KEGG   PATHWAY: gaf00590
Entry
gaf00590                    Pathway                                
Name
Arachidonic acid metabolism - Gambusia affinis (western mosquitofish)
Class
Metabolism; Lipid metabolism
Pathway map
gaf00590  Arachidonic acid metabolism
gaf00590

Other DBs
GO: 0019369
Organism
Gambusia affinis (western mosquitofish) [GN:gaf]
Gene
122833061  proca1; uncharacterized protein proca1 [KO:K01047] [EC:3.1.1.4]
122819596  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
122819710  pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
122827867  group 3 secretory phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
122821499  pla2g10; group 10 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
122828290  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
122828291  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
122842916  pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
122829058  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
122829097  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
122838744  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
122821315  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
122829972  pla2g6; LOW QUALITY PROTEIN: 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
122846558  plb1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
122825857  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
122846165  phospholipase A and acyltransferase 4-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
122836962  phospholipase A and acyltransferase 3-like isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
122826947  plaat1l; phospholipase A and acyltransferase 1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
122827777  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
122819447  pdcl; phosducin-like protein [KO:K00509] [EC:1.14.99.1]
122828438  ptgs1; prostaglandin G/H synthase 1 isoform X1 [KO:K00509] [EC:1.14.99.1]
122838735  ptgs2b; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
122846770  ptges; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
122828209  ptgesl; prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
122837536  ptges3a; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
122839019  ptges3b; prostaglandin E synthase 3b isoform X1 [KO:K15730] [EC:5.3.99.3]
122842620  cbr1; carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
122834478  prxl2b; prostamide/prostaglandin F synthase [KO:K15717] [EC:1.11.1.20]
122844754  zgc:56585; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
122828958  hpgd; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
122835737  tbxas1; thromboxane-A synthase [KO:K01832] [EC:5.3.99.5]
122844471  lipocalin-like [KO:K01830] [EC:5.3.99.2]
122823927  lipocalin-like [KO:K01830] [EC:5.3.99.2]
122833576  ptgis; prostacyclin synthase [KO:K01831] [EC:5.3.99.4]
122834642  prostacyclin synthase-like [KO:K01831] [EC:5.3.99.4]
122843057  alox5a; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
122826774  lta4h; leukotriene A-4 hydrolase [KO:K01254] [EC:3.3.2.6]
122831526  prostaglandin reductase 3-like [KO:K07119] [EC:1.3.1.48]
122845771  ptgr2; prostaglandin reductase 2 [KO:K13949] [EC:1.3.1.48]
122820375  prostaglandin reductase 1-like [KO:K13948] [EC:1.3.1.74 1.3.1.48]
122820386  prostaglandin reductase 1-like [KO:K13948] [EC:1.3.1.74 1.3.1.48]
122837076  ltc4s; leukotriene C4 synthase isoform X1 [KO:K00807] [EC:4.4.1.20]
122819179  ggt5b; glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
122819302  ggt1b; glutathione hydrolase 1 proenzyme isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
122828301  ggt5a; gamma-glutamyltransferase 5a [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
122828305  ggt1a; LOW QUALITY PROTEIN: gamma-glutamyltransferase 1a [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
122838806  gpx4a; glutathione peroxidase 4a isoform X1 [KO:K05361] [EC:1.11.1.12]
122840802  phospholipid hydroperoxide glutathione peroxidase-like [KO:K05361] [EC:1.11.1.12]
122838407  cytochrome P450 2J4-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
122838408  cytochrome P450 2J4-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
122838409  cytochrome P450 2J4-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
122838410  cytochrome P450 2J4-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
122838411  cytochrome P450 2J4-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
122829086  cytochrome P450 2U1 isoform X1 [KO:K07422] [EC:1.14.14.80]
122820467  alox12; arachidonate 12-lipoxygenase, 12S-type [KO:K00458] [EC:1.13.11.31]
122825686  hydroperoxide isomerase ALOXE3-like [KO:K18684] [EC:4.2.1.152 5.4.4.7]
122845455  zgc:152891; polyunsaturated fatty acid lipoxygenase ALOX8 [KO:K08022] [EC:1.13.11.33 1.13.11.-]
122830234  polyunsaturated fatty acid lipoxygenase ALOX15B-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
122829020  arachidonate 12-lipoxygenase, 12R-type-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
122829021  arachidonate 12-lipoxygenase, 12R-type-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
122826945  ephx2; bifunctional epoxide hydrolase 2 isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
gaf00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

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