KEGG   PATHWAY: dnm04514
Entry
dnm04514                    Pathway                                
Name
Cell adhesion molecules - Dasypus novemcinctus (nine-banded armadillo)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
dnm04514  Cell adhesion molecules
dnm04514

Other DBs
GO: 0050839
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
101421117  CD2; T-cell surface antigen CD2 isoform X1 [KO:K06449]
101417384  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
101432127  IGSF11; immunoglobulin superfamily member 11 [KO:K06791]
101423192  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
101414633  CD274; programmed cell death 1 ligand 1 [KO:K06745]
101415501  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
101412832  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
101415938  CTLA4; cytotoxic T-lymphocyte protein 4 isoform X1 [KO:K06538]
101420642  ICOSLG; ICOS ligand [KO:K06710]
101416651  ICOS; inducible T-cell costimulator [KO:K06713]
101415145  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
101437028  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101443412  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
101438478  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
101440773  HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
101433781  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
101435501  HLA class II histocompatibility antigen, DQ alpha 1 chain-like [KO:K06752]
101435917  HLA class II histocompatibility antigen, DQ alpha 2 chain-like isoform X1 [KO:K06752]
101436345  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
101437751  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
101415573  HLA class II histocompatibility antigen, DP beta 1 chain-like isoform X1 [KO:K06752]
101417015  HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [KO:K06752]
101417743  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
101421271  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101421706  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
101411381  CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
101428513  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
101420800  saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751]
101415823  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101418741  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
101446223  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101415391  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
101439136  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101439564  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101435448  HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
111758663  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
101430252  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X2 [KO:K06751]
101444704  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
101426756  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101438484  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101411165  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
101427038  HLA class I histocompatibility antigen, B-37 alpha chain-like isoform X1 [KO:K06751]
101412608  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101447227  HLA class I histocompatibility antigen, Cw-14 alpha chain-like [KO:K06751]
101442840  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
101411454  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
101413764  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101415824  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
105744147  saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751]
101441690  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101444673  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101428809  HLA class I histocompatibility antigen, B-59 alpha chain-like [KO:K06751]
101412139  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101442557  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
101432742  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101437850  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X3 [KO:K06751]
101422560  saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751]
101427325  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101445227  saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751]
101421532  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101424781  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101430113  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101435675  HLA class I histocompatibility antigen, B-15 alpha chain-like isoform X2 [KO:K06751]
101419419  HLA class I histocompatibility antigen, B-73 alpha chain-like [KO:K06751]
101442251  HLA class I histocompatibility antigen, Cw-3 alpha chain-like [KO:K06751]
101439095  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101411831  HLA class I histocompatibility antigen, B-38 alpha chain-like [KO:K06751]
101422917  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101412902  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101422259  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101412468  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101414493  HLA class I histocompatibility antigen, B-42 alpha chain-like isoform X1 [KO:K06751]
101442691  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101432034  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
101424334  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101415212  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101442654  BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
101423203  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
101421485  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
101433987  PDCD1LG2; programmed cell death 1 ligand 2 isoform X3 [KO:K06708]
101411763  CD276; CD276 antigen [KO:K06746]
101441279  VTCN1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
101435928  PDCD1; programmed cell death protein 1 [KO:K06744]
101440382  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
101426835  CD40LG; CD40 ligand [KO:K03161]
101420812  ALCAM; CD166 antigen isoform X1 [KO:K06547]
101416292  CD6; T-cell differentiation antigen CD6 isoform X2 [KO:K06456]
101447759  PVR; poliovirus receptor [KO:K06539]
101419349  CD226; CD226 antigen [KO:K06567]
101422649  NECTIN2; LOW QUALITY PROTEIN: nectin-2 [KO:K06531]
101429768  TIGIT; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
101429504  ITGAL; integrin alpha-L [KO:K05718]
101436037  LOW QUALITY PROTEIN: integrin beta-2 [KO:K06464]
101427372  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
101434965  ICAM2; intercellular adhesion molecule 2 [KO:K06523]
101429136  intercellular adhesion molecule 3 [KO:K06486]
101447165  CD22; B-cell receptor CD22 [KO:K06467]
101447100  receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
101428111  LOW QUALITY PROTEIN: sialoadhesin-like [KO:K06548]
101428480  SIGLEC1; LOW QUALITY PROTEIN: sialoadhesin [KO:K06548]
101424478  SPN; leukosialin [KO:K06477]
101447095  NECTIN3; nectin-3 isoform X1 [KO:K06592]
101423278  CLDN12; claudin-12 [KO:K06087]
101447459  CLDN11; claudin-11 [KO:K06087]
101439409  CLDN10; claudin-10 isoform X1 [KO:K06087]
101441900  CLDN1; claudin-1 [KO:K06087]
101442334  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
101413480  CLDN14; claudin-14 [KO:K06087]
101441290  CLDN6; claudin-6 [KO:K06087]
101441726  CLDN9; claudin-9 [KO:K06087]
101438150  CLDN4; claudin-4 [KO:K06087]
101418006  CLDN19; claudin-19 [KO:K06087]
101433876  CLDN2; claudin-2 [KO:K06087]
101421454  CLDN3; claudin-3 [KO:K06087]
101416315  CLDN25; putative claudin-25 [KO:K06087]
101425087  CLDN23; claudin-23 [KO:K06087]
101445859  CLDN20; claudin-20 [KO:K06087]
101410640  CLDN34; claudin-34 [KO:K06087]
101433682  CLDN18; claudin-18 isoform X1 [KO:K06087]
101414272  CLDN5; claudin-5 [KO:K06087]
101413056  CLDN7; claudin-7 [KO:K06087]
101411848  claudin-17 [KO:K06087]
101435214  CLDN22; claudin-22 [KO:K06087]
101436064  putative claudin-24 [KO:K06087]
101416898  CLDN15; claudin-15 [KO:K06087]
101445217  OCLN; occludin [KO:K06088]
101428495  F11R; junctional adhesion molecule A [KO:K06089]
101424392  JAM2; junctional adhesion molecule B [KO:K06735]
101422596  JAM3; junctional adhesion molecule C isoform X2 [KO:K06785]
101422502  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
101439282  CDH5; cadherin-5 [KO:K06533]
101441845  PECAM1; platelet endothelial cell adhesion molecule [KO:K06471]
101432905  CD99L2; CD99 antigen-like protein 2 [KO:K06520]
101436077  CD99; CD99 antigen [KO:K06520]
101432429  ITGAM; integrin alpha-M [KO:K06461]
101419295  SELPLG; LOW QUALITY PROTEIN: P-selectin glycoprotein ligand 1 [KO:K06544]
101446112  SELP; P-selectin isoform X1 [KO:K06496]
101425815  ITGA4; integrin alpha-4 [KO:K06483]
101428656  ITGB1; integrin beta-1 [KO:K05719]
101430321  ITGA9; integrin alpha-9 [KO:K06585]
101433545  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
101416622  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
101447757  MADCAM1; LOW QUALITY PROTEIN: mucosal addressin cell adhesion molecule 1 [KO:K06779]
101443530  SELL; L-selectin [KO:K06495]
101434106  CD34; hematopoietic progenitor cell antigen CD34 [KO:K06474]
101432445  GLG1; Golgi apparatus protein 1 [KO:K06816]
101443096  SELE; E-selectin isoform X2 [KO:K06494]
101437806  NECTIN1; LOW QUALITY PROTEIN: nectin-1 [KO:K06081]
101427254  CDH2; cadherin-2 [KO:K06736]
101439294  NCAM2; neural cell adhesion molecule 2 [KO:K06491]
101430112  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
101425639  L1CAM; LOW QUALITY PROTEIN: neural cell adhesion molecule L1 [KO:K06550]
101428499  CADM1; cell adhesion molecule 1 isoform X1 [KO:K06781]
101447277  NEGR1; neuronal growth regulator 1 isoform X1 [KO:K06775]
101444757  NTNG1; netrin-G1 [KO:K07522]
101441358  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
101436515  NTNG2; netrin-G2 [KO:K16359]
101421347  LRRC4; leucine-rich repeat-containing protein 4 isoform X1 [KO:K16351]
101437067  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X4 [KO:K05695] [EC:3.1.3.48]
101446848  LRRC4B; LOW QUALITY PROTEIN: leucine-rich repeat-containing protein 4B [KO:K16360]
101438375  SDC1; syndecan-1 [KO:K06257]
101437692  SDC2; syndecan-2 [KO:K16336]
101446714  SDC3; syndecan-3 [KO:K16337]
101420599  SDC4; syndecan-4 [KO:K16338]
101438715  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
101428761  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
101423380  ITGA8; integrin alpha-8 [KO:K06584]
101430950  NRXN2; LOW QUALITY PROTEIN: neurexin-2-beta [KO:K07377]
101421170  NLGN2; LOW QUALITY PROTEIN: neuroligin-2 [KO:K07378]
101434814  NLGN1; neuroligin-1 isoform X2 [KO:K07378]
101438313  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
101414134  neuroligin-4, X-linked isoform X2 [KO:K07378]
101432763  PTPRS; receptor-type tyrosine-protein phosphatase S [KO:K06778] [EC:3.1.3.48]
101430194  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
101442341  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
101417251  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
101443578  SLITRK5; SLIT and NTRK-like protein 5 [KO:K25836]
101441823  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
101436161  PTPRD; receptor-type tyrosine-protein phosphatase delta isoform X2 [KO:K06777] [EC:3.1.3.48]
101428611  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
101430350  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
101438453  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
101442777  CNTN1; contactin-1 isoform X1 [KO:K06759]
101438621  PTPRM; receptor-type tyrosine-protein phosphatase mu [KO:K05693] [EC:3.1.3.48]
101418321  CNTN2; contactin-2 [KO:K06760]
101413510  NFASC; neurofascin isoform X1 [KO:K06757]
101440808  CNTNAP1; contactin-associated protein 1 [KO:K07379]
101414313  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
101444305  MPZ; myelin protein P0 [KO:K06770]
101437046  MAG; myelin-associated glycoprotein isoform X1 [KO:K06771]
101418309  CDH1; cadherin-1 [KO:K05689]
101419402  VCAN; versican core protein [KO:K06793]
101416334  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101414502  CDH3; cadherin-3 [KO:K06796]
101422943  cadherin-4 [KO:K06797]
101444880  NEO1; neogenin isoform X1 [KO:K06766]
Reference
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
dnm04520  Adherens junction
dnm04530  Tight junction
dnm04610  Complement and coagulation cascades
dnm04660  T cell receptor signaling pathway
dnm04670  Leukocyte transendothelial migration
KO pathway
ko04514   
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