Entry Name Lysosome - Canis lupus familiaris (dog)
Description Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class Cellular Processes; Transport and catabolismBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Canis lupus familiaris (dog) [GN:
cfa ]
Gene 486245 ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X2 [KO:K02154 ]
607705 ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154 ]
482779 ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154 ]
483691 TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154 ]
477929 ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146 ]
479685 ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146 ]
486953 ATP6V1H; V-type proton ATPase subunit H isoform X2 [KO:K02144 ]
479877 ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155 ]
482528 ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X2 [KO:K03661 ]
476191 WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738 ]
476283 NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442 ]
480460 ARSG; arylsulfatase G precursor [KO:K12381 ] [EC:3.1.6.-]
476995 LAMP1; lysosome-associated membrane glycoprotein 1 isoform X2 [KO:K06528 ]
481037 LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528 ]
607186 LAMP3; lysosome-associated membrane glycoprotein 3 [KO:K06562 ]
478435 SCARB2; lysosome membrane protein 2 isoform X2 [KO:K12384 ]
403698 NPC1; NPC intracellular cholesterol transporter 1 precursor [KO:K12385 ]
403920 NPC2; NPC intracellular cholesterol transporter 2 precursor [KO:K13443 ]
478909 SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347 ]
486543 SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398 ]
475042 LAPTM4B; lysosomal-associated transmembrane protein 4B isoform X1 [KO:K12387 ]
475678 LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387 ]
487324 LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387 ]
480669 ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642 ]
477456 ABCB9; ATP-binding cassette sub-family B member 9 isoform X2 [KO:K05656 ]
486117 ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305 ] [EC:3.6.1.6 ]
485498 CLN5; ceroid-lipofuscinosis neuronal protein 5 precursor [KO:K12390 ]
476086 MFSD8; major facilitator superfamily domain-containing protein 8 isoform X2 [KO:K12307 ]
475443 GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239 ] [EC:2.7.8.17 ]
100856506 GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087 ]
490019 NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125 ] [EC:3.1.4.45 ]
484067 IGF2R; cation-independent mannose-6-phosphate receptor precursor [KO:K06564 ]
477700 M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089 ]
477568 CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646 ]
479666 AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391 ]
480253 AP1G2; AP-1 complex subunit gamma-like 2 isoform X5 [KO:K12391 ]
486344 AP1B1; AP-1 complex subunit beta-1 isoform X2 [KO:K12392 ]
609840 AP1M1; AP-1 complex subunit mu-1 isoform X1 [KO:K12393 ]
611211 AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393 ]
611468 AP1S2; AP-1 complex subunit sigma-2 isoform X2 [KO:K12394 ]
476750 AP3D1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396 ]
479053 AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397 ]
607494 AP3S1; AP-3 complex subunit sigma-1 isoform X4 [KO:K12399 ]
478304 AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400 ]
483125 AP4B1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401 ]
480283 AP4S1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403 ]
100684998 LOW QUALITY PROTEIN: AP-4 complex subunit sigma-1-like [KO:K12403 ]
481266 GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X2 [KO:K12404 ]
483310 GGA3; ADP-ribosylation factor-binding protein GGA3 [KO:K12404 ]
608555 GGA2; ADP-ribosylation factor-binding protein GGA2 isoform X3 [KO:K12404 ]
490004 LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363 ]
119871594 LOW QUALITY PROTEIN: lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1 [KO:K19363 ]
Compound Reference Authors Eskelinen EL, Tanaka Y, Saftig P
Title At the acidic edge: emerging functions for lysosomal membrane proteins.
Journal Reference Authors Neufeld EF
Title Lysosomal storage diseases.
Journal Reference Authors von Figura K, Hasilik A
Title Lysosomal enzymes and their receptors.
Journal Reference Authors Janvier K, Bonifacino JS
Title Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
Journal Reference Authors Vergarajauregui S, Puertollano R
Title Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
Journal Reference Authors Jaskolka MC, Winkley SR, Kane PM
Title RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
Journal Reference Authors Majdoul S, Compton AA
Title Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
Journal Related cfa04130 SNARE interactions in vesicular transport
KO pathway LinkDB All DBs
