KEGG   PATHWAY: cfr04530
Entry
cfr04530                    Pathway                                
Name
Tight junction - Camelus ferus (Wild Bactrian camel)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
cfr04530  Tight junction
cfr04530

Other DBs
GO: 0005923
Organism
Camelus ferus (Wild Bactrian camel) [GN:cfr]
Gene
102503457  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
102503487  EPB41L4B; LOW QUALITY PROTEIN: band 4.1-like protein 4B [KO:K21111]
102503577  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102503879  RAB8B; ras-related protein Rab-8B [KO:K07902]
102504447  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
102504512  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
102504560  BVES; blood vessel epicardial substance isoform X2 [KO:K21108]
102504594  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
102504854  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
102505031  [KO:K07374]
102505057  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
102505098  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
102505358  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
102505598  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
102505604  [KO:K07374]
102506216  CLDN15; claudin-15 [KO:K06087]
102506255  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102506459  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102506683  ACTR3B; LOW QUALITY PROTEIN: actin-related protein 3B [KO:K18584]
102506715  SYMPK; LOW QUALITY PROTEIN: symplekin [KO:K06100]
102506840  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
102506971  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
102507120  MSN; moesin [KO:K05763]
102507360  [KO:K04237]
102507622  DLG2; disks large homolog 2 isoform X10 [KO:K12075]
102507629  [KO:K06099]
102507851  MYL6; myosin light polypeptide 6 isoform X2 [KO:K12751]
102507886  ACTR2; actin-related protein 2 [KO:K17260]
102507993  RHOA; transforming protein RhoA [KO:K04513]
102508023  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
102508100  CLDN12; claudin-12 [KO:K06087]
102508255  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
102508342  MYH11; myosin-11 isoform X2 [KO:K10352]
102508381  [KO:K07374]
102508504  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
102508764  CLDN25; putative claudin-25 [KO:K06087]
102508936  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
102508985  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102509034  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
102509370  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
102509393  [KO:K05692]
102509395  [KO:K05754]
102509448  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102509512  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
102509636  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102509649  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102509650  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102509804  ARHGEF18; rho guanine nucleotide exchange factor 18 [KO:K21066]
102509837  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
102509870  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
102510135  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
102510276  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2 [KO:K07198] [EC:2.7.11.31]
102510343  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
102510666  [KO:K12757]
102511037  SYNPO; synaptopodin [KO:K21112]
102511070  [KO:K12757]
102511098  ACTN4; alpha-actinin-4 isoform X6 [KO:K05699]
102511602  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
102511766  YBX3; LOW QUALITY PROTEIN: Y-box-binding protein 3 [KO:K06099]
102512237  TJAP1; tight junction-associated protein 1 isoform X2 [KO:K06105]
102512533  [KO:K07374]
102512572  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
102512738  WAS; wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
102512897  CRB3; protein crumbs homolog 3 [KO:K06090]
102512967  DLG3; disks large homolog 3 isoform X4 [KO:K21098]
102513102  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
102513121  RDX; LOW QUALITY PROTEIN: radixin [KO:K05762]
102513659  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X11 [KO:K13305] [EC:2.3.2.26]
102513964  AMOTL2; LOW QUALITY PROTEIN: angiomotin-like protein 2 [KO:K06104]
102514032  ACTB; actin, cytoplasmic 1 [KO:K05692]
102514218  CLDN3; claudin-3 [KO:K06087]
102514271  LLGL2; LOW QUALITY PROTEIN: LLGL scribble cell polarity complex component 2 [KO:K06094]
102514304  AFDN; LOW QUALITY PROTEIN: afadin [KO:K05702]
102514458  CLDN4; claudin-4 [KO:K06087]
102514486  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102514488  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
102514622  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3 [KO:K04354]
102514640  CLDN23; claudin-23 [KO:K06087]
102514672  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X6 [KO:K12791]
102515148  CLDN2; claudin-2 [KO:K06087]
102515180  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
102515233  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform X3 [KO:K13365]
102515362  STK11; LOW QUALITY PROTEIN: serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
102515804  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
102515991  [KO:K07374]
102516135  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
102516161  ARHGAP17; LOW QUALITY PROTEIN: rho GTPase-activating protein 17 [KO:K20638]
102516333  [KO:K05692]
102516450  RAP1A; ras-related protein Rap-1A [KO:K04353]
102516721  CD1E; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD1e, membrane-associated [KO:K06448]
102516801  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
102516888  CLDN1; claudin-1 [KO:K06087]
102516893  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102516943  JUN; transcription factor AP-1 [KO:K04448]
102516974  [KO:K06448]
102517084  RAB13; ras-related protein Rab-13 isoform X1 [KO:K06109]
102517144  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
102517146  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
102517174  CLDN18; claudin-18 isoform X1 [KO:K06087]
102517200  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
102517224  [KO:K06448]
102517225  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
102517227  CLDN19; claudin-19 isoform X2 [KO:K06087]
102517393  PCNA; proliferating cell nuclear antigen [KO:K04802]
102517457  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3 [KO:K04354]
102517494  CLDN7; claudin-7 [KO:K06087]
102517685  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
102517723  [KO:K06448]
102517791  ACTR3; actin-related protein 3 [KO:K18584]
102517830  MAGI1; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
102517958  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X2 [KO:K07200]
102517964  [KO:K06448]
102517974  RAB8A; ras-related protein Rab-8A [KO:K07901]
102518177  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
102518227  MPDZ; LOW QUALITY PROTEIN: multiple PDZ domain protein [KO:K06095]
102518229  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
102518309  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102518561  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102519035  CTTN; src substrate cortactin isoform X1 [KO:K06106]
102519089  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
102519562  JAM3; junctional adhesion molecule C [KO:K06785]
102519581  ACTG1; actin, cytoplasmic 2 [KO:K05692]
102519604  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102519721  MARVELD3; MARVEL domain-containing protein 3 [KO:K21099]
102519828  F11R; junctional adhesion molecule A [KO:K06089]
102520048  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102520251  AMOT; angiomotin isoform X1 [KO:K16819]
102520287  CGN; cingulin [KO:K06102]
102520318  CLDN10; claudin-10 isoform X1 [KO:K06087]
102520349  MYH9; LOW QUALITY PROTEIN: myosin-9 [KO:K10352]
102520724  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
102520731  MYH10; LOW QUALITY PROTEIN: myosin-10 [KO:K10352]
102520792  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
102521054  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
102521251  CLDN14; claudin-14 [KO:K06087]
102521570  CLDN20; LOW QUALITY PROTEIN: claudin-20 [KO:K06087]
102521584  [KO:K06087]
102521748  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
102521750  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
102521891  PATJ; inaD-like protein isoform X1 [KO:K06092]
102522019  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
102522122  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
102522237  TUBA4A; tubulin alpha-4A chain [KO:K07374]
102522243  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
102522300  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102522374  CLDN6; claudin-6 [KO:K06087]
102522492  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
102522569  PARD6G; partitioning defective 6 homolog gamma isoform X1 [KO:K06093]
102522633  CLDN9; claudin-9 [KO:K06087]
102522716  NF2; merlin isoform X1 [KO:K16684]
102522876  [KO:K06448]
102522963  [KO:K07374]
102523136  CLDN17; claudin-17 [KO:K06087]
102523179  CLDN11; claudin-11 [KO:K06087]
102523258  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
102523381  EZR; ezrin [KO:K08007]
102523383  CLDN8; claudin-8 [KO:K06087]
102523424  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
102523441  GATA4; LOW QUALITY PROTEIN: transcription factor GATA-4 [KO:K09183]
102523443  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
102523472  TUBA1A; tubulin alpha-1A chain [KO:K07374]
102523585  MARVELD2; LOW QUALITY PROTEIN: MARVEL domain-containing protein 2 [KO:K17291]
102524099  OCLN; occludin [KO:K06088]
102524206  MYH14; myosin-14 isoform X1 [KO:K10352]
102524480  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
102524518  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
102524531  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
106728419  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
106730937  [KO:K06087]
116656633  CLDN34; claudin-34 isoform X1 [KO:K06087]
116660018  [KO:K06087]
116660822  [KO:K05692]
116660982  CLDN5; claudin-5 [KO:K06087]
116664416  [KO:K07839]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
cfr04520  Adherens junction
cfr04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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