KEGG PATHWAY: gaf03440

KEGG

PATHWAY: gaf03440

Entry

gaf03440                    Pathway

Name

Homologous recombination - Gambusia affinis (western mosquitofish)

Description

Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.

Class

Genetic Information Processing; Replication and repair

Pathway map

Homologous recombination

Other DBs

GO:

Organism

Gambusia affinis (western mosquitofish) [GN:gaf]

Gene

mus81; LOW QUALITY PROTEIN: crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]

top3a; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]

pold1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]

[KO:K10605] [EC:2.3.2.27]

eme1; crossover junction endonuclease EME1 isoform X1 [KO:K10882] [EC:3.1.22.-]

xrcc2; DNA repair protein XRCC2 [KO:K10879]

topbp1; DNA topoisomerase 2-binding protein 1 [KO:K10728]

rbbp8; DNA endonuclease RBBP8 isoform X1 [KO:K20773] [EC:3.1.-.-]

xrcc3; DNA repair protein XRCC3 isoform X1 [KO:K10880]

ssbp1; single-stranded DNA-binding protein, mitochondrial [KO:K03111]

top3b; DNA topoisomerase 3-beta-1 isoform X1 [KO:K03165] [EC:5.6.2.1]

pold2; DNA polymerase delta subunit 2 [KO:K02328]

pold4; DNA polymerase delta subunit 4 [KO:K03505]

palb2; partner and localizer of BRCA2 [KO:K10897]

rad54b; DNA repair and recombination protein RAD54B isoform X1 [KO:K10877] [EC:5.6.2.-]

nbn; nibrin [KO:K10867]

rpa2; replication protein A 32 kDa subunit [KO:K10739]

atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]

brca2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]

brip1; Fanconi anemia group J protein isoform X1 [KO:K15362] [EC:5.6.2.3]

rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]

mre11a; double-strand break repair protein MRE11 isoform X1 [KO:K10865]

blm; Bloom syndrome protein homolog isoform X1 [KO:K10901] [EC:5.6.2.4]

rad52; DNA repair protein RAD52 homolog isoform X1 [KO:K10873]

sycp3; synaptonemal complex protein 3 [KO:K19528]

rad54l; DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]

babam1; BRISC and BRCA1-A complex member 1 [KO:K20776]

rad51c; DNA repair protein RAD51 homolog 3 [KO:K10870]

bard1; BRCA1-associated RING domain protein 1 [KO:K10683]

pold3; DNA polymerase delta subunit 3 isoform X1 [KO:K03504]

rpa3; replication protein A 14 kDa subunit [KO:K10740]

rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]

rad51d; DNA repair protein RAD51 homolog 4 isoform X1 [KO:K10871]

uimc1; BRCA1-A complex subunit RAP80 isoform X1 [KO:K20775]

babam2; BRISC and BRCA1-A complex member 2 [KO:K12173]

abraxas1; BRCA1-A complex subunit Abraxas 1 isoform X1 [KO:K20774]

brcc3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]

Reference

Authors

Maloisel L, Fabre F, Gangloff S.

Title

DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.

Journal

Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07

Reference

Authors

Haruta-Takahashi N, Iwasaki H.

Title

[Recombination mediators]

Journal

Seikagaku 79:449-53 (2007)

Reference

Authors

Ouyang KJ, Woo LL, Ellis NA.

Title

Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.

Journal

Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003

Reference

Authors

Kawabata M, Kawabata T, Nishibori M.

Title

Role of recA/RAD51 family proteins in mammals.

Journal

Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987

Reference

Authors

Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.

Title

Mitotic recombination in Saccharomyces cerevisiae.

Journal

Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3

Reference

Authors

Heyer WD, Li X, Rolfsmeier M, Zhang XP.

Title

Rad54: the Swiss Army knife of homologous recombination?

Journal

Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481

Reference

Authors

Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.

Title

Recombination proteins and rescue of arrested replication forks.

Journal

DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016

KO pathway

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