KEGG   PATHWAY: afb00564
Entry
afb00564                    Pathway                                
Name
Glycerophospholipid metabolism - Anoplopoma fimbria (sablefish)
Class
Metabolism; Lipid metabolism
Pathway map
afb00564  Glycerophospholipid metabolism
afb00564

Module
afb_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:afb00564]
afb_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:afb00564]
afb_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:afb00564]
Other DBs
GO: 0006650
Organism
Anoplopoma fimbria (sablefish) [GN:afb]
Gene
129109645  gpd1l; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
129099982  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
129105840  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic-like [KO:K00006] [EC:1.1.1.8]
129111630  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic-like [KO:K00006] [EC:1.1.1.8]
129111689  gpd2; glycerol-3-phosphate dehydrogenase, mitochondrial [KO:K00111] [EC:1.1.5.3]
129100848  gpat2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
129091549  gpam; glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
129101099  agpat9l; glycerol-3-phosphate acyltransferase 3-like [KO:K13506] [EC:2.3.1.15]
129101271  glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
129102403  gpat4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
129102499  gpat3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
129102322  agpat2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
129092549  agpat4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
129104680  agpat3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
129091959  agpat5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
129103439  lclat1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
129110009  mboat1; lysophospholipid acyltransferase 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
129107177  mboat2b; lysophospholipid acyltransferase 2b [KO:K13517] [EC:2.3.1.51 2.3.1.-]
129103297  mboat2a; lysophospholipid acyltransferase 2 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
129107016  gnpat; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
129107028  LOW QUALITY PROTEIN: dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
129093505  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
129094330  plpp2b; phospholipid phosphatase 2b [KO:K01080] [EC:3.1.3.4]
129094814  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
129095761  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
129101378  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
129102120  plpp1a; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
129113861  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
129103440  plpp2a; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
129098880  ppap2d; phosphatidic acid phosphatase type 2D [KO:K01080] [EC:3.1.3.4]
129105278  zgc:123305 isoform X1 [KO:K15728] [EC:3.1.3.4]
129110604  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
129110988  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
129106824  phosphatidate phosphatase LPIN1-like [KO:K15728] [EC:3.1.3.4]
129102662  lpin1a; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
129101067  plpp5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
129092585  plpp4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
129099413  dgkaa; diacylglycerol kinase, alpha a [KO:K00901] [EC:2.7.1.107]
129105366  dgkab; diacylglycerol kinase, alpha b isoform X1 [KO:K00901] [EC:2.7.1.107]
129090156  LOW QUALITY PROTEIN: diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
129111982  diacylglycerol kinase zeta-like isoform X1 [KO:K00901] [EC:2.7.1.107]
129112341  dgki; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
129096482  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
129108080  dgkzb; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
129093464  si:dkey-172j4.3; diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
129104278  dgkh; LOW QUALITY PROTEIN: diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
129104324  diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
129088901  diacylglycerol kinase delta-like isoform X1 [KO:K00901] [EC:2.7.1.107]
129109101  dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
129112453  chpt1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
129106071  cept1b; choline/ethanolaminephosphotransferase 1b [KO:K13644] [EC:2.7.8.1 2.7.8.2]
129091448  sphingomyelin synthase-related protein 1-like [KO:K22697] [EC:3.1.4.62]
129092336  sphingomyelin synthase-related protein 1-like isoform X1 [KO:K22697] [EC:3.1.4.62]
129096349  sgms2a; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
129092072  sgms1a; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
129093440  phosphatidylcholine:ceramide cholinephosphotransferase 2-like [KO:K04714] [EC:2.7.8.27 3.1.4.62]
129110467  pld1b; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
129113330  pld2; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
129103324  pld1a; phospholipase D1a isoform X1 [KO:K01115] [EC:3.1.4.4]
129089719  pld7; uncharacterized protein pld7 isoform X1 [KO:K16860] [EC:3.1.4.4]
129103533  5'-3' exonuclease PLD4 [KO:K16860] [EC:3.1.4.4]
129115726  pld3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
129108588  lcat; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
129100660  group 3 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
129095924  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
129096139  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129101358  pla2g1b; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129101573  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
129102259  pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129102622  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
129102638  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
129092519  pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
129098577  pla2g10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129092787  pla2g4f.1; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
129098367  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
129094097  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
129095507  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
129116800  LOW QUALITY PROTEIN: 85/88 kDa calcium-independent phospholipase A2-like [KO:K16343] [EC:3.1.1.4]
129107591  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
129103966  plb1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
129090199  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
129111527  plaat1l; phospholipase A and acyltransferase 1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
129103068  phospholipase A and acyltransferase 4-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
129109694  lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
129100928  lpcat2; LOW QUALITY PROTEIN: lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
129097262  lpcat1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
129093098  lpcat4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
129109538  lpcat3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
129110577  lypla1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
129108287  pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
129097104  lypla2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
129095290  pnpla6; patatin-like phospholipase domain-containing protein 6 isoform X1 [KO:K14676] [EC:3.1.1.5]
129101074  pnpla7b; patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
129102189  pnpla7a; patatin-like phospholipase domain-containing protein 7a [KO:K14676] [EC:3.1.1.5]
129107012  gpcpd1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
129091686  choline O-acetyltransferase-like [KO:K00623] [EC:2.3.1.6]
129092733  chata; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
129093565  ache; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
129112853  cAMP-regulated D2 protein [KO:K01049] [EC:3.1.1.7]
129108077  chka; choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
129108124  chkb; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
129098783  phospho1; probable phosphatase phospho1 isoform X1 [KO:K06124] [EC:3.1.3.75]
129110990  LOW QUALITY PROTEIN: choline-phosphate cytidylyltransferase B-like [KO:K00968] [EC:2.7.7.15]
129113487  LOW QUALITY PROTEIN: choline-phosphate cytidylyltransferase B-like [KO:K00968] [EC:2.7.7.15]
129114474  pcyt1aa; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
129107139  selenoi; ethanolaminephosphotransferase 1 isoform X1 [KO:K00993] [EC:2.7.8.1]
129105954  etnk2; ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
129112338  etnk1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
129108236  zgc:113516; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
129096455  pcyt2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
129098695  ethanolamine-phosphate cytidylyltransferase-like [KO:K00967] [EC:2.7.7.14]
129090267  pmt; phosphoethanolamine methyltransferase isoform X1 [KO:K05929] [EC:2.1.1.103]
129093193  etnppl; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
129091496  pemt; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
129100963  cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
129101128  cds1; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
129104484  pla1a; LOW QUALITY PROTEIN: phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
129109464  ptdss1a; phosphatidylserine synthase 1 isoform X1 [KO:K08729] [EC:2.7.8.-]
129097419  ptdss1b; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
129108540  ptdss2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
129102540  pisd; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
129090931  LOW QUALITY PROTEIN: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
129092703  crls1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
129099276  tafazzin [KO:K13511] [EC:2.3.1.-]
129107050  lpgat1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1 [KO:K13514] [EC:2.3.1.-]
129098723  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
129109625  mboat7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
afb00010  Glycolysis / Gluconeogenesis
afb00260  Glycine, serine and threonine metabolism
afb00561  Glycerolipid metabolism
afb00562  Inositol phosphate metabolism
afb00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
afb00565  Ether lipid metabolism
afb00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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