Entry
Name
Cell adhesion molecules - Dasypus novemcinctus (nine-banded armadillo)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:
dnm ]
Gene
101417384 VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268 ]
101412832 CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413 ]
101415145 LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752 ]
101437028 LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
101443412 LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752 ]
101438478 HLA class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
101440773 HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752 ]
101433781 HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752 ]
101435501 HLA class II histocompatibility antigen, DQ alpha 1 chain-like [KO:K06752 ]
101435917 HLA class II histocompatibility antigen, DQ alpha 2 chain-like isoform X1 [KO:K06752 ]
101436345 DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752 ]
101437751 HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752 ]
101415573 HLA class II histocompatibility antigen, DP beta 1 chain-like isoform X1 [KO:K06752 ]
101417015 HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [KO:K06752 ]
101417743 HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752 ]
101421271 HLA class II histocompatibility antigen, DM alpha chain [KO:K06752 ]
101421706 HLA class II histocompatibility antigen, DM beta chain [KO:K06752 ]
101428513 class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751 ]
101420800 saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751 ]
101415823 patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751 ]
101418741 HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751 ]
101446223 saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751 ]
101415391 HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751 ]
101439136 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
101439564 patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751 ]
101435448 HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751 ]
111758663 HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751 ]
101430252 class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X2 [KO:K06751 ]
101444704 popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751 ]
101426756 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
101438484 patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751 ]
101411165 popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751 ]
101427038 HLA class I histocompatibility antigen, B-37 alpha chain-like isoform X1 [KO:K06751 ]
101412608 patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751 ]
101447227 HLA class I histocompatibility antigen, Cw-14 alpha chain-like [KO:K06751 ]
101442840 HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751 ]
101411454 HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751 ]
101413764 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
101415824 patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751 ]
105744147 saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751 ]
101441690 saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751 ]
101444673 patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751 ]
101428809 HLA class I histocompatibility antigen, B-59 alpha chain-like [KO:K06751 ]
101412139 LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
101442557 HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751 ]
101432742 patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751 ]
101437850 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X3 [KO:K06751 ]
101422560 saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751 ]
101427325 patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751 ]
101445227 saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751 ]
101421532 saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751 ]
101424781 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
101430113 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
101435675 HLA class I histocompatibility antigen, B-15 alpha chain-like isoform X2 [KO:K06751 ]
101419419 HLA class I histocompatibility antigen, B-73 alpha chain-like [KO:K06751 ]
101442251 HLA class I histocompatibility antigen, Cw-3 alpha chain-like [KO:K06751 ]
101439095 saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751 ]
101411831 HLA class I histocompatibility antigen, B-38 alpha chain-like [KO:K06751 ]
101422917 patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751 ]
101412902 patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751 ]
101422259 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
101412468 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
101414493 HLA class I histocompatibility antigen, B-42 alpha chain-like isoform X1 [KO:K06751 ]
101442691 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
101432034 H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
101424334 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
101415212 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
101442654 BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751 ]
101433987 PDCD1LG2; programmed cell death 1 ligand 2 isoform X3 [KO:K06708 ]
101441279 VTCN1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747 ]
101440382 CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
101429768 TIGIT; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350 ]
101419295 SELPLG; LOW QUALITY PROTEIN: P-selectin glycoprotein ligand 1 [KO:K06544 ]
101447757 MADCAM1; LOW QUALITY PROTEIN: mucosal addressin cell adhesion molecule 1 [KO:K06779 ]
101425639 L1CAM; LOW QUALITY PROTEIN: neural cell adhesion molecule L1 [KO:K06550 ]
101421347 LRRC4; leucine-rich repeat-containing protein 4 isoform X1 [KO:K16351 ]
101446848 LRRC4B; LOW QUALITY PROTEIN: leucine-rich repeat-containing protein 4B [KO:K16360 ]
Reference
Authors
Barclay AN.
Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
Journal
Reference
Authors
Sharpe AH, Freeman GJ.
Title
The B7-CD28 superfamily.
Journal
Reference
Authors
Grewal IS, Flavell RA.
Title
CD40 and CD154 in cell-mediated immunity.
Journal
Reference
Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
Journal
Reference
Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
Title
Cell adhesion and polarity during immune interactions.
Journal
Reference
Authors
Dejana E.
Title
Endothelial cell-cell junctions: happy together.
Journal
Reference
Authors
Bazzoni G.
Title
The JAM family of junctional adhesion molecules.
Journal
Reference
Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
Title
Endothelial function and hemostasis.
Journal
Reference
Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
Title
Cell adhesion molecules--update.
Journal
Reference
Authors
Muller WA.
Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
Journal
Reference
Authors
Yamagata M, Sanes JR, Weiner JA.
Title
Synaptic adhesion molecules.
Journal
Reference
Authors
Ethell IM, Pasquale EB.
Title
Molecular mechanisms of dendritic spine development and remodeling.
Journal
Reference
Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
Journal
Reference
Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
Journal
Reference
Authors
Dunican DJ, Doherty P.
Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
Journal
Reference
Authors
Girault JA, Peles E.
Title
Development of nodes of Ranvier.
Journal
Reference
Authors
Arroyo EJ, Scherer SS.
Title
On the molecular architecture of myelinated fibers.
Journal
Reference
Authors
Salzer JL.
Title
Polarized domains of myelinated axons.
Journal
Reference
Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
Title
Roles and modes of action of nectins in cell-cell adhesion.
Journal
Reference
Authors
Nakanishi H, Takai Y.
Title
Roles of nectins in cell adhesion, migration and polarization.
Journal
Reference
Authors
Siu MK, Cheng CY.
Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
Journal
Reference
Authors
Lee NP, Cheng CY.
Title
Adaptors, junction dynamics, and spermatogenesis.
Journal
Reference
Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
Journal
Reference
Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
Title
Cadherin-based cell adhesion in neuromuscular development.
Journal
Reference
Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
Journal
Related pathway
dnm04610 Complement and coagulation cascades
dnm04660 T cell receptor signaling pathway
dnm04670 Leukocyte transendothelial migration
KO pathway
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