KEGG   PATHWAY: ko04070
Entry
ko04070                     Pathway                                
Name
Phosphatidylinositol signaling system
Class
Environmental Information Processing; Signal transduction
Pathway map
ko04070  Phosphatidylinositol signaling system
ko04070

Drug
D04789  Lubeluzole (USAN/INN)
Orthology
K00888  phosphatidylinositol 4-kinase A [EC:2.7.1.67]
K19801  phosphatidylinositol 4-kinase B [EC:2.7.1.67]
K13711  phosphatidylinositol 4-kinase type 2 [EC:2.7.1.67]
K21797  phosphatidylinositol 4-phosphatase [EC:3.1.3.-]
K21798  phosphatidylinositol 4-phosphatase [EC:3.1.3.-]
K00889  1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
K01099  inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
K20278  inositol polyphosphate 5-phosphatase INPP5E [EC:3.1.3.36]
K20279  synaptojanin [EC:3.1.3.36]
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K03084  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
K15909  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
K01109  inositol polyphosphate-4-phosphatase [EC:3.1.3.66]
K00921  1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
K01108  myotubularin [EC:3.1.3.64 3.1.3.95]
K18081  myotubularin-related protein 1/2 [EC:3.1.3.64 3.1.3.95]
K18082  myotubularin-related protein 3/4 [EC:3.1.3.48 3.1.3.64 3.1.3.95]
K18083  myotubularin-related protein 6/7/8 [EC:3.1.3.64 3.1.3.95]
K18086  myotubularin-related protein 14 [EC:3.1.3.64 3.1.3.95]
K00920  1-phosphatidylinositol-5-phosphate 4-kinase [EC:2.7.1.149]
K13084  phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78]
K00914  phosphatidylinositol 3-kinase [EC:2.7.1.137]
K00923  phosphatidylinositol-4-phosphate 3-kinase [EC:2.7.1.154]
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05857  phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
K05860  phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K05861  phosphatidylinositol phospholipase C, zeta [EC:3.1.4.11]
K00915  inositol-polyphosphate multikinase [EC:2.7.1.140 2.7.1.151]
K00911  1D-myo-inositol-triphosphate 3-kinase [EC:2.7.1.127]
K01106  inositol polyphosphate 5-phosphatase INPP5A [EC:3.1.3.56]
K00913  inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase [EC:2.7.1.159 2.7.1.134]
K10572  inositol-pentakisphosphate 2-kinase [EC:2.7.1.158]
K19786  inositol-pentakisphosphate 2-kinase [EC:2.7.1.158]
K07756  inositol-hexakisphosphate 5-kinase [EC:2.7.4.21]
K13024  inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase [EC:2.7.4.24]
K01107  inositol polyphosphate 1-phosphatase [EC:3.1.3.57]
K15422  3'(2'), 5'-bisphosphate nucleotidase / inositol polyphosphate 1-phosphatase [EC:3.1.3.7 3.1.3.57]
K01092  myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]
K10047  inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase [EC:3.1.3.25 3.1.3.93]
K18649  inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase [EC:3.1.3.25 3.1.3.93 3.1.3.15]
K15759  Golgi-resident PAP phosphatase [EC:3.1.3.7]
K00901  diacylglycerol kinase (ATP) [EC:2.7.1.107]
K00981  phosphatidate cytidylyltransferase [EC:2.7.7.41]
K00999  CDP-diacylglycerol--inositol 3-phosphatidyltransferase [EC:2.7.8.11]
K04958  inositol 1,4,5-triphosphate receptor type 1
K04959  inositol 1,4,5-triphosphate receptor type 2
K04960  inositol 1,4,5-triphosphate receptor type 3
K02677  classical protein kinase C alpha type [EC:2.7.11.13]
K19662  classical protein kinase C beta type [EC:2.7.11.13]
K19663  classical protein kinase C gamma type [EC:2.7.11.13]
K02183  calmodulin
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
ko04020  Calcium signaling pathway
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
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