Entry Name Gastric acid secretion - Camelus ferus (Wild Bactrian camel)
Description Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetycholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+,K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and thereby H+ secretion into the stomach lumen.
Class Organismal Systems; Digestive systemBRITE hierarchy
Pathway map Other DBs Organism Camelus ferus (Wild Bactrian camel) [GN:
cfr ]
Gene 102504487 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630 ]
102505216 ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540 ]
102505338 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
102506589 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
102508164 ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540 ]
102508487 KCNQ1; potassium voltage-gated channel subfamily KQT member 1 isoform X1 [KO:K04926 ]
102508547 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634 ]
102509058 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3 [KO:K05858 ] [EC:3.1.4.11 ]
102509102 KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913 ]
102509134 CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183 ]
102509736 ATP1A1; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539 ] [EC:7.2.2.13 ]
102512557 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
102513431 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
102513996 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
102514618 KCNJ15; ATP-sensitive inward rectifier potassium channel 15 [KO:K05008 ]
102515443 KCNE2; potassium voltage-gated channel subfamily E member 2 [KO:K04896 ]
102516053 ATP1A2; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539 ] [EC:7.2.2.13 ]
102516595 KCNJ10; ATP-sensitive inward rectifier potassium channel 10 [KO:K05003 ]
102516646 ATP1A4; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539 ] [EC:7.2.2.13 ]
102517415 ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540 ]
102518290 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630 ]
102518443 CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195 ]
102521238 KCNJ1; ATP-sensitive inward rectifier potassium channel 1 isoform X3 [KO:K04995 ]
102521522 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
102521814 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
102521934 KCNK10; potassium channel subfamily K member 10 isoform X1 [KO:K04920 ]
102522167 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
102522331 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
102524078 ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Schubert ML, Peura DA
Title Control of gastric acid secretion in health and disease.
Journal Reference Authors Urushidani T, Forte JG
Title Signal transduction and activation of acid secretion in the parietal cell.
Journal Reference Authors Yao X, Forte JG
Title Cell biology of acid secretion by the parietal cell.
Journal Reference Authors Heitzmann D, Warth R
Title No potassium, no acid: K+ channels and gastric acid secretion.
Journal Reference Authors Kopic S, Murek M, Geibel JP
Title Revisiting the parietal cell.
Journal Reference Authors Schubert ML
Title Gastric secretion.
Journal Reference Authors Konturek SJ, Konturek PC, Brzozowski T, Konturek JW, Pawlik WW
Title From nerves and hormones to bacteria in the stomach; Nobel prize for achievements in gastrology during last century.
Journal J Physiol Pharmacol 56:507-30 (2005)
Reference Authors Forte JG, Zhu L
Title Apical recycling of the gastric parietal cell H,K-ATPase.
Journal Reference Authors Szaszak M, Christian F, Rosenthal W, Klussmann E
Title Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.
Journal Reference Authors Heitzmann D, Warth R
Title Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
Journal Reference Authors Heitzmann D, Grahammer F, von Hahn T, Schmitt-Graff A, Romeo E, Nitschke R, Gerlach U, Lang HJ, Verrey F, Barhanin J, Warth R
Title Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells.
Journal Reference Authors Seidler U, Song P, Xiao F, Riederer B, Bachmann O, Chen M
Title Recent advances in the molecular and functional characterization of acid/base and electrolyte transporters in the basolateral membranes of gastric and duodenal epithelial cells.
Journal Related cfr04974 Protein digestion and absorption
KO pathway
