KEGG   PATHWAY: acs03320
Entry
acs03320                    Pathway                                
Name
PPAR signaling pathway - Anolis carolinensis (green anole)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
acs03320  PPAR signaling pathway
acs03320

Organism
Anolis carolinensis (green anole) [GN:acs]
Gene
100557499  cd36; CD36 molecule [KO:K06259]
100564797  slc27a1; solute carrier family 27 member 1 [KO:K08745] [EC:6.2.1.-]
100553682  slc27a4; solute carrier family 27 member 4 [KO:K08745] [EC:6.2.1.-]
100562367  very long-chain acyl-CoA synthetase [KO:K08746] [EC:6.2.1.- 6.2.1.3]
100564801  slc27a5; solute carrier family 27 member 5 [KO:K08746] [EC:6.2.1.- 6.2.1.3]
100555843  slc27a6; solute carrier family 27 member 6 [KO:K08749]
100562032  fabp1; fatty acid binding protein 1 [KO:K08750]
100566943  fabp2; fatty acid binding protein 2 [KO:K08751]
100557324  fabp3; fatty acid binding protein 3 [KO:K08752]
100554943  fatty acid-binding protein, adipocyte [KO:K08753]
107983445  fatty acid-binding protein, adipocyte-like [KO:K08753]
100555334  fabp5; fatty acid-binding protein, epidermal [KO:K08754]
100556796  fabp6; fatty acid binding protein 6 [KO:K08755]
100562795  fabp7; fatty acid binding protein 7 [KO:K08756]
100567786  ppara; peroxisome proliferator activated receptor alpha [KO:K07294]
100561503  rxra; retinoic acid receptor RXR-alpha [KO:K08524]
100554139  retinoic acid receptor RXR-alpha-B [KO:K08525]
100552327  ppard; peroxisome proliferator activated receptor delta [KO:K04504]
100557020  pparg; peroxisome proliferator activated receptor gamma [KO:K08530]
100559696  hmgcs2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 [KO:K01641] [EC:2.3.3.10]
100559772  hmgcs1; 3-hydroxy-3-methylglutaryl-CoA synthase 1 [KO:K01641] [EC:2.3.3.10]
100557921  apoa2; apolipoprotein A2 [KO:K08758]
103281631  apoc3; apolipoprotein C-III [KO:K08759]
100560016  pltp; phospholipid transfer protein [KO:K08761]
100557147  me1; NADP-dependent malic enzyme [KO:K00029] [EC:1.1.1.40]
100566225  me3; malic enzyme 3 [KO:K00029] [EC:1.1.1.40]
100551818  fads2; fatty acid desaturase 2 [KO:K10226] [EC:1.14.19.3]
100564278  scd; stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
103278919  scd5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
100562614  cholesterol 7-alpha-monooxygenase [KO:K00489] [EC:1.14.14.23]
100551876  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase [KO:K07431] [EC:1.14.14.139]
100562756  7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase-like [KO:K07431] [EC:1.14.14.139]
100562953  7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase-like [KO:K07431] [EC:1.14.14.139]
100565509  7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase-like [KO:K07431] [EC:1.14.14.139]
100565705  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase-like [KO:K07431] [EC:1.14.14.139]
100565905  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase-like [KO:K07431] [EC:1.14.14.139]
100566106  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase-like [KO:K07431] [EC:1.14.14.139]
100551676  7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [KO:K07431] [EC:1.14.14.139]
100567692  nr1h3; nuclear receptor subfamily 1 group H member 3 [KO:K08536]
100565025  sterol 26-hydroxylase, mitochondrial [KO:K00488] [EC:1.14.15.15]
100561275  dbi; diazepam binding inhibitor, acyl-CoA binding protein [KO:K08762]
100556298  lpl; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
100553430  acsl6; acyl-CoA synthetase long-chain family member 6 [KO:K01897] [EC:6.2.1.3]
100561703  acsl5; acyl-CoA synthetase long-chain family member 5 [KO:K01897] [EC:6.2.1.3]
100563733  acsl1; acyl-CoA synthetase long-chain family member 1 [KO:K01897] [EC:6.2.1.3]
100564931  acsl4; acyl-CoA synthetase long-chain family member 4 [KO:K01897] [EC:6.2.1.3]
100565928  acsbg1; acyl-CoA synthetase bubblegum family member 1 [KO:K15013] [EC:6.2.1.3]
100558466  ehhadh; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
100567075  acaa1; acetyl-CoA acyltransferase 1 [KO:K07513] [EC:2.3.1.16]
100559527  scp2; sterol carrier protein 2 [KO:K08764] [EC:2.3.1.176]
100560789  acox3; acyl-CoA oxidase 3, pristanoyl [KO:K00232] [EC:1.3.3.6]
100562736  acox1; acyl-CoA oxidase 1 [KO:K00232] [EC:1.3.3.6]
100556696  acox2; acyl-CoA oxidase 2 [KO:K10214] [EC:1.17.99.3]
100554332  cpt1a; carnitine palmitoyltransferase 1A [KO:K08765] [EC:2.3.1.21]
100560465  cpt1c; carnitine palmitoyltransferase 1C [KO:K08765] [EC:2.3.1.21]
100551969  cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
100564964  carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
100559925  cpt2; carnitine palmitoyltransferase 2 [KO:K08766] [EC:2.3.1.21]
100562130  acadl; acyl-CoA dehydrogenase, long chain [KO:K00255] [EC:1.3.8.8]
100566884  acadm; acyl-CoA dehydrogenase, C-4 to C-12 straight chain [KO:K00249] [EC:1.3.8.7]
100566321  sorbs1; sorbin and SH3 domain containing 1 [KO:K06086]
103280236  plin1; perilipin 1 [KO:K08768]
100560306  plin2; perilipin 2 [KO:K17284]
100568236  adipoq; adiponectin, C1Q and collagen domain containing [KO:K07296]
100552848  interstitial collagenase-like [KO:K01388] [EC:3.4.24.7]
100553051  neutrophil collagenase [KO:K01388] [EC:3.4.24.7]
100556484  ilk; integrin linked kinase [KO:K06272] [EC:2.7.11.1]
100559955  pdpk1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100552299  ubc; ubiquitin C [KO:K08770]
100553923  pck1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
100557794  pck2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
100558273  gk; glycerol kinase [KO:K00864] [EC:2.7.1.30]
100562966  aqp7; aquaporin 7 [KO:K08771]
100559365  aquaporin-7-like [KO:K08771]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
acs00071  Fatty acid degradation
acs00120  Primary bile acid biosynthesis
acs00564  Glycerophospholipid metabolism
acs04920  Adipocytokine signaling pathway
KO pathway
ko03320   
LinkDB

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