KEGG   PATHWAY: acs00830
Entry
acs00830                    Pathway                                
Name
Retinol metabolism - Anolis carolinensis (green anole)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
acs00830  Retinol metabolism
acs00830

Other DBs
GO: 0006776
Organism
Anolis carolinensis (green anole) [GN:acs]
Gene
100563614  bco1; beta-carotene oxygenase 1 [KO:K00515] [EC:1.13.11.63]
100552939  adh1a; alcohol dehydrogenase 1A [KO:K13951] [EC:1.1.1.1]
100553136  adh1b; alcohol dehydrogenase 1B [KO:K13951] [EC:1.1.1.1]
100553662  ADH1D; alcohol dehydrogenase 1B [KO:K13951] [EC:1.1.1.1]
100553462  adh1c; alcohol dehydrogenase 1B [KO:K13951] [EC:1.1.1.1]
100553863  ADH1E; alcohol dehydrogenase 1B [KO:K13951] [EC:1.1.1.1]
100554058  ADH1F; alcohol dehydrogenase 1B [KO:K13951] [EC:1.1.1.1]
100554246  ADH1G; alcohol dehydrogenase 1B [KO:K13951] [EC:1.1.1.1]
100554636  ADH7A; alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
100554442  ADH1H; alcohol dehydrogenase 1B [KO:K13951] [EC:1.1.1.1]
100554830  ADH7B; alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
100555026  ADH7C; alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
100557775  adh5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
100557137  dhrs3; dehydrogenase/reductase 3 [KO:K11146] [EC:1.1.1.300]
100553479  dehydrogenase/reductase SDR family member 4 [KO:K11147] [EC:1.1.-.-]
100557514  dhrs9; dehydrogenase/reductase SDR family member 9 [KO:K11149] [EC:1.1.-.-]
100560987  rdh8; retinol dehydrogenase 8 (all-trans) [KO:K11150] [EC:1.1.1.-]
100565664  retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
100566498  retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
100564585  retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
100560710  rdh10; retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]
100565110  retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]
100557577  retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
100556987  retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
100557184  retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
100557378  retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
100567570  retinol dehydrogenase 16 [KO:K11154] [EC:1.1.1.-]
100559445  retinol dehydrogenase 2 [KO:K11154] [EC:1.1.1.-]
100559642  retinol dehydrogenase 7 [KO:K11154] [EC:1.1.1.-]
100556847  sdr16c5; short chain dehydrogenase/reductase family 16C member 5 [KO:K15734] [EC:1.1.1.105]
100556742  epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
103281170  epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
100557327  epidermal retinol dehydrogenase 2-like [KO:K15734] [EC:1.1.1.105]
100556351  epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
100555957  epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
100557526  epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
100557132  epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
100564174  hsd17b6; hydroxysteroid 17-beta dehydrogenase 6 [KO:K13369] [EC:1.1.1.62 1.1.1.105 1.1.1.239]
100552136  lrat; lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) [KO:K00678] [EC:2.3.1.135]
100551857  dgat1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
100555332  pnpla4; patatin like phospholipase domain containing 4 [KO:K11157] [EC:3.1.1.-]
100556137  rpe65; RPE65, retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
100561257  rdh5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]
100565879  aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]
100565091  aldehyde oxidase-like [KO:K00157] [EC:1.2.3.1]
100565481  aldehyde oxidase 1-like [KO:K00157] [EC:1.2.3.1]
100565681  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
100556217  aldh1a2; aldehyde dehydrogenase 1 family member A2 [KO:K07249] [EC:1.2.1.36]
100566345  aldh1a1; aldehyde dehydrogenase 1 family member A1 [KO:K07249] [EC:1.2.1.36]
100555228  aldh1a3; aldehyde dehydrogenase 1 family member A3 [KO:K07249] [EC:1.2.1.36]
100564658  cytochrome P450 26A1 [KO:K07437] [EC:1.14.14.-]
100564860  cytochrome P450 26C1 [KO:K12665] [EC:1.14.14.-]
100561903  cytochrome P450 2C18 [KO:K07413] [EC:1.14.14.1]
100565059  cytochrome P450 2C18 [KO:K07413] [EC:1.14.14.1]
100562097  cytochrome P450 2C9 [KO:K07413] [EC:1.14.14.1]
100562499  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
100552964  cytochrome P450 2C23 [KO:K07413] [EC:1.14.14.1]
100554667  cytochrome P450 2B4 [KO:K07413] [EC:1.14.14.1]
100560019  cytochrome P450 2C29 [KO:K07413] [EC:1.14.14.1]
100562300  cytochrome P450 2C19 [KO:K07413] [EC:1.14.14.1]
100555955  cytochrome P450 3A9 [KO:K07424] [EC:1.14.14.1]
100557851  cytochrome P450 3A6 [KO:K07424] [EC:1.14.14.1]
100558437  cytochrome P450 3A9 [KO:K07424] [EC:1.14.14.1]
100558240  cytochrome P450 3A29 [KO:K07424] [EC:1.14.14.1]
100551965  cyp2w3; cytochrome P450 2W3 [KO:K07423] [EC:1.14.14.-]
100560793  cyp2w1; cytochrome P450 2W1 [KO:K07423] [EC:1.14.14.-]
100552049  UDP-glucuronosyltransferase 1-6 [KO:K00699] [EC:2.4.1.17]
100566309  UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
100566109  UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
100560189  UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
100552879  all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
100554362  all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
100552731  retsat; retinol saturase [KO:K09516] [EC:1.3.99.23]
100554559  all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
100557779  cytochrome P450 27C1 [KO:K17951] [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
LinkDB

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