KEGG   PATHWAY: bta04612
Entry
bta04612                    Pathway                                
Name
Antigen processing and presentation - Bos taurus (cow)
Class
Organismal Systems; Immune system
Pathway map
bta04612  Antigen processing and presentation
bta04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Bos taurus (cow) [GN:bta]
Gene
100125917  RFXANK; DNA-binding protein RFXANK [KO:K08062]
100139049  KLRC1; killer cell lectin-like receptor subfamily C, member 1 [KO:K06541]
100140174  [KO:K06541]
100300510  [KO:K10785]
100300850  [KO:K10784]
100336105  PSME3; proteasome activator complex subunit 3 isoform X2 [KO:K06698]
100336869  [KO:K06541]
100847738  [KO:K06541]
100848815  [KO:K06752]
100852061  [KO:K07980]
104970137  [KO:K06541]
112446743  [KO:K06541]
132344816  [KO:K06698]
280729  B2M; beta-2-microglobulin precursor [KO:K08055]
280943  TNF; tumor necrosis factor [KO:K03156]
281036  CALR; calreticulin precursor [KO:K08057]
281060  CD8A; T-cell surface glycoprotein CD8 alpha chain precursor [KO:K06458]
281105  CTSB; cathepsin B precursor [KO:K01363] [EC:3.4.22.1]
281108  CTSV; cathepsin L2 precursor [KO:K01365] [EC:3.4.22.15]
281237  IFNG; interferon gamma precursor [KO:K04687]
281281  LGMN; legumain precursor [KO:K01369] [EC:3.4.22.34]
281586  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
281713  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
281803  PDIA3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
281827  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
281831  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
281832  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
282254  HSPA1A; heat shock 70 kDa protein 1B [KO:K03283]
282490  BOLA-DMA; HLA class II histocompatibility antigen, DM alpha chain precursor [KO:K06752]
282491  BOLA-DMB; major histocompatibility complex, class II, DM beta precursor [KO:K06752]
282493  BOLA-DOB; HLA class II histocompatibility antigen, DO beta chain precursor [KO:K06752]
282494  BOLA-DQA5; major histocompatibility complex, class II, DQ alpha 5 precursor [KO:K06752]
282495  BOLA-DQB; major histocompatibility complex, class II, DQ beta precursor [KO:K06752]
282497  BOLA-DYA; major histocompatibility complex, class II, DY alpha precursor [KO:K06752]
282498  BOLA-DYB; major histocompatibility complex, class II, DY beta precursor [KO:K06752]
282530  BOLA-DRB3; major histocompatibility complex, class II, DRB3 [KO:K06752]
282535  BOLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
282860  KIR2DL5A; killer cell immunoglobulin-like receptor 2DL5A precursor [KO:K24232]
327711  CTSS; cathepsin S precursor [KO:K01368] [EC:3.4.22.27]
353254  KIR3DL1; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 precursor [KO:K07980]
407098  CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
407129  CANX; calnexin precursor [KO:K08054]
407173  JSP.1; MHC Class I JSP.1 precursor [KO:K06751]
415113  HSPA5; endoplasmic reticulum chaperone BiP precursor [KO:K09490] [EC:3.6.4.10]
444877  KLRD1; natural killer cells antigen CD94 [KO:K06516]
493736  KIR3DS1; killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1 precursor [KO:K07980]
493737  KIR2DS1; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 precursor [KO:K07980]
504335  TAPBP; tapasin precursor [KO:K08058]
506214  BOLA-DRA; major histocompatibility complex, class II, DR alpha precursor [KO:K06752]
507917  [KO:K06751]
508633  CD8B; T-cell surface glycoprotein CD8 beta chain precursor [KO:K06459]
508720  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
509513  [KO:K10785]
509857  PSME2; proteasome activator complex subunit 2 [KO:K06697]
510041  PSME1; proteasome activator complex subunit 1 [KO:K06696]
510417  BOLA-NC1; non-classical MHC class I antigen precursor [KO:K06751]
512672  [KO:K06751]
513869  [KO:K06541]
514897  NKG2A; NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
515200  CTSL; procathepsin L precursor [KO:K01365] [EC:3.4.22.15]
515712  BOLA; MHC class I heavy chain isoform 1 precursor [KO:K06751]
524959  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
525727  BOLA-DOA; HLA class II histocompatibility antigen, DO alpha chain precursor [KO:K06752]
529141  TAPBPL; tapasin-related protein precursor [KO:K28445]
533050  BoLA; major histocompatibility complex, class I, A precursor [KO:K06751]
534003  NFYC; nuclear transcription factor Y subunit gamma [KO:K08066]
536558  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
537065  KIR3DL2; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 precursor [KO:K07980]
538700  BOLA-DRB2; HLA class II histocompatibility antigen, DR beta 5 chain isoform X3 [KO:K06752]
539241  BLA-DQB; boLa class II histocompatibility antigen, DQB*0101 beta chain precursor [KO:K06752]
539584  NFYA; nuclear transcription factor Y subunit alpha [KO:K08064]
539835  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
539884  RFX5; DNA-binding protein RFX5 [KO:K08061]
540190  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
540760  RFXAP; regulatory factor X-associated protein [KO:K08063]
613384  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
614382  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
614781  [KO:K07980]
615930  IFI30; gamma-interferon-inducible lysosomal thiol reductase precursor [KO:K08059]
616942  [KO:K06751]
618565  [KO:K06516]
618722  DSB; MHC class II antigen DS beta [KO:K06752]
618733  [KO:K05654] [EC:7.4.2.14]
767874  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
767904  MGC126945; LOW QUALITY PROTEIN: uncharacterized protein LOC767904 [KO:K06751]
783680  [KO:K08055]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
bta03050  Proteasome
bta04650  Natural killer cell mediated cytotoxicity
bta04660  T cell receptor signaling pathway
KO pathway
ko04612   

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