KEGG   PATHWAY: cmk04070
Entry
cmk04070                    Pathway                                
Name
Phosphatidylinositol signaling system - Callorhinchus milii (elephant shark)
Class
Environmental Information Processing; Signal transduction
Pathway map
cmk04070  Phosphatidylinositol signaling system
cmk04070

Organism
Callorhinchus milii (elephant shark) [GN:cmk]
Gene
103171709  [KO:K05858] [EC:3.1.4.11]
103171932  pi4k2a; phosphatidylinositol 4-kinase type 2-alpha [KO:K13711] [EC:2.7.1.67]
103172674  [KO:K00901] [EC:2.7.1.107]
103173408  [KO:K00901] [EC:2.7.1.107]
103173892  pi4kb; phosphatidylinositol 4-kinase beta [KO:K19801] [EC:2.7.1.67]
103174900  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923] [EC:2.7.1.154]
103175241  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103175619  [KO:K02677] [EC:2.7.11.13]
103175828  pi4k2b; phosphatidylinositol 4-kinase type 2-beta [KO:K13711] [EC:2.7.1.67]
103175843  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103175953  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
103176143  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
103176337  pip4k2aa; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
103176536  inpp1; inositol polyphosphate 1-phosphatase [KO:K01107] [EC:3.1.3.57]
103176603  mtmr14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
103176653  ip6k2; inositol hexakisphosphate kinase 2 [KO:K07756] [EC:2.7.4.21]
103176753  ip6k1; inositol hexakisphosphate kinase 1 [KO:K07756] [EC:2.7.4.21]
103177132  [KO:K01109] [EC:3.1.3.66]
103177560  ocrl; inositol polyphosphate 5-phosphatase OCRL isoform X1 [KO:K01099] [EC:3.1.3.36]
103177640  [KO:K00901] [EC:2.7.1.107]
103177781  [KO:K02649]
103178107  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
103178229  mtmr7b; myotubularin-related protein 7b [KO:K18083] [EC:3.1.3.64 3.1.3.95]
103178360  mtmr1b; myotubularin-related protein 1b isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
103178361  mtm1; myotubularin isoform X1 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
103178403  ppip5k2; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1 [KO:K13024] [EC:2.7.4.24]
103178658  mtmr8; myotubularin-related protein 8 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
103179101  inppl1a; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A [KO:K15909] [EC:3.1.3.86]
103179112  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103179118  [KO:K07756] [EC:2.7.4.21]
103179631  inpp5b; type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [KO:K01099] [EC:3.1.3.36]
103180430  [KO:K01106] [EC:3.1.3.56]
103180496  mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
103180693  plce1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
103180747  impa1; inositol monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
103180765  bpnt2; inositol monophosphatase 3 [KO:K15759] [EC:3.1.3.7]
103180796  calm2a; calmodulin 2a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
103180851  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103180872  cds1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
103180913  ipmkb; inositol polyphosphate multikinase isoform X1 [KO:K00915] [EC:2.7.1.140 2.7.1.151]
103181014  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
103181657  [KO:K20279] [EC:3.1.3.36]
103182064  [KO:K02649]
103182539  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
103182640  dgkb; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
103182762  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
103182909  [KO:K00901] [EC:2.7.1.107]
103182931  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
103183266  mtmr6; myotubularin-related protein 6 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
103183929  [KO:K21797] [EC:3.1.3.-]
103184004  pi4kab; phosphatidylinositol 4-kinase, catalytic, alpha b [KO:K00888] [EC:2.7.1.67]
103184098  mtmr2; myotubularin-related protein 2 isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
103184230  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103184352  mtmr3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
103184698  inpp5e; phosphatidylinositol polyphosphate 5-phosphatase type IV [KO:K20278] [EC:3.1.3.36]
103185072  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103185096  [KO:K02183]
103185350  [KO:K02183]
103185398  itpk1a; inositol-tetrakisphosphate 1-kinase a [KO:K00913] [EC:2.7.1.159 2.7.1.134]
103185456  inpp5f; phosphatidylinositide phosphatase SAC2 isoform X1 [KO:K21798] [EC:3.1.3.-]
103185584  [KO:K05861] [EC:3.1.4.11]
103185799  inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X2 [KO:K03084] [EC:3.1.3.86]
103186275  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
103186617  prkcba; protein kinase C, beta a [KO:K19662] [EC:2.7.11.13]
103186638  [KO:K00901] [EC:2.7.1.107]
103187290  synj1; synaptojanin-1 isoform X2 [KO:K20279] [EC:3.1.3.36]
103187499  [KO:K05858] [EC:3.1.4.11]
103187607  dgkh; diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
103187625  itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
103187635  [KO:K05858] [EC:3.1.4.11]
103187668  [KO:K02183]
103188137  [KO:K00889] [EC:2.7.1.68]
103188433  ppip5k1a; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1 [KO:K13024] [EC:2.7.4.24]
103188780  ippk; inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
103188869  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103189073  [KO:K00920] [EC:2.7.1.149]
103189580  [KO:K02183]
103189661  calm1a; calmodulin-1a [KO:K02183]
103189707  [KO:K05857] [EC:3.1.4.11]
103189708  [KO:K05857] [EC:3.1.4.11]
103189804  plcd4b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
103190084  si:dkey-172j4.3; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
103190206  [KO:K00920] [EC:2.7.1.149]
103190745  dgke; diacylglycerol kinase epsilon isoform X1 [KO:K00901] [EC:2.7.1.107]
103190839  [KO:K15759] [EC:3.1.3.7]
103190888  [KO:K00911] [EC:2.7.1.127]
103191060  pip4p2; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase [KO:K13084] [EC:3.1.3.78]
103191064  [KO:K02183]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
cmk04020  Calcium signaling pathway
cmk04144  Endocytosis
cmk04510  Focal adhesion
KO pathway
ko04070   

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