KEGG   PATHWAY: dme00280
Entry
dme00280                    Pathway                                
Name
Valine, leucine and isoleucine degradation - Drosophila melanogaster (fruit fly)
Class
Metabolism; Amino acid metabolism
Pathway map
dme00280  Valine, leucine and isoleucine degradation
dme00280

Module
dme_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:dme00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG10399  Hmgcl; 3-Hydroxymethyl-3-methylglutaryl-CoA lyase, isoform B [KO:K01640] [EC:4.1.3.4]
Dmel_CG10932  Acat1; Acetyl-CoA acetyltransferase 1, isoform B [KO:K00626] [EC:2.3.1.9]
Dmel_CG11241  CG11241; uncharacterized protein, isoform C [KO:K00827] [EC:2.6.1.44 2.6.1.40]
Dmel_CG1140  SCOT; Succinyl-CoA:3-ketoacid CoA transferase, isoform A [KO:K01027] [EC:2.8.3.5]
Dmel_CG12262  Mcad; Medium-chain acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
Dmel_CG15093  CG15093; uncharacterized protein, isoform E [KO:K23146]
Dmel_CG1673  Bcat; branched chain amino acid transaminase [KO:K00826] [EC:2.6.1.42]
Dmel_CG17691  BckdhB; branched chain keto acid dehydrogenase E1 subunit beta, isoform E [KO:K00167] [EC:1.2.4.4]
Dmel_CG17896  CG17896; uncharacterized protein, isoform B [KO:K00140] [EC:1.2.1.18 1.2.1.27]
Dmel_CG18155  Acsf3; Acyl-CoA synthetase family member 3 [KO:K18660] [EC:6.2.1.76 6.2.1.-]
Dmel_CG2118  Mccc1; Methylcrotonoyl-CoA carboxylase 1, isoform C [KO:K01968] [EC:6.4.1.4]
Dmel_CG31075  CG31075; uncharacterized protein, isoform B [KO:K00128] [EC:1.2.1.3]
Dmel_CG3267  Mccc2; Methylcrotonoyl-CoA carboxylase 2 [KO:K01969] [EC:6.4.1.4]
Dmel_CG3752  Aldh; aldehyde dehydrogenase, isoform B [KO:K00128] [EC:1.2.1.3]
Dmel_CG3902  CG3902; uncharacterized protein [KO:K09478] [EC:1.3.8.5]
Dmel_CG4311  Hmgs; HMG coenzyme A synthase, isoform F [KO:K01641] [EC:2.3.3.10]
Dmel_CG4389  Mtpalpha; mitochondrial trifunctional protein alpha subunit, isoform A [KO:K07515] [EC:4.2.1.17 1.1.1.211]
Dmel_CG4581  Mtpbeta; mitochondrial trifunctional protein beta subunit [KO:K07509] [EC:2.3.1.16]
Dmel_CG4600  yip2; yippee interacting protein 2 [KO:K07508] [EC:2.3.1.16]
Dmel_CG4703  Arc42; Activator-recruited cofactor subunit 42 [KO:K00248] [EC:1.3.8.1]
Dmel_CG4860  CG4860; uncharacterized protein [KO:K00248] [EC:1.3.8.1]
Dmel_CG5044  Hibch; 3-hydroxyisobutyryl-CoA hydrolase, isoform A [KO:K05605] [EC:3.1.2.4]
Dmel_CG5599  Dbct; dihydrolipoamide branched chain transacylase E2 [KO:K09699] [EC:2.3.1.168]
Dmel_CG6543  Echs1; Enoyl-CoA hydratase, short chain 1, isoform A [KO:K07511] [EC:4.2.1.17]
Dmel_CG6638  CG6638; uncharacterized protein [KO:K00253] [EC:1.3.8.4]
Dmel_CG7113  scu; scully, isoform A [KO:K08683] [EC:1.1.1.35 1.1.1.178]
Dmel_CG7430  CG7430; uncharacterized protein, isoform B [KO:K00382] [EC:1.8.1.4]
Dmel_CG7433  Gabat; gamma-aminobutyric acid transaminase, isoform C [KO:K13524] [EC:2.6.1.19 2.6.1.22]
Dmel_CG8199  BckdhA; branched chain keto acid dehydrogenase E1 subunit alpha [KO:K00166] [EC:1.2.4.4]
Dmel_CG8778  CG8778; uncharacterized protein [KO:K05607] [EC:4.2.1.18]
Dmel_CG9149  Acat2; Acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
Dmel_CG9629  Aldh7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
dme00020  Citrate cycle (TCA cycle)
dme00240  Pyrimidine metabolism
dme00290  Valine, leucine and isoleucine biosynthesis
dme00640  Propanoate metabolism
dme00900  Terpenoid backbone biosynthesis
KO pathway
ko00280   

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