KEGG   PATHWAY: eee04810
Entry
eee04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Electrophorus electricus (electric eel)
Class
Cellular Processes; Cell motility
Pathway map
eee04810  Regulation of actin cytoskeleton
eee04810

Other DBs
GO: 0030036
Organism
Electrophorus electricus (electric eel) [GN:eee]
Gene
113567915  [KO:K05754]
113567938  c6; complement component C6 [KO:K03995]
113567981  [KO:K02649]
113568006  [KO:K05719]
113568043  [KO:K03914]
113568058  [KO:K05759]
113568362  [KO:K04358]
113568414  [KO:K04456] [EC:2.7.11.1]
113568528  [KO:K02085]
113568533  [KO:K05718]
113568728  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113569081  [KO:K06482]
113569661  [KO:K12755]
113569760  pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
113569771  [KO:K04438]
113569982  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
113570316  pip4k2c; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
113570362  [KO:K04275]
113570523  chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
113570573  [KO:K00907] [EC:2.7.11.18]
113570686  itga10; integrin alpha-10 [KO:K06586]
113570755  [KO:K12753]
113570756  crkl; crk-like protein [KO:K04438]
113570786  fgf10; fibroblast growth factor 10 [KO:K04358]
113571031  [KO:K10351]
113571167  [KO:K08007]
113571234  iqgap3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
113571245  [KO:K05725] [EC:2.7.10.2]
113571264  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
113571327  pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
113571331  [KO:K04133]
113571342  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113571697  [KO:K03916]
113571897  arhgef1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
113572041  wasf1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
113572052  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
113572054  itgb8; integrin beta-8 [KO:K06591]
113572085  [KO:K04513]
113572248  [KO:K06269] [EC:3.1.3.16]
113572287  [KO:K04366] [EC:2.7.11.1]
113572439  [KO:K05704] [EC:2.7.10.2]
113572458  itga7; integrin alpha-7 isoform X1 [KO:K06583]
113572532  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
113572585  [KO:K04393]
113572638  [KO:K03916]
113572682  [KO:K03915]
113572712  [KO:K17260]
113572826  itgb3; integrin beta-3 [KO:K06493]
113572862  [KO:K07860]
113572921  limk2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
113573024  [KO:K05627]
113573027  c5; complement C5 [KO:K03994]
113573210  [KO:K06476]
113573277  [KO:K06493]
113573290  apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
113573364  [KO:K04129]
113573599  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
113573657  chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
113573703  gsn; gelsolin isoform X1 [KO:K05768]
113573728  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
113573735  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
113573753  [KO:K05769]
113573809  [KO:K27976]
113573903  [KO:K05769]
113573979  limk1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
113574000  [KO:K00907] [EC:2.7.11.18]
113574149  [KO:K08007]
113574177  lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
113574264  [KO:K07861]
113574477  [KO:K00889] [EC:2.7.1.68]
113574607  cyfip1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
113574674  [KO:K05699]
113574713  [KO:K05766] [EC:3.1.3.16 3.1.3.48]
113574731  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
113574768  itgb1; integrin beta-1 [KO:K05719]
113574856  [KO:K04639]
113575042  scin; adseverin [KO:K05768]
113575082  [KO:K27976]
113575198  [KO:K04347]
113575273  [KO:K00889] [EC:2.7.1.68]
113575309  [KO:K04392]
113575389  [KO:K05759]
113575458  [KO:K04393]
113575555  [KO:K00889] [EC:2.7.1.68]
113575581  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
113575586  [KO:K04358]
113575754  rras2; ras-related protein R-Ras2 [KO:K07830]
113575817  [KO:K23612]
113575836  [KO:K04513]
113575855  [KO:K05720]
113575940  itgb7; integrin beta-7 [KO:K06590]
113576019  [KO:K05755]
113576211  itga2; integrin alpha-2 [KO:K06481]
113576222  fgf22; fibroblast growth factor 22 [KO:K04358]
113576241  rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
113576303  [KO:K05704] [EC:2.7.10.2]
113576367  [KO:K04410] [EC:2.7.11.1]
113576413  itga5; integrin alpha-5 [KO:K06484]
113576533  [KO:K26108]
113576794  pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
113576872  [KO:K12758]
113576883  [KO:K06269] [EC:3.1.3.16]
113576927  ssh1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
113576959  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
113577041  itga8; integrin alpha-8 [KO:K06584]
113577112  itgb5; integrin beta-5 [KO:K06588]
113577123  rgcc; regulator of cell cycle RGCC [KO:K26108]
113577151  [KO:K05740]
113577153  [KO:K04358]
113577217  [KO:K06464]
113577375  nras; GTPase NRas [KO:K07828]
113577615  lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
113577720  [KO:K03099]
113577831  kng1; kininogen-1 [KO:K03898]
113577848  fgf4; fibroblast growth factor 4 [KO:K04358]
113577916  [KO:K05627]
113577967  fgf3; fibroblast growth factor 3 [KO:K04358]
113578009  sos1; son of sevenless homolog 1 [KO:K03099]
113578087  [KO:K04358]
113578091  fgf23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
113578361  [KO:K00889] [EC:2.7.1.68]
113578378  akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113578538  abi2; abl interactor 2 isoform X1 [KO:K05751]
113578559  actr3; actin-related protein 3 [KO:K18584]
113578658  [KO:K05732]
113578705  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
113578786  fgf19; fibroblast growth factor 19 [KO:K22603]
113578884  c7; complement component C7 [KO:K03996]
113578896  brk1; protein BRICK1 [KO:K05752]
113579113  [KO:K12757]
113579240  fgf20; fibroblast growth factor 20 [KO:K04358]
113579247  cfl1; cofilin-1 [KO:K05765]
113579256  [KO:K05627]
113579317  [KO:K12757]
113579351  cfl2; cofilin-2 [KO:K05765]
113579372  [KO:K04410] [EC:2.7.11.1]
113579380  vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
113579639  [KO:K04456] [EC:2.7.11.1]
113579657  actr2; actin-related protein 2 [KO:K17260]
113579694  [KO:K02833]
113579735  [KO:K04130]
113579855  pfn4; profilin-4 isoform X1 [KO:K05759]
113579942  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
113580068  [KO:K00889] [EC:2.7.1.68]
113580203  [KO:K00907] [EC:2.7.11.18]
113580257  [KO:K04639]
113580267  [KO:K05757]
113580274  rras; ras-related protein R-Ras [KO:K07830]
113580284  rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
113580336  [KO:K05762]
113580354  [KO:K13710]
113580463  [KO:K05722]
113580494  iqgap2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
113580495  f2r; proteinase-activated receptor 1 [KO:K03914]
113580611  [KO:K04366] [EC:2.7.11.1]
113580699  [KO:K10031]
113580868  [KO:K12758]
113580904  [KO:K05692]
113580997  arhgef12; rho guanine nucleotide exchange factor 12 [KO:K07532]
113581016  gna12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
113581043  fam49a; protein FAM49A isoform X1 [KO:K27976]
113581289  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
113581312  hras; GTPase HRas [KO:K02833]
113581447  nckap1l; nck-associated protein 1-like [KO:K05750]
113581460  [KO:K04358]
113581478  [KO:K07831]
113581484  [KO:K04359]
113581526  [KO:K06485]
113581716  [KO:K00920] [EC:2.7.1.149]
113581843  [KO:K04291]
113581882  [KO:K05765]
113581978  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
113582006  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
113582049  [KO:K05700]
113582103  itga11; integrin alpha-11 [KO:K06587]
113582116  [KO:K04438]
113582234  [KO:K06269] [EC:3.1.3.16]
113582345  [KO:K12755]
113582430  pdgfc; platelet-derived growth factor C [KO:K05450]
113582524  [KO:K05743] [EC:2.7.11.1]
113582530  itgb6; integrin beta-6 isoform X1 [KO:K06589]
113582600  [KO:K04189]
113582642  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
113582658  [KO:K05766] [EC:3.1.3.16 3.1.3.48]
113582771  [KO:K05766] [EC:3.1.3.16 3.1.3.48]
113582797  [KO:K04513]
113582930  [KO:K23612]
113583039  myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K12756]
113583053  arhgef6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
113583072  [KO:K04513]
113583144  [KO:K05741]
113583379  [KO:K10031]
113583546  slc9a1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
113583609  [KO:K05754]
113583613  [KO:K10351]
113583629  [KO:K06269] [EC:3.1.3.16]
113583634  c9; complement component C9 [KO:K04000]
113583643  [KO:K05766] [EC:3.1.3.16 3.1.3.48]
113583656  [KO:K06587]
113583705  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
113583782  [KO:K00907] [EC:2.7.11.18]
113584274  [KO:K05717]
113584370  itgae; integrin alpha-E isoform X1 [KO:K06524]
113584625  [KO:K04392]
113584672  [KO:K04369] [EC:2.7.12.2]
113584720  nckap1; nck-associated protein 1 isoform X1 [KO:K05750]
113584750  itga3; integrin alpha-3 isoform X1 [KO:K06482]
113584782  [KO:K10352]
113584784  [KO:K10352]
113584852  myh9; myosin-9 isoform X1 [KO:K10352]
113584976  [KO:K04358]
113584997  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113584998  itga4; integrin alpha-4 [KO:K06483]
113585129  enah; LOW QUALITY PROTEIN: protein enabled homolog [KO:K05746]
113585138  [KO:K05758]
113585161  [KO:K17260]
113585300  [KO:K04189]
113585352  fgf7; fibroblast growth factor 7 [KO:K04358]
113585459  [KO:K04358]
113585519  fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
113585569  actb; actin, cytoplasmic 1 [KO:K05692]
113585589  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
113585613  chrm4; muscarinic acetylcholine receptor M4 [KO:K04132]
113585737  [KO:K17386]
113585976  [KO:K00889] [EC:2.7.1.68]
113586139  cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
113586200  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
113586382  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
113586599  [KO:K06485]
113586656  [KO:K04393]
113586857  [KO:K05733] [EC:2.7.11.1]
113587028  [KO:K08007]
113587089  [KO:K04513]
113587165  [KO:K02649]
113587186  [KO:K05764]
113587239  [KO:K00907] [EC:2.7.11.18]
113587285  [KO:K04513]
113587510  [KO:K03996]
113587515  [KO:K06461]
113587734  [KO:K05751]
113587946  [KO:K04361] [EC:2.7.10.1]
113587958  itgb4; integrin beta-4 isoform X1 [KO:K06525]
113588015  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
113588107  [KO:K04291]
113588109  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
113588166  [KO:K00907] [EC:2.7.11.18]
113588173  [KO:K04362] [EC:2.7.10.1]
113588232  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113588249  rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
113588326  itga9; integrin alpha-9 [KO:K06585]
113588345  [KO:K05754]
113588356  wasf2; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
113588371  diaph2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
113588388  itga6; integrin alpha-6 isoform X1 [KO:K06485]
113588416  [KO:K04358]
113588486  [KO:K05754]
113588491  [KO:K17388] [EC:2.7.11.39]
113588524  [KO:K07827]
113588584  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113588662  [KO:K13710]
113588676  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
113588775  [KO:K06482]
113588786  [KO:K10352]
113588804  itgav; integrin alpha-V [KO:K06487]
113588809  ppp1r12b; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
113588867  [KO:K05764]
113588908  mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
113588939  [KO:K04369] [EC:2.7.12.2]
113589054  [KO:K00920] [EC:2.7.1.149]
113589062  c8g; complement component C8 gamma chain [KO:K03999]
113589130  [KO:K05732]
113589172  [KO:K22429]
113589230  [KO:K06269] [EC:3.1.3.16]
113589328  [KO:K04347]
113589334  [KO:K05768]
113589363  fgf2; fibroblast growth factor 2 [KO:K18497]
113589387  fgf16; fibroblast growth factor 16 [KO:K04358]
113589562  vav1; proto-oncogene vav isoform X1 [KO:K05730]
113589671  fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
113589839  [KO:K05736] [EC:2.7.11.1]
113589852  [KO:K07827]
113589856  fgf5; fibroblast growth factor 5 [KO:K04358]
113589928  [KO:K05699]
113589954  [KO:K05755]
113590057  [KO:K06269] [EC:3.1.3.16]
113590074  msn; moesin isoform X1 [KO:K05763]
113590159  [KO:K05742]
113590302  [KO:K27976]
113590308  [KO:K05768]
113590386  itga1; integrin alpha-1 [KO:K06480]
113590490  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
113590517  [KO:K04358]
113590621  [KO:K04358]
113590645  ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
113590710  [KO:K05759]
113590739  [KO:K05764]
113590831  [KO:K17457]
113590856  [KO:K04347]
113591036  c8b; complement component C8 beta chain [KO:K03998]
113591037  c8a; complement component C8 alpha chain [KO:K03997]
113591186  arhgef4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
113591262  [KO:K05700]
113591380  [KO:K04131]
113591428  ins; insulin [KO:K04526]
113591632  [KO:K04129]
113591659  [KO:K04131]
113591753  mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
113592047  [KO:K04371] [EC:2.7.11.24]
113592099  mras; ras-related protein M-Ras isoform X1 [KO:K07831]
113592115  [KO:K05760]
113592196  [KO:K12756]
113592322  f2; prothrombin [KO:K01313] [EC:3.4.21.5]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
eee04010  MAPK signaling pathway
eee04510  Focal adhesion
eee04520  Adherens junction
KO pathway
ko04810   

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