KEGG   DISEASE: HIV感染症
エントリ  
H01563                                                             
名称    
HIV感染症
概要    
The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS). Two types of HIV has been characterized. HIV-1 is the most virulent and pathogenic strain. Worldwide, the predominant virus is HIV-1. The relatively uncommon HIV-2 type is concentrated in West Africa and is rarely found elsewhere. Infection with HIV occurs by transfer of blood, semen, and breast milk. The identification of HIV as the causative agent of AIDS catalyzed efforts to develop antiviral agents. The licenced anti-HIV drugs fall into some categories: reverse transcriptase inhibitors (NRTIs and NNRTIs), integrase inhibitors, protease inhibitors (PIs), fusion inhibitors (FIs), and coreceptor inhibitors. The advent of highly active antiretroviral therapy (HAART) as the standard of care for the treatment of HIV infection was seminal in reducing the morbidity and mortality associated with HIV infection and progression to AIDS. Combination antiretroviral therapy dramatically suppresses HIV replication and reduces the plasma HIV-1 viral load, resulting in significant reconstitution of the immune system. Genetic susceptibility to HIV infection and AIDS progression is variable among individuals and populations, and in part genetically determined. Genetic variants of genes encoding HIV co-receptors and their chemokine ligands have been described, and some of these variants were associated with resistance to HIV infection and/or disease progression.
カテゴリ  
感染症
階層分類  
感染症疾患 [BR:jp08401]
 ウイルス感染症
  ssRNA-RTウイルスによる感染症
   H01563  HIV感染症
ICD-11 による疾患分類 [BR:jp08403]
 01 感染症・寄生虫症
  ヒト免疫不全ウイルス病
   1C62  結核またはマラリアが言及されていないヒト免疫不全ウイルス病
    H01563  HIV感染症
パスウェイ 
hsa05170  ヒト免疫不全ウイルス1感染
関連パスウェイ
hsa04060  Cytokine-cytokine receptor interaction
hsa04061  Viral protein interaction with cytokine and cytokine receptor
hsa04062  Chemokine signaling pathway
hsa04620  Toll-like receptor signaling pathway
ネットワーク
nt06123  TNF signaling (viruses and bacteria)
nt06124  Chemokine signaling (viruses)
nt06129  MHC presentation (viruses)
nt06130  Cell cycle (viruses)
nt06131  Apoptosis (viruses and bacteria)
nt06134  CGAS-STING signaling (viruses and bacteria)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
nt06516  TNF signaling
nt06517  TLR signaling
nt06520  CGAS-STING signaling
病因遺伝子 
CCR5 (resistance) [HSA:1234] [KO:K04180]
CCR2 (resistance) [HSA:729230] [KO:K04177]
TLR3 (resistance) [HSA:7098] [KO:K05401]
CXCL12 (resistance) [HSA:6387] [KO:K10031]
CCL2 (resistance) [HSA:6347] [KO:K14624]
CCL3 (resistance) [HSA:6348] [KO:K05408]
CCL11 (resistance) [HSA:6356] [KO:K16597]
IL10 (susceptibility) [HSA:3586] [KO:K05443]
CD209 (susceptibility) [HSA:30835] [KO:K06563]
HLA-C (susceptibility) [HSA:3107] [KO:K06751]
CCL3L1 (susceptibility) [HSA:6349] [KO:K05408]
IFNG (rapid progression) [HSA:3458] [KO:K04687]
CX3CR1 (rapid progression) [HSA:1524] [KO:K04192]
CXCR1 (slow progression) [HSA:3577] [KO:K04175]
IL4R (slow progression) [HSA:3566] [KO:K05071]
CCL5 (delayed/rapid progression) [HSA:6352] [KO:K12499]
KIR3DL1 (delayed/rapid progression) [HSA:3811] [KO:K07980]
病原体   
Human immunodeficiency virus 1 (HIV-1) [GN:T40001]
Human immunodeficiency virus 2 (HIV-2) [GN:T40002]
治療薬   
リトナビル [DR:D00427]
ホスアンプレナビルカルシウム水和物 [DR:D02867]
アタザナビル硫酸塩 [DR:D01276]
ダルナビルエタノール付加物 [DR:D06478]
ジドブジン [DR:D00413]
ラミブジン [DR:D00353]
アバカビル硫酸塩 [DR:D00891]
テノホビルジソプロキシルフマル酸塩 [DR:D01982]
エムトリシタビン [DR:D01199]
ネビラピン [DR:D00435]
エファビレンツ [DR:D00896]
エトラビリン [DR:D04112]
リルピビリン [DR:D09720]
リルピビリン塩酸塩 [DR:D09958]
ドラビリン [DR:D10624]
ラルテグラビルカリウム [DR:D07133]
ドルテグラビルナトリウム [DR:D10113]
カボテグラビル [DR:D10548]
カボテグラビルナトリウム [DR:D10549]
ジドブジン・ラミブジン [DR:D07507]
アバカビル硫酸塩・ラミブジン [DR:D08775]
エムトリシタビン・テノホビルジソプロキシルフマル酸塩 [DR:D02297]
エルビテグラビル・コビシスタット・エムトリシタビン・テノホビルジソプロキシル [DR:D10756]
ロピナビル・リトナビル [DR:D02498]
ドルテグラビル・アバカビル・ラミブジン [DR:D10600]
ダルナビルエタノール付加物・コビシスタット [DR:D10832]
エムトリシタビン・テノホビルアラフェナミド [DR:D10835]
エルビテグラビル・コビシスタット・エムトリシタビン・テノホビルアラフェナミド [DR:D10755]
エムトリシタビン・リルピビリン・テノホビルアラフェナミド [DR:D10836]
ビクテグラビル・エムトリシタビン・テノホビルアラフェナミド [DR:D11039]
ドルテグラビルナトリウム・リルピビリン塩酸塩 [DR:D11282]
ダルナビル・コビシスタット・エムトリシタビン・テノホビルアラフェナミド [DR:D11382]
ドルテグラビル・ラミブジン [DR:D11522]
マラビロク [DR:D06670] (CCR5指向性)
エンフビルチド [DR:D02499]
エルビテグラビル [DR:D06677]
コメント  
See also H00406 Acquired immunodeficiency syndrome (AIDS).
リンク   
ICD-11: 1C62
ICD-10: B24
MeSH: D015658
OMIM: 609423
文献    
  著者
Yousaf MZ, Zia S, Babar ME, Ashfaq UA
  タイトル
The epidemic of HIV/AIDS in developing countries; the current scenario in Pakistan.
  雑誌
Virol J 8:401 (2011)
DOI:10.1186/1743-422X-8-401
文献    
PMID:20149939 (CCR5)
  著者
An P, Winkler CA
  タイトル
Host genes associated with HIV/AIDS: advances in gene discovery.
  雑誌
Trends Genet 26:119-31 (2010)
DOI:10.1016/j.tig.2010.01.002
文献    
PMID:16978874 (CCR5, CCR2, CX3CR1, CCL3, CCL4, CCL5, CXCL12)
  著者
Arenzana-Seisdedos F, Parmentier M
  タイトル
Genetics of resistance to HIV infection: Role of co-receptors and co-receptor ligands.
  雑誌
Semin Immunol 18:387-403 (2006)
DOI:10.1016/j.smim.2006.07.007
文献    
PMID:15167933 (CCR5, CCR2, CCL5, CXCL12, CXCR6, CCL2, CCL7. CCL11, IL10)
  著者
O'Brien SJ, Nelson GW
  タイトル
Human genes that limit AIDS.
  雑誌
Nat Genet 36:565-74 (2004)
DOI:10.1038/ng1369
文献    
PMID:22174453 (TLR3)
  著者
Sironi M, Biasin M, Cagliani R, Forni D, De Luca M, Saulle I, Lo Caputo S, Mazzotta F, Macias J, Pineda JA, Caruz A, Clerici M
  タイトル
A common polymorphism in TLR3 confers natural resistance to HIV-1 infection.
  雑誌
J Immunol 188:818-23 (2012)
DOI:10.4049/jimmunol.1102179
文献    
PMID:11121048 (IL10)
  著者
Shin HD, Winkler C, Stephens JC, Bream J, Young H, Goedert JJ, O'Brien TR, Vlahov D, Buchbinder S, Giorgi J, Rinaldo C, Donfield S, Willoughby A, O'Brien SJ, Smith MW
  タイトル
Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10.
  雑誌
Proc Natl Acad Sci U S A 97:14467-72 (2000)
DOI:10.1073/pnas.97.26.14467
文献    
PMID:15564514 (CD209)
  著者
Martin MP, Lederman MM, Hutcheson HB, Goedert JJ, Nelson GW, van Kooyk Y, Detels R, Buchbinder S, Hoots K, Vlahov D, O'Brien SJ, Carrington M
  タイトル
Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection.
  雑誌
J Virol 78:14053-6 (2004)
DOI:10.1128/JVI.78.24.14053-14056.2004
文献    
PMID:30128812 (HLA-C)
  著者
Bardeskar NS, Chavan V, Ahir-Bist S, Nanavati R, Samant-Mavani P, Mehta P, Mania-Pramanik J
  タイトル
Human leukocyte antigen (HLA)-C and its association with HIV-1 transmission in discordant couple and mother-to-child cohorts.
  雑誌
Immunogenetics 70:633-638 (2018)
DOI:10.1007/s00251-018-1075-1
文献    
PMID:19812560 (CCL3L1)
  著者
Urban TJ, Weintrob AC, Fellay J, Colombo S, Shianna KV, Gumbs C, Rotger M, Pelak K, Dang KK, Detels R, Martinson JJ, O'Brien SJ, Letvin NL, McMichael AJ, Haynes BF, Carrington M, Telenti A, Michael NL, Goldstein DB
  タイトル
CCL3L1 and HIV/AIDS susceptibility.
  雑誌
Nat Med 15:1110-2 (2009)
DOI:10.1038/nm1009-1110
文献    
PMID:12854077 (IFNG)
  著者
An P, Vlahov D, Margolick JB, Phair J, O'Brien TR, Lautenberger J, O'Brien SJ, Winkler CA
  タイトル
A tumor necrosis factor-alpha-inducible promoter variant of interferon-gamma accelerates CD4+ T cell depletion in human immunodeficiency virus-1-infected individuals.
  雑誌
J Infect Dis 188:228-31 (2003)
DOI:10.1086/376455
文献    
PMID:10731151 (CX3CR1)
  著者
Faure S, Meyer L, Costagliola D, Vaneensberghe C, Genin E, Autran B, Delfraissy JF, McDermott DH, Murphy PM, Debre P, Theodorou I, Combadiere C
  タイトル
Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1.
  雑誌
Science 287:2274-7 (2000)
DOI:10.1126/science.287.5461.2274
文献    
PMID:17360650 (CXCR1)
  著者
Vasilescu A, Terashima Y, Enomoto M, Heath S, Poonpiriya V, Gatanaga H, Do H, Diop G, Hirtzig T, Auewarakul P, Lauhakirti D, Sura T, Charneau P, Marullo S, Therwath A, Oka S, Kanegasaki S, Lathrop M, Matsushima K, Zagury JF, Matsuda F
  タイトル
A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1+ patients.
  雑誌
Proc Natl Acad Sci U S A 104:3354-9 (2007)
DOI:10.1073/pnas.0611670104
文献    
PMID:16189667 (IL4R)
  著者
Soriano A, Lozano F, Oliva H, Garcia F, Nomdedeu M, De Lazzari E, Rodriguez C, Barrasa A, Lorenzo JI, Del Romero J, Plana M, Miro JM, Gatell JM, Vives J, Gallart T
  タイトル
Polymorphisms in the interleukin-4 receptor alpha chain gene influence susceptibility to HIV-1 infection and its progression to AIDS.
  雑誌
Immunogenetics 57:644-54 (2005)
DOI:10.1007/s00251-005-0041-x
文献    
PMID:18976921 (KIR3DL1)
  著者
Carrington M, Martin MP, van Bergen J
  タイトル
KIR-HLA intercourse in HIV disease.
  雑誌
Trends Microbiol 16:620-7 (2008)
DOI:10.1016/j.tim.2008.09.002
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