KEGG   PATHWAY: bbub04260
Entry
bbub04260                   Pathway                                
Name
Cardiac muscle contraction - Bubalus bubalis (water buffalo)
Description
Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR.
Class
Organismal Systems; Circulatory system
Pathway map
bbub04260  Cardiac muscle contraction
bbub04260

Other DBs
GO: 0060048
Organism
Bubalus bubalis (water buffalo) [GN:bbub]
Gene
102389068  [KO:K00420]
102389327  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
102389368  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X2 [KO:K23450]
102389682  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
102389794  [KO:K02263]
102389855  [KO:K02272]
102390411  TPM1; tropomyosin alpha-1 chain isoform X16 [KO:K10373]
102390547  MYL4; myosin light chain 4 isoform X2 [KO:K12750]
102390748  [KO:K23449]
102391265  [KO:K02272]
102391404  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
102391468  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
102391573  [KO:K02272]
102391576  [KO:K02267]
102391598  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
102392517  [KO:K00420]
102393025  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
102393147  [KO:K00416]
102393356  [KO:K00415]
102393363  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
102393658  [KO:K02270]
102393778  [KO:K00418]
102393946  [KO:K00413]
102393988  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
102394134  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
102394175  TPM2; tropomyosin beta chain isoform X2 [KO:K10374]
102394237  [KO:K09290]
102395196  [KO:K02270]
102395257  [KO:K02266]
102395499  [KO:K02266]
102395589  [KO:K02271]
102396221  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X6 [KO:K00476] [EC:1.14.11.16]
102396230  SLC8A1; sodium/calcium exchanger 1 isoform X2 [KO:K05849]
102396600  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
102396703  MYL3; myosin light chain 3 [KO:K12749]
102396784  [KO:K02271]
102396896  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
102397191  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
102397215  [KO:K02270]
102397329  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
102397899  SLC9A7; sodium/hydrogen exchanger 7 isoform X1 [KO:K12041]
102398267  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
102398794  [KO:K02268]
102398834  [KO:K02273]
102399169  SLC8A2; sodium/calcium exchanger 2 isoform X2 [KO:K05849]
102399788  [KO:K02272]
102400348  [KO:K02270]
102400496  [KO:K09290]
102400788  [KO:K02272]
102401416  MYH6; myosin-6 [KO:K17751]
102401420  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
102401461  [KO:K02272]
102401698  [KO:K02271]
102401750  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
102401827  CASQ2; calsequestrin-2 [KO:K23445]
102402622  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
102402708  [KO:K00415]
102402860  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X3 [KO:K04860]
102403111  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
102403241  [KO:K02264]
102403764  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
102403799  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
102403818  [KO:K02263]
102404294  [KO:K02270]
102404308  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
102404630  [KO:K02272]
102404930  [KO:K00411] [EC:7.1.1.8]
102405249  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
102405290  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
102405660  [KO:K00414]
102405960  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 isoform X2 [KO:K01539] [EC:7.2.2.13]
102406515  [KO:K02271]
102406537  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X2 [KO:K04858]
102406685  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X3 [KO:K04864]
102406695  SLC9A6; sodium/hydrogen exchanger 6 isoform X2 [KO:K12041]
102406763  [KO:K02273]
102406871  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
102407133  [KO:K02272]
102407190  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X9 [KO:K04850]
102407399  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
102407546  [KO:K02265]
102407672  TNNT2; troponin T, cardiac muscle isoform X5 [KO:K12045]
102407803  [KO:K02270]
102407968  [KO:K02272]
102408049  [KO:K02272]
102409578  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X2 [KO:K04865]
102409584  RYR2; ryanodine receptor 2 [KO:K04962]
102410790  [KO:K02265]
102411142  [KO:K02271]
102411768  [KO:K02266]
102412471  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
102412641  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
102413190  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X2 [KO:K04870]
102413284  TNNI3; troponin I, cardiac muscle isoform X1 [KO:K12044]
102413395  [KO:K02271]
102413515  MYH7; myosin-7 [KO:K17751]
102413847  [KO:K02267]
102414062  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
102414919  [KO:K00417]
102415069  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
102415299  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
102416106  [KO:K00417]
112578088  [KO:K00416]
112581375  [KO:K02272]
112582984  [KO:K00416]
112583857  [KO:K09290]
123327865  [KO:K02270]
123328075  [KO:K00417]
123329348  [KO:K02268]
123331105  [KO:K02272]
123331570  [KO:K02270]
123331610  [KO:K02270]
123332034  [KO:K02270]
123332056  [KO:K02270]
123333121  [KO:K02268]
123333838  [KO:K02273]
123334257  [KO:K02270]
123465060  [KO:K00419]
123465130  [KO:K02272]
123465923  [KO:K00416]
56055836  COX3; cytochrome c oxidase subunit III [KO:K02262]
56055854  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
56055856  COX2; cytochrome c oxidase subunit II [KO:K02261]
56055863  H0I40_mgp01; cytochrome b [KO:K00412]
Compound
C00076  Calcium cation
C00080  H+
C00238  Potassium cation
C01330  Sodium cation
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:16799263
  Authors
Endoh M
  Title
Signal transduction and Ca2+ signaling in intact myocardium.
  Journal
J Pharmacol Sci 100:525-37 (2006)
DOI:10.1254/jphs.CPJ06009X
Reference
PMID:18981594
  Authors
Endoh M
  Title
Cardiac Ca2+ signaling and Ca2+ sensitizers.
  Journal
Circ J 72:1915-25 (2008)
DOI:10.1253/circj.CJ-08-0838
Reference
PMID:16552170
  Authors
Bers DM, Despa S
  Title
Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.
  Journal
J Pharmacol Sci 100:315-22 (2006)
DOI:10.1254/jphs.CPJ06001X
Reference
PMID:10747208
  Authors
Gordon AM, Homsher E, Regnier M
  Title
Regulation of contraction in striated muscle.
  Journal
Physiol Rev 80:853-924 (2000)
DOI:10.1152/physrev.2000.80.2.853
Reference
PMID:16701909
  Authors
Phrommintikul A, Chattipakorn N
  Title
Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death.
  Journal
Int J Cardiol 112:142-52 (2006)
DOI:10.1016/j.ijcard.2005.11.106
Reference
PMID:16096350
  Authors
Lacinova L
  Title
Voltage-dependent calcium channels.
  Journal
Gen Physiol Biophys 24 Suppl 1:1-78 (2005)
Reference
PMID:12763850
  Authors
Lingrel J, Moseley A, Dostanic I, Cougnon M, He S, James P, Woo A, O'Connor K, Neumann J
  Title
Functional roles of the alpha isoforms of the Na,K-ATPase.
  Journal
Ann N Y Acad Sci 986:354-9 (2003)
DOI:10.1111/j.1749-6632.2003.tb07214.x
Reference
PMID:11294886
  Authors
Berg JS, Powell BC, Cheney RE
  Title
A millennial myosin census.
  Journal
Mol Biol Cell 12:780-94 (2001)
DOI:10.1091/mbc.12.4.780
Reference
PMID:15736582
  Authors
Parmacek MS, Solaro RJ
  Title
Biology of the troponin complex in cardiac myocytes.
  Journal
Prog Cardiovasc Dis 47:159-76 (2004)
DOI:10.1016/j.pcad.2004.07.003
Reference
PMID:14659803
  Authors
Yamashita H, Sugiura S, Fujita H, Yasuda S, Nagai R, Saeki Y, Sunagawa K, Sugi H
  Title
Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
  Journal
Cardiovasc Res 60:580-8 (2003)
DOI:10.1016/j.cardiores.2003.09.011
Reference
PMID:19403607
  Authors
Pritchard TJ, Kranias EG
  Title
Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis.
  Journal
J Physiol 587:3125-33 (2009)
DOI:10.1113/jphysiol.2009.172171
Reference
PMID:28596175
  Authors
Landstrom AP, Dobrev D, Wehrens XHT
  Title
Calcium Signaling and Cardiac Arrhythmias.
  Journal
Circ Res 120:1969-1993 (2017)
DOI:10.1161/CIRCRESAHA.117.310083
Related
pathway
bbub04020  Calcium signaling pathway
KO pathway
ko04260   

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