KEGG   PATHWAY: ko04070
Entry
ko04070                     Pathway                                
Name
Phosphatidylinositol signaling system
Class
Environmental Information Processing; Signal transduction
Pathway map
ko04070  Phosphatidylinositol signaling system
ko04070

Drug
D04789  Lubeluzole (USAN/INN)
Orthology
K00888  PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
K00901  dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]
K00911  ITPK; 1D-myo-inositol-triphosphate 3-kinase [EC:2.7.1.127]
K00913  ITPK1; inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase [EC:2.7.1.159 2.7.1.134]
K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
K00915  IPMK, IPK2; inositol-polyphosphate multikinase [EC:2.7.1.140 2.7.1.151]
K00920  PIP4K2; 1-phosphatidylinositol-5-phosphate 4-kinase [EC:2.7.1.149]
K00921  PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00923  PIK3C2; phosphatidylinositol-4-phosphate 3-kinase [EC:2.7.1.154]
K00981  E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]
K00999  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [EC:2.7.8.11]
K01092  E3.1.3.25, IMPA, suhB; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]
K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
K01106  INPP5A; inositol polyphosphate 5-phosphatase INPP5A [EC:3.1.3.56]
K01107  INPP1; inositol polyphosphate 1-phosphatase [EC:3.1.3.57]
K01108  MTM1; myotubularin [EC:3.1.3.64 3.1.3.95]
K01109  INPP4; inositol polyphosphate-4-phosphatase [EC:3.1.3.66]
K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K02183  CALM; calmodulin
K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02677  PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
K05857  PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K05860  PLCE; phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
K05861  PLCZ; phosphatidylinositol phospholipase C, zeta [EC:3.1.4.11]
K07756  IP6K, IHPK; inositol-hexakisphosphate 5-kinase [EC:2.7.4.21]
K10047  VTC4; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase [EC:3.1.3.25 3.1.3.93]
K10572  IPPK; inositol-pentakisphosphate 2-kinase [EC:2.7.1.158]
K13024  PPIP5K, VIP; inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase [EC:2.7.4.24]
K13084  TMEM55; phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78]
K13711  PI4K2; phosphatidylinositol 4-kinase type 2 [EC:2.7.1.67]
K15422  SAL; 3'(2'), 5'-bisphosphate nucleotidase / inositol polyphosphate 1-phosphatase [EC:3.1.3.7 3.1.3.57]
K15759  IMPAD1, IMPA3; Golgi-resident PAP phosphatase [EC:3.1.3.7]
K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
K18081  MTMR1_2; myotubularin-related protein 1/2 [EC:3.1.3.64 3.1.3.95]
K18082  MTMR3_4, ZFYVE10_11; myotubularin-related protein 3/4 [EC:3.1.3.48 3.1.3.64 3.1.3.95]
K18083  MTMR6_7_8; myotubularin-related protein 6/7/8 [EC:3.1.3.64 3.1.3.95]
K18086  MTMR14; myotubularin-related protein 14 [EC:3.1.3.64 3.1.3.95]
K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase [EC:3.1.3.25 3.1.3.93 3.1.3.15]
K19662  PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
K19663  PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
K19786  IPK1; inositol-pentakisphosphate 2-kinase [EC:2.7.1.158]
K19801  PI4KB; phosphatidylinositol 4-kinase B [EC:2.7.1.67]
K20278  INPP5E; inositol polyphosphate 5-phosphatase INPP5E [EC:3.1.3.36]
K20279  SYNJ; synaptojanin [EC:3.1.3.36]
K21797  SAC1, SACM1L; phosphatidylinositol 4-phosphatase [EC:3.1.3.-]
K21798  SAC2, INPP5F; phosphatidylinositol 4-phosphatase [EC:3.1.3.-]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
ko04020  Calcium signaling pathway
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion

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