Homo sapiens (human): 1137
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Entry
1137 CDS
T01001
Symbol
CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4
Name
(RefSeq) cholinergic receptor nicotinic alpha 4 subunit
KO
K04806
nicotinic acetylcholine receptor alpha-4
Organism
hsa
Homo sapiens (human)
Pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04082
Neuroactive ligand signaling
hsa04725
Cholinergic synapse
hsa05033
Nicotine addiction
hsa05207
Chemical carcinogenesis - receptor activation
Network
nt06210
ERK signaling (cancer)
nt06219
JAK-STAT signaling (cancer)
nt06544
Neuroactive ligand signaling
Element
N01342
Nicotine to Jak-STAT signaling pathway
N01344
NNK/NNN to RAS-ERK signaling pathway
N01895
Transport of natrium/calcium, CHRN
Disease
H00807
Nocturnal frontal lobe epilepsy
Drug target
Acetylcholine (
DG01133
):
D00999
<JP/US>
Altinicline maleate:
D02839
Atracurium (
DG00771
):
D00758
<US>
Cisatracurium:
D00759
<US>
Cytisinicline:
D07770
Dexmecamylamine (
DG01378
):
D10111
D10112
Dimethyltubocurarine:
D07272
Doxacurium chloride:
D00760
Fazadinium bromide:
D07273
Hexamethonium bromide:
D02204
Ispronicline:
D08935
Lobeline (
DG01287
):
D02202
D02364
D08138
Mecamylamine (
DG00252
):
D00611
<US>
Mivacurium chloride:
D00763
Nicotine (
DG00994
):
D03365
<JP/US>
D05156
D05157
Pancuronium (
DG00769
):
D00492
Pipecuronium bromide:
D00764
Pozanicline (
DG01288
):
D09367
D09368
Rivanicline galactarate:
D08987
Rocuronium bromide:
D00765
<JP/US>
Sofinicline (
DG01286
):
D09382
D09383
Tebanicline tosylate:
D06016
Tubocurarine (
DG00767
):
D02207
D08655
Varenicline (
DG00995
):
D06282
<JP/US>
D08669
Vecuronium (
DG00770
):
D00767
<US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
1137 (CHRNA4)
04082 Neuroactive ligand signaling
1137 (CHRNA4)
09150 Organismal Systems
09156 Nervous system
04725 Cholinergic synapse
1137 (CHRNA4)
09160 Human Diseases
09161 Cancer: overview
05207 Chemical carcinogenesis - receptor activation
1137 (CHRNA4)
09165 Substance dependence
05033 Nicotine addiction
1137 (CHRNA4)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:
hsa04040
]
1137 (CHRNA4)
Ion channels [BR:
hsa04040
]
Ligand-gated channels
Acetylcholine (nicotinic)
1137 (CHRNA4)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Neur_chan_memb
Neur_chan_LBD
Motif
Other DBs
NCBI-GeneID:
1137
NCBI-ProteinID:
NP_000735
OMIM:
118504
HGNC:
1958
Ensembl:
ENSG00000101204
UniProt:
P43681
Q59FV0
B4DK78
Structure
PDB
PDBj
LinkDB
All DBs
Position
20:complement(63343223..63361349)
Genome browser
AA seq
627 aa
AA seq
DB search
MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISD
VVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWR
PDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFG
SWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIR
RLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTS
LVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKR
PSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGP
SCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEG
GVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSV
SPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDR
IFLWMFIIVCLLGTVGLFLPPWLAGMI
NT seq
1884 nt
NT seq
+upstream
nt +downstream
nt
atggagctagggggccccggagcgccgcggctgctgccgccgctgctgctgcttctgggg
accggcctcctgcgcgccagcagccatgtggagacccgggcccacgccgaggagcggctc
ctgaagaaactcttctccggttacaacaagtggtcccgacccgtggccaacatctcggac
gtggtcctcgtccgcttcggcctgtccatcgctcagctcattgacgtggatgagaagaac
cagatgatgaccacgaacgtatgggtgaagcaggagtggcacgactacaagctgcgctgg
gacccagctgactatgagaatgtcacctccatccgcatcccctccgagctcatctggcgg
ccggacatcgtcctctacaacaatgctgacggggacttcgcggtcacccacctgaccaag
gcccacctgttccatgacgggcgggtgcagtggactcccccggccatttacaagagctcc
tgcagcatcgacgtcaccttcttccccttcgaccagcagaactgcaccatgaaattcggc
tcctggacctacgacaaggccaagatcgacctggtgaacatgcacagccgcgtggaccag
ctggacttctgggagagtggcgagtgggtcatcgtggatgccgtgggcacctacaacacc
aggaagtacgagtgctgtgccgagatctacccggacatcacctatgccttcgtcatccgg
cggctgccgctcttctacaccatcaacctcatcatcccctgcctgctcatctcctgcctc
accgtgctggtcttctacctgccctccgagtgtggcgagaagatcacgctgtgcatctcc
gtgctgctgtcgctcaccgtcttcctgctgctcatcaccgagatcatcccgtccacctca
ctggtcatcccactcatcggcgagtacctgctgttcaccatgatcttcgtcaccctgtcc
atcgtcatcacggtcttcgtgctcaacgtgcaccaccgctcgccacgcacgcacaccatg
cccacctgggtacgcagggtcttcctggacatcgtgccacgcctgctcctcatgaagcgg
ccgtccgtggtcaaggacaattgccggcggctcatcgagtccatgcataagatggccagt
gccccgcgcttctggcccgagccagaaggggagccccctgccacgagcggcacccagagc
ctgcacccgccctcaccgtccttctgtgtccccctggatgtgccggctgagcctgggcct
tcctgcaagtcaccctccgaccagctccctcctcagcagcccctggaagctgagaaagcc
agcccccacccctcgcctggaccctgccgcccgccccacggcacccaggcaccagggctg
gccaaagccaggtccctcagcgtccagcacatgtccagccctggcgaagcggtggaaggc
ggcgtccggtgccggtctcggagcatccagtactgtgttccccgagacgatgccgccccc
gaggcagatggccaggctgccggcgccctggcctctcgcaacacccactcggctgagctc
ccacccccagaccagccctctccgtgcaaatgcacatgcaagaaggagccctcttcggtg
tccccgagcgccacggtcaagacccgcagcaccaaagcgccgcccccgcacctgcccctg
tcgccggccctgacccgggcggtggagggcgtccagtacattgcagaccacctgaaggcc
gaagacacagacttctcggtgaaggaggactggaagtacgtggccatggtcatcgaccgc
atcttcctctggatgttcatcatcgtctgcctgctggggacggtgggcctcttcctgccg
ccctggctggctggcatgatctag
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