KEGG   PATHWAY: bta00564
Entry
bta00564                    Pathway                                
Name
Glycerophospholipid metabolism - Bos taurus (cow)
Class
Metabolism; Lipid metabolism
Pathway map
bta00564  Glycerophospholipid metabolism
bta00564

Module
bta_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:bta00564]
bta_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:bta00564]
bta_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:bta00564]
Other DBs
GO: 0006650
Organism
Bos taurus (cow) [GN:bta]
Gene
100125779  PCYT1A; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
100336631  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100336649  PTDSS2; phosphatidylserine synthase 2 isoform X1 [KO:K08730] [EC:2.7.8.29]
100336936  CDS1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
100337447  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
101905992  [KO:K01080] [EC:3.1.3.4]
107132066  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
112443425  [KO:K01047] [EC:3.1.1.4]
282137  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha precursor [KO:K13509] [EC:2.3.1.51]
282271  PLA2G15; phospholipase A2 group XV precursor [KO:K06129] [EC:3.1.1.5]
282457  PLA2G1B; phospholipase A2 preproprotein [KO:K01047] [EC:3.1.1.4]
360197  PEMT; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
494318  PLA2G2D1; calcium-dependent phospholipase A2 PLA2G2D1 precursor [KO:K01047] [EC:3.1.1.4]
497202  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
503625  PLA2G2D4; calcium-dependent phospholipase A2 PLA2G2D4 precursor [KO:K01047] [EC:3.1.1.4]
504236  MBOAT7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
504545  PLPP2; phospholipid phosphatase 2 precursor [KO:K01080] [EC:3.1.3.4]
504650  CEPT1; choline/ethanolaminephosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
504948  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial precursor [KO:K00111] [EC:1.1.5.3]
504978  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
505332  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial [KO:K01613] [EC:4.1.1.65]
505485  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
506243  PLA2G2E; group IIE secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
506348  DGKA; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
506381  SELENOI; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
506508  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
506607  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
506802  PLA2G16; group XVI phospholipase A2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
507201  PLA2G2A; phospholipase A2, membrane associated precursor [KO:K01047] [EC:3.1.1.4]
507456  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
509819  PTDSS1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
510274  PCYT2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
510842  LPCAT4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
510960  LCAT; phosphatidylcholine-sterol acyltransferase precursor [KO:K00650] [EC:2.3.1.43]
511291  CHPT1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
511614  GPAT4; glycerol-3-phosphate acyltransferase 4 precursor [KO:K13506] [EC:2.3.1.15]
511887  DGKZ; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
512112  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta precursor [KO:K13509] [EC:2.3.1.51]
512761  CRLS1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
513389  DGKD; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
514448  LPIN2; phosphatidate phosphatase LPIN2 isoform X4 [KO:K15728] [EC:3.1.3.4]
514456  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
514554  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
514646  LPCAT2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
514865  CHKA; choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
515135  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
515177  TAFAZZIN; tafazzin isoform X1 [KO:K13511] [EC:2.3.1.-]
515186  ETNPPL; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
515361  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
515900  PLA1A; phospholipase A1 member A precursor [KO:K13618] [EC:3.1.1.111]
518371  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
518469  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X2 [KO:K18695] [EC:3.1.4.2]
518523  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
519739  GPAT3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
520912  LCLAT1; lysocardiolipin acyltransferase 1 isoform X1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
520954  SGMS2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
521383  PLA2G2A; phospholipase A2, membrane associated precursor [KO:K01047] [EC:3.1.1.4]
521637  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
522159  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
522866  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
524639  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase [KO:K06124] [EC:3.1.3.75]
524732  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
525042  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
525072  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
526175  PCYT1B; choline-phosphate cytidylyltransferase B [KO:K00968] [EC:2.7.7.15]
526364  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
526739  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
527214  PLA2G12A; group XIIA secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
527631  PLA2G3; group 3 secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
529067  PPAPDC1A; phosphatidate phosphatase PPAPDC1A [KO:K18693] [EC:3.6.1.75 3.1.3.4]
530095  DGKI; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
530414  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
531209  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
533229  ETNK2; ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
533538  SGMS1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
534038  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
535126  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial precursor [KO:K00995] [EC:2.7.8.5]
535381  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
536213  CHKB; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
536255  PNPLA7; patatin-like phospholipase domain-containing protein 7 isoform X5 [KO:K14676] [EC:3.1.1.5]
537171  DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
537224  LPIN1; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
537533  DGKH; diacylglycerol kinase eta isoform X4 [KO:K00901] [EC:2.7.1.107]
538147  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
538800  GNPAT; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
539992  LYPLA1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
540446  ACHE; acetylcholinesterase precursor [KO:K01049] [EC:3.1.1.7]
540644  SAMD8; sphingomyelin synthase-related protein 1 isoform X1 [KO:K22697] [EC:3.1.4.62]
540705  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
541208  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
541284  MBOAT1; lysophospholipid acyltransferase 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
541294  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
613932  PLD3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
613966  [KO:K01047] [EC:3.1.1.4]
614402  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
614834  CDS2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
614911  PLA2G5; phospholipase A2 group V precursor [KO:K01047] [EC:3.1.1.4]
615045  [KO:K01047] [EC:3.1.1.4]
616337  PLPP5; phospholipid phosphatase 5 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
617172  PLPP1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
617707  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
618367  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
767822  PNPLA6; patatin-like phospholipase domain-containing protein 6 [KO:K14676] [EC:3.1.1.5]
782114  [KO:K06128] [EC:3.1.1.5]
784764  LYPLA2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
785489  MBOAT2; lysophospholipid acyltransferase 2 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
788450  LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
789315  PLD4; 5'-3' exonuclease PLD4 isoform X6 [KO:K16860] [EC:3.1.4.4]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
bta00010  Glycolysis / Gluconeogenesis
bta00260  Glycine, serine and threonine metabolism
bta00561  Glycerolipid metabolism
bta00562  Inositol phosphate metabolism
bta00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
bta00565  Ether lipid metabolism
bta00620  Pyruvate metabolism
KO pathway
ko00564   

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