KEGG   PATHWAY: eee04530
Entry
eee04530                    Pathway                                
Name
Tight junction - Electrophorus electricus (electric eel)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
eee04530  Tight junction
eee04530

Other DBs
GO: 0005923
Organism
Electrophorus electricus (electric eel) [GN:eee]
Gene
113587867  crb3; protein crumbs homolog 3 [KO:K06090]
113579553  cldn34; claudin-34 [KO:K06087]
113578027  claudin-34-like [KO:K06087]
113582380  claudin-1-like [KO:K06087]
113574792  claudin-4-like [KO:K06087]
113574986  claudin-23-like [KO:K06087]
113574153  claudin-4-like [KO:K06087]
113576166  claudin-11-like [KO:K06087]
113576472  claudin-11-like [KO:K06087]
113580104  claudin-10-like [KO:K06087]
113586445  cldn19; claudin-19 isoform X1 [KO:K06087]
113583628  claudin-15-like [KO:K06087]
113585661  claudin-10-like [KO:K06087]
113585667  claudin-10-like isoform X1 [KO:K06087]
113582986  claudin-1-like [KO:K06087]
113589321  claudin-7-A [KO:K06087]
113588546  claudin-10-like isoform X1 [KO:K06087]
113588742  claudin-7-B-like [KO:K06087]
113587864  claudin-4-like [KO:K06087]
113572157  cldn20; claudin-20 [KO:K06087]
113575043  claudin-4-like [KO:K06087]
113574206  claudin-4-like [KO:K06087]
113575289  claudin-3-like [KO:K06087]
113575297  claudin-3-like [KO:K06087]
113579554  putative claudin-24 [KO:K06087]
113574657  claudin-14-like [KO:K06087]
113578730  claudin-8-like [KO:K06087]
113580127  claudin-10-like [KO:K06087]
113583225  claudin-4-like [KO:K06087]
113580301  claudin-10-like [KO:K06087]
113582456  claudin-14-like [KO:K06087]
113587967  claudin-18-like [KO:K06087]
113590064  claudin-4-like [KO:K06087]
113590265  claudin-9-like [KO:K06087]
113591236  claudin-9-like [KO:K06087]
113591447  claudin-15-like [KO:K06087]
113570775  claudin-20-like [KO:K06087]
113573219  claudin-like protein ZF-A89 [KO:K06087]
113574518  claudin-like protein ZF-A89 [KO:K06087]
113575931  claudin-18-like [KO:K06087]
113574108  claudin-4-like [KO:K06087]
113575080  claudin-like protein ZF-A89 [KO:K06087]
113577162  claudin-23-like [KO:K06087]
113575360  claudin-4-like [KO:K06087]
113576610  claudin-like protein ZF-A9 [KO:K06087]
113578632  putative claudin-24 [KO:K06087]
113576756  claudin-23-like [KO:K06087]
113576757  claudin-23-like [KO:K06087]
113579805  claudin-15-like [KO:K06087]
113585607  putative claudin-24 [KO:K06087]
113584957  claudin-4-like [KO:K06087]
113569075  claudin-15-like [KO:K06087]
113591141  claudin-23-like [KO:K06087]
113590268  claudin-4-like [KO:K06087]
113590269  claudin-4-like [KO:K06087]
113590270  claudin-4-like [KO:K06087]
113590272  claudin-like protein ZF-A89 [KO:K06087]
113590273  claudin-like protein ZF-A89 [KO:K06087]
113590274  claudin-4-like [KO:K06087]
113590275  claudin-4-like [KO:K06087]
113590277  claudin-3-like [KO:K06087]
113590278  claudin-3-like [KO:K06087]
113571062  cldn5; claudin-5 [KO:K06087]
113573692  claudin-15-like [KO:K06087]
113578729  claudin-8-like [KO:K06087]
113577066  cldn12; claudin-12 [KO:K06087]
113583516  ocln; occludin [KO:K06088]
113587965  occludin-like [KO:K06088]
113583961  occludin-like [KO:K06088]
113570217  f11r; junctional adhesion molecule A [KO:K06089]
113574581  jam2; junctional adhesion molecule B [KO:K06735]
113567717  junctional adhesion molecule B-like [KO:K06735]
113574634  junctional adhesion molecule C-like isoform X1 [KO:K06785]
113585111  junctional adhesion molecule C-like [KO:K06785]
113588146  bves; blood vessel epicardial substance isoform X1 [KO:K21108]
113575458  cell division control protein 42 homolog [KO:K04393]
113586656  cell division control protein 42 homolog isoform X1 [KO:K04393]
113572585  cell division control protein 42 homolog [KO:K04393]
113585692  partitioning defective 6 homolog gamma-like [KO:K06093]
113575673  partitioning defective 6 homolog gamma-like [KO:K06093]
113587976  partitioning defective 6 homolog beta-like isoform X1 [KO:K06093]
113573637  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
113579871  mpp5; MAGUK p55 subfamily member 5 [KO:K06091]
113587728  mpp4; MAGUK p55 subfamily member 4 [KO:K21109]
113576202  tight junction protein ZO-3-like [KO:K06097]
113574468  patj; inaD-like protein [KO:K06092]
113591685  mpdz; multiple PDZ domain protein [KO:K06095]
113586870  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
113584149  prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
113582207  angiomotin-like [KO:K16819]
113575895  amotl2; angiomotin-like protein 2 [KO:K06104]
113587590  angiomotin-like 2a [KO:K06104]
113578978  angiomotin-like protein 1 [KO:K06104]
113574894  rho GTPase-activating protein 17-like isoform X1 [KO:K20638]
113573208  rho GTPase-activating protein 17-like [KO:K20638]
113584625  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
113575309  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113577757  nf2; merlin isoform X1 [KO:K16684]
113574049  merlin-like isoform X1 [KO:K16684]
113577648  llgl2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
113584937  llgl1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
113579531  disks large homolog 1-like isoform X1 [KO:K12076]
113590541  dlg1; disks large homolog 1 isoform X1 [KO:K12076]
113589904  scrib; LOW QUALITY PROTEIN: protein scribble homolog [KO:K16175]
113583192  protein scribble homolog [KO:K16175]
113578036  ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
113586037  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
113569990  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
113579598  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
113591355  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
113587414  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
113579365  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
113585754  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
113582095  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like isoform X1 [KO:K04354]
113587338  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform-like [KO:K04354]
113572467  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
113591642  partitioning defective 3 homolog isoform X1 [KO:K04237]
113579404  partitioning defective 3 homolog [KO:K04237]
113581762  tight junction protein ZO-1-like isoform X1 [KO:K05701]
113576698  LOW QUALITY PROTEIN: tight junction protein ZO-1-like [KO:K05701]
113572753  tjap1; tight junction-associated protein 1 [KO:K06105]
113579027  dlg2; disks large homolog 2 [KO:K12075]
113582656  dlg3; disks large homolog 3 isoform X1 [KO:K21098]
113584271  nedd4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
113584578  nedd4l; E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
113590612  cingulin-like [KO:K06102]
113572624  cingulin-like isoform X1 [KO:K06102]
113575723  cgnl1; cingulin-like protein 1 isoform X1 [KO:K21110]
113571869  cingulin-like protein 1 isoform X1 [KO:K21110]
113589117  arhgef2; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 2 [KO:K12791]
113584952  LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 2-like [KO:K12791]
113575836  rho-related GTP-binding protein RhoA-B [KO:K04513]
113582797  transforming protein RhoA-like [KO:K04513]
113587089  rho-related GTP-binding protein RhoA-C isoform X1 [KO:K04513]
113587285  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
113583072  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
113572085  rho-related GTP-binding protein RhoA-D [KO:K04513]
113571114  gata4; transcription factor GATA-4 [KO:K09183]
113575756  MARVEL domain-containing protein 3-like isoform X1 [KO:K21099]
113585990  MARVEL domain-containing protein 3-like [KO:K21099]
113576764  map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
113578033  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
113574265  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
113586292  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
113586306  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
113571260  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
113589106  transcription factor AP-1-like [KO:K04448]
113582834  transcription factor AP-1-like [KO:K04448]
113568701  transcription factor AP-1-like [KO:K04448]
113573602  cftr; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
113572459  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
113573784  sympk; symplekin [KO:K06100]
113582494  pcna; proliferating cell nuclear antigen [KO:K04802]
113578962  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
113588422  G1/S-specific cyclin-D1-like [KO:K04503]
113576854  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
113582633  runt-related transcription factor 1-like isoform X1 [KO:K08367]
113575597  hspa4; heat shock 70 kDa protein 4 [KO:K09489]
113584052  heat shock 70 kDa protein 4-like [KO:K09489]
113576831  Na(+)/H(+) exchange regulatory cofactor NHE-RF1-like [KO:K13365]
113572816  Na(+)/H(+) exchange regulatory cofactor NHE-RF1-like [KO:K13365]
113574149  ezrin-like isoform X1 [KO:K08007]
113587028  ezrin-like isoform X1 [KO:K08007]
113571167  ezrin-like isoform X1 [KO:K08007]
113580336  radixin isoform X1 [KO:K05762]
113590074  msn; moesin isoform X1 [KO:K05763]
113572717  protein kinase C epsilon type-like isoform X1 [KO:K18050] [EC:2.7.11.13]
113572795  protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
113580904  actin, cytoplasmic 1 [KO:K05692]
113585569  actb; actin, cytoplasmic 1 [KO:K05692]
113580442  cacna1d; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
113579158  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
113572229  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
113589755  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
113580330  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
113576303  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
113572439  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
113569665  LOW QUALITY PROTEIN: src substrate cortactin-like [KO:K06106]
113580128  cttn; src substrate cortactin isoform X1 [KO:K06106]
113579657  actr2; actin-related protein 2 [KO:K17260]
113585161  actin-related protein 2-A-like [KO:K17260]
113572712  actin-related protein 2-A isoform X1 [KO:K17260]
113578559  actr3; actin-related protein 3 [KO:K18584]
113580267  actin-related protein 2/3 complex subunit 1A-A-like [KO:K05757]
113582006  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
113569982  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
113583705  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
113585138  actin-related protein 2/3 complex subunit 2-A-like [KO:K05758]
113573735  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
113576019  actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
113589954  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
113583609  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
113588486  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
113567915  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
113588345  actin-related protein 2/3 complex subunit 5-A-like [KO:K05754]
113577285  whamm; WASP homolog-associated protein with actin, membranes and microtubules isoform X1 [KO:K20479]
113581095  wiskott-Aldrich syndrome protein-like [KO:K05747]
113579131  was; wiskott-Aldrich syndrome protein [KO:K05747]
113581169  vasodilator-stimulated phosphoprotein-like isoform X1 [KO:K06274]
113591278  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
113581910  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
113587857  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
113592026  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
113578307  rab13; ras-related protein Rab-13 [KO:K06109]
113577828  rho guanine nucleotide exchange factor 28-like [KO:K21066]
113584136  rho guanine nucleotide exchange factor 18-like [KO:K21066]
113588249  rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
113588491  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.1]
113576241  rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
113583613  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
113571031  LOW QUALITY PROTEIN: myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
113571909  band 4.1-like protein 5 [KO:K21111]
113582890  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
113589709  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
113570222  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
113584832  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
113568139  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
113592101  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
113587227  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
113578530  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
113573808  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
113581537  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
113570062  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
113584782  myosin-9-like [KO:K10352]
113584784  myosin-10 [KO:K10352]
113584852  myh9; myosin-9 isoform X1 [KO:K10352]
113588786  myosin-11-like [KO:K10352]
113575982  myosin light polypeptide 6 isoform X1 [KO:K12751]
113590296  myosin light polypeptide 6-like isoform X1 [KO:K12751]
113582345  myosin regulatory light polypeptide 9-like [KO:K12755]
113569661  myosin regulatory light polypeptide 9 [KO:K12755]
113579317  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
113579113  myosin regulatory light chain 2, smooth muscle minor isoform-like isoform X1 [KO:K12757]
113585004  uncharacterized protein LOC113585004 [KO:K06786]
113580709  igsf5; immunoglobulin superfamily member 5 [KO:K06786]
113580438  LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1-like [KO:K05631]
113580745  magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
113588226  synpo; synaptopodin isoform X1 [KO:K21112]
113589928  alpha-actinin-4-like [KO:K05699]
113574674  alpha-actinin-1 isoform X1 [KO:K05699]
113574951  MICAL-like protein 2 isoform X1 [KO:K21068]
113580252  micall2; MICAL-like protein 2 [KO:K21068]
113582881  rab8a; ras-related protein Rab-8A [KO:K07901]
113567561  ras-related protein Rab-8B [KO:K07902]
113573109  rab8b; ras-related protein Rab-8B [KO:K07902]
113578024  rap guanine nucleotide exchange factor 6-like [KO:K08020]
113586523  ras-related protein Rap-1b-like [KO:K04353]
113572077  rap1a; ras-related protein Rap-1A [KO:K04353]
113568006  integrin beta-1-like isoform X1 [KO:K05719]
113574768  itgb1; integrin beta-1 [KO:K05719]
113570299  afdn; afadin [KO:K05702]
113575593  tjp2; tight junction protein ZO-2 [KO:K06098]
113580041  tight junction protein ZO-2-like isoform X1 [KO:K06098]
113586113  rap guanine nucleotide exchange factor 2-like isoform X1 [KO:K08018]
113570740  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
113579235  ras-related protein Rap-2c [KO:K07839]
113583503  marveld2; MARVEL domain-containing protein 2 [KO:K17291]
113583939  MARVEL domain-containing protein 2-like isoform X1 [KO:K17291]
113588693  tubulin alpha-1A chain-like isoform X1 [KO:K07374]
113588694  tubulin alpha-1B chain [KO:K07374]
113572092  tubulin alpha chain, testis-specific-like [KO:K07374]
113578577  tubulin alpha-1C chain isoform X1 [KO:K07374]
113578583  tubulin alpha-1A chain [KO:K07374]
113583891  tubulin alpha chain, testis-specific-like [KO:K07374]
113580047  tubulin alpha chain isoform X1 [KO:K07374]
113584283  tubulin alpha chain-like [KO:K07374]
113584284  tubulin alpha chain-like [KO:K07374]
113579196  tubulin alpha chain-like [KO:K07374]
113590646  tubulin alpha chain-like isoform X1 [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
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Related
pathway
eee04520  Adherens junction
eee04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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