KEGG PATHWAY: eee04530

KEGG

PATHWAY: eee04530

Entry

eee04530                    Pathway

Name

Tight junction - Electrophorus electricus (electric eel)

Description

Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.

Class

Cellular Processes; Cellular community - eukaryotes

Pathway map

Tight junction

Other DBs

GO:

Organism

Electrophorus electricus (electric eel) [GN:eee]

Gene

arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]

ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]

f11r; junctional adhesion molecule A [KO:K06089]

prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]

afdn; afadin [KO:K05702]

rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]

cldn5; claudin-5 [KO:K06087]

gata4; transcription factor GATA-4 [KO:K09183]

[KO:K04440] [EC:2.7.11.24]

rap1a; ras-related protein Rap-1A [KO:K04353]

cldn20; claudin-20 [KO:K06087]

[KO:K04426] [EC:2.7.11.25]

[KO:K05704] [EC:2.7.10.2]

cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]

[KO:K18050] [EC:2.7.11.13]

tjap1; tight junction-associated protein 1 [KO:K06105]

[KO:K18050] [EC:2.7.11.13]

rab8b; ras-related protein Rab-8B [KO:K07902]

cftr; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]

pard6a; partitioning defective 6 homolog alpha [KO:K06093]

arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]

sympk; symplekin [KO:K06100]

[KO:K04440] [EC:2.7.11.24]

patj; inaD-like protein [KO:K06092]

jam2; junctional adhesion molecule B [KO:K06735]

itgb1; integrin beta-1 [KO:K05719]

tjp2; tight junction protein ZO-2 [KO:K06098]

hspa4; heat shock 70 kDa protein 4 [KO:K09489]

cgnl1; cingulin-like protein 1 isoform X1 [KO:K21110]

amotl2; angiomotin-like protein 2 [KO:K06104]

rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]

[KO:K05704] [EC:2.7.10.2]

map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]

erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]

cldn12; claudin-12 [KO:K06087]

whamm; WASP homolog-associated protein with actin, membranes and microtubules isoform X1 [KO:K20479]

llgl2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]

nf2; merlin isoform X1 [KO:K16684]

[KO:K04440] [EC:2.7.11.24]

ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]

rab13; ras-related protein Rab-13 [KO:K06109]

actr3; actin-related protein 3 [KO:K18584]

ccnd1; G1/S-specific cyclin-D1 [KO:K04503]

dlg2; disks large homolog 2 [KO:K12075]

was; wiskott-Aldrich syndrome protein [KO:K05747]

ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]

cldn34; claudin-34 [KO:K06087]

actr2; actin-related protein 2 [KO:K17260]

mpp5; MAGUK p55 subfamily member 5 [KO:K06091]

cttn; src substrate cortactin isoform X1 [KO:K06106]

micall2; MICAL-like protein 2 [KO:K21068]

map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]

cacna1d; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]

igsf5; immunoglobulin superfamily member 5 [KO:K06786]

magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]

prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]

prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]

arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]

pcna; proliferating cell nuclear antigen [KO:K04802]

dlg3; disks large homolog 3 isoform X1 [KO:K21098]

rab8a; ras-related protein Rab-8A [KO:K07901]

stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]

marveld2; MARVEL domain-containing protein 2 [KO:K17291]

ocln; occludin [KO:K06088]

arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]

prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]

nedd4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]

nedd4l; E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]

myh9; myosin-9 isoform X1 [KO:K10352]

llgl1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]

actb; actin, cytoplasmic 1 [KO:K05692]

[KO:K04382] [EC:3.1.3.16]

mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]

[KO:K04440] [EC:2.7.11.24]

cldn19; claudin-19 isoform X1 [KO:K06087]

[KO:K18952] [EC:2.7.11.13]

mpp4; MAGUK p55 subfamily member 4 [KO:K21109]

[KO:K04345] [EC:2.7.11.11]

crb3; protein crumbs homolog 3 [KO:K06090]

bves; blood vessel epicardial substance isoform X1 [KO:K21108]

synpo; synaptopodin isoform X1 [KO:K21112]

rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]

[KO:K17388] [EC:2.7.11.39]

arhgef2; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 2 [KO:K12791]

prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]

map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]

scrib; LOW QUALITY PROTEIN: protein scribble homolog [KO:K16175]

msn; moesin isoform X1 [KO:K05763]

dlg1; disks large homolog 1 isoform X1 [KO:K12076]

[KO:K04345] [EC:2.7.11.11]

mpdz; multiple PDZ domain protein [KO:K06095]

[KO:K04345] [EC:2.7.11.11]

Compound

Calcium cation

Reference

Authors

Zihni C, Mills C, Matter K, Balda MS

Title

Tight junctions: from simple barriers to multifunctional molecular gates.

Journal

Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80

Reference

Authors

Martin-Belmonte F, Perez-Moreno M

Title

Epithelial cell polarity, stem cells and cancer.

Journal

Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169

Reference

Authors

Weber C, Fraemohs L, Dejana E

Title

The role of junctional adhesion molecules in vascular inflammation.

Journal

Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096

Reference

Authors

Miyoshi J, Takai Y

Title

Molecular perspective on tight-junction assembly and epithelial polarity.

Journal

Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008

Reference

Authors

Mertens AE, Pegtel DM, Collard JG

Title

Tiam1 takes PARt in cell polarity.

Journal

Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001

Reference

Authors

Shin K, Fogg VC, Margolis B

Title

Tight junctions and cell polarity.

Journal

Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219

Reference

Authors

Kooistra MR, Dube N, Bos JL

Title

Rap1: a key regulator in cell-cell junction formation.

Journal

J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306

Reference

Authors

Gonzalez-Mariscal L, Tapia R, Chamorro D

Title

Crosstalk of tight junction components with signaling pathways.

Journal

Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018

Reference

Authors

Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D

Title

Polarity complex proteins.

Journal

Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029

Reference

Authors

Iden S, Collard JG

Title

Crosstalk between small GTPases and polarity proteins in cell polarization.

Journal

Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521

Reference

Authors

Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ

Title

PKC and the control of localized signal dynamics.

Journal

Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847

Reference

Authors

Terry S, Nie M, Matter K, Balda MS

Title

Rho signaling and tight junction functions.

Journal

Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009

Reference

Authors

Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS

Title

Bves modulates tight junction associated signaling.

Journal

PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563

Reference

Authors

Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P

Title

Regulation of small GTPases at epithelial cell-cell junctions.

Journal

Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101

Reference

Authors

Lickert H, Van Campenhout CA

Title

Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.

Journal

Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792

Reference

Authors

Spadaro D, Tapia R, Pulimeno P, Citi S

Title

The control of gene expression and cell proliferation by the epithelial apical junctional complex.

Journal

Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083

Reference

Authors

Moleirinho S, Guerrant W, Kissil JL

Title

The Angiomotins--from discovery to function.

Journal

FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006

Reference

Authors

Rodriguez-Boulan E, Macara IG

Title

Organization and execution of the epithelial polarity programme.

Journal

Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775

Reference

Authors

Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G

Title

Tight junctions and the regulation of gene expression.

Journal

Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009

Reference

Authors

Mack NA, Georgiou M

Title

The interdependence of the Rho GTPases and apicobasal cell polarity.

Journal

Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768

Reference

Authors

Citi S, Guerrera D, Spadaro D, Shah J

Title

Epithelial junctions and Rho family GTPases: the zonular signalosome.

Journal

Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760

Reference

Authors

Zihni C, Terry SJ

Title

RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.

Journal

Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020

Reference

Authors

Nakano A, Takashima S

Title

LKB1 and AMP-activated protein kinase: regulators of cell polarity.

Journal

Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x

Reference

Authors

Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B

Title

Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.

Journal

J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200

Reference

Authors

Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T

Title

The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.

Journal

Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551

Reference

Authors

Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA

Title

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.

Journal

Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298

Related
pathway

Adherens junction

Regulation of actin cytoskeleton

KO pathway

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