KEGG   PATHWAY: ecoa00230
Entry
ecoa00230                   Pathway                                
Name
Purine metabolism - Escherichia coli APEC O78 (APEC)
Class
Metabolism; Nucleotide metabolism
Pathway map
ecoa00230  Purine metabolism
ecoa00230

Module
ecoa_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ecoa00230]
ecoa_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ecoa00230]
ecoa_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ecoa00230]
ecoa_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ecoa00230]
ecoa_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ecoa00230]
ecoa_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ecoa00230]
ecoa_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:ecoa00230]
Other DBs
GO: 0006163 0042278
Organism
Escherichia coli APEC O78 (APEC) [GN:ecoa]
Gene
APECO78_18990  ADP-ribose pyrophosphatase NudF [KO:K01515] [EC:3.6.1.13 3.6.1.-]
APECO78_20775  adenosine nucleotide hydrolase NudE [KO:K08312] [EC:3.6.1.-]
APECO78_03365  phosphopentomutase [KO:K01839] [EC:5.4.2.7]
APECO78_20690  putative mutase [KO:K01839] [EC:5.4.2.7]
APECO78_06985  phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
APECO78_09910  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
APECO78_15380  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
APECO78_00790  phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
APECO78_16225  phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
APECO78_13060  phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
APECO78_16515  phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
APECO78_16220  phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
APECO78_06110  N5-carboxyaminoimidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
APECO78_06115  phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
APECO78_16090  phosphoribosylaminoimidazole-succinocarboxamide [KO:K01923] [EC:6.3.2.6]
APECO78_09615  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
APECO78_00795  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
APECO78_05865  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
APECO78_05920  ushA; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor [KO:K11751] [EC:3.1.3.5 3.6.1.45]
APECO78_17310  stationary phase survival protein SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
APECO78_06915  UMP phosphatase [KO:K02566] [EC:3.1.3.5]
APECO78_20785  GMP/IMP nucleotidase [KO:K20881] [EC:3.1.3.-]
APECO78_05905  inosine/guanosine kinase [KO:K00892] [EC:2.7.1.73]
APECO78_15765  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
APECO78_03370  deoD; purine nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
APECO78_05460  hypothetical protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
APECO78_16695  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
APECO78_04065  hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
APECO78_16270  inosine 5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
APECO78_16320  mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-phosphodiesterase [KO:K00940] [EC:2.7.4.6]
APECO78_03420  inosine/xanthosine triphosphatase [KO:K01529] [EC:3.6.1.73]
APECO78_18505  dITP/XTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
APECO78_04620  xanthine-guanine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
APECO78_18045  xanthine dehydrogenase subunit XdhA [KO:K00087] [EC:1.17.1.4]
APECO78_18050  xanthine dehydrogenase subunit XdhB [KO:K13479] [EC:1.17.1.4]
APECO78_18055  xanthine dehydrogenase iron-sulfur-binding subunit [KO:K13480]
APECO78_04950  oxidoreductase with molybdenum-binding domain [KO:K11177] [EC:1.17.1.4]
APECO78_04955  oxidoreductase [KO:K11178] [EC:1.17.1.4]
APECO78_04960  aldehyde oxidoreductase 2Fe-2S subunit [KO:K13483]
APECO78_16265  guaA; GMP synthase [KO:K01951] [EC:6.3.5.2]
APECO78_03965  guanosine 5'-monophosphate oxidoreductase [KO:K00364] [EC:1.7.1.7]
APECO78_18130  guanine deaminase [KO:K01487] [EC:3.5.4.3]
APECO78_22080  guanylate kinase [KO:K00942] [EC:2.7.4.8]
APECO78_15000  ribonucleotide-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
APECO78_16965  ribonucleotide-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
APECO78_15005  putative ribonucleotide reductase, beta subunit [KO:K00526] [EC:1.17.4.1]
APECO78_16970  nrdF; ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
APECO78_02160  anaerobic ribonucleoside triphosphate reductase [KO:K21636] [EC:1.1.98.6]
APECO78_04240  dgt; deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
APECO78_15270  5'-nucleotidase [KO:K08722] [EC:3.1.3.89]
APECO78_03040  hypothetical protein [KO:K06952] [EC:3.1.3.89]
APECO78_04665  hypothetical protein [KO:K06952] [EC:3.1.3.89]
APECO78_06200  hypothetical protein [KO:K06952] [EC:3.1.3.89]
APECO78_14760  hypothetical protein [KO:K06952] [EC:3.1.3.89]
APECO78_22090  bifunctional (p)ppGpp synthetase II/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
APECO78_16235  exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
APECO78_22735  guanosine pentaphosphate phosphohydrolase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
APECO78_17535  (p)ppGpp synthetase I [KO:K00951] [EC:2.7.6.5]
APECO78_22860  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
APECO78_01815  adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
APECO78_11925  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
APECO78_13720  AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
APECO78_17595  hypothetical protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
APECO78_22175  cryptic adenine deaminase [KO:K01486] [EC:3.5.4.2]
APECO78_02045  cpdB; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein [KO:K01119] [EC:3.1.4.16 3.1.3.6]
APECO78_05890  adenylate kinase [KO:K00939] [EC:2.7.4.3]
APECO78_17520  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
APECO78_18980  cyclic 3',5'-adenosine monophosphate phosphodiesterase [KO:K03651] [EC:3.1.4.53]
APECO78_03705  diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
APECO78_17340  adenylylsulfate kinase [KO:K00860] [EC:2.7.1.25]
APECO78_17345  sulfate adenylyltransferase [KO:K00956] [EC:2.7.7.4]
APECO78_17350  sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
APECO78_13630  hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
APECO78_06055  allantoinase [KO:K01466] [EC:3.5.2.5]
APECO78_06075  allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
APECO78_06070  hypothetical protein [KO:K14977] [EC:3.5.3.26]
APECO78_06020  ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
APECO78_06080  ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
APECO78_05140  carbamate kinase [KO:K00926] [EC:2.7.2.2]
APECO78_06100  carbamate kinase [KO:K00926] [EC:2.7.2.2]
APECO78_18085  amino acid kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ecoa00030  Pentose phosphate pathway
ecoa00220  Arginine biosynthesis
ecoa00250  Alanine, aspartate and glutamate metabolism
ecoa00260  Glycine, serine and threonine metabolism
ecoa00340  Histidine metabolism
ecoa00630  Glyoxylate and dicarboxylate metabolism
ecoa00730  Thiamine metabolism
ecoa00740  Riboflavin metabolism
ecoa00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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