KEGG   PATHWAY: csyr04514
Entry
csyr04514                   Pathway                                
Name
Cell adhesion molecules - Carlito syrichta (Philippine tarsier)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
csyr04514  Cell adhesion molecules
csyr04514

Other DBs
GO: 0050839
Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103249440  CD6; T-cell differentiation antigen CD6 [KO:K06456]
103249833  GLG1; Golgi apparatus protein 1 [KO:K06816]
103250260  NLGN3; neuroligin-3 isoform X2 [KO:K07378]
103250407  ICAM3; intercellular adhesion molecule 3 [KO:K06486]
103250682  NECTIN2; nectin-2 [KO:K06531]
103250901  CLDN15; claudin-15 [KO:K06087]
103251072  NRXN2; neurexin-2-beta [KO:K07377]
103251393  [KO:K06751]
103251727  CDH3; cadherin-3 [KO:K06796]
103251751  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
103251952  SLITRK4; SLIT and NTRK-like protein 4 isoform X1 [KO:K25835]
103252040  CLDN6; claudin-6 [KO:K06087]
103252041  CLDN9; claudin-9 [KO:K06087]
103252060  CDH5; cadherin-5 [KO:K06533]
103252157  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
103252318  JAML; junctional adhesion molecule-like [KO:K28137]
103252597  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
103252995  CLDN23; claudin-23 [KO:K06087]
103253502  NTNG1; netrin-G1 [KO:K07522]
103253692  CD22; B-cell receptor CD22 isoform X1 [KO:K06467]
103253693  MAG; myelin-associated glycoprotein [KO:K06771]
103253740  CD99; CD99 antigen [KO:K06520]
103253747  [KO:K06592]
103254135  CLDN14; claudin-14 [KO:K06087]
103254574  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
103254992  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
103255013  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
103255115  L1CAM; neural cell adhesion molecule L1 [KO:K06550]
103255186  [KO:K06809]
103255322  NLGN1; neuroligin-1 [KO:K07378]
103255387  NEO1; neogenin [KO:K06766]
103256188  [KO:K06585]
103256205  CLDN11; claudin-11 isoform X1 [KO:K06087]
103256945  [KO:K06752]
103257015  PTPRF; receptor-type tyrosine-protein phosphatase F [KO:K05695] [EC:3.1.3.48]
103257026  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
103257038  NCAM1; neural cell adhesion molecule 1 isoform X5 [KO:K06491]
103257081  PTPRD; receptor-type tyrosine-protein phosphatase delta isoform X3 [KO:K06777] [EC:3.1.3.48]
103257526  NEGR1; neuronal growth regulator 1 [KO:K06775]
103258044  CLDN4; claudin-4 [KO:K06087]
103258362  PVR; poliovirus receptor [KO:K06539]
103258677  VTCN1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
103258835  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
103258929  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
103259098  SLITRK2; SLIT and NTRK-like protein 2 isoform X1 [KO:K25833]
103259745  [KO:K05693] [EC:3.1.3.48]
103259856  SDC4; syndecan-4 [KO:K16338]
103260120  ITGAL; integrin alpha-L [KO:K05718]
103260184  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
103260259  MPZ; LOW QUALITY PROTEIN: myelin protein P0 [KO:K06770]
103260263  CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160]
103260344  CD274; programmed cell death 1 ligand 1 [KO:K06745]
103260347  PDCD1LG2; LOW QUALITY PROTEIN: programmed cell death 1 ligand 2 [KO:K06708]
103260420  CADM1; cell adhesion molecule 1 [KO:K06781]
103260503  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
103261286  ALCAM; CD166 antigen isoform X1 [KO:K06547]
103261501  NRXN3; neurexin 3 isoform X1 [KO:K07377]
103261829  NECTIN1; nectin-1 [KO:K06081]
103261972  VCAN; versican core protein isoform X1 [KO:K06793]
103262170  CD99L2; CD99 antigen-like protein 2 [KO:K06520]
103262509  SDC1; syndecan-1 [KO:K06257]
103262522  CD2; T-cell surface antigen CD2 isoform X1 [KO:K06449]
103262681  [KO:K06752]
103262695  [KO:K06752]
103262757  [KO:K06752]
103262792  SLITRK5; SLIT and NTRK-like protein 5 [KO:K25836]
103262803  PECAM1; platelet endothelial cell adhesion molecule [KO:K06471]
103262952  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
103263231  CLDN7; claudin-7 isoform X1 [KO:K06087]
103263605  ITGA9; integrin alpha-9 [KO:K06585]
103263681  SELP; P-selectin [KO:K06496]
103263682  SELL; LOW QUALITY PROTEIN: L-selectin [KO:K06495]
103263683  SELE; E-selectin [KO:K06494]
103263899  ITGB2; integrin beta-2 [KO:K06464]
103264224  CLDN8; claudin-8 [KO:K06087]
103264225  CLDN17; claudin-17 [KO:K06087]
103264400  ITGAM; integrin alpha-M [KO:K06461]
103264529  ITGA8; integrin alpha-8 [KO:K06584]
103264556  CLDN20; claudin-20 [KO:K06087]
103264616  NLGN2; neuroligin-2 [KO:K07378]
103264708  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
103265096  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
103265416  PDCD1; programmed cell death protein 1 [KO:K06744]
103265727  CLDN12; claudin-12 [KO:K06087]
103265735  SDC2; syndecan-2 [KO:K16336]
103266179  [KO:K06087]
103266180  CLDN22; claudin-22 [KO:K06087]
103266905  [KO:K06752]
103266944  CADM3; cell adhesion molecule 3 isoform X2 [KO:K06780]
103267098  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
103267282  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
103267346  CDH4; cadherin-4 isoform X1 [KO:K06797]
103267365  [KO:K06752]
103267557  JAM2; junctional adhesion molecule B [KO:K06735]
103267738  CNTN1; contactin-1 isoform X1 [KO:K06759]
103267842  [KO:K07378]
103267988  [KO:K06752]
103268155  ITGAV; integrin alpha-V [KO:K06487]
103268306  TIGIT; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
103268377  F11R; junctional adhesion molecule A [KO:K06089]
103268467  [KO:K06751]
103268676  [KO:K05689]
103268681  SDC3; syndecan-3 isoform X2 [KO:K16337]
103268981  SIGLEC1; LOW QUALITY PROTEIN: sialoadhesin [KO:K06548]
103269706  NRXN1; neurexin-1 isoform X10 [KO:K07377]
103270208  [KO:K10785]
103270219  [KO:K10785]
103270328  CD226; CD226 antigen [KO:K06567]
103270357  OCLN; occludin isoform X1 [KO:K06088]
103270702  CNTNAP1; contactin-associated protein 1 [KO:K07379]
103270788  CD34; hematopoietic progenitor cell antigen CD34 [KO:K06474]
103270895  ITGB8; integrin beta-8 [KO:K06591]
103271428  IGSF11; immunoglobulin superfamily member 11 isoform X1 [KO:K06791]
103271436  [KO:K06751]
103271929  [KO:K06752]
103271936  [KO:K06752]
103272282  [KO:K06752]
103272617  ICOSLG; ICOS ligand [KO:K06710]
103272700  [KO:K06464]
103272733  CD40LG; CD40 ligand isoform X1 [KO:K03161]
103273336  ITGA6; integrin alpha-6 isoform X2 [KO:K06485]
103273408  JAM3; LOW QUALITY PROTEIN: junctional adhesion molecule C [KO:K06785]
103273427  ITGA4; integrin alpha-4 [KO:K06483]
103273493  CD276; CD276 antigen [KO:K06746]
103273534  [KO:K06751]
103273536  [KO:K06751]
103274023  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
103274064  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
103274065  CLDN1; claudin-1 [KO:K06087]
103274113  CDH2; cadherin-2 isoform X1 [KO:K06736]
103274618  ITGB7; integrin beta-7 [KO:K06590]
103274708  CLDN10; claudin-10 isoform X1 [KO:K06087]
103275005  SLITRK3; SLIT and NTRK-like protein 3 isoform X1 [KO:K25834]
103275067  CLDN18; claudin-18 isoform X1 [KO:K06087]
103275195  CLDN19; claudin-19 [KO:K06087]
103275437  CXADR; coxsackievirus and adenovirus receptor [KO:K06788]
103275455  CLDN2; claudin-2 [KO:K06087]
103275959  CLDN25; putative claudin-25 [KO:K06087]
103276097  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
103276636  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
103276810  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
103276858  CD28; T-cell-specific surface glycoprotein CD28 isoform X1 [KO:K06470]
103276859  CTLA4; cytotoxic T-lymphocyte protein 4 isoform X1 [KO:K06538]
103276881  ICOS; inducible T-cell costimulator [KO:K06713]
103276998  [KO:K06751]
103277080  [KO:K06751]
103277277  CNTN2; contactin-2 [KO:K06760]
103277278  NFASC; neurofascin isoform X2 [KO:K06757]
110596462  SPN; leukosialin [KO:K06477]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
csyr04520  Adherens junction
csyr04530  Tight junction
csyr04610  Complement and coagulation cascades
csyr04660  T cell receptor signaling pathway
csyr04670  Leukocyte transendothelial migration
KO pathway
ko04514   

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