KEGG   PATHWAY: bbub00350
Entry
bbub00350                   Pathway                                
Name
Tyrosine metabolism - Bubalus bubalis (water buffalo)
Class
Metabolism; Amino acid metabolism
Pathway map
bbub00350  Tyrosine metabolism
bbub00350

Module
bbub_M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:bbub00350]
bbub_M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:bbub00350]
bbub_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:bbub00350]
Other DBs
GO: 0006570
Organism
Bubalus bubalis (water buffalo) [GN:bbub]
Gene
102403169  GOT1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
102410683  GOT1L1; putative aspartate aminotransferase, cytoplasmic 2 [KO:K14454] [EC:2.6.1.1]
102398657  GOT2; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
102410958  TAT; tyrosine aminotransferase isoform X1 [KO:K00815] [EC:2.6.1.5]
102390358  L-amino-acid oxidase isoform X1 [KO:K03334] [EC:1.4.3.2]
102390534  IL4I1; L-amino-acid oxidase isoform X3 [KO:K03334] [EC:1.4.3.2]
102400700  HPD; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
102398902  HGD; homogentisate 1,2-dioxygenase isoform X1 [KO:K00451] [EC:1.13.11.5]
102394972  GSTZ1; maleylacetoacetate isomerase isoform X2 [KO:K01800] [EC:5.2.1.2]
102396258  FAH; fumarylacetoacetase isoform X1 [KO:K01555] [EC:3.7.1.2]
102408280  TYR; tyrosinase [KO:K00505] [EC:1.14.18.1]
102395073  TH; tyrosine 3-monooxygenase [KO:K00501] [EC:1.14.16.2]
102401407  DCT; L-dopachrome tautomerase [KO:K01827] [EC:5.3.3.12]
102405492  TYRP1; 5,6-dihydroxyindole-2-carboxylic acid oxidase isoform X2 [KO:K00506] [EC:1.14.18.-]
102405051  DDC; aromatic-L-amino-acid decarboxylase isoform X1 [KO:K01593] [EC:4.1.1.28 4.1.1.105]
102409301  DBH; dopamine beta-hydroxylase [KO:K00503] [EC:1.14.17.1]
102410415  PNMT; phenylethanolamine N-methyltransferase [KO:K00553] [EC:2.1.1.28]
102392023  TOMT; transmembrane O-methyltransferase isoform X1 [KO:K00545] [EC:2.1.1.6]
102404714  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
102405347  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
102402256  LOW QUALITY PROTEIN: primary amine oxidase, liver isozyme-like [KO:K00276] [EC:1.4.3.21]
102399859  primary amine oxidase, liver isozyme isoform X1 [KO:K00276] [EC:1.4.3.21]
102402572  membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
102403974  AOC2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
102395921  aldehyde dehydrogenase family 3 member B1 isoform X3 [KO:K00129] [EC:1.2.1.5]
102396234  ALDH3B1; aldehyde dehydrogenase family 3 member B1 isoform X1 [KO:K00129] [EC:1.2.1.5]
102398004  ALDH3A1; aldehyde dehydrogenase, dimeric NADP-preferring isoform X1 [KO:K00129] [EC:1.2.1.5]
102408659  ADH1C; alcohol dehydrogenase 1C [KO:K13951] [EC:1.1.1.1]
102408967  LOW QUALITY PROTEIN: all-trans-retinol dehydrogenase [NAD(+)] ADH7 [KO:K13951] [EC:1.1.1.1]
102407428  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
102407124  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
102407762  ADH6; alcohol dehydrogenase 6 isoform X1 [KO:K13952] [EC:1.1.1.1]
102407971  TPO; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
102391150  aldehyde oxidase 4 isoform X1 [KO:K00157] [EC:1.2.3.1]
102391488  aldehyde oxidase 2 isoform X1 [KO:K00157] [EC:1.2.3.1]
102390255  AOX1; aldehyde oxidase isoform X1 [KO:K00157] [EC:1.2.3.1]
102396452  FAHD1; acylpyruvase FAHD1, mitochondrial [KO:K01557] [EC:3.7.1.5]
102403512  MIF; macrophage migration inhibitory factor [KO:K07253] [EC:5.3.2.1]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
bbub00020  Citrate cycle (TCA cycle)
bbub00360  Phenylalanine metabolism
bbub00400  Phenylalanine, tyrosine and tryptophan biosynthesis
bbub00620  Pyruvate metabolism
bbub00650  Butanoate metabolism
KO pathway
ko00350   
LinkDB

DBGET integrated database retrieval system