KEGG   PATHWAY: aamp04142
Entry
aamp04142                   Pathway                                
Name
Lysosome - Arvicola amphibius (Eurasian water vole)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
aamp04142  Lysosome
aamp04142

Other DBs
GO: 0005764
Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119799743  Ap3m1; AP-3 complex subunit mu-1 isoform X1 [KO:K12398]
119799760  Ctsb; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
119799789  Cln5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
119799825  [KO:K01319] [EC:3.4.21.20]
119800158  Ap1g2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
119800288  Entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
119800801  Gba; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
119800895  Sort1; sortilin [KO:K12388]
119801285  Ap4b1; AP-4 complex subunit beta-1 [KO:K12401]
119801328  Ctsk; cathepsin K [KO:K01371] [EC:3.4.22.38]
119801353  Dnase2b; deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
119801374  Ctss; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
119801384  Manba; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
119801727  [KO:K01206] [EC:3.2.1.51]
119801737  Ap1g1; LOW QUALITY PROTEIN: AP-1 complex subunit gamma-1 [KO:K12391]
119801787  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
119801966  Galns; N-acetylgalactosamine-6-sulfatase [KO:K01132] [EC:3.1.6.4]
119801978  Meak7; MTOR-associated protein MEAK7 [KO:K27947]
119802059  Dnase2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
119802120  Ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
119802278  Man2b1; lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
119802300  Pla2g15; LOW QUALITY PROTEIN: phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
119802656  Ap3s2; AP-3 complex subunit sigma-2 [KO:K12399]
119802769  Ap3b2; LOW QUALITY PROTEIN: AP-3 complex subunit beta-2 [KO:K12397]
119802841  Napsa; napsin-A isoform X1 [KO:K08565] [EC:3.4.23.-]
119803098  Ctsc; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
119803229  Gns; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
119803508  Cd63; CD63 antigen [KO:K06497]
119803598  Gnptab; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
119804585  Lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
119804594  Ap1s2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
119804927  Gla; alpha-galactosidase A isoform X1 [KO:K01189] [EC:3.2.1.22]
119805085  Ids; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
119805234  [KO:K12394]
119805330  Atp6ap1; V-type proton ATPase subunit S1 [KO:K03662]
119806249  [KO:K01197] [EC:3.2.1.35]
119806679  Atp6v0a4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
119806714  M6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
119807426  [KO:K01197] [EC:3.2.1.35]
119807427  [KO:K01197] [EC:3.2.1.35]
119807428  [KO:K01197] [EC:3.2.1.35]
119807574  Sumf1; formylglycine-generating enzyme isoform X1 [KO:K13444] [EC:1.8.3.7]
119807755  [KO:K06546]
119808375  Laptm4a; lysosomal-associated transmembrane protein 4A [KO:K12387]
119808382  [KO:K01197] [EC:3.2.1.35]
119809115  Ap3b1; AP-3 complex subunit beta-1 [KO:K12397]
119809241  Hyal1; hyaluronidase-1 [KO:K01197] [EC:3.2.1.35]
119809244  Hyal3; hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
119809582  Slc17a5; sialin [KO:K12301]
119809603  Ctsh; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
119809643  Arsb; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
119809654  Hyal2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
119809688  Acp5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
119810046  Ap1m2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
119810190  Glb1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
119810409  Hexa; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
119810774  Hexb; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
119810818  Lipa; lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
119810850  Dmxl2; dmX-like protein 2 isoform X1 [KO:K24155]
119811093  Gnptg; N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X1 [KO:K10087]
119811158  Atp6v0a1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
119811294  Cltc; clathrin heavy chain 1 [KO:K04646]
119811301  Lamp1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
119811309  Asah1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
119811359  Gga3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
119811669  Ctns; cystinosin [KO:K12386]
119811743  Hgsnat; heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
119811779  Tcirg1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
119812003  Sgsh; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
119812147  Ap1m1; AP-1 complex subunit mu-1 [KO:K12393]
119812171  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
119812383  Gm2a; ganglioside GM2 activator [KO:K12383]
119812738  Ap3m2; AP-3 complex subunit mu-2 [KO:K12398]
119812935  Gaa; lysosomal alpha-glucosidase isoform X1 [KO:K12316] [EC:3.2.1.20]
119813010  Cd68; macrosialin [KO:K06501]
119813034  Nagpa; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
119813264  Aga; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
119813286  Litaf; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
119813399  Arsg; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
119813402  Naglu; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
119814106  Npc1; NPC intracellular cholesterol transporter 1 [KO:K12385]
119814226  Ctsz; cathepsin Z [KO:K08568] [EC:3.4.18.1]
119814374  Ctsa; lysosomal protective protein isoform X2 [KO:K13289] [EC:3.4.16.5]
119814690  Wdr7; WD repeat-containing protein 7 [KO:K24738]
119814781  Ap4e1; AP-4 complex subunit epsilon-1 [KO:K12400]
119814843  Ctsw; cathepsin W [KO:K08569] [EC:3.4.22.-]
119815031  Ap3d1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
119815237  Gga2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
119815437  Ap3s1; AP-3 complex subunit sigma-1 [KO:K12399]
119815623  Dmxl1; dmX-like protein 1 isoform X1 [KO:K24155]
119815701  Acp2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
119816443  [KO:K09600] [EC:3.4.22.-]
119816595  [KO:K09599] [EC:3.4.22.-]
119816795  Cltb; clathrin light chain B [KO:K04645]
119816800  Laptm5; lysosomal-associated transmembrane protein 5 [KO:K12387]
119816842  Smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
119816897  Ppt1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
119816905  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
119817311  Fuca1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
119817631  Ctsv; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
119817670  Tpp1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
119817762  Cln3; battenin [KO:K12389]
119818545  Ctsf; cathepsin F [KO:K01373] [EC:3.4.22.41]
119819177  Lgmn; legumain [KO:K01369] [EC:3.4.22.34]
119819287  Abca2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
119819554  Ap4s1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
119819640  Npc2; NPC intracellular cholesterol transporter 2 [KO:K13443]
119819691  Galc; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
119820331  Igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
119820367  Slc11a1; natural resistance-associated macrophage protein 1 isoform X1 [KO:K12347]
119820624  Ncoa7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
119820927  Cd164; sialomucin core protein 24 isoform X1 [KO:K06546]
119821056  Idua; alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
119821111  Fuca2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
119821390  Ap1s3; AP-1 complex subunit sigma-3 [KO:K12395]
119821544  Psapl1; LOW QUALITY PROTEIN: proactivator polypeptide-like 1 [KO:K12382]
119822292  Slc11a2; natural resistance-associated macrophage protein 2 [KO:K21398]
119822483  Neu1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
119822496  Ppt2; lysosomal thioesterase PPT2 [KO:K01074] [EC:3.1.2.22]
119822846  Laptm4b; lysosomal-associated transmembrane protein 4B [KO:K12387]
119822848  Arsa; arylsulfatase A isoform X1 [KO:K01134] [EC:3.1.6.8]
119823016  [KO:K12382]
119823589  Gga1; ADP-ribosylation factor-binding protein GGA1 [KO:K12404]
119823607  Naga; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
119824140  Ap1b1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
119824183  Lamp3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
119824633  Ap4m1; AP-4 complex subunit mu-1 [KO:K12402]
119824748  Gusb; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
119824754  Atp6v0a2; V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
119824843  Ap1s1; AP-1 complex subunit sigma-1A [KO:K12394]
119825460  Mcoln1; mucolipin-1 isoform X1 [KO:K04992]
119825504  Abcb9; ATP-binding cassette sub-family B member 9 [KO:K05656]
119826034  Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146]
119826211  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
119826320  Clta; clathrin light chain A [KO:K04644]
119826453  [KO:K12307]
119826593  Ctso; cathepsin O isoform X1 [KO:K01374] [EC:3.4.22.42]
119827825  Scarb2; lysosome membrane protein 2 [KO:K12384]
119827852  Ctse; cathepsin E [KO:K01382] [EC:3.4.23.34]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
aamp00511  Other glycan degradation
aamp00531  Glycosaminoglycan degradation
aamp04130  SNARE interactions in vesicular transport
aamp04140  Autophagy - animal
aamp04144  Endocytosis
KO pathway
ko04142   

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