KEGG   PATHWAY: byi00260
Entry
byi00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia sp. YI23
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
byi00260  Glycine, serine and threonine metabolism
byi00260

Module
byi_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:byi00260]
byi_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:byi00260]
byi_M00555  Betaine biosynthesis, choline => betaine [PATH:byi00260]
byi_M00621  Glycine cleavage system [PATH:byi00260]
byi_M00919  Ectoine degradation, ectoine => aspartate [PATH:byi00260]
byi_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:byi00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia sp. YI23 [GN:byi]
Gene
BYI23_A017300  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BYI23_B011760  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BYI23_A011860  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BYI23_B011260  homoserine kinase [KO:K02204] [EC:2.7.1.39]
BYI23_A011870  threonine synthase [KO:K01733] [EC:4.2.3.1]
BYI23_A018310  Threonine aldolase [KO:K01620] [EC:4.1.2.48]
BYI23_A011040  threonine aldolase [KO:K01620] [EC:4.1.2.48]
BYI23_D006640  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BYI23_A021710  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BYI23_C011530  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BYI23_D007780  Serine--glyoxylate transaminase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
BYI23_C006700  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00018] [EC:1.1.1.29]
BYI23_C009010  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BYI23_A000770  putative 2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BYI23_A014830  Gluconate 2-dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BYI23_A019240  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BYI23_A012120  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BYI23_D015380  Hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
BYI23_C005550  hypothetical protein [KO:K11529] [EC:2.7.1.165]
BYI23_A002040  phosphoglycerate mutase 1 family [KO:K01834] [EC:5.4.2.11]
BYI23_A003330  Phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
BYI23_C002270  D-isomer specific 2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BYI23_A000140  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BYI23_D000950  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BYI23_D003040  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BYI23_A019910  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BYI23_A015130  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BYI23_A021720  short-chain dehydrogenase/reductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BYI23_C005250  putative short-chain dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BYI23_B013170  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
BYI23_B013180  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BYI23_A026260  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
BYI23_A026280  glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
BYI23_D010890  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BYI23_B014740  FAD-dependent pyridine nucleotide-disulfide oxidoreductase [KO:K00382] [EC:1.8.1.4]
BYI23_B007170  putative dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BYI23_A016170  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BYI23_A009060  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BYI23_A026270  glycine cleavage system H protein [KO:K02437]
BYI23_C008510  creatinase [KO:K08688] [EC:3.5.3.3]
BYI23_D013110  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BYI23_A017760  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BYI23_D001370  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BYI23_B012650  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BYI23_B012640  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BYI23_C006870  aldehyde dehydrogenase (NAD) family protein [KO:K00130] [EC:1.2.1.8]
BYI23_B001500  betaine-aldehyde dehydrogenase protein [KO:K00130] [EC:1.2.1.8]
BYI23_C005510  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BYI23_D006570  Rieske (2Fe-2S) domain-containing protein [KO:K00479] [EC:1.14.13.251]
BYI23_B001510  Rieske (2Fe-2S) domain-containing protein [KO:K00479] [EC:1.14.13.251]
BYI23_C008390  iron-sulfur cluster-binding protein [KO:K00479] [EC:1.14.13.251]
BYI23_B012530  Rieske (2Fe-2S) domain protein [KO:K00479] [EC:1.14.13.251]
BYI23_C011500  ferredoxin [KO:K21832] [EC:1.14.13.251]
BYI23_B012520  Oxidoreductase FAD-binding domain protein [KO:K21832] [EC:1.14.13.251]
BYI23_B012570  NADH:flavin oxidoreductase/NADH oxidase [KO:K21833] [EC:1.5.7.3]
BYI23_B012560  hypothetical protein [KO:K21834]
BYI23_B012550  Electron transfer flavoprotein alpha subunit [KO:K25960]
BYI23_B012540  putative electron transfer flavoprotein beta-subunit [KO:K25961]
BYI23_B012780  sarcosine oxidase, alpha subunit family [KO:K00302] [EC:1.5.3.24 1.5.3.1]
BYI23_B012800  sarcosine oxidase, beta subunit family [KO:K00303] [EC:1.5.3.24 1.5.3.1]
BYI23_B012770  Sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
BYI23_B012790  sarcosine oxidase delta subunit heterotetrameric [KO:K00304] [EC:1.5.3.24 1.5.3.1]
BYI23_B012810  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
BYI23_A026240  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
BYI23_A002920  threonine dehydratase, biosynthetic [KO:K01754] [EC:4.3.1.19]
BYI23_A011960  putative amino-acid dehydratase [KO:K01754] [EC:4.3.1.19]
BYI23_B003690  eutB; ectoine utilization protein EutB [KO:K01754] [EC:4.3.1.19]
BYI23_B011700  tryptophan synthase, alpha chain [KO:K01695] [EC:4.2.1.20]
BYI23_B011720  tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
BYI23_B003710  peptidase M24 [KO:K15783] [EC:3.5.4.44]
BYI23_B003720  eute; ectoine utilization protein EutE [KO:K15784] [EC:3.5.1.125]
BYI23_B003750  aminotransferase class-III [KO:K15785] [EC:2.6.1.76]
BYI23_B003740  aldehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
byi00010  Glycolysis / Gluconeogenesis
byi00020  Citrate cycle (TCA cycle)
byi00230  Purine metabolism
byi00250  Alanine, aspartate and glutamate metabolism
byi00270  Cysteine and methionine metabolism
byi00290  Valine, leucine and isoleucine biosynthesis
byi00300  Lysine biosynthesis
byi00330  Arginine and proline metabolism
byi00460  Cyanoamino acid metabolism
byi00470  D-Amino acid metabolism
byi00564  Glycerophospholipid metabolism
byi00600  Sphingolipid metabolism
byi00620  Pyruvate metabolism
byi00630  Glyoxylate and dicarboxylate metabolism
byi00640  Propanoate metabolism
byi00680  Methane metabolism
byi00860  Porphyrin metabolism
byi00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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