PERK signaling for neuroprotection.
  Journal
J Neurochem 142:812-826 (2017)
DOI:10.1111/jnc.14112
Reference
PMID:32204380
  Authors
Rozpedek-Kaminska W, Siwecka N, Wawrzynkiewicz A, Wojtczak R, Pytel D, Diehl JA, Majsterek I
  Title
The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases.
  Journal
Int J Mol Sci 21:E2108 (2020)
DOI:10.3390/ijms21062108
Reference
PMID:24619348
  Authors
Hetz C, Mollereau B
  Title
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
  Journal
Nat Rev Neurosci 15:233-49 (2014)
DOI:10.1038/nrn3689
Reference
PMID:19230774
  Authors
Bezprozvanny I
  Title
Calcium signaling and neurodegenerative diseases.
  Journal
Trends Mol Med 15:89-100 (2009)
DOI:10.1016/j.molmed.2009.01.001
Reference
PMID:31795242
  Authors
Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS
  Title
The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
  Journal
Int J Mol Sci 20:E6004 (2019)
DOI:10.3390/ijms20236004
Reference
PMID:27873462
  Authors
Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A
  Title
Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment.
  Journal
CNS Neurosci Ther 23:5-22 (2017)
DOI:10.1111/cns.12655
Reference
PMID:19828789
  Authors
Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH Jr, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, Pigino G, Brady ST
  Title
Axonal transport defects in neurodegenerative diseases.
  Journal
J Neurosci 29:12776-86 (2009)
DOI:10.1523/JNEUROSCI.3463-09.2009
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:23361386
  Authors
Millecamps S, Julien JP
  Title
Axonal transport deficits and neurodegenerative diseases.
  Journal
Nat Rev Neurosci 14:161-76 (2013)
DOI:10.1038/nrn3380
Reference
PMID:31558780
  Authors
Sleigh JN, Rossor AM, Fellows AD, Tosolini AP, Schiavo G
  Title
Axonal transport and neurological disease.
  Journal
Nat Rev Neurol 15:691-703 (2019)
DOI:10.1038/s41582-019-0257-2
Reference
PMID:20434225
  Authors
Perlson E, Maday S, Fu MM, Moughamian AJ, Holzbaur EL
  Title
Retrograde axonal transport: pathways to cell death?
  Journal
Trends Neurosci 33:335-44 (2010)
DOI:10.1016/j.tins.2010.03.006
Related
pathway
rbb00190  Oxidative phosphorylation
rbb03050  Proteasome
rbb04020  Calcium signaling pathway
rbb04120  Ubiquitin mediated proteolysis
rbb04137  Mitophagy - animal
rbb04140  Autophagy - animal
rbb04141  Protein processing in endoplasmic reticulum
rbb04142  Lysosome
rbb04210  Apoptosis
rbb04310  Wnt signaling pathway
rbb04724  Glutamatergic synapse
rbb04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
LinkDB

DBGET integrated database retrieval system