Entry
Name
Lysosome - Bos taurus (cow)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Bos taurus (cow) [GN:
bta ]
Gene
338038 ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 [KO:K02154 ]
286768 ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 [KO:K02154 ]
518974 ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154 ]
513684 TCIRG1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154 ]
282148 ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146 ]
511839 ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146 ]
782343 LOW QUALITY PROTEIN: V-type proton ATPase subunit H-like [KO:K02144 ]
327687 ATP6AP1; V-type proton ATPase subunit S1 precursor [KO:K03662 ]
550622 ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155 ]
505684 ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661 ]
541071 NCOA7; nuclear receptor coactivator 7 isoform X7 [KO:K25442 ]
510967 CTSW; cathepsin W precursor [KO:K08569 ] [EC:3.4.22.-]
529295 PSAPL1; proactivator polypeptide-like 1 precursor [KO:K12382 ]
504524 GM2A; ganglioside GM2 activator precursor [KO:K12383 ]
281897 LAMP1; lysosome-associated membrane glycoprotein 1 precursor [KO:K06528 ]
529148 LAMP2; lysosome-associated membrane glycoprotein 2 isoform 2 precursor [KO:K06528 ]
531327 LAMP3; lysosome-associated membrane glycoprotein 3 [KO:K06562 ]
533177 SCARB2; lysosome membrane protein 2 precursor [KO:K12384 ]
286772 NPC1; NPC intracellular cholesterol transporter 1 precursor [KO:K12385 ]
280815 NPC2; NPC intracellular cholesterol transporter 2 precursor [KO:K13443 ]
282470 SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347 ]
521189 SLC11A2; natural resistance-associated macrophage protein 2 [KO:K21398 ]
112441543 natural resistance-associated macrophage protein 2-like [KO:K21398 ]
512464 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2-like [KO:K21398 ]
404155 LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387 ]
404135 LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387 ]
512361 LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387 ]
100299651 ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642 ]
529923 ABCB9; ABC-type oligopeptide transporter ABCB9 [KO:K05656 ]
509820 CD164; sialomucin core protein 24 precursor [KO:K06546 ]
529186 CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390 ]
515944 MFSD8; major facilitator superfamily domain-containing protein 8 [KO:K12307 ]
509610 GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239 ] [EC:2.7.8.17 ]
508713 GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087 ]
100138633 N-acetylglucosamine-1-phosphotransferase subunit gamma-like [KO:K10087 ]
515935 NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor [KO:K01125 ] [EC:3.1.4.45 ]
281849 IGF2R; cation-independent mannose-6-phosphate receptor precursor [KO:K06564 ]
281291 M6PR; cation-dependent mannose-6-phosphate receptor precursor [KO:K10089 ]
510539 GGA3; ADP-ribosylation factor-binding protein GGA3 [KO:K12404 ]
534634 GGA1; ADP-ribosylation factor-binding protein GGA1 [KO:K12404 ]
517031 GGA2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404 ]
520564 LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363 ]
Compound
Reference
Authors
Eskelinen EL, Tanaka Y, Saftig P
Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
Journal
Reference
Authors
Neufeld EF
Title
Lysosomal storage diseases.
Journal
Reference
Authors
von Figura K, Hasilik A
Title
Lysosomal enzymes and their receptors.
Journal
Reference
Authors
Janvier K, Bonifacino JS
Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
Journal
Reference
Authors
Vergarajauregui S, Puertollano R
Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
Journal
Reference
Authors
Jaskolka MC, Winkley SR, Kane PM
Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
Journal
Reference
Authors
Majdoul S, Compton AA
Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
Journal
Related pathway
bta04130 SNARE interactions in vesicular transport
KO pathway
LinkDB
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