KEGG   PATHWAY: cgib00590
Entry
cgib00590                   Pathway                                
Name
Arachidonic acid metabolism - Carassius gibelio (silver crucian carp)
Class
Metabolism; Lipid metabolism
Pathway map
cgib00590  Arachidonic acid metabolism
cgib00590

Other DBs
GO: 0019369
Organism
Carassius gibelio (silver crucian carp) [GN:cgib]
Gene
127970713  group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
127952397  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
127963415  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
127964176  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
127972205  uncharacterized protein LOC127972205 [KO:K01047] [EC:3.1.1.4]
127949236  group XIIA secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
127977195  group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
128026677  group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
128018450  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
128018451  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
128029355  uncharacterized protein LOC128029355 [KO:K01047] [EC:3.1.1.4]
128020830  group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
127951049  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
127958220  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127958222  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127958226  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127975981  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
127976023  cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
127938002  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
128031646  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
128014908  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
128014909  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
128014910  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
128014911  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
128015010  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
128015011  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
128015012  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
128015013  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
128027394  cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
127943243  85/88 kDa calcium-independent phospholipase A2-like isoform X1 [KO:K16343] [EC:3.1.1.4]
127987925  85/88 kDa calcium-independent phospholipase A2-like isoform X1 [KO:K16343] [EC:3.1.1.4]
127984207  si:dkey-177p2.18; phospholipase B1, membrane-associated isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
127933494  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
127976371  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
127938651  phospholipase B1, membrane-associated-like isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
127971657  retinoic acid receptor responder 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
127971758  phospholipase A and acyltransferase 3-like isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
127978634  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
128027025  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
128027152  phospholipase A and acyltransferase 3-like isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
128027155  phospholipase A and acyltransferase 3-like isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
128027520  phospholipase A and acyltransferase 3-like isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
127958462  prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
127997173  prostaglandin G/H synthase 1-like [KO:K00509] [EC:1.14.99.1]
127983392  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
127950607  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
127939042  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
128027375  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
127958377  prostaglandin E synthase-like [KO:K15729] [EC:5.3.99.3]
128006238  prostaglandin E synthase-like [KO:K15729] [EC:5.3.99.3]
127962893  prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
127944790  prostaglandin E synthase 3-like [KO:K15730] [EC:5.3.99.3]
127945059  prostaglandin E synthase 3-like isoform X1 [KO:K15730] [EC:5.3.99.3]
128011631  prostaglandin E synthase 3-like [KO:K15730] [EC:5.3.99.3]
128012048  prostaglandin E synthase 3-like isoform X1 [KO:K15730] [EC:5.3.99.3]
127949742  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
127985943  carbonyl reductase 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
128018510  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
128022057  prostamide/prostaglandin F synthase [KO:K15717] [EC:1.11.1.20]
127941507  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
127956137  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
127948363  15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
127985635  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
127985636  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
127985637  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
128016546  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
127934180  thromboxane-A synthase [KO:K01832] [EC:5.3.99.5]
127976933  thromboxane-A synthase-like [KO:K01832] [EC:5.3.99.5]
127946148  lipocalin-like isoform X1 [KO:K01830] [EC:5.3.99.2]
127957115  zgc:153704; lipocalin-like [KO:K01830] [EC:5.3.99.2]
127976510  lipocalin-like [KO:K01830] [EC:5.3.99.2]
128013389  lipocalin-like [KO:K01830] [EC:5.3.99.2]
127988131  lipocalin-like [KO:K01830] [EC:5.3.99.2]
127959175  prostacyclin synthase-like [KO:K01831] [EC:5.3.99.4]
128015881  prostacyclin synthase-like [KO:K01831] [EC:5.3.99.4]
127955930  polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
127967689  polyunsaturated fatty acid 5-lipoxygenase-like isoform X1 [KO:K00461] [EC:1.13.11.34]
127970034  polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
128026407  polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
127956839  leukotriene A-4 hydrolase [KO:K01254] [EC:3.3.2.6]
127977404  leukotriene A-4 hydrolase-like [KO:K01254] [EC:3.3.2.6]
127933599  LOW QUALITY PROTEIN: prostaglandin reductase 2-like [KO:K13949] [EC:1.3.1.48]
127962130  prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
128017127  prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
127971302  leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
127971303  leukotriene C4 synthase-like [KO:K00807] [EC:4.4.1.20]
128026932  leukotriene C4 synthase-like [KO:K00807] [EC:4.4.1.20]
127980758  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
127964066  glutathione hydrolase 1 proenzyme-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
127966010  glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
127966011  glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
127948937  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
128018430  LOW QUALITY PROTEIN: gamma-glutamyltransferase 1a [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
128018431  gamma-glutamyltransferase 5a isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
128020700  glutathione hydrolase 5 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
127951669  phospholipid hydroperoxide glutathione peroxidase [KO:K05361] [EC:1.11.1.12]
127943422  glutathione peroxidase 4a isoform X1 [KO:K05361] [EC:1.11.1.12]
127938347  phospholipid hydroperoxide glutathione peroxidase-like [KO:K05361] [EC:1.11.1.12]
127944356  cytochrome P450 2J4-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
127944764  cytochrome P450 2J3-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
127956825  cytochrome P450 2J3-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
127939007  cytochrome P450 2J4-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
127939011  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
127939012  cytochrome P450 2J3-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
127948990  cytochrome P450 2U1 [KO:K07422] [EC:1.14.14.80]
127961063  arachidonate 12-lipoxygenase, 12S-type [KO:K00458] [EC:1.13.11.31]
128017081  polyunsaturated fatty acid 5-lipoxygenase-like isoform X1 [KO:K00458] [EC:1.13.11.31]
128017082  polyunsaturated fatty acid lipoxygenase ALOX12-like isoform X1 [KO:K00458] [EC:1.13.11.31]
127985407  si:dkey-17e16.9; hydroperoxide isomerase ALOXE3 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
127934057  arachidonate 12-lipoxygenase, 12R-type-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
128013818  hydroperoxide isomerase ALOXE3-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
128014767  polyunsaturated fatty acid lipoxygenase ALOX15B-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
127976311  bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
128031809  bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
cgib00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

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