KEGG   PATHWAY: biu03013
Entry
biu03013                    Pathway                                
Name
Nucleocytoplasmic transport - Bos indicus (zebu cattle)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
biu03013  Nucleocytoplasmic transport
biu03013

Other DBs
GO: 0050658
Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109559038  AAAS; aladin [KO:K14320]
109557302  NUPL2; nucleoporin-like protein 2 isoform X1 [KO:K14321]
109566516  GLE1; nucleoporin GLE1 [KO:K18723]
109572233  DDX19A; ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
109572235  ATP-dependent RNA helicase DDX19A isoform X1 [KO:K18655] [EC:5.6.2.7]
109567306  RAE1; mRNA export factor isoform X1 [KO:K14298]
109569188  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
109566557  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
109573656  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
109566113  E3 SUMO-protein ligase RanBP2-like isoform X1 [KO:K12172] [EC:2.3.2.-]
109559855  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
109578627  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
109560815  SUMO3; small ubiquitin-related modifier 3 [KO:K12160]
109569637  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
109569782  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
109576321  SEC13; protein SEC13 homolog [KO:K14004]
109558400  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
109553848  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
109577801  SEH1L; nucleoporin SEH1 [KO:K14299]
109564035  NUP43; nucleoporin Nup43 [KO:K14305]
109559445  NUP37; nucleoporin Nup37 [KO:K14302]
109570413  AHCTF1; protein ELYS isoform X1 [KO:K25129]
109572137  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
109566841  NUP58; nucleoporin p58/p45 [KO:K14307]
109560610  nuclear pore complex protein Nup54 [KO:K14308]
109557667  NUP205; nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
109565659  NUP188; nucleoporin NUP188 homolog [KO:K14311]
109574940  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
109572767  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
109565773  NUP35; nucleoporin NUP53 [KO:K14313]
109556273  NDC1; nucleoporin NDC1 [KO:K14315]
109556729  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
109575914  NUP210; LOW QUALITY PROTEIN: nuclear pore membrane glycoprotein 210 [KO:K14314]
109578562  nuclear envelope pore membrane protein POM 121C-like [KO:K14316]
109576602  POM121L2; POM121-like protein 2 [KO:K14316]
109560424  TMEM33; transmembrane protein 33 [KO:K20724]
109560428  transmembrane protein 33-like [KO:K20724]
109570337  TPR; nucleoprotein TPR [KO:K09291]
109559901  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
109576972  NUP153; nuclear pore complex protein Nup153 [KO:K14296]
109557234  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
109555154  KPNA1; importin subunit alpha-5 [KO:K23940]
109574292  KPNA2; importin subunit alpha-1 [KO:K15043]
109578238  KPNA7; importin subunit alpha-8 [KO:K15043]
109558797  KPNA4; LOW QUALITY PROTEIN: importin subunit alpha-3 [KO:K23583]
109566726  KPNA3; importin subunit alpha-4 isoform X1 [KO:K23583]
109563789  KPNA5; importin subunit alpha-6 [KO:K15042]
109572457  KPNA6; importin subunit alpha-7 [KO:K15042]
109573769  KPNB1; importin subunit beta-1 [KO:K14293]
109574671  TNPO1; transportin-1 [KO:K18752]
109561543  TNPO2; transportin-2 isoform X1 [KO:K18727]
109557611  TNPO3; transportin-3 isoform X1 [KO:K15436]
109564777  IPO4; importin-4 [KO:K20221]
109566922  IPO5; importin-5 [KO:K20222]
109569594  IPO7; importin-7 [KO:K20223]
109559555  IPO8; importin-8 isoform X1 [KO:K18755]
109574923  IPO11; importin-11 [KO:K25201]
109556393  IPO13; importin-13 isoform X1 [KO:K25202]
109575562  SNUPN; snurportin-1 [KO:K13151]
109566195  XPO1; exportin-1 [KO:K14290]
109567527  CSE1L; exportin-2 [KO:K18423]
109559274  XPOT; exportin-T isoform X1 [KO:K14288]
109566854  XPO4; exportin-4 isoform X1 [KO:K25203]
109577118  XPO5; exportin-5 [KO:K14289]
109578537  XPO6; exportin-6 [KO:K25204]
109575051  RANBP17; ran-binding protein 17 isoform X1 [KO:K24115]
109571399  RAN; GTP-binding nuclear protein Ran [KO:K07936]
109562689  GTP-binding nuclear protein Ran-like [KO:K07936]
109567253  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
109563706  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
109560978  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
109563063  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
109556287  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
109558625  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
109555831  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
109556279  MAGOH; protein mago nashi homolog [KO:K12877]
109559658  MAGOHB; protein mago nashi homolog 2 [KO:K12877]
109573854  CASC3; protein CASC3 [KO:K14323]
109574262  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
109564806  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
109566853  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
109578556  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
109561636  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
109575443  PNN; pinin [KO:K13114]
109574142  ALYREF; THO complex subunit 4 [KO:K12881]
109560814  UPF1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
109567876  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
109576742  UPF3B; LOW QUALITY PROTEIN: regulator of nonsense transcripts 3B [KO:K14328]
109567113  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
109554394  NXF1; nuclear RNA export factor 1 [KO:K14284]
109555062  nuclear RNA export factor 3-like [KO:K14284]
109554829  LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284]
109554900  nuclear RNA export factor 3-like [KO:K14284]
109568054  NXT1; NTF2-related export protein 1 [KO:K14285]
109555445  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
109577017  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
109573766  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
109559387  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
109577785  THOC1; THO complex subunit 1 [KO:K12878]
109555185  THOC2; THO complex subunit 2 [KO:K12879]
109571315  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
109578646  THOC6; THO complex subunit 6 homolog isoform X1 [KO:K13175]
109571517  THO complex subunit 7 homolog [KO:K13176]
109576349  THOC7; THO complex subunit 7 homolog [KO:K13176]
109564166  THOC3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
biu03015  mRNA surveillance pathway
KO pathway
ko03013   
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