KEGG   PATHWAY: cery00260
Entry
cery00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Chanodichthys erythropterus (predatory carp)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cery00260  Glycine, serine and threonine metabolism
cery00260

Module
cery_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cery00260]
cery_M00047  Creatine pathway [PATH:cery00260]
cery_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cery00260]
cery_M00555  Betaine biosynthesis, choline => betaine [PATH:cery00260]
cery_M00621  Glycine cleavage system [PATH:cery00260]
cery_M00974  Betaine metabolism, animals, betaine => glycine [PATH:cery00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Chanodichthys erythropterus (predatory carp) [GN:cery]
Gene
137002484  agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
137004822  pipox; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
137005473  psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
137006136  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
137006625  sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
137007142  tdh2; L-threonine dehydrogenase 2 isoform X1 [KO:K15789] [EC:1.1.1.103]
137007154  [KO:K15789] [EC:1.1.1.103]
137008031  tha1; threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]
137010137  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
137010743  shmt2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]
137011289  [KO:K01758] [EC:4.4.1.1]
137011349  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
137011538  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
137012161  dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
137012162  bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
137012407  pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
137012504  shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
137012527  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
137015037  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
137015256  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
137016991  [KO:K00273] [EC:1.4.3.3]
137017184  grhpra; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
137017642  aoc2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
137019420  tdh; L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]
137020122  pgam1a; phosphoglycerate mutase 1a [KO:K01834] [EC:5.4.2.11]
137020329  [KO:K01754] [EC:4.3.1.19]
137021210  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
137021476  zgc:162816; D-serine dehydratase isoform X1 [KO:K20498] [EC:4.3.1.18]
137021819  alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
137022726  gcsha; glycine cleavage system protein H (aminomethyl carrier), a [KO:K02437]
137023009  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
137026522  amt; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
137027011  alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
137027386  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
137028883  sardh; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]
137028978  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
137029739  si:ch211-127i16.2; probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
137030896  gcshb; glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]
137031975  cbsa; cystathionine beta-synthase a isoform X1 [KO:K01697] [EC:4.2.1.22]
137032535  pgam1b; phosphoglycerate mutase 1b [KO:K01834] [EC:5.4.2.11]
137033149  grhprb; glyoxylate reductase/hydroxypyruvate reductase b [KO:K00049] [EC:1.1.1.79 1.1.1.81]
137033680  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
137034016  [KO:K00273] [EC:1.4.3.3]
137034017  [KO:K00273] [EC:1.4.3.3]
137034059  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
137034324  dao.3; D-amino-acid oxidase, tandem duplicate 3 [KO:K00273] [EC:1.4.3.3]
137035565  mao; amine oxidase [flavin-containing] isoform X1 [KO:K00274] [EC:1.4.3.4]
137035676  cbsb; cystathionine beta-synthase b isoform X1 [KO:K01697] [EC:4.2.1.22]
137036053  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cery00010  Glycolysis / Gluconeogenesis
cery00020  Citrate cycle (TCA cycle)
cery00230  Purine metabolism
cery00250  Alanine, aspartate and glutamate metabolism
cery00270  Cysteine and methionine metabolism
cery00290  Valine, leucine and isoleucine biosynthesis
cery00330  Arginine and proline metabolism
cery00470  D-Amino acid metabolism
cery00564  Glycerophospholipid metabolism
cery00600  Sphingolipid metabolism
cery00620  Pyruvate metabolism
cery00630  Glyoxylate and dicarboxylate metabolism
cery00640  Propanoate metabolism
cery00860  Porphyrin metabolism
cery00920  Sulfur metabolism
KO pathway
ko00260   

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