KEGG   PATHWAY: cjc03008
Entry
cjc03008                    Pathway                                
Name
Ribosome biogenesis in eukaryotes - Callithrix jacchus (white-tufted-ear marmoset)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
Pathway map
cjc03008  Ribosome biogenesis in eukaryotes
cjc03008

Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100385057  SPATA5; ribosome biogenesis protein SPATA5 isoform X1 [KO:K14575]
100385616  FCF1; rRNA-processing protein FCF1 homolog isoform X4 [KO:K14566]
100386340  REXO5; RNA exonuclease 5 isoform X2 [KO:K14570] [EC:3.1.-.-]
100386563  POP5; ribonuclease P/MRP protein subunit POP5 isoform X1 [KO:K03537] [EC:3.1.26.5]
100386800  NAT10; RNA cytidine acetyltransferase isoform X1 [KO:K14521] [EC:2.3.1.-]
100386998  [KO:K14284]
100387426  NOL6; nucleolar protein 6 isoform X1 [KO:K14544]
100387555  SBDS; ribosome maturation protein SBDS [KO:K14574]
100388145  UTP14C; U3 small nucleolar RNA-associated protein 14 homolog C [KO:K14567]
100388181  XRN2; 5'-3' exoribonuclease 2 isoform X1 [KO:K12619] [EC:3.1.13.-]
100388528  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
100388771  POP1; ribonucleases P/MRP protein subunit POP1 isoform X2 [KO:K01164] [EC:3.1.26.5]
100389380  WDR36; WD repeat-containing protein 36 [KO:K14554]
100389616  GAR1; H/ACA ribonucleoprotein complex subunit 1 isoform X2 [KO:K11128]
100390141  UTP14A; U3 small nucleolar RNA-associated protein 14 homolog A isoform X1 [KO:K14567]
100390384  SNU13; NHP2-like protein 1 isoform X3 [KO:K12845]
100390454  NHP2; H/ACA ribonucleoprotein complex subunit 2 [KO:K11129]
100390480  PWP2; periodic tryptophan protein 2 homolog isoform X3 [KO:K14558]
100390988  IMP4; U3 small nucleolar ribonucleoprotein protein IMP4 isoform X1 [KO:K14561]
100391357  GNL2; nucleolar GTP-binding protein 2 isoform X1 [KO:K14537]
100391444  UTP6; U3 small nucleolar RNA-associated protein 6 homolog isoform X1 [KO:K14557]
100391650  TCOF1; treacle protein isoform X1 [KO:K14562]
100392426  DKC1; H/ACA ribonucleoprotein complex subunit DKC1 isoform X2 [KO:K11131] [EC:5.4.99.-]
100392626  GNL3; guanine nucleotide-binding protein-like 3 [KO:K14538]
100392840  TBL3; transducin beta-like protein 3 isoform X1 [KO:K14555]
100394672  POP7; ribonuclease P protein subunit p20 isoform X1 [KO:K14527] [EC:3.1.26.5]
100394793  RPP25L; ribonuclease P protein subunit p25-like protein [KO:K14525] [EC:3.1.26.5]
100394942  EIF6; eukaryotic translation initiation factor 6 [KO:K03264]
100396151  POP4; ribonuclease P protein subunit p29 [KO:K03538] [EC:3.1.26.5]
100396666  WDR75; WD repeat-containing protein 75 [KO:K14552]
100397211  [KO:K14570] [EC:3.1.-.-]
100397387  NXF3; nuclear RNA export factor 3 isoform X6 [KO:K14284]
100398207  RIOK1; serine/threonine-protein kinase RIO1 [KO:K07178] [EC:2.7.11.1]
100398373  WDR3; WD repeat-containing protein 3 isoform X1 [KO:K14556]
100398529  RRP7A; ribosomal RNA-processing protein 7 homolog A [KO:K14545]
100399011  MPHOSPH10; U3 small nucleolar ribonucleoprotein protein MPP10 isoform X1 [KO:K14559]
100399143  LSG1; large subunit GTPase 1 homolog [KO:K14539] [EC:3.6.1.-]
100399568  EFL1; elongation factor-like GTPase 1 isoform X1 [KO:K14536] [EC:3.6.5.-]
100399719  NXF1; nuclear RNA export factor 1 isoform X2 [KO:K14284]
100399975  WDR43; WD repeat-containing protein 43 isoform X1 [KO:K14546]
100400534  GTPBP4; nucleolar GTP-binding protein 1 [KO:K06943]
100400781  RBM28; RNA-binding protein 28 isoform X1 [KO:K14573]
100400787  RAN; GTP-binding nuclear protein Ran [KO:K07936]
100401215  UTP4; U3 small nucleolar RNA-associated protein 4 homolog isoform X6 [KO:K14548]
100401657  RPP25; ribonuclease P protein subunit p25 [KO:K14525] [EC:3.1.26.5]
100401722  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
100401830  RIOK2; serine/threonine-protein kinase RIO2 [KO:K07179] [EC:2.7.11.1]
100402600  NOP58; nucleolar protein 58 isoform X2 [KO:K14565]
100403182  NOP56; nucleolar protein 56 [KO:K14564]
100403290  REXO1; RNA exonuclease 1 homolog isoform X1 [KO:K14570] [EC:3.1.-.-]
100403517  NVL; nuclear valosin-containing protein-like isoform X1 [KO:K14571]
100403652  RPP40; ribonuclease P protein subunit p40 isoform X1 [KO:K14530] [EC:3.1.26.5]
100404165  RPP38; ribonuclease P protein subunit p38 [KO:K14523] [EC:3.1.26.5]
100405107  NXT1; NTF2-related export protein 1 [KO:K14285]
100405453  NOB1; RNA-binding protein NOB1 [KO:K11883]
100405849  UTP18; U3 small nucleolar RNA-associated protein 18 homolog [KO:K14553]
100406743  NOP10; H/ACA ribonucleoprotein complex subunit 3 [KO:K11130]
100407425  GNL3L; guanine nucleotide-binding protein-like 3-like protein isoform X1 [KO:K14538]
100408246  HEATR1; HEAT repeat-containing protein 1 [KO:K14550]
100408938  RPP30; ribonuclease P protein subunit p30 isoform X1 [KO:K03539] [EC:3.1.26.5]
100409166  [KO:K14560]
100409888  REXO2; oligoribonuclease, mitochondrial isoform X2 [KO:K13288] [EC:3.1.-.-]
100410049  UTP15; U3 small nucleolar RNA-associated protein 15 homolog [KO:K14549]
100410392  XPO1; exportin-1 isoform X1 [KO:K14290]
100410924  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
100411554  EMG1; ribosomal RNA small subunit methyltransferase NEP1 isoform X1 [KO:K14568] [EC:2.1.1.260]
100412435  NMD3; 60S ribosomal export protein NMD3 isoform X4 [KO:K07562]
100412539  RCL1; RNA 3'-terminal phosphate cyclase-like protein isoform X1 [KO:K11108]
100412678  XRN1; 5'-3' exoribonuclease 1 isoform X7 [KO:K12618] [EC:3.1.13.-]
100412824  FBL; rRNA 2'-O-methyltransferase fibrillarin isoform X1 [KO:K14563] [EC:2.1.1.-]
100414021  CSNK2A1; LOW QUALITY PROTEIN: casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
100414467  FBLL1; rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 [KO:K14563] [EC:2.1.1.-]
100414839  DROSHA; ribonuclease 3 isoform X1 [KO:K03685] [EC:3.1.26.3]
100414986  [KO:K14284]
100895978  [KO:K03115]
100897011  AK6; adenylate kinase isoenzyme 6 isoform X2 [KO:K18532] [EC:2.7.4.3]
103787500  [KO:K11130]
103789626  [KO:K11130]
103790736  [KO:K14284]
103791808  [KO:K11130]
103794563  [KO:K18532] [EC:2.7.4.3]
110006321  [KO:K01986]
118143272  [KO:K01981]
118143273  [KO:K14483]
118143276  [KO:K14483]
118143379  [KO:K01981]
118143561  [KO:K14483]
118144046  [KO:K14483]
118144047  [KO:K14483]
118144515  [KO:K01981]
118144616  [KO:K01981]
118145175  [KO:K01981]
118145183  [KO:K14483]
118145184  [KO:K14483]
118145185  [KO:K14483]
118145842  [KO:K14483]
118145843  [KO:K14483]
118145845  [KO:K14483]
118146455  [KO:K01981]
118146559  [KO:K01981]
118146614  [KO:K01981]
118147117  [KO:K14483]
118147118  [KO:K14483]
118147478  [KO:K01981]
118147644  [KO:K01981]
118147653  [KO:K01981]
118147658  [KO:K14483]
118147659  [KO:K14483]
118147660  [KO:K14483]
118147885  [KO:K01981]
118148057  [KO:K01981]
118148092  [KO:K01981]
118148205  [KO:K01981]
118148247  [KO:K14483]
118148249  [KO:K14483]
118148250  [KO:K14483]
118148353  [KO:K01981]
118148522  [KO:K01981]
118148741  [KO:K14483]
118148742  [KO:K14483]
118148743  [KO:K14483]
118149087  [KO:K14483]
118149566  [KO:K01981]
118149572  [KO:K01981]
118149583  [KO:K01981]
118149594  [KO:K01981]
118149605  [KO:K01981]
118149616  [KO:K01981]
118149627  [KO:K01981]
118149632  [KO:K01981]
118149637  [KO:K01981]
118149643  [KO:K14483]
118149644  [KO:K14483]
118149648  [KO:K01981]
118149659  [KO:K01981]
118150032  [KO:K14483]
118150318  [KO:K01981]
118150389  [KO:K01981]
118150395  [KO:K14483]
118150398  [KO:K14483]
118150676  [KO:K01981]
118150681  [KO:K14483]
118150683  [KO:K14483]
118150787  [KO:K01981]
118150858  [KO:K01981]
118150859  [KO:K01981]
118151690  [KO:K01981]
118151721  [KO:K14483]
118151722  [KO:K14483]
118151803  [KO:K01981]
118151910  [KO:K01981]
118152425  [KO:K14483]
118152516  [KO:K01981]
118153073  [KO:K14567]
118153174  [KO:K01981]
118153176  [KO:K14483]
118153177  [KO:K14483]
118153178  [KO:K14483]
118153181  [KO:K14483]
118153281  [KO:K01981]
118154081  [KO:K01981]
118154113  [KO:K14483]
118154114  [KO:K14483]
118154115  [KO:K14483]
118154116  [KO:K14483]
118154117  [KO:K14483]
118154119  [KO:K14483]
118154192  [KO:K01981]
118154295  [KO:K01981]
118154825  [KO:K14483]
128930254  [KO:K01981]
128930255  [KO:K01981]
128930256  [KO:K01981]
128930257  [KO:K01981]
128930258  [KO:K01981]
128930259  [KO:K01981]
128930260  [KO:K01981]
128930261  [KO:K01981]
128930262  [KO:K01981]
128930263  [KO:K01981]
128930264  [KO:K01981]
128930778  [KO:K01986]
128930779  [KO:K01979]
128930796  [KO:K01979]
128930797  [KO:K01979]
128930798  [KO:K01982]
128930799  [KO:K01982]
128930800  [KO:K01986]
128930801  [KO:K01986]
Reference
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
DOI:10.1039/b919670f
Reference
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
DOI:10.1128/MCB.00380-07
Reference
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
DOI:10.1261/rna.1792109
Reference
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
DOI:10.1016/j.yexcr.2004.03.016
Reference
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
DOI:10.1016/j.bbamcr.2009.10.009
Related
pathway
cjc03010  Ribosome
KO pathway
ko03008   

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