KEGG   PATHWAY: esp03320
Entry
esp03320                    Pathway                                
Name
PPAR signaling pathway - Etheostoma spectabile (orangethroat darter)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
esp03320  PPAR signaling pathway
esp03320

Organism
Etheostoma spectabile (orangethroat darter) [GN:esp]
Gene
116669401  [KO:K08751]
116669668  [KO:K08756]
116670782  [KO:K00507] [EC:1.14.19.1]
116670957  acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
116671246  [KO:K08765] [EC:2.3.1.21]
116671370  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
116671424  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
116672175  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
116672830  [KO:K07294]
116672894  acsl3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
116673290  cd36; platelet glycoprotein 4 isoform X1 [KO:K06259]
116673863  [KO:K00488] [EC:1.14.15.15]
116673976  [KO:K08762]
116674125  gk; glycerol kinase isoform X1 [KO:K00864] [EC:2.7.1.30]
116674195  acadl; long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00255] [EC:1.3.8.8]
116674596  dbi; acyl-CoA-binding protein [KO:K08762]
116674779  [KO:K04504]
116676532  [KO:K08525]
116677320  [KO:K08749]
116677604  slc27a6; long-chain fatty acid transport protein 6 [KO:K08749]
116677877  [KO:K08749]
116678350  [KO:K08761]
116679866  [KO:K08756]
116683564  [KO:K06086]
116685273  [KO:K08761]
116686574  [KO:K17284]
116687521  [KO:K08746] [EC:6.2.1.- 6.2.1.3]
116687542  slc27a2; very long-chain acyl-CoA synthetase [KO:K08746] [EC:6.2.1.- 6.2.1.3]
116687862  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
116687875  pparg; peroxisome proliferator-activated receptor gamma [KO:K08530]
116688240  [KO:K08771]
116689120  [KO:K15013] [EC:6.2.1.3]
116690034  [KO:K08750]
116690228  [KO:K01897] [EC:6.2.1.3]
116691040  [KO:K08524]
116691403  me1; NADP-dependent malic enzyme [KO:K00029] [EC:1.1.1.40]
116691459  [KO:K08758]
116691651  [KO:K08753]
116691766  nr1h3; oxysterols receptor LXR-alpha [KO:K08536]
116692336  [KO:K04504]
116693333  [KO:K10226] [EC:1.14.19.3]
116693334  [KO:K10226] [EC:1.14.19.3]
116693640  [KO:K07294]
116693871  [KO:K08746] [EC:6.2.1.- 6.2.1.3]
116694557  [KO:K08765] [EC:2.3.1.21]
116694687  cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K08765] [EC:2.3.1.21]
116694784  acsbg1; long-chain-fatty-acid--CoA ligase ACSBG1 [KO:K15013] [EC:6.2.1.3]
116694952  acsbg2; long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1 [KO:K15013] [EC:6.2.1.3]
116695129  lpl; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
116695130  [KO:K01059] [EC:3.1.1.34]
116695515  [KO:K08767]
116695737  [KO:K08526]
116695793  cpt2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
116696870  [KO:K01897] [EC:6.2.1.3]
116697257  [KO:K08755]
116697434  acsl4; long-chain-fatty-acid--CoA ligase 4 [KO:K01897] [EC:6.2.1.3]
116697553  [KO:K00488] [EC:1.14.15.15]
116697745  me3; NADP-dependent malic enzyme, mitochondrial [KO:K00029] [EC:1.1.1.40]
116697840  [KO:K00864] [EC:2.7.1.30]
116698260  ehhadh; peroxisomal bifunctional enzyme isoform X1 [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
116698785  [KO:K01897] [EC:6.2.1.3]
116698840  [KO:K08745] [EC:6.2.1.-]
116699099  [KO:K01897] [EC:6.2.1.3]
116699114  scp2; non-specific lipid-transfer protein [KO:K08764] [EC:2.3.1.176]
116699150  acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
116699432  [KO:K17284]
116699572  [KO:K08767]
116699647  [KO:K00489] [EC:1.14.14.23]
116699738  [KO:K08755]
116699759  [KO:K07431] [EC:1.14.14.139]
116699762  [KO:K08751]
116700041  acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
116700545  ubb; LOW QUALITY PROTEIN: polyubiquitin-B [KO:K08770]
116701018  [KO:K06272] [EC:2.7.11.1]
116701025  acsl6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
116701227  [KO:K08752]
116701402  [KO:K08525]
116701817  [KO:K08752]
116702582  [KO:K08765] [EC:2.3.1.21]
116703666  slc27a1; long-chain fatty acid transport protein 1 [KO:K08745] [EC:6.2.1.-]
116703933  slc27a4; long-chain fatty acid transport protein 4 [KO:K08745] [EC:6.2.1.-]
116704096  rxra; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
116704632  [KO:K08749]
116705697  [KO:K00507] [EC:1.14.19.1]
116706142  fabp7; fatty acid-binding protein, brain [KO:K08756]
116707175  [KO:K00232] [EC:1.3.3.6]
116707222  [KO:K00232] [EC:1.3.3.6]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
esp00071  Fatty acid degradation
esp00120  Primary bile acid biosynthesis
esp00564  Glycerophospholipid metabolism
esp04920  Adipocytokine signaling pathway
KO pathway
ko03320   

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